The histamine H4receptor mediates inflammation and Th17 responses in preclinical models of arthritis

Cutting Edge: Histamine Receptor H4 Activation Positively Regulates In Vivo IL-4 and IFN-  Production by Invariant NKT Cells

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Histamine production by human neutrophils

(2013) Lorena Alcañiz et al.   FASEB JOURNAL

Antagonism of the histamine H4 receptor reduces LPS-induced TNF production in vivo

(2013) Jeffery M. Cowden et al.   INFLAMMATION RESEARCH

Human basophils interact with memory T cells to augment Th17 responses

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Opposite Effects of Mepyramine on JNJ 7777120-Induced Amelioration of Experimentally Induced Asthma in Mice in Sensitization and Provocation

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Human Memory Th17 Cells Express a Functional Histamine H4 Receptor

(2011) Susanne Mommert et al.   AMERICAN JOURNAL OF PATHOLOGY

Anti-citrullinated protein antibodies in rheumatoid arthritis: a functional role for mast cells and basophils?

(2011) J. Suurmond et al.   ANNALS OF THE RHEUMATIC DISEASES

Histamine H4 receptor activation enhances LPS-induced IL-6 production in mast cells via ERK and PI3K activation

(2011) Pragnya Desai et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The histamine H4 receptor: Targeting inflammatory disorders

(2011) Miriam Walter et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Histamine H4 receptor antagonism inhibits allergen-specific T-cell responses mediated by human dendritic cells

(2010) Kristina Lundberg et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Histidine decarboxylase but not histamine receptor 1 or 2 deficiency protects from K/BxN serum-induced arthritis

(2009) N. Rajasekaran et al.   INTERNATIONAL IMMUNOLOGY

The histamine H4 receptor is functionally expressed on TH2 cells

(2009) Ralf Gutzmer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Histamine H4 Receptor Mediates Inflammation and Pruritus in Th2-Dependent Dermal Inflammation

(2009) Jeffery M. Cowden et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo

(2009) Mandy J McGeachy et al.   NATURE IMMUNOLOGY

Protocol for the induction of arthritis in C57BL/6 mice

(2008) Julia J Inglis et al.   Nature Protocols

The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines

(2008) Robin L. Thurmond et al.   NATURE REVIEWS DRUG DISCOVERY