Novel histamine H4receptor ligands and their potential therapeutic applications: an update

The therapeutic potential of histamine receptor ligands in inflammatory bowel disease

(2014) Detlef Neumann et al.   BIOCHEMICAL PHARMACOLOGY

Histamine H4receptor as a new therapeutic target for choroidal neovascularization in age-related macular degeneration

(2014) Hiroki Kaneko et al.   BRITISH JOURNAL OF PHARMACOLOGY

Activation of histamine H4 receptors decreases epithelial-to-mesenchymal transition progress by inhibiting transforming growth factor-β1 signalling pathway in non-small cell lung cancer

(2014) Wen-Ke Cai et al.   EUROPEAN JOURNAL OF CANCER

Discovery and SAR of 6-Alkyl-2,4-diaminopyrimidines as Histamine H4 Receptor Antagonists

(2014) Brad M. Savall et al.   JOURNAL OF MEDICINAL CHEMISTRY

Functional characterization of histamine H4 receptor on human mast cells

(2014) E. Angel Jemima et al.   MOLECULAR IMMUNOLOGY

The role of ligand efficiency metrics in drug discovery

(2014) Andrew L. Hopkins et al.   NATURE REVIEWS DRUG DISCOVERY

Delineating the Role of Histamine-1- and -4-Receptors in a Mouse Model of Th2-Dependent Antigen-Specific Skin Inflammation

(2014) Subhashree Mahapatra et al.   PLoS One

The histamine H4receptor mediates inflammation and Th17 responses in preclinical models of arthritis

(2013) Jeffery M Cowden et al.   ANNALS OF THE RHEUMATIC DISEASES

Synthesis and Functional Characterization of Imbutamine Analogs as Histamine H3and H4Receptor Ligands

(2013) Roland Geyer et al.   ARCHIV DER PHARMAZIE

A novel series of histamine H4 receptor antagonists based on the pyrido[3,2-d]pyrimidine scaffold: Comparison of hERG binding and target residence time with PF-3893787

(2013) Mounir Andaloussi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A selective antagonist of histamine H4receptors prevents antigen-induced airway inflammation and bronchoconstriction in guinea pigs: involvement of lipocortin-1

(2013) T Somma et al.   BRITISH JOURNAL OF PHARMACOLOGY

Antagonism of histamine H4receptors exacerbates clinical and pathological signs of experimental autoimmune encephalomyelitis

(2013) C Ballerini et al.   BRITISH JOURNAL OF PHARMACOLOGY

Increased expression of the histamine H4 receptor following differentiation and mediation of the H4 receptor on interleukin-8 mRNA expression in HaCaT keratinocytes

(2013) Eriko Suwa et al.   EXPERIMENTAL DERMATOLOGY

Histamine induces chemotaxis and phagocytosis in murine bone marrow-derived macrophages and RAW 264.7 macrophage-like cells via histamine H4-receptor

(2013) Christoph P. Czerner et al.   INFLAMMATION RESEARCH

Antagonism of the histamine H4 receptor reduces LPS-induced TNF production in vivo

(2013) Jeffery M. Cowden et al.   INFLAMMATION RESEARCH

Histamine induces proliferation in keratinocytes from patients with atopic dermatitis through the histamine 4 receptor

(2013) Franziska Glatzer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Bispyrimidines as Potent Histamine H4 Receptor Ligands: Delineation of Structure–Activity Relationships and Detailed H4 Receptor Binding Mode

(2013) Harald Engelhardt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacological profile of astemizole-derived compounds at the histamine H1 and H4 receptor—H1/H4 receptor selectivity

(2013) Eva Wagner et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

The dual H3/4R antagonist thioperamide does not fully mimic the effects of the ‘standard’ H4R antagonist JNJ 7777120 in experimental murine asthma

(2013) Detlef Neumann et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Pleiotropic effect of histamine H4 receptor modulation in the central nervous system

(2013) Nicoletta Galeotti et al.   NEUROPHARMACOLOGY

Protection of Radiation-Induced Damage to the Hematopoietic System, Small Intestine and Salivary Glands in Rats by JNJ7777120 Compound, a Histamine H4 Ligand

(2013) Diego J. Martinel Lamas et al.   PLoS One

The antagonism of histamine H1 and H4 receptors ameliorates chronic allergic dermatitis via anti-pruritic and anti-inflammatory effects in NC/Nga mice

(2012) Y. Ohsawa et al.   ALLERGY

Histamine H4receptor antagonists as potent modulators of mammalian vestibular primary neuron excitability

(2012) G Desmadryl et al.   BRITISH JOURNAL OF PHARMACOLOGY

Detailed structure–activity relationship of indolecarboxamides as H4 receptor ligands

(2012) Harald Engelhardt et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Advantages of histamine H4 receptor antagonist usage with H1 receptor antagonist for the treatment of murine allergic contact dermatitis

(2012) Ayuko Matsushita et al.   EXPERIMENTAL DERMATOLOGY

Histamine H4 receptor ligands and their potential therapeutic applications: an update

(2012) Róbert Kiss et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Impact of Lipophilic Efficiency on Compound Quality

(2012) Ákos Tarcsay et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effects of Histamine H4 Receptor Ligands in a Mouse Model of Gastric Ulceration

(2012) Maristella Adami et al.   PHARMACOLOGY

Deletion and Down-Regulation of HRH4 Gene in Gastric Carcinomas: A Potential Correlation with Tumor Progression

(2012) Chao Zhang et al.   PLoS One

Synthesis of novel histamine H4 receptor antagonists

(2011) Charlotte A.L. Lane et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Defining Desirable Central Nervous System Drug Space through the Alignment of Molecular Properties, in Vitro ADME, and Safety Attributes

(2010) Travis T. Wager et al.   ACS Chemical Neuroscience

Polymorphisms in human histamine receptor H4 gene are associated with atopic dermatitis

(2010) B. Yu et al.   BRITISH JOURNAL OF DERMATOLOGY