What is the potential for inhaled p38 inhibitors in the treatment of chronic obstructive pulmonary disease?

Inhalation by Design: Novel Ultra-Long-Acting β2-Adrenoreceptor Agonists for Inhaled Once-Daily Treatment of Asthma and Chronic Obstructive Pulmonary Disease That Utilize a Sulfonamide Agonist Headgroup

(2010) Paul A. Glossop et al.   JOURNAL OF MEDICINAL CHEMISTRY

Aerosol drug delivery: developments in device design and clinical use

(2010) Myrna B Dolovich et al.   LANCET

Efficacy and safety of pamapimod in patients with active rheumatoid arthritis receiving stable methotrexate therapy

(2009) R E Alten et al.   ANNALS OF THE RHEUMATIC DISEASES

Evaluation of the efficacy and safety of pamapimod, a p38 MAP kinase inhibitor, in a double-blind, methotrexate-controlled study of patients with active rheumatoid arthritis

(2009) Stanley B. Cohen et al.   ARTHRITIS AND RHEUMATISM

Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: Results of two randomized, double-blind, placebo-controlled clinical studies

(2009) Nemanja Damjanov et al.   ARTHRITIS AND RHEUMATISM

Inhibition of p38: Has the fat lady sung?

(2009) Mark C. Genovese   ARTHRITIS AND RHEUMATISM

Selective p38α Inhibitors Clinically Evaluated for the Treatment of Chronic Inflammatory Disorders

(2009) David M. Goldstein et al.   JOURNAL OF MEDICINAL CHEMISTRY

Glucocorticoid resistance in inflammatory diseases

(2009) Peter J Barnes et al.   LANCET

The as-yet unfulfilled promise of p38 MAPK inhibitors

(2009) Susan E. Sweeney   Nature Reviews Rheumatology

Frontrunners in novel pharmacotherapy of COPD

(2008) P BARNES   CURRENT OPINION IN PHARMACOLOGY

Therapeutic potential of inhaled p38 mitogen-activated protein kinase inhibitors for inflammatory pulmonary diseases

(2008) Puneet Chopra et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Increased activation of p38 MAPK in COPD

(2007) T. Renda et al.   EUROPEAN RESPIRATORY JOURNAL

Do airway clearance mechanisms influence the local and systemic effects of inhaled corticosteroids?

(2007) Staffan Edsbäcker et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS