Review
Immunology
Hassan Dianat-Moghadam, Reza Nedaeinia, Mohsen Keshavarz, Mehdi Azizi, Mohammad Kazemi, Rasoul Salehi
Summary: Angiogenesis is a characteristic of cancer biology, and current therapies targeting tumor vasculature have limitations. By combining immunotherapy and nanocarriers, the efficacy of antiangiogenic agents could be improved while reducing the dosage of chemotherapy drugs. Furthermore, the combination of immunotherapies and nano-based delivery systems can extend the window of vascular normalization and overcome the challenges of antiangiogenic agents in treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Mengqi Xu, Cong Mao, Haoting Chen, Lu Liu, Yabin Wang, Abid Hussain, Sulei Li, Xu Zhang, Ruslan G. Tuguntaev, Xing-Jie Liang, Weisheng Guo, Feng Cao
Summary: In this study, researchers developed a theranostic nanoprobes for the precise regression of vulnerable atherosclerotic plaque (VASPs). The nanoprobes showed high specific accumulation in VASPs and achieved efficient plaque ablation and biological suppression of foamy macrophages. The study demonstrated the potential of targeted photodynamic therapy for the treatment of atherosclerosis.
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Cell Biology
Yun Liu, Nenggan Huang, Shijie Liao, Emel Rothzerg, Felix Yao, Yihe Li, David Wood, Jiake Xu
Summary: Osteosarcoma is the most common primary malignant bone tumor, with incidence peaking during adolescence. Despite improvements in prognosis with the introduction of neoadjuvant chemotherapy, outcomes have not significantly improved since then. Novel therapeutic strategies are urgently needed as an adjunct to conventional treatment modalities to improve outcomes for patients with osteosarcoma.
CELL PROLIFERATION
(2021)
Review
Oncology
Seyed Esmaeil Ahmadi, Ashkan Shabannezhad, Amir Kahrizi, Armin Akbar, Seyed Mehrab Safdari, Taraneh Hoseinnezhad, Mohammad Zahedi, Soroush Sadeghi, Mahsa Golizadeh Mojarrad, Majid Safa
Summary: TF is a protein involved in blood clotting and has been found to play a role in cancer development and progression. This review provides an overview of TF's structure and its involvement in signaling pathways that promote cancer cell survival. TF overexpression is associated with aggressive tumors and poor prognosis. The review also explores TF's role in promoting cancer cell metastasis and other processes. Various TF-targeted therapies have been developed and are being evaluated in clinical studies. Retargeting TF using TF-conjugated nanoparticles shows promise. Despite challenges, TF may be a potential molecule for further cancer therapy.
BIOMARKER RESEARCH
(2023)
Article
Medicine, Research & Experimental
Yifan Liu, Yansha Sun, Peng Wang, Songling Li, Yiwei Dong, Min Zhou, Bizhi Shi, Hua Jiang, Ruixin Sun, Zonghai Li
Summary: In this study, the combined antitumor activity of FAP-targeted and CLDN18.2-targeted CAR-T cells against PDAC was explored. The results showed that prior infusion of FAP-targeted CAR-T cells could eliminate CAFs and enhance the anti-PDAC efficacy of subsequently infused CLDN18.2-targeted CAR-T cells. Moreover, FAP-targeted CAR-T cells could suppress the recruitment of MDSCs and promote the survival of CD8(+) T cells and CAR-T cells in tumor tissue.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Microbiology
Jessica Santa Cruz de Carvalho Martins, Thiago das Chagas Sousa, Maria de Lourdes de Aguiar Oliveira, Etel Rodrigues Pereira Gimba, Marilda Mendonca Siqueira, Aline da Rocha Matos
Summary: Influenza A virus (IAV) infection causes an acute and highly contagious disease. This study found that the expression levels of total osteopontin (tOPN) and its splicing isoform (OPN4) were higher in respiratory samples from IAV cases, suggesting their potential use as biomarkers to evaluate disease outcomes.
