Targeting Ca2+transport in cancer: close reality or long perspective?

Regulation of macroautophagy in ovarian cancer cells in vitro and in vivo by controlling Glucose regulatory protein 78 and AMPK

(2015) Prabodh K. Kandala et al.   Oncotarget

Lipid rafts couple store-operated Ca 2+ entry to constitutive activation of PKB/Akt in a Ca 2+ /calmodulin-, Src- and PP2A-mediated pathway and promote melanoma tumor growth

(2012) Shlomit Fedida-Metula et al.   CARCINOGENESIS

Mitochondrial Ca2+ signals in autophagy

(2012) César Cárdenas et al.   CELL CALCIUM

Autophagy in tumor suppression and cancer therapy

(2012) Che-Pei Kung et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Local Gene Delivery for Cancer Therapy

(2012) Lili Zhao et al.   CURRENT GENE THERAPY

Calcium Channels and Pumps in Cancer: Changes and Consequences

(2012) Gregory R. Monteith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ion channels and transporters in cancer. 1. Ion channels and cell proliferation in cancer

(2011) Andrea Becchetti   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Ion channels and transporters in cancer. 6. Vascularizing the tumor: TRP channels as molecular targets

(2011) Alessandra Fiorio Pla et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Ins(1,4,5)P3receptor-mediated Ca2+signaling and autophagy induction are interrelated

(2011) Jean-Paul Decuypere et al.   Autophagy

GMI, an immunomodulatory protein fromGanoderma microsporum, induces autophagy in non-small cell lung cancer cells

(2011) I-Lun Hsin et al.   Autophagy

Orai1/CRACM1 overexpression suppresses cell proliferation via attenuation of the store-operated calcium influx-mediated signalling pathway in A549 lung cancer cells

(2011) Ming-Feng Hou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Changes in mitochondrial redox state, membrane potential and calcium precede mitochondrial dysfunction in doxorubicin-induced cell death

(2011) Andrey V. Kuznetsov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Endoplasmic reticulum calcium pumps and cancer

(2011) Atousa Arbabian et al.   BIOFACTORS

Plasma membrane calcium ATPases and cancer

(2011) Merril C Curry et al.   BIOFACTORS

A dual role for Ca2+ in autophagy regulation

(2011) Jean-Paul Decuypere et al.   CELL CALCIUM

Orai1 and CRAC Channel Dependence of VEGF-Activated Ca 2+ Entry and Endothelial Tube Formation

(2011) Jing Li et al.   CIRCULATION RESEARCH

Calcium gradients underlying cell migration

(2011) Chaoliang Wei et al.   CURRENT OPINION IN CELL BIOLOGY

Calcium entry via ORAI1 regulates glioblastoma cell proliferation and apoptosis

(2011) Huiling Liu et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

STIM and Orai proteins and the non-capacitative ARC channels

(2011) Trevor et al.   Frontiers in Bioscience-Landmark

Targeting mitochondria as a therapeutic target in cancer

(2011) Charles E. Wenner   JOURNAL OF CELLULAR PHYSIOLOGY

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

State-of-the-art gene-based therapies: the road ahead

(2011) Mark A. Kay   NATURE REVIEWS GENETICS

Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis

(2011) Y.-F. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The calcium sensor STIM1 is regulated by androgens in prostate stromal cells

(2011) Paul A. Berry et al.   PROSTATE

Molecular mechanisms underlying Ca2+-mediated motility of human pancreatic duct cells

(2010) Hui Dong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The role of TRPC6 in HGF-induced cell proliferation of human prostate cancer DU145 and PC3 cells

(2010) Yong Wang et al.   ASIAN JOURNAL OF ANDROLOGY

The platinum (II) complex [Pt(O,O′-acac)(γ-acac)(DMS)] alters the intracellular calcium homeostasis in MCF-7 breast cancer cells

(2010) Antonella Muscella et al.   BIOCHEMICAL PHARMACOLOGY

Induction of Ca2+-driven apoptosis in chronic lymphocytic leukemia cells by peptide-mediated disruption of Bcl-2-IP3 receptor interaction

(2010) F. Zhong et al.   BLOOD

Caffeine-Mediated Inhibition of Calcium Release Channel Inositol 1,4,5-Trisphosphate Receptor Subtype 3 Blocks Glioblastoma Invasion and Extends Survival

(2010) S. S. Kang et al.   CANCER RESEARCH

Role of Cationic Channel TRPV2 in Promoting Prostate Cancer Migration and Progression to Androgen Resistance

(2010) M. Monet et al.   CANCER RESEARCH

Store-Independent Activation of Orai1 by SPCA2 in Mammary Tumors

(2010) Mingye Feng et al.   CELL

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

(2010) César Cárdenas et al.   CELL

TRPM7 regulates the migration of human nasopharyngeal carcinoma cell by mediating Ca2+ influx

(2010) Jian-Peng Chen et al.   CELL CALCIUM

Anticancer Properties of Indole Compounds: Mechanism of Apoptosis Induction and Role in Chemotherapy

(2010) Aamir Ahmad et al.   CURRENT DRUG TARGETS

What made sesquiterpene lactones reach cancer clinical trials?

