Glucocorticoid-induced tumor necrosis factor receptor–related protein co-stimulation facilitates tumor regression by inducing IL-9–producing helper T cells

The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells

(2014) Frédérique Végran et al.   NATURE IMMUNOLOGY

Update on the role of ipilimumab in melanoma and first data on new combination therapies

(2013) Michele Maio et al.   CURRENT OPINION IN ONCOLOGY

Interleukin-9 Is Required for Allergic Airway Inflammation Mediated by the Cytokine TSLP

(2013) Weiguo Yao et al.   IMMUNITY

Th9 cells: differentiation and disease

(2013) Mark H. Kaplan   IMMUNOLOGICAL REVIEWS

Th9 cell development requires a BATF-regulated transcriptional network

(2013) Rukhsana Jabeen et al.   JOURNAL OF CLINICAL INVESTIGATION

Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies

(2013) Yannick Bulliard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

GITR-Dependent Regulation of 4-1BB Expression: Implications for T Cell Memory and Anti-4-1BB-Induced Pathology

(2013) G. H. Y. Lin et al.   JOURNAL OF IMMUNOLOGY

Modulation of GITR for cancer immunotherapy

(2012) David A Schaer et al.   CURRENT OPINION IN IMMUNOLOGY

Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity

(2012) Suzanne L Topalian et al.   CURRENT OPINION IN IMMUNOLOGY

Notch Receptors and Smad3 Signaling Cooperate in the Induction of Interleukin-9-Producing T Cells

(2012) Wassim Elyaman et al.   IMMUNITY

Nuclear Factor of Activated T Cells 1 (NFAT1)-induced Permissive Chromatin Modification Facilitates Nuclear Factor-κB (NF-κB)-mediated Interleukin-9 (IL-9) Transactivation

(2012) Arijita Jash et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Th9 cells promote antitumor immune responses in vivo

(2012) Yong Lu et al.   JOURNAL OF CLINICAL INVESTIGATION

TGF-  Converts Apoptotic Stimuli into the Signal for Th9 Differentiation

(2012) M. Takami et al.   JOURNAL OF IMMUNOLOGY

OX40 signaling favors the induction of TH9 cells and airway inflammation

(2012) Xiang Xiao et al.   NATURE IMMUNOLOGY

Robust tumor immunity to melanoma mediated by interleukin-9–producing T cells

(2012) Rahul Purwar et al.   NATURE MEDICINE

Differential macrophage programming in the tumor microenvironment

(2012) Brian Ruffell et al.   TRENDS IN IMMUNOLOGY

Memory Type 2 Helper T Cells Induce Long-Lasting Antitumor Immunity by Activating Natural Killer Cells

(2011) M. Kitajima et al.   CANCER RESEARCH

Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer

(2011) Lucia De Monte et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Th2 Responses to Helminth Parasites Can Be Therapeutically Enhanced by, but Are Not Dependent upon, GITR-GITR Ligand Costimulation In Vivo

(2011) N. van der Werf et al.   JOURNAL OF IMMUNOLOGY

Regulating Il9 transcription in T helper cells

(2011) Narayanan B. Perumal et al.   TRENDS IN IMMUNOLOGY

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Interferon-Regulatory Factor 4 Is Essential for the Developmental Program of T Helper 9 Cells

(2010) Valérie Staudt et al.   IMMUNITY

Mature B Cells Are Critical to T-cell-mediated Tumor Immunity Induced by an Agonist Anti-GITR Monoclonal Antibody

(2010) Pengfei Zhou et al.   JOURNAL OF IMMUNOTHERAPY

Regulation of IL-9 expression by IL-25 signaling

(2010) Pornpimon Angkasekwinai et al.   NATURE IMMUNOLOGY

The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation

(2010) Hua-Chen Chang et al.   NATURE IMMUNOLOGY

Agonist Anti-GITR Monoclonal Antibody Induces Melanoma Tumor Immunity in Mice by Altering Regulatory T Cell Stability and Intra-Tumor Accumulation

(2010) Adam D. Cohen et al.   PLoS One

Adoptive immunotherapy of cancer using CD4+ T cells

(2009) Pawel Muranski et al.   CURRENT OPINION IN IMMUNOLOGY

Roles of Idiotype-Specific T Cells in Myeloma Cell Growth and Survival: Th1 and CTL Cells Are Tumoricidal while Th2 Cells Promote Tumor Growth

(2008) S. Hong et al.   CANCER RESEARCH

Regulatory T Cell-Resistant CD8+ T Cells Induced by Glucocorticoid-Induced Tumor Necrosis Factor Receptor Signaling

(2008) H. Nishikawa et al.   CANCER RESEARCH

Multiple roles for CD4+T cells in anti-tumor immune responses

(2008) Richard Kennedy et al.   IMMUNOLOGICAL REVIEWS

Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset

(2008) Marc Veldhoen et al.   NATURE IMMUNOLOGY

IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3− effector T cells

(2008) Valérie Dardalhon et al.   NATURE IMMUNOLOGY