ARC15105 Is a Potent Antagonist of Von Willebrand Factor Mediated Platelet Activation and Adhesion

A dose ranging phase I/II trial of the von Willebrand factor inhibiting aptamer ARC1779 in patients with congenital thrombotic thrombo - cytopenic purpura

(2011) Petra Jilma-Stohlawetz et al.   THROMBOSIS AND HAEMOSTASIS

Inhibition of cell adhesion by anti-P-selectin aptamer: a new potential therapeutic agent for sickle cell disease

(2010) D. R. Gutsaeva et al.   BLOOD

Nucleic acid aptamers as antithrombotic agents: Opportunities in extracellular therapeutics

(2010) Thomas Povsic et al.   THROMBOSIS AND HAEMOSTASIS

A randomised pilot trial of the anti-von Willebrand factor aptamer ARC1779 in patients with type 2b von Willebrand disease

(2010) Petra Paulinska et al.   THROMBOSIS AND HAEMOSTASIS

Inhibition of von Willebrand factor by ARC1779 in patients with acute thrombotic thrombocytopenic purpura

(2010) Bernd Jilma et al.   THROMBOSIS AND HAEMOSTASIS

The aptamer ARC1779 blocks von Willebrand factor-dependent platelet function in patients with thrombotic thrombocytopenic purpura ex vivo

(2010) Florian B. Mayr et al.   TRANSFUSION

Pharmacokinetic, pharmacodynamic and clinical profile of novel antiplatelet drugs targeting vascular diseases

(2009) Jolanta M Siller-Matula et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of von Willebrand factor-mediated platelet activation and thrombosis by the anti-von Willebrand factor A1-domain aptamer ARC1779

(2009) J. L. DIENER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Multiple electrode aggregometry predicts stent thrombosis better than the vasodilator-stimulated phosphoprotein phosphorylation assay

(2009) J. M. SILLER-MATULA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The aptamer ARC1779 is a potent and specific inhibitor of von willebrand factor mediatedex vivoplatelet function in acute myocardial infarction

(2009) Alexander O. Spiel et al.   PLATELETS

Cross validation of the Multiple Electrode Aggregometry

(2009) Jolanta Siller-Matula et al.   THROMBOSIS AND HAEMOSTASIS

The effect of antiplatelet drugs clopidogrel and aspirin is less immediately after stent implantation

(2009) Jolanta M. Siller-Matula et al.   THROMBOSIS RESEARCH

Von Willebrand Factor in Cardiovascular Disease

(2008) Alexander O. Spiel et al.   CIRCULATION