Toxoplasmahistone acetylation remodelers as novel drug targets

Lysine Acetylation Is Widespread on Proteins of Diverse Function and Localization in the Protozoan Parasite Toxoplasma gondii

(2012) Victoria Jeffers et al.   EUKARYOTIC CELL

New antibacterials for the treatment of toxoplasmosis; a patent review

(2012) Juan Bautista Rodriguez et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

HDAC inhibitors for the treatment of cutaneous T-cell lymphomas

(2012) Sophia Rangwala et al.   Future Medicinal Chemistry

Brain cancer mortality rates increase with Toxoplasma gondii seroprevalence in France

(2012) Marion Vittecoq et al.   INFECTION GENETICS AND EVOLUTION

Congenital parasitic infections: A review

(2011) Yves Carlier et al.   ACTA TROPICA

Small Molecule Inhibitors of Histone Acetyltransferases as Epigenetic Tools and Drug Candidates

(2011) Silviya D. Furdas et al.   ARCHIV DER PHARMAZIE

Histone variants and epigenetic inheritance

(2011) Gang Yuan et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Vorinostat-Induced Apoptosis in Mantle Cell Lymphoma Is Mediated by Acetylation of Proapoptotic BH3-Only Gene Promoters

(2011) S. Xargay-Torrent et al.   CLINICAL CANCER RESEARCH

HDAC inhibitors in parasitic diseases

(2011) Katherine T Andrews et al.   IMMUNOLOGY AND CELL BIOLOGY

Histone H4 Acetylation Differentially Modulates Arginine Methylation by an inCisMechanism

(2011) You Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting HDACs: A Promising Therapy for Alzheimer's Disease

(2011) Ke Xu et al.   Oxidative Medicine and Cellular Longevity

Involvement of a Toxoplasma gondii Chromatin Remodeling Complex Ortholog in Developmental Regulation

(2011) Peggy J. Rooney et al.   PLoS One

Aberrant Regulation of HDAC2 Mediates Proliferation of Hepatocellular Carcinoma Cells by Deregulating Expression of G1/S Cell Cycle Proteins

(2011) Ji Heon Noh et al.   PLoS One

Activity of the Histone Deacetylase Inhibitor FR235222 on Toxoplasma gondii: Inhibition of Stage Conversion of the Parasite Cyst Form and Study of New Derivative Compounds

(2010) D. Maubon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Chromatin modifications: implications in the regulation of gene expression inToxoplasma gondii

(2010) Alexandre Bougdour et al.   CELLULAR MICROBIOLOGY

MYST Family Lysine Acetyltransferase Facilitates Ataxia Telangiectasia Mutated (ATM) Kinase-mediated DNA Damage Response inToxoplasma gondii

(2010) Nathalie Vonlaufen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A decade of epigenetic research in Toxoplasma gondii

(2010) Stacy E. Dixon et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Regions of intrinsic disorder help identify a novel nuclear localization signal in Toxoplasma gondii histone acetyltransferase TgGCN5-B

(2010) Stacy E. Dixon et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The Apicomplexan AP2 family: Integral factors regulating Plasmodium development

(2010) Heather J. Painter et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

An insertional trap for conditional gene expression in Toxoplasma gondii: Identification of TAF250 as an essential gene

(2010) Lauren Jammallo et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Epigenetic mechanisms regulate stage differentiation in the minimized protozoanGiardia lamblia

(2010) Sabrina Sonda et al.   MOLECULAR MICROBIOLOGY

The program for processing newly synthesized histones H3.1 and H4

(2010) Eric I Campos et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Is there any role of Toxoplasma gondii in the etiology of obsessive–compulsive disorder?

(2010) Ozlem Miman et al.   PSYCHIATRY RESEARCH

Regulation of Cellular Metabolism by Protein Lysine Acetylation

(2010) S. Zhao et al.   SCIENCE

Toxoplasma gondii: epidemiology, feline clinical aspects, and prevention

(2010) Stacey A. Elmore et al.   TRENDS IN PARASITOLOGY

Toxoplasma gondii Lysine Acetyltransferase GCN5-A Functions in the Cellular Response to Alkaline Stress and Expression of Cyst Genes

(2010) Arunasalam Naguleswaran et al.   PLoS Pathogens

A Complex Small RNA Repertoire Is Generated by a Plant/Fungal-Like Machinery and Effected by a Metazoan-Like Argonaute in the Single-Cell Human Parasite Toxoplasma gondii

(2010) Laurence Braun et al.   PLoS Pathogens

Histone Deacetylases Play a Major Role in the Transcriptional Regulation of the Plasmodium falciparum Life Cycle

(2010) Balbir K. Chaal et al.   PLoS Pathogens

Antimalarial and antileishmanial activities of histone deacetylase inhibitors with triazole-linked cap group

(2009) Vishal Patil et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Enhancing the apoptotic and therapeutic effects of HDAC inhibitors

(2009) Ailsa J. Frew et al.   CANCER LETTERS

RNA-mediated chromatin-based silencing in plants

(2009) Marjori Matzke et al.   CURRENT OPINION IN CELL BIOLOGY

Drug inhibition of HDAC3 and epigenetic control of differentiation in Apicomplexa parasites

(2009) Alexandre Bougdour et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Toxoplasma H2A Variants Reveal Novel Insights into Nucleosome Composition and Functions for this Histone Family

(2009) Maria C. Dalmasso et al.   JOURNAL OF MOLECULAR BIOLOGY

Global Histone Analysis by Mass Spectrometry Reveals a High Content of Acetylated Lysine Residues in the Malaria ParasitePlasmodium falciparum

(2009) Morten B. Trelle et al.   JOURNAL OF PROTEOME RESEARCH

Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni

(2009) Florence Dubois et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Protein methyltransferases as a target class for drug discovery

(2009) Robert A. Copeland et al.   NATURE REVIEWS DRUG DISCOVERY

Toxoplasma and schizophrenia

(2009) R. H. YOLKEN et al.   PARASITE IMMUNOLOGY

Proteome-wide prediction of acetylation substrates

(2009) A. Basu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Sir2 Paralogues Cooperate to Regulate Virulence Genes and Antigenic Variation in Plasmodium falciparum

(2009) Christopher J Tonkin et al.   PLOS BIOLOGY

Potent Antimalarial Activity of Histone Deacetylase Inhibitor Analogues

(2008) K. T. Andrews et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Histone Acetyltransferase Inhibitor Anacardic Acid Causes Changes in Global Gene Expression during In VitroPlasmodium falciparumDevelopment

(2008) Long Cui et al.   EUKARYOTIC CELL

Plasmodium chabaudi: Efficacy of artemisinin+curcumin combination treatment on a clone selected for artemisinin resistance in mice

(2008) Axel Martinelli et al.   EXPERIMENTAL PARASITOLOGY

Schistosoma mansoni: Developmental arrest of miracidia treated with histone deacetylase inhibitors

(2008) A. Azzi et al.   EXPERIMENTAL PARASITOLOGY

Nicotinamide inhibits Plasmodium falciparum Sir2 activity in vitro and parasite growth

(2008) Dhaneswar Prusty et al.   FEMS MICROBIOLOGY LETTERS

An apicomplexan ankyrin-repeat histone deacetylase with relatives in photosynthetic eukaryotes

(2008) S. Dean Rider et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Biochemical characterization of Plasmodium falciparum Sir2, a NAD+-dependent deacetylase

(2008) Subhra Prakash Chakrabarty et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The transcription of bradyzoite genes inToxoplasma gondiiis controlled by autonomous promoter elements

(2008) Michael S. Behnke et al.   MOLECULAR MICROBIOLOGY