Targeting mitochondria as a therapeutic target in cancer

Mitochondrial regulation of cell death: Processing of apoptosis-inducing factor (AIF)

(2010) Erik Norberg et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Apoptosis is regulated by the VDAC1 N-terminal region and by VDAC oligomerization: release of cytochrome c, AIF and Smac/Diablo

(2010) Varda Shoshan-Barmatz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Integrating stress signals at the endoplasmic reticulum: The BCL-2 protein family rheostat

(2010) Diego Rodriguez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

(2010) César Cárdenas et al.   CELL

Hexokinase II detachment from the mitochondria potentiates cisplatin induced cytotoxicity through a caspase-2 dependent mechanism

(2010) Nataly Shulga et al.   CELL CYCLE

A functional RNAi screen identifies hexokinase 1 as a modifier of type II apoptosis

(2010) Anja Schindler et al.   CELLULAR SIGNALLING

Resveratrol: Challenges in Translation to the Clinic -- A Critical Discussion

(2010) L. Subramanian et al.   CLINICAL CANCER RESEARCH

Autophagy for the avoidance of degenerative, inflammatory, infectious, and neoplastic disease

(2010) Guido Kroemer et al.   CURRENT OPINION IN CELL BIOLOGY

The role of p53 in glucose metabolism

(2010) Eric C Cheung et al.   CURRENT OPINION IN CELL BIOLOGY

FoxOs Inhibit mTORC1 and Activate Akt by Inducing the Expression of Sestrin3 and Rictor

(2010) Chia-Chen Chen et al.   DEVELOPMENTAL CELL

Targeting mitochondria for cancer therapy

(2010) David M. Hockenbery   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

FOXO3a Regulates Glycolysis via Transcriptional Control of Tumor Suppressor TSC1

(2010) Shikha Khatri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ethanol sensitizes mitochondria to the permeability transition by inhibiting deacetylation of cyclophilin-D mediated by sirtuin-3

(2010) Nataly Shulga et al.   JOURNAL OF CELL SCIENCE

HMGB1-induced autophagy promotes chemotherapy resistance in leukemia cells

(2010) L Liu et al.   LEUKEMIA

Metabolic flexibility and cell hierarchy in metastatic cancer

(2010) Michael V. Berridge et al.   MITOCHONDRION

Inositol 1,4,5-trisphosphate-induced Ca2+ signalling is involved in estradiol-induced breast cancer epithelial cell growth

(2010) Cécilia Szatkowski et al.   Molecular Cancer

A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications

(2010) Zhi Sheng et al.   NATURE MEDICINE

Targeting mitochondria for cancer therapy

(2010) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

HMGB1 release and redox regulates autophagy and apoptosis in cancer cells

(2010) D Tang et al.   ONCOGENE

Mnk earmarks eIF4E for cancer therapy

(2010) N. Hay   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of autophagy by ROS: physiology and pathology

(2010) Ruth Scherz-Shouval et al.   TRENDS IN BIOCHEMICAL SCIENCES

Hypoxia-induced autophagy: cell death or cell survival?

(2009) Nathalie M Mazure et al.   CURRENT OPINION IN CELL BIOLOGY

HIF-1: upstream and downstream of cancer metabolism

(2009) Gregg L Semenza   CURRENT OPINION IN GENETICS & DEVELOPMENT

ERK and cell death: Mechanisms of ERK-induced cell death - apoptosis, autophagy and senescence

(2009) Sebastien Cagnol et al.   FEBS Journal

Cyclophilin D Interacts with Bcl2 and Exerts an Anti-apoptotic Effect

(2009) Roman A. Eliseev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial function and energy metabolism in cancer cells: Past overview and future perspectives

(2009) Avraham Mayevsky   MITOCHONDRION

mTORC1 Hyperactivity Inhibits Serum Deprivation-Induced Apoptosis via Increased Hexokinase II and GLUT1 Expression, Sustained Mcl-1 Expression, and Glycogen Synthase Kinase 3  Inhibition

(2009) P. T. Bhaskar et al.   MOLECULAR AND CELLULAR BIOLOGY

Small mitochondria-targeting molecules as anti-cancer agents

(2009) Feng Wang et al.   MOLECULAR ASPECTS OF MEDICINE

The Warburg effect and mitochondrial stability in cancer cells

(2009) Vladimir Gogvadze et al.   MOLECULAR ASPECTS OF MEDICINE

Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment

(2008) Meghan B. Azad et al.   ANTIOXIDANTS & REDOX SIGNALING

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting Bcl-2-IP3 Receptor Interaction to Reverse Bcl-2's Inhibition of Apoptotic Calcium Signals

(2008) Yi-Ping Rong et al.   MOLECULAR CELL

Targeting mitochondrial permeability in cancer drug development

(2008) Michael V. Berridge et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Regulation of cancer cell metabolism by hypoxia-inducible factor 1

(2008) Gregg L. Semenza   SEMINARS IN CANCER BIOLOGY