Targeting 5-lipoxygenase-activating protein in asthma and chronic obstructive pulmonary disease

The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesisin vitroandin vivoby targeting 5-lipoxygenase-activating protein (FLAP)

(2014) C Pergola et al.   BRITISH JOURNAL OF PHARMACOLOGY

Liquid chromatography–mass spectrometry measurement of leukotrienes in asthma and other respiratory diseases

(2014) Paolo Montuschi et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Lipid mediators and allergic diseases

(2013) Laura B. Fanning et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Recent Advances in the Search for Novel 5-Lipoxygenase Inhibitors

(2013) Dieter Steinhilber et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Asthma and Chronic Obstructive Pulmonary Disease

(2013) Dirkje S. Postma et al.   CLINICS IN CHEST MEDICINE

Cellular and Molecular Mechanisms of Chronic Obstructive Pulmonary Disease

(2013) Peter J. Barnes   CLINICS IN CHEST MEDICINE

Addition of a 5-lipoxygenase-activating protein inhibitor to an inhaled corticosteroid (ICS) or an ICS/long-acting beta-2-agonist combination in subjects with asthma

(2013) Neil G. Snowise et al.   CURRENT MEDICAL RESEARCH AND OPINION

Efficacy, safety and tolerability of GSK2190915, a 5-lipoxygenase activating protein inhibitor, in adults and adolescents with persistent asthma: a randomised dose-ranging study

(2013) Richard MA Follows et al.   RESPIRATORY RESEARCH

Lipoxygenase inhibitor MK886 potentiates TRAIL-induced apoptosis through CHOP- and p38 MAPK-mediated up-regulation of death receptor 5 in malignant glioma

(2012) Ji Sun Woo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The 5-lipoxygenase-activating protein inhibitor, GSK2190915, attenuates the early and late responses to inhaled allergen in mild asthma

(2012) S. E. Kent et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Risk-to-benefit ratio of inhaled corticosteroids in patients with COPD

(2012) David Price et al.   Primary Care Respiratory Journal

Roflumilast as add-on therapy to conventional inhalers in COPD: a cost–effectiveness analysis

(2012) Sabina A Antoniu   Journal of Comparative Effectiveness Research

Leukotrienes and airway inflammation

(2011) Katsuhide Okunishi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

5-Lipoxygenase-Activating Protein (FLAP) Inhibitors. Part 4: Development of 3-[3-tert-Butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic Acid (AM803), a Potent, Oral, Once Daily FLAP Inhibitor

(2011) Nicholas S. Stock et al.   JOURNAL OF MEDICINAL CHEMISTRY

New therapeutic options in the management of COPD – focus on roflumilast

(2011) Sabina Antoniu   International Journal of Chronic Obstructive Pulmonary Disease

Pharmacodynamics and Pharmacokinetics of AM103, a Novel Inhibitor of 5-Lipoxygenase-Activating Protein (FLAP)

(2010) G Bain et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation

(2010) Daniel S. Lorrain et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Location, Location, Location: Compartmentalization of Early Events in Leukotriene Biosynthesis

(2010) Marcia E. Newcomer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

5-Lipoxygenase-activating protein inhibitors. Part 2: 3-{5-((S)-1-Acetyl-2,3-dihydro-1H-indol-2-ylmethoxy)-3-tert-butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-1H-indol-2-yl}-2,2-dimethyl-propionic acid (AM679)—A potent FLAP inhibitor

(2009) Nicholas Stock et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Novel 5-Lipoxygenase-Activating Protein Inhibitor, AM679, Reduces Inflammation in the Respiratory Syncytial Virus-Infected Mouse Eye

(2009) A. Musiyenko et al.   Clinical and Vaccine Immunology

MK-886, an inhibitor of the 5-lipoxygenase-activating protein, inhibits cyclooxygenase-1 activity and suppresses platelet aggregation

(2009) Andreas Koeberle et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

LC/MS/MS analysis of leukotriene B4 and other eicosanoids in exhaled breath condensate for assessing lung inflammation☆

(2009) Paolo Montuschi   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Leukotriene B4 is essential for selective eosinophil recruitment following allergen challenge of CD4+ cells in a model of chronic eosinophilic inflammation

(2008) Alessandra Bonacini Cheraim et al.   LIFE SCIENCES