Glucocorticoid-induced TNFR-related gene (GITR) as a therapeutic target for immunotherapy

Chemokine regulation of innate lymphoid cell tissue distribution and function

(2018) Alessandra Soriani et al.   CYTOKINE & GROWTH FACTOR REVIEWS

GITR cosignal in ILC2s controls allergic lung inflammation

(2018) Hiroyuki Nagashima et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Next generation of immune checkpoint therapy in cancer: new developments and challenges

(2018) Julian A. Marin-Acevedo et al.   Journal of Hematology & Oncology

The promise and challenges of immune agonist antibody development in cancer

(2018) Patrick A. Mayes et al.   NATURE REVIEWS DRUG DISCOVERY

Influenza-Activated ILC1s Contribute to Antiviral Immunity Partially Influenced by Differential GITR Expression

(2018) Neha Vashist et al.   Frontiers in Immunology

Potential effect of tumor-specific Treg-targeted antibodies in the treatment of human cancers: A bioinformatics analysis

(2017) Luigi Cari et al.   OncoImmunology

GITR ligand fusion protein agonist enhances the tumor antigen–specific CD8 T-cell response and leads to long-lasting memory

(2017) Nick M. Durham et al.   Journal for ImmunoTherapy of Cancer

Dual Roles for Regulatory T-cell Depletion and Costimulatory Signaling in Agonistic GITR Targeting for Tumor Immunotherapy

(2016) Ashley E. Mahne et al.   CANCER RESEARCH

Rationale for anti-GITR cancer immunotherapy

(2016) Deborah A. Knee et al.   EUROPEAN JOURNAL OF CANCER

Modulation of tumor immunity: a patent evaluation of WO2015026684A1

(2016) Giuseppe Nocentini et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

GITR Activation Positively Regulates Immune Responses against Toxoplasma gondii

(2016) Frederico R. C. Costa et al.   PLoS One

GITR+ regulatory T cells in the treatment of autoimmune diseases

(2015) Maria Grazia Petrillo et al.   AUTOIMMUNITY REVIEWS

Authentic GITR Signaling Fails To Induce Tumor Regression unless Foxp3+Regulatory T Cells Are Depleted

(2015) Young H. Kim et al.   JOURNAL OF IMMUNOLOGY

Glucocorticoid-induced tumor necrosis factor receptor–related protein co-stimulation facilitates tumor regression by inducing IL-9–producing helper T cells

(2015) Il-Kyu Kim et al.   NATURE MEDICINE

GITR subverts Foxp3+ Tregs to boost Th9 immunity through regulation of histone acetylation

(2015) Xiang Xiao et al.   Nature Communications

Enhanced CD8 T Cell Responses through GITR-Mediated Costimulation Resolve Chronic Viral Infection

(2015) Maria Fernanda Pascutti et al.   PLoS Pathogens

Glucocorticoid-Induced Tumour Necrosis Factor Receptor-Related Protein: A Key Marker of Functional Regulatory T Cells

(2015) Simona Ronchetti et al.   Journal of Immunology Research

Cell-specific and context-dependent effects of GITR in cancer, autoimmunity, and infection

(2014) Derek L. Clouthier et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Genetic and epigenetic basis of Treg cell development and function: from a FoxP3-centered view to an epigenome-defined view of natural Treg cells

(2014) Hiromasa Morikawa et al.   IMMUNOLOGICAL REVIEWS

JNK2 Regulates the Functional Plasticity of Naturally Occurring T Regulatory Cells and the Enhancement of Lung Allergic Responses

(2014) Anthony Joetham et al.   JOURNAL OF IMMUNOLOGY

Combined PD-1 blockade and GITR triggering induce a potent antitumor immunity in murine cancer models and synergizes with chemotherapeutic drugs

(2014) Lei Lu et al.   Journal of Translational Medicine

Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells

(2014) Shawn A Mahmud et al.   NATURE IMMUNOLOGY

The TNF family in T cell differentiation and function – Unanswered questions and future directions

(2014) Michael Croft   SEMINARS IN IMMUNOLOGY

Expansion of regulatory GITR+CD25low/-CD4+ T cells in systemic lupus erythematosus patients

(2014) Giuseppe Nocentini et al.   ARTHRITIS RESEARCH & THERAPY

Combination of Alphavirus Replicon Particle-Based Vaccination with Immunomodulatory Antibodies: Therapeutic Activity in the B16 Melanoma Mouse Model and Immune Correlates

(2014) F. Avogadri et al.   Cancer Immunology Research

In Vivo Targeting of Intratumor Regulatory T Cells Using PEG-Modified Single-Walled Carbon Nanotubes

(2013) Cristiano Sacchetti et al.   BIOCONJUGATE CHEMISTRY

Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies

(2013) Yannick Bulliard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Secreted and Transmembrane 1A Is a Novel Co-Stimulatory Ligand

(2013) Duncan Howie et al.   PLoS One

Characterization of a new regulatory CD4+ T cell subset in primary Sjogren's syndrome

(2013) A. Alunno et al.   RHEUMATOLOGY

GITR Pathway Activation Abrogates Tumor Immune Suppression through Loss of Regulatory T-cell Lineage Stability

(2013) D. A. Schaer et al.   Cancer Immunology Research

Modulation of GITR for cancer immunotherapy

(2012) David A Schaer et al.   CURRENT OPINION IN IMMUNOLOGY

Enhanced GITR/GITRL interactions augment IL-27 expression and induce IL-10-producing Tr-1 like cells

(2012) Yijun Carrier et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TGF-β of lung cancer microenvironment upregulates B7H1 and GITRL expression in dendritic cells and is associated with regulatory T cell generation

(2012) XIAO YAN NI et al.   ONCOLOGY REPORTS

Up-Regulation of GITRL on Dendritic Cells by WGP Improves Anti-Tumor Immunity in Murine Lewis Lung Carcinoma

(2012) Jie Tian et al.   PLoS One

Pharmacological modulation of GITRL/GITR system: therapeutic perspectives

(2011) Giuseppe Nocentini et al.   BRITISH JOURNAL OF PHARMACOLOGY

CD4+CD25lowGITR+ cells: A novel human CD4+ T-cell population with regulatory activity

(2011) Rodolfo Bianchini et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Th2 Responses to Helminth Parasites Can Be Therapeutically Enhanced by, but Are Not Dependent upon, GITR-GITR Ligand Costimulation In Vivo

(2011) N. van der Werf et al.   JOURNAL OF IMMUNOLOGY

Soluble multi-trimeric TNF superfamily ligand adjuvants enhance immune responses to a HIV-1 Gag DNA vaccine

(2011) Saravana K. Kanagavelu et al.   VACCINE

Control of Immunity by the TNFR-Related Molecule OX40 (CD134)

(2010) Michael Croft   Annual Review of Immunology

CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodies

(2010) H. E. Kohrt et al.   BLOOD

The glucocorticoid-induced TNF receptor family-related protein (GITR) is critical to the development of acute pancreatitis in mice

(2010) M Galuppo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Depletion of regulatory T cells by anti-GITR mAb as a novel mechanism for cancer immunotherapy

(2010) David Coe et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Glucocorticoid-Induced TNFR family Related gene (GITR) enhances dendritic cell activity

(2010) Simona Ronchetti et al.   IMMUNOLOGY LETTERS

GITR engagement preferentially enhances proliferation of functionally competent CD4+CD25+FoxP3+ regulatory T cells

(2010) Gongxian Liao et al.   INTERNATIONAL IMMUNOLOGY

CD8 T Cell-Intrinsic GITR Is Required for T Cell Clonal Expansion and Mouse Survival following Severe Influenza Infection

(2010) L. M. Snell et al.   JOURNAL OF IMMUNOLOGY

Combining T-cell Vaccination and Application of Agonistic Anti-GITR mAb (DTA-1) Induces Complete Eradication of HPV Oncogene Expressing Tumors in Mice