Review
Oncology
Richard P. Tucker, Martin Degen
Summary: Tumor microenvironment (TME) plays a crucial role in tumor progression and provides potential targets for anti-cancer therapy. The tenascin family, especially tenascin-C and tenascin-W, shows promise as diagnostic and targetable molecules for cancer treatment purposes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Fangpeng Shu, Taowei Yang, Xuefeng Zhang, Wenbin Chen, Kaihui Wu, Junqi Luo, Xumin Zhou, Guochang Liu, Jianming Lu, Xiangming Mao
Summary: The study demonstrates the development of an organic nanoagent with oxygen-evolved and targeted ability for improved phototherapeutic efficacy. The nanoagent shows catalase-like activity in the presence of hydrogen peroxide and improved generation of reactive oxygen species under near-infrared laser irradiation. Targeted uptake in tumor cells and superior phototherapeutic efficacy over non-targeted counterparts are confirmed in vitro and in vivo.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
L. Pedrosa, I. K. Araujo, M. Cuatrecasas, G. Soy, S. Lopez, J. Maurel, C. Sanchez-Montes, C. Montironi, T. Sauri, O. Sendino, F. M. Perez, F. Ausania, G. Fernandez-Esparrach, F. M. Esposito, E. C. Vaquero, A. Gines
Summary: The integration of transcriptomic testing into EUS-FNA samples is important for precision oncology in PDAC. The NanoString platform allows for transcriptome profiling in low yield RNA samples. The study found differential gene expression between EUS and surgical samples, with a more enriched cancer-associated fibroblasts and epithelial-mesenchymal transition transcriptomic profile observed in surgical specimens and more immunological biomarkers represented in EUS-FNA samples.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Review
Pharmacology & Pharmacy
Yang Zheng, Heling Peng, Xu Hu, Yong Ou, Dong Wang, Han Wang, Shangqing Ren
Summary: This review discusses the molecular profile of urachal carcinoma (UrC) and identifies potential targets for personalized treatment, as well as immune checkpoint inhibitors representing underlying biomarkers. The most commonly mutated genes in UrC were TP53 (70%), KRAS (28.3%), MYC (20.3%), SMAD4 (18.2%), and GNAS (18%). Targeted therapy, especially EGFR-targeting therapy, may provide curative efficacy for UrC patients by applying specific molecular markers.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Miguel-Angel Berciano-Guerrero, Rocio Lavado-Valenzuela, Aurelio Moya, Luis delaCruz-Merino, Fatima Toscano, Javier Valdivia, Victoria Castellon, Fernando Henao-Carrasco, Pilar Sancho, Juan-Luis Onieva-Zafra, Ismael Navas-Delgado, Antonio Rueda-Dominguez, Elisabeth Perez-Ruiz, Emilio Alba
Summary: Targeted therapy in metastatic melanoma can activate and inhibit gene expression, providing potential biomarkers for immune reinduction response. This study analyzed blood samples from patients and identified genes involved in the treatment. Further research is needed to validate these results.
Article
Pharmacology & Pharmacy
Danqing Xin, Tingting Li, Xili Chu, Hongfei Ke, Dexiang Liu, Zhen Wang
Summary: This study demonstrates the key role of OPN in EVs-mediated neuroinflammation following hypoxia-ischemia (HI) in neonatal mice. By preventing NE-kappa B-mediated OPN expression, MSCs-EVs suppressed neuroinflammation, synaptic damage, and microglial phagocytosis after HI injury.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Chang Liu, Sijie Li, Xiaoxiao Zhang, Chunxiang Jin, Baofeng Zhao, Liying Li, Qing Robert Miao, Ying Jin, Zhimin Fan
Summary: NgBR plays a role in regulating metabolism and paclitaxel resistance in breast cancer, and may be a new therapeutic target for improving chemoresistance in ER-positive breast cancer.
CANCER GENE THERAPY
(2023)
Article
Oncology
Pan Zhang, Su Bin Lim, Kuan Jiang, Ti Weng Chew, Boon Chuan Low, Chwee Teck Lim
Summary: The study reveals that cancer extracellular vesicles (EVs) contain abundant mRNAs, which can contribute to tumor angiogenesis through intercellular transfer.
Review
Oncology
Anna Sebestyen, Laszlo Kopper, Titanilla Danko, Jozsef Timar
Summary: Cancer hypoxia, caused by deficient vascularization and systemic hypoxia of the patient, leads to genetic reprogramming by HIF and activation of oncogene-driven signaling pathways. The consequences include angiogenic phenotype, novel metabolic profile, and immunosuppressive microenvironment, all contributing to therapy resistance. Developing targeted therapies of hypoxia is crucial to improve the efficacy of anti-cancer treatment modalities.
