Novel drug targets based on metallobiology of Alzheimer's disease

Three-Dimensional Tomographic Imaging and Characterization of Iron Compounds within Alzheimer's Plaque Core Material

(2017) Joanna F. Collingwood et al.   JOURNAL OF ALZHEIMERS DISEASE

PBT2 Rapidly Improves Cognition in Alzheimer's Disease: Additional Phase II Analyses

(2017) Noel G. Faux et al.   JOURNAL OF ALZHEIMERS DISEASE

Copper toxicity in the general population

(2010) George J. Brewer   CLINICAL NEUROPHYSIOLOGY

Up-Regulation of Hypoxia-Inducible Factor (HIF)-1α and HIF-Target Genes in Cortical Neurons by the Novel Multifunctional Iron Chelator Anti-Alzheimer Drug, M30

(2010) Y. Avramovich-Tirosh et al.   Current Alzheimer Research

Current therapeutic targets for the treatment of Alzheimer’s disease

(2010) Joshua D Grill et al.   Expert Review of Neurotherapeutics

Current status on Alzheimer disease molecular genetics: from past, to present, to future

(2010) K. Bettens et al.   HUMAN MOLECULAR GENETICS

AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

(2010) Valérie Vingtdeux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process

(2010) Bart De Strooper   PHYSIOLOGICAL REVIEWS

Ceruloplasmin fragmentation is implicated in 'free' copper deregulation of Alzheimer disease

(2010) Rosanna Squitti et al.   Prion

Pulse EPR Spectroscopy Reveals the Coordination Sphere of Copper(II) Ions in the 1–16 Amyloid-β Peptide: A Key Role of the First Two N-Terminus Residues

(2009) Pierre Dorlet et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ternary Complexes of Iron, Amyloid-β, and Nitrilotriacetic Acid: Binding Affinities, Redox Properties, and Relevance to Iron-Induced Oxidative Stress in Alzheimer’s Disease

(2009) Dianlu Jiang et al.   BIOCHEMISTRY

Aβ-mediated ROS production by Cu ions: Structural insights, mechanisms and relevance to Alzheimer's disease

(2009) Christelle Hureau et al.   BIOCHIMIE

The Cu(II)/Aβ/Human Serum Albumin Model of Control Mechanism for Copper-Related Amyloid Neurotoxicity

(2009) Małgorzata Rózga et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The chemistry of Alzheimer’s disease

(2009) Arvi Rauk   CHEMICAL SOCIETY REVIEWS

Glycosylated tetrahydrosalens as multifunctional molecules for Alzheimer's therapy

(2009) Tim Storr et al.   DALTON TRANSACTIONS

In vitro studies of 3-hydroxy-4-pyridinones and their glycosylated derivatives as potential agents for Alzheimer's disease

(2009) David E. Green et al.   DALTON TRANSACTIONS

Paradoxical Condensation of Copper with Elevated β-Amyloid in Lipid Rafts under Cellular Copper Deficiency Conditions

(2009) Ya Hui Hung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Importance of dynamical processes in the coordination chemistry and redox conversion of copper amyloid-β complexes

(2009) Christelle Hureau et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Copper in the brain and Alzheimer’s disease

(2009) Ya Hui Hung et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Demonstration of aluminum in amyloid fibers in the cores of senile plaques in the brains of patients with Alzheimer’s disease

(2009) Sakae Yumoto et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD

(2009) Masashi Kitazawa et al.   JOURNAL OF NEUROCHEMISTRY

Zn(II)- and Cu(II)-induced non-fibrillar aggregates of amyloid-β (1-42) peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators

(2009) Vello Tõugu et al.   JOURNAL OF NEUROCHEMISTRY

Pleomorphic Copper Coordination by Alzheimer’s Disease Amyloid-β Peptide

(2009) Simon C. Drew et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Alanine-2 Carbonyl is an Oxygen Ligand in Cu2+Coordination of Alzheimer’s Disease Amyloid-β Peptide − Relevance to N-Terminally Truncated Forms

(2009) Simon C. Drew et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design, Selection, and Characterization of Thioflavin-Based Intercalation Compounds with Metal Chelating Properties for Application in Alzheimer’s Disease

(2009) Cristina Rodríguez-Rodríguez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Amyloid plaques in PSAPP mice bind less metal than plaques in human Alzheimer's disease

(2009) Andreana C. Leskovjan et al.   NEUROIMAGE

Longitudinal prognostic value of serum "free" copper in patients with Alzheimer disease

(2009) R. Squitti et al.   NEUROLOGY

Down-regulation of aminolevulinate synthase, the rate-limiting enzyme for heme biosynthesis in Alzheimer's disease

(2009) Barney E. Dwyer et al.   NEUROSCIENCE LETTERS

Nanoparticle–chelator conjugates as inhibitors of amyloid-β aggregation and neurotoxicity: A novel therapeutic approach for Alzheimer disease

(2009) Gang Liu et al.   NEUROSCIENCE LETTERS

S100A7, a Novel Alzheimer's Disease Biomarker with Non-Amyloidogenic α-Secretase Activity Acts via Selective Promotion of ADAM-10

(2009) Weiping Qin et al.   PLoS One

Aluminum and Silica in Drinking Water and the Risk of Alzheimer's Disease or Cognitive Decline: Findings From 15-Year Follow-up of the PAQUID Cohort

(2008) V. Rondeau et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Structural Studies of Copper(I) Complexes of Amyloid-β Peptide Fragments: Formation of Two-Coordinate Bis(histidine) Complexes

(2008) Richard A. Himes et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease

(2008) Jack T. Rogers et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Amyloid β−Cu2+Complexes in both Monomeric and Fibrillar Forms Do Not Generate H2O2Catalytically but Quench Hydroxyl Radicals†

(2008) Rebecca C. Nadal et al.   BIOCHEMISTRY

Direct Evidence That All Three Histidine Residues Coordinate to Cu(II) in Amyloid-β1−16†

(2008) Byong-kyu Shin et al.   BIOCHEMISTRY

Physiological and pathological aspects of Aβ in iron homeostasis via 5'UTR in the APP mRNA and the therapeutic use of iron-chelators

(2008) Yael Avramovich-Tirosh et al.   BMC NEUROSCIENCE

An observational study on the influence of the APOE-ε4 allele on the correlation between ‘free’ copper toxicosis and EEG activity in Alzheimer disease

(2008) Filippo Zappasodi et al.   BRAIN RESEARCH

Green tea epigallocatechin-3-gallate (EGCG) reduces β-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice

(2008) Kavon Rezai-Zadeh et al.   BRAIN RESEARCH

Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain

(2008) Li-Hong Zhang et al.   BRAIN RESEARCH BULLETIN

Isomerization of the Asp7 Residue Results in Zinc‐Induced Oligomerization of Alzheimer’s Disease Amyloid β(1–16) Peptide

(2008) Philipp O. Tsvetkov et al.   CHEMBIOCHEM

Alzheimer Disease and the Role of Free Radicals in the Pathogenesis of the Disease

(2008) George Perry et al.   CNS & Neurological Disorders-Drug Targets

Simultaneous Manipulation of Multiple Brain Targets by Green Tea Catechins: A Potential Neuroprotective Strategy for Alzheimer and Parkinson Diseases

(2008) Silvia A. Mandel et al.   CNS Neuroscience & Therapeutics

Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-β peptide

(2008) Peter Faller et al.   DALTON TRANSACTIONS

A comparison of rapid-scanning X-ray fluorescence mapping and magnetic resonance imaging to localize brain iron distribution

(2008) Richard P.E. McCrea et al.   EUROPEAN JOURNAL OF RADIOLOGY

Effects of oral aluminum exposure on behavior and neurogenesis in a transgenic mouse model of Alzheimer's disease

(2008) D. Ribes et al.   EXPERIMENTAL NEUROLOGY

The use of copper-lowering therapy with tetrathiomolybdate in medicine

(2008) George J Brewer   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Sequestration of Copper from β-Amyloid Promotes Selective Lysis by Cyclen-Hybrid Cleavage Agents

(2008) Wei-hui Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Anti-neurodegeneration Drug Clioquinol Inhibits the Aging-associated Protein CLK-1

(2008) Ying Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of zinc(II)-promoted amyloid formation: zinc(II) binding facilitates the transition from the partially α-helical conformer to aggregates of amyloid β protein(1–28)

(2008) Christine Talmard et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

A potential pathogenetic role of iron in Alzheimer's disease

(2008) Laura Silvestri et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

(2008) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Amyloid-β Peptide of Alzheimer’s Disease Binds CuIin a Linear Bis-His Coordination Environment: Insight into a Possible Neuroprotective Mechanism for the Amyloid-β Peptide

(2008) Jason Shearer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Zinc-Amyloid β Interactions on a Millisecond Time-Scale Stabilize Non-fibrillar Alzheimer-Related Species

(2008) Dror Noy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

(2008) Lars Lannfelt et al.   LANCET NEUROLOGY

Metallo-complex activation of neuroprotective signalling pathways as a therapeutic treatment for Alzheimer’s disease

(2008) Laura Bica et al.   Molecular BioSystems

Altered expression and distribution of zinc transporters in APP/PS1 transgenic mouse brain

(2008) Li-Hong Zhang et al.   NEUROBIOLOGY OF AGING

Benefits from Dietary Polyphenols for Brain Aging and Alzheimer’s Disease

(2008) L. Rossi et al.   NEUROCHEMICAL RESEARCH

Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ

(2008) Paul A. Adlard et al.   NEURON

Therapeutics for Alzheimer’s disease based on the metal hypothesis

(2008) Ashley I. Bush et al.   Neurotherapeutics

Regulating amyloid precursor protein synthesis through an internal ribosomal entry site

(2008) Monique E. Beaudoin et al.   NUCLEIC ACIDS RESEARCH

Aluminum Modulates Effects of βAmyloid1–42 on Neuronal Calcium Homeostasis and Mitochondria Functioning and Is Altered in a Triple Transgenic Mouse Model of Alzheimer's Disease

(2008) Denise Drago et al.   REJUVENATION RESEARCH

Lipoic Acid: A Novel Therapeutic Approach for Multiple Sclerosis and Other Chronic Inflammatory Diseases of the CNS

(2008) Sonemany Salinthone et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Targeting multiple Alzheimer’s disease etiologies with multimodal neuroprotective and neurorestorative iron chelators

(2007) Tamar Amit et al.   FASEB JOURNAL

Binding of zinc(II) and copper(II) to the full-length Alzheimer’s amyloid-β peptide

(2007) Vello Tõugu et al.   JOURNAL OF NEUROCHEMISTRY

NMR Studies of the Zn2+Interactions with Rat and Human β-Amyloid (1−28) Peptides in Water-Micelle Environment

(2007) Elena Gaggelli et al.   JOURNAL OF PHYSICAL CHEMISTRY B