(2010) Corinna Hoffmann et al.   JOURNAL OF IMMUNOTHERAPY

Agonist Anti-GITR Monoclonal Antibody Induces Melanoma Tumor Immunity in Mice by Altering Regulatory T Cell Stability and Intra-Tumor Accumulation

(2010) Adam D. Cohen et al.   PLoS One

The GITRL–GITR system alters TLR-4 expression on DC during fungal infection

(2009) Anna Vecchiarelli et al.   CELLULAR IMMUNOLOGY

Sequence, structure, function, immunity: structural genomics of costimulation

(2009) Kausik Chattopadhyay et al.   IMMUNOLOGICAL REVIEWS

The Glucocorticoid-Induced TNF Receptor-Related Protein (GITR)-GITR Ligand Pathway Acts As a Mediator of Cutaneous Dendritic Cell Migration and Promotes T Cell-Mediated Acquired Immunity

(2009) Y. Kamimura et al.   JOURNAL OF IMMUNOLOGY

GITR Triggering Induces Expansion of Both Effector and Regulatory CD4+ T Cells In Vivo

(2009) R. W. van Olffen et al.   JOURNAL OF IMMUNOLOGY

Identification of Glucocorticoid-Induced TNF Receptor-Related Protein Ligand on Keratinocytes: Ligation by GITR Induces Keratinocyte Chemokine Production and Augments T-Cell Proliferation

(2009) Aideen M. Byrne et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Therapeutic Immunity by Adoptive Tumor-primed CD4+ T-cell Transfer in Combination With In Vivo GITR Ligation

(2009) Zuqiang Liu et al.   MOLECULAR THERAPY

Key Role of the GITR/GITRLigand Pathway in the Development of Murine Autoimmune Diabetes: A Potential Therapeutic Target

(2009) Sylvaine You et al.   PLoS One

Neutralization of tumor-derived soluble Glucocorticoid-Induced TNFR-Related Protein ligand increases NK cell anti-tumor reactivity

(2008) K. M. Baltz et al.   BLOOD

Localized expression of GITR-L in the tumor microenvironment promotes CD8+ T cell dependent anti-tumor immunity

(2008) John S. Cho et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Regulatory T Cell-Resistant CD8+ T Cells Induced by Glucocorticoid-Induced Tumor Necrosis Factor Receptor Signaling

(2008) H. Nishikawa et al.   CANCER RESEARCH

Construction and Preclinical Characterization of Fc-mGITRL for the Immunotherapy of Cancer

(2008) P. Hu et al.   CLINICAL CANCER RESEARCH

Enhancement of T-cell-mediated anti-tumour immunity via the ectopically expressed glucocorticoid-induced tumour necrosis factor receptor-related receptor ligand (GITRL) on tumours

(2008) Jinhua Piao et al.   IMMUNOLOGY

Glucocorticoid-induced Tumor Necrosis Factor Receptor Negatively Regulates Activation of Human Primary Natural Killer (NK) Cells by Blocking Proliferative Signals and Increasing NK Cell Apoptosis

(2008) Baoying Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucocorticoid-Induced Tumor Necrosis Factor Receptor-Related (GITR)-Fc Fusion Protein Inhibits GITR Triggering and Protects from the Inflammatory Response after Spinal Cord Injury

(2008) G. Nocentini et al.   MOLECULAR PHARMACOLOGY

NGF-promoted axon growth and target innervation requires GITRL-GITR signaling

(2008) Gerard W O'Keeffe et al.   NATURE NEUROSCIENCE

Co-Immunization of Mice with a Retroviral DNA Vaccine and GITRL-Encoding Plasmid Augments Vaccine-Induced Protection Against Retrovirus Infection

(2008) Ulf Dittmer et al.   VIRAL IMMUNOLOGY

Reverse signaling initiated from GITRL induces NF-κB activation through ERK in the inflammatory activation of macrophages

(2007) Eun Mi Bae et al.   MOLECULAR IMMUNOLOGY