PATHOLOGY & ONCOLOGY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Ramesh Butti, Ramakrishna Nimma, Gautam Kundu, Anuradha Bulbule, Totakura V. S. Kumar, Vinoth Prasanna Gunasekaran, Deepti Tomar, Dhiraj Kumar, Anupama Mane, Satyajit S. Gill, Tushar Patil, Georg F. Weber, Gopal C. Kundu
Summary: This study reveals the crosstalk between cancer cells and stromal fibroblasts that drives tumor progression. Tumor cells stimulate fibroblasts to differentiate into myofibroblasts by secreting OPN, which in turn secrete CXCL12 to promote epithelial to mesenchymal transition in tumor cells.
Review
Oncology
Remya Raja, Christopher Wu, Francesca Limbeck, Kristina Butler, Abhinav P. Acharya, Marion Curtis
Summary: Metabolism is essential for energy generation in living organisms and cells. Disruption of metabolic homeostasis, especially in obesity, can lead to inflammation and metabolic syndrome. Immune cells in adipose tissue play a role in maintaining metabolic balance, but during obesity, the increase in pro-inflammatory cells may worsen metabolic dysfunction.
Article
Multidisciplinary Sciences
Jennifer Cable, Edith Heard, Tetsuro Hirose, Kannanganattu Prasanth, Ling-Ling Chen, Jonathan E. Henninger, Sofia A. Quinodoz, David L. Spector, Sarah D. Diermeier, Allison M. Porman, Dhiraj Kumar, Mark W. Feinberg, Xiaohua Shen, Juan Pablo Unfried, Rory Johnson, Chun-Kan Chen, Jeremy E. Wilusz, Adelheid Lempradl, Sean E. McGeary, Lamia Wahba, Anna Marie Pyle, Amanda E. Hargrove, Matthew D. Simon, Marco Marcia, Roza K. Przanowska, Howard Y. Chang, Samie R. Jaffrey, Lydia M. Contreras, Qi Chen, Junchao Shi, Joshua T. Mendell, Lin He, Erwei Song, John L. Rinn, Mukesh Kumar Lalwani, Murat Can Kalem, Edward B. Chuong, Lynne E. Maquat, Xuhang Liu
Summary: The human transcriptome contains a variety of noncoding RNAs that play important roles in transcriptional regulation, epigenetic modifications, translation, and cell signaling. Research on noncoding RNAs in disease mechanisms and as potential drug targets is ongoing. The Keystone eSymposium on Noncoding RNAs aimed to accelerate the understanding of RNA basic biology and facilitate the translation of findings into clinical applications by bringing together researchers in RNA biology, structure, and technologies.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Poonam R. Pandey, Ken H. Young, Dhiraj Kumar, Neeraj Jain
Summary: The tumor immune microenvironment (TIME) plays a crucial role in tumor growth and metastasis by influencing the balance of immune-suppressive and cytotoxic responses. RNA-based therapeutics targeting RNA regulators in the TIME show promise in cancer immunotherapy.
Article
Medicine, Research & Experimental
Ashwin Porwal, Gopal Kundu, Gajanan Bhagwat, Ramesh Butti
Summary: An herbal formulation called AnoSpray was tested for its therapeutic effects on anorectal diseases. The results showed that AnoSpray significantly suppressed the migration of inflammatory cells and the expression of inflammatory cytokines. Similar effects were also observed in clinical specimens.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Astronomy & Astrophysics
Shubhankar Suman, Santosh Kumar, Bo-Hyun Moon, Jerry Angdisen, Bhaskar V. S. Kallakury, Kamal Datta, Albert J. Fornace
Summary: The study suggests that aspirin can reduce the pro-inflammatory PGE2 levels induced by high-LET ionizing radiation, but it does not have the ability to reduce high-LET ionizing radiation-induced GI tumorigenesis in Apc(1638N/+) mice.
LIFE SCIENCES IN SPACE RESEARCH
(2021)
Article
Oncology
N. N. Radharani, Amit S. Yadav, Ramakrishna Nimma, T. V. Santosh Kumar, Anuradha Bulbule, Venkatesh Chanukuppa, Dhiraj Kumar, Srinivas Patnaik, Srikanth Rapole, Gopal C. Kundu
Summary: Tumor-associated macrophages (TAMs) promote tumor progression by interacting with breast cancer cells, expressing various proteins, including cytokines that enrich cancer stem cells (CSCs). TAMs produce high levels of Interleukin-6 (IL-6) through p38-MAPK pathway upon interaction with breast cancer cells. TAM-derived IL-6 activates Signal transducer and activator of transcription 3 (STAT-3) pathway, promotes CSC enrichment and influences tumor growth in breast cancer.
CANCER CELL INTERNATIONAL
(2022)
Article
Biotechnology & Applied Microbiology
Chaitali Surve, Ananya Banerjee, S. Anupriya, Rajasree Chakraborty, Dhiraj Kumar, Ramesh Butti, Mahadeo Gorain, Sabyasachi Parida, Gopal C. Kundu, Supriya Shidhaye, Srinivas Patnaik
Summary: The efficacy of novel methotrexate-loaded nanoparticles (MTX-NPs) in the treatment of breast cancer was evaluated in vitro and in vivo. The results showed that MTX-NPs have improved cellular uptake and in vivo efficacy, making them a promising candidate for breast cancer treatment.
Article
Biology
Shubhankar Suman, Santosh Kumar, Bhaskar V. S. Kallakury, Bo-Hyun Moon, Jerry Angdisen, Kamal Datta, Albert J. Fornace
Summary: This study provides experimental evidence that cancer risk after exposure to GCR could largely depend on doses received from constituent heavy ions.
RADIATION AND ENVIRONMENTAL BIOPHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Santosh Kumar, Shubhankar Suman, Bo-Hyun Moon, Albert J. Fornace Jr, Kamal Datta
Summary: This study reveals that radiation exposure induces long-term oxidative stress in colonic epithelial cells, which is associated with colon carcinogenesis. The NADPH oxidase pathway may play a critical role in propagating this oxidative stress after radiation exposure.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Oncology
Elaina Kwiatkowski, Shubhankar Suman, Bhaskar V. S. Kallakury, Kamal Datta, Albert J. Fornace Jr, Santosh Kumar
Summary: This study assessed the expression of multiple stem cell markers in premalignant tumors after low- and high-LET radiation. The results showed a correlation between increased levels of stemness markers and fi-catenin activation in premalignant tumors, particularly in tumors induced by high-LET radiation. The study highlights the complex relationship between radiation types and stem cell phenotypes, and their potential influence on carcinogenesis processes.
Article
Cell Biology
Nick A. Kuburich, Petra den Hollander, Maria Castaneda, Mika Pietila, Ximing Tang, Harsh Batra, Francisco Martinez-Pena, Tanvi H. Visal, Tieling Zhou, Breanna R. Demestichas, Ritesh Dontula, Jojo Y. Liu, Joanna Joyce Maddela, Reethi S. Padmanabhan, Lan Thi Hanh Phi, Matthew J. Rosolen, Thiru Sabapathy, Dhiraj Kumar, Filippo G. Giancotti, Luke L. Lairson, Maria Gabriela Raso, Rama Soundararajan, Sendurai A. Mani
Summary: Epithelial-mesenchymal transition (EMT) is a critical factor in cancer metastasis, and the phosphorylation of vimentin plays a crucial role in stemness and metastasis.
Article
Biotechnology & Applied Microbiology
Ankit P. Jain, Aneesha Radhakrishnan, Sneha Pinto, Krishna Patel, Manish Kumar, Vishalakshi Nanjappa, Remya Raja, Thottethodi Subrahmanya Keshava Prasad, Premendu P. Mathur, David Sidransky, Aditi Chatterjee, Harsha Gowda
Summary: Resistance to cancer chemotherapy, especially in head and neck squamous cell carcinoma (HNSCC), is a significant global health burden. Despite the proven therapeutic target of EGFR, cellular heterogeneity and specific signaling pathways (such as the PTK2 pathway) play crucial roles in therapeutic resistance.
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2021)
