Article
Food Science & Technology
Jieping Yang, Patrizia Maria Germano, Suwan Oh, Sijia Wang, Jing Wang, Rupo Lee, Hayden Paige, Scarlet Yang, Susanne M. Henning, Jin Zhong, Jonathan P. Jacobs, Zhaoping Li
Summary: This study found that dietary supplementation of pomegranate extract (PomX) can ameliorate colitis and reduce inflammatory markers in mice fed a Western diet. These effects may be mediated by the impact of PomX on the gut microbiome.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Environmental Sciences
Takuro Okamura, Masahide Hamaguchi, Yuka Hasegawa, Yoshitaka Hashimoto, Saori Majima, Takafumi Senmaru, Emi Ushigome, Naoko Nakanishi, Mai Asano, Masahiro Yamazaki, Ryoichi Sasano, Yuki Nakanishi, Hiroshi Seno, Hirohisa Takano, Michiaki Fukui
Summary: The study found that microplastics can cause metabolic disturbances, such as diabetes and nonalcoholic fatty liver disease, in mice on a high-fat diet. The results highlight the importance of reducing oral exposure to microplastics through environmental measures to improve metabolic disturbance under high-fat diet conditions.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2023)
Review
Medicine, Research & Experimental
Yao Tong, Huiru Gao, Qiuchen Qi, Xiaoyan Liu, Juan Li, Jie Gao, Peilong Li, Yunshan Wang, Lutao Du, Chuanxin Wang
Summary: Gastrointestinal cancer is a major cause of cancer-related deaths, with a high fat diet and gut microbiome imbalance potentially driving its occurrence and progression through inflammation and changes in the immune environment.
Article
Nutrition & Dietetics
Chen-Wen Lu, Wen-Jhen Wu, Thi Kim Ngan Nguyen, Szu-Chuan Shen, Yeh-B. Wu, Hui-Ju Liang, Chung-Hsin Wu
Summary: This study investigated the effects of oral ovatodiolide and antcin K (OAK) supplements on high-fat diet-induced cardiovascular dysfunction in apolipoprotein E (ApoE)-knockout mice. Oral OAK supplements significantly alleviated cardiovascular dysfunction in the experimental mice, potentially by reducing lipid accumulation in the artery and oxidative stress and inflammation in the cardiovascular tissue.
Article
Immunology
Rong Tan, Huiwei Dong, Zhengshan Chen, Min Jin, Jing Yin, Haibei Li, Danyang Shi, Yifan Shao, Huaran Wang, Tianjiao Chen, Dong Yang, Junwen Li
Summary: Unhealthy dietary habits are associated with increased incidence of chronic diseases, with high-fat and high-fructose diets leading to reduced defecation volume, increased levels of pro-inflammatory cytokines and IgG in serum, inflammatory cell infiltration in intestinal tissue, changes in microbial composition, alterations in microbial metabolites, and potential causes of constipation and inflammation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Endocrinology & Metabolism
Kathryn M. Spitler, Shwetha K. Shetty, Emily M. Cushing, Kelli L. Sylvers-Davie, Brandon S. J. Davies
Summary: Hepatocyte-specific loss of ANGPTL4 does not improve triglyceride phenotypes during high-fat feeding, but these mice show improved glucose tolerance after chronic high-fat diet. Additionally, Angptl4(LivKO) mice have decreased fasting plasma triglyceride levels after an 18-h fast, but not after a 6-h fast.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Immunology
Jasmine George, Yuanyuan Zhang, Jacob Sloan, Joya M. Sims, John D. Imig, Xueying Zhao
Summary: The deficiency of Tim-1 exacerbates lipid accumulation and liver fibrosis induced by a high-fat diet, likely through increased infiltration and activation of inflammatory cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Sarah E. Elzinga, Rosemary Henn, Benjamin J. Murdock, Bhumsoo Kim, John M. Hayes, Faye Mendelson, Ian Webber-Davis, Sam Teener, Crystal Pacut, Stephen I. Lentz, Eva L. Feldman
Summary: Obesity, prediabetes, and diabetes are associated with neurodegenerative diseases, particularly Alzheimer's disease and Alzheimer's disease related dementias, through the activation of innate inflammatory signaling, potentially via the cGAS/STING pathway.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Ophthalmology
Jinghua Bu, Minjie Zhang, Yang Wu, Nan Jiang, Yuli Guo, Xin He, Hui He, M. Vimalin Jeyalatha, Peter Sol Reinach, Zuguo Liu, Wei Li
Summary: High-fat diet-induced declines in PPAR-gamma expression and activation of MAPK and NF-kappa B signaling pathways may lead to meibomian gland inflammation and dysfunction in mice, characterized by lipid accumulation, inflammatory cell infiltration, apoptosis, and mitochondria damage. Treatment involving dietary shifts and medication administration can alleviate this inflammation.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Plant Sciences
Wenshuai Wang, Yaohan Zhang, Zhiying Wang, Jianjun Zhang, Le Jia
Summary: This study investigated the protective effects of Ganoderma lucidum polysaccharides (GLP) on high-fat diet-induced hyperlipidemia and explored the underlying mechanism. The results showed that GLP decreased body weight gain, reduced lipid levels, alleviated tissue injury, and improved oxidative stress and inflammation response. GLP also modulated bile acids synthesis, lipid regulatory factors, and promoted reverse cholesterol transport.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ornella Selmin, Andreas J. Papoutsis, Sabine Hazan, Christopher Smith, Nick Greenfield, Micah G. Donovan, Spencer N. Wren, Thomas C. Doetschman, Justin M. Snider, Ashley J. Snider, Sherry H-H Chow, Donato F. Romagnolo
Summary: This study compared the effects of a typical Western diet and a soybean oil-rich n-6HFD on gut inflammation and microbiome using a mouse model. The results showed that n-6HFD induced colonic inflammation and altered gut bacterial composition, promoting the growth of proinflammatory bacteria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Leila F. Coelho, Mateus B. Casaro, Willian R. Ribeiro, Eduardo Mendes, Gilson Murata, Patricia Xander, Adriana Lino-dos-Santos-Franco, Fernando A. Oliveira, Caroline M. Ferreira
Summary: This study investigates the influence of a high-sugar diet on allergic contact dermatitis (ACD) in mice. The results suggest that a high-sugar diet may increase liver cholesterol and triglyceride levels, worsen dermatitis symptoms, and cause an increase in skin epithelial thickness.
Article
Biochemistry & Molecular Biology
Aden Geonhee Lee, Sora Kang, Hye Ji Yoon, Suyeol Im, Seung Jun Oh, Youngmi Kim Pak
Summary: This study comprehensively investigated the distribution and physiological effects of microplastics (MPs) using in silico, in vitro, and in vivo approaches. The results showed that styrene exhibited the highest binding affinity for immune cells. Furthermore, oral administration of fluorescent-labeled PS-MPs to high-fat diet-induced obese mice led to the co-existence of MPs with immune cells in the blood, exacerbating impaired glucose metabolism and insulin resistance and promoting systemic inflammation. Additionally, MPs were detected throughout the brain, with increased activation of microglia in the hypothalamus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Allergy
Anne-Catherine Ruehl-Muth, Mareike D. Maler, Philipp R. Esser, Stefan F. Martin
Summary: This study found that a high-fat diet may increase sensitization and elicitation of allergic contact dermatitis (CHS), particularly impacting the resistance of mice lacking Toll-like receptors 2 and 4.
CONTACT DERMATITIS
(2021)
Article
Food Science & Technology
Xu Yan, Yuanyuan Zhai, Wenling Zhou, Yuan Qiao, Lingling Guan, Hao Liu, Jizhi Jiang, Liang Peng
Summary: Rutin supplementation can alleviate obesity and metabolic disorders induced by high-fat diet through modulating the composition of intestinal flora. Rutin supplementation reduces body-weight gain, improves insulin resistance, and acts favorably on intestinal barrier, reducing endotoxemia and systemic inflammation. Antibiotic treatment and fecal microbiota transplantation demonstrate the importance of intestinal flora in the beneficial effects of rutin on obesity control.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Endocrinology & Metabolism
Daisuke Chujo, Akihisa Imagawa, Kazuki Yasuda, Norio Abiru, Takuya Awata, Tomoyasu Fukui, Hiroshi Ikegami, Eiji Kawasaki, Takeshi Katsuki, Tetsuro Kobayashi, Junji Kozawa, Kan Nagasawa, Hiroshi Ohtsu, Yoichi Oikawa, Haruhiko Osawa, Akira Shimada, Masayuki Shimoda, Kazuma Takahashi, Kyoichiro Tsuchiya, Tetsuro Tsujimoto, Hisafumi Yasuda, Toshiaki Hanafusa, Hiroshi Kajio
Summary: The Japanese Type 1 Diabetes Database Study (TIDE-J) aims to establish a multi-center prospective longitudinal database of three T1D subtypes, with the goal of revealing distinct clinical courses and identifying novel markers for diagnosis. The study collects clinical data, genetic information, and biobanking samples annually to investigate clinical outcomes and predict disease severity in patients with T1D.
DIABETOLOGY INTERNATIONAL
(2022)
Article
Cardiac & Cardiovascular Systems
Yukio Hiroi, Hiroshi Ohtsu, Yukari Uemura, Kayoko Hayakawa, Yusuke Asai, Satoshi Kutsuna, Mari Terada, Wataru Sugiura, Norio Ohmagari
Summary: This study analyzed the incidence and prognosis of cardiovascular complications in COVID-19 patients in Japan. The results showed that although cardiovascular complications were rare in Japan, they were associated with poor prognosis.
CIRCULATION JOURNAL
(2022)
Article
Geriatrics & Gerontology
Yusuke Asai, Hidetoshi Nomoto, Kayoko Hayakawa, Nobuaki Matsunaga, Shinya Tsuzuki, Mari Terada, Hiroshi Ohtsu, Koji Kitajima, Kumiko Suzuki, Tetsuya Suzuki, Keiji Nakamura, Shinichiro Morioka, Sho Saito, Fumitake Saito, Norio Ohmagari
Summary: This study analyzed the clinical and epidemiological characteristics of elderly COVID-19 patients in different age groups and found differences among age groups. Most patients had at least one comorbidity, and hypertension was high in all age groups. The proportion of patients with dementia, cardiovascular disease, and cerebrovascular disease increased with age.
Article
Public, Environmental & Occupational Health
Yumi Matsushita, Tetsuji Yokoyama, Kayoko Hayakawa, Nobuaki Matsunaga, Hiroshi Ohtsu, Sho Saito, Mari Terada, Setsuko Suzuki, Shinichiro Morioka, Satoshi Kutsuna, Tetsuya Mizoue, Hisao Hara, Akio Kimura, Norio Ohmagari
Summary: Former smoking, but not current smoking, was associated with increased risk of severe COVID-19 in both men and women, suggesting that smoking cessation may reduce the risk of severe COVID-19 by preventing smoking-related comorbidities.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Peripheral Vascular Disease
Kazunori Omote, Isao Yokota, Toshiyuki Nagai, Ichiro Sakuma, Yoshihisa Nakagawa, Kiwamu Kamiya, Hiroshi Iwata, Katsumi Miyauchi, Yukio Ozaki, Kiyoshi Hibi, Takafumi Hiro, Yoshihiro Fukumoto, Hiroyoshi Mori, Seiji Hokimoto, Yasuo Ohashi, Hiroshi Ohtsu, Hisao Ogawa, Hiroyuki Daida, Satoshi Iimuro, Hiroaki Shimokawa, Yasushi Saito, Takeshi Kimura, Masunori Matsuzaki, Ryozo Nagai, Toshihisa Anzai
Summary: The prognostic value of HDL-C level after statin therapy is limited in patients with stable CAD.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2022)
Article
Infectious Diseases
Hidetoshi Nomoto, Setsuko Suzuki, Yusuke Asai, Kayoko Hayakawa, Hiroyuki Gatanaga, Mari Terada, Kumiko Suzuki, Hiroshi Ohtsu, Ako Toyoda, Norio Ohmagari
Summary: The study aimed to analyze the clinical characteristics and outcomes of immunosuppressed COVID-19 inpatients. The results showed that immunosuppressed patients were older and had a higher severity of illness. The prognosis varied according to the different immunosuppressed states, possibly due to the severity of the underlying diseases.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2022)
Article
Endocrinology & Metabolism
Daisuke Chujo, Toshiaki Kurokawa, Akitsu Kawabe, Nobuyuki Takahashi, Fuyuki Inagaki, Koya Shinohara, Shotaro Hagiwara, Yoshihiro Edamoto, Norio Ohmagari, Fumihiko Hinoshita, Tsuyoshi Tajima, Hiroshi Kajio, Hiroshi Ohtsu, Nobuyuki Takemura, Shinichi Matsumoto, Masayuki Shimoda
Summary: A case of allogeneic islet transplantation in Japan was reported, with a focus on using an original assessment method to