(2010) Akram Ghantous et al.   DRUG DISCOVERY TODAY

Targeting TRPC6 channels in oesophageal carcinoma growth

(2010) Xia Ding et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis

(2010) Feifan Zhou et al.   FEBS Journal

Generation of Cyclic ADP-ribose and Nicotinic Acid Adenine Dinucleotide Phosphate by CD38 for Ca2+Signaling in Interleukin-8-treated Lymphokine-activated Killer Cells

(2010) So-Young Rah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Golgi Calcium Pump Secretory Pathway Calcium ATPase 1 (SPCA1) Is a Key Regulator of Insulin-like Growth Factor Receptor (IGF1R) Processing in the Basal-like Breast Cancer Cell Line MDA-MB-231

(2010) Desma M. Grice et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Native Store-operated Calcium Channel Encoded by Orai3

(2010) Rajender K. Motiani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Down-regulation of Orai3 arrests cell-cycle progression and induces apoptosis in breast cancer cells but not in normal breast epithelial cells

(2010) Malika Faouzi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Calcium wave signaling in cancer cells

(2010) Jai Parkash et al.   LIFE SCIENCES

Inositol 1,4,5-trisphosphate-induced Ca2+ signalling is involved in estradiol-induced breast cancer epithelial cell growth

(2010) Cécilia Szatkowski et al.   Molecular Cancer

Alisol B, a Novel Inhibitor of the Sarcoplasmic/Endoplasmic Reticulum Ca2+ ATPase Pump, Induces Autophagy, Endoplasmic Reticulum Stress, and Apoptosis

(2010) B. Y. K. Law et al.   MOLECULAR CANCER THERAPEUTICS

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

PMCA2 regulates apoptosis during mammary gland involution and predicts outcome in breast cancer

(2010) J. VanHouten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PML Regulates Apoptosis at Endoplasmic Reticulum by Modulating Calcium Release

(2010) C. Giorgi et al.   SCIENCE

Ion channels and the hallmarks of cancer

(2010) Natalia Prevarskaya et al.   TRENDS IN MOLECULAR MEDICINE

Orai1 contributes to the establishment of an apoptosis-resistant phenotype in prostate cancer cells

(2010) M Flourakis et al.   Cell Death & Disease

Evidence that TRPM7 is required for breast cancer cell proliferation

(2009) Arnaud Guilbert et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Effects of TRPM8 on the proliferation and motility of prostate cancer PC-3 cells

(2009) Zhong-Hua Yang et al.   ASIAN JOURNAL OF ANDROLOGY

Artemisinin induces doxorubicin resistance in human colon cancer cells via calcium-dependent activation of HIF-1α and P-glycoprotein overexpression

(2009) C Riganti et al.   BRITISH JOURNAL OF PHARMACOLOGY

Orai1 and STIM1 Are Critical for Breast Tumor Cell Migration and Metastasis

(2009) Shengyu Yang et al.   CANCER CELL

Abnormal expression, localization and interaction of canonical transient receptor potential ion channels in human breast cancer cell lines and tissues: a potential target for breast cancer diagnosis and therapy

(2009) Ebru Aydar et al.   Cancer Cell International

Critical role of TRPC6 channels in VEGF-mediated angiogenesis

(2009) Ruiliang Ge et al.   CANCER LETTERS

Plasma membrane calcium ATPase 4 and the remodeling of calcium homeostasis in human colon cancer cells

(2009) Cho S. Aung et al.   CARCINOGENESIS

The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1

(2009) J M Vicencio et al.   CELL DEATH AND DIFFERENTIATION

HIF-1α inhibition as a novel mechanism of cardiac glycosides in cancer therapeutics

(2009) Jianqing Lin et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Calcium flickers steer cell migration

(2009) Chaoliang Wei et al.   NATURE

NAADP mobilizes calcium from acidic organelles through two-pore channels

(2009) Peter J. Calcraft et al.   NATURE

Calcium Pumps in Health and Disease

(2009) Marisa Brini et al.   PHYSIOLOGICAL REVIEWS

The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor

(2009) Y.-P. Rong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intramitochondrial calcium regulation by the FHIT gene product sensitizes to apoptosis

(2009) A. Rimessi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Markers of squamous cell carcinoma in sarco/endoplasmic reticulum Ca2+ ATPase 2 heterozygote mice keratinocytes

(2009) Jeong Hee Hong et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Novel role for the transient receptor potential channel TRPM2 in prostate cancer cell proliferation

(2009) X Zeng et al.   PROSTATE CANCER AND PROSTATIC DISEASES

STIM and Orai: the long-awaited constituents of store-operated calcium entry

(2009) Péter Várnai et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

N,N-dimethyl-D-erythro-sphingosine increases intracellular Ca2+ concentration via Na+-Ca2+-exchanger in HCT116 human colon cancer cells

(2008) Hyo-Lim Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

HGF/SF and menthol increase human glioblastoma cell calcium and migration

(2008) Robert Wondergem et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Akt kinase reducing endoplasmic reticulum Ca2+ release protects cells from Ca2+-dependent apoptotic stimuli

(2008) Saverio Marchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ATP2A3 gene is involved in cancer susceptibility

(2008) Branka Korošec et al.   CANCER GENETICS AND CYTOGENETICS

Eag1: An Emerging Oncological Target

(2008) L. A. Pardo et al.   CANCER RESEARCH

Does autophagy have a license to kill mammalian cells?

(2008) F Scarlatti et al.   CELL DEATH AND DIFFERENTIATION

Stim1 and Orai1 Mediate CRAC Currents and Store-Operated Calcium Entry Important for Endothelial Cell Proliferation

(2008) Iskandar F. Abdullaev et al.   CIRCULATION RESEARCH

Cardiac Glycosides as Novel Cancer Therapeutic Agents

(2008) R. A. Newman et al.   MOLECULAR INTERVENTIONS

A nomenclature for ligand-gated ion channels

(2008) Graham L. Collingridge et al.   NEUROPHARMACOLOGY

Digoxin and other cardiac glycosides inhibit HIF-1  synthesis and block tumor growth

(2008) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis

(2008) T. Szado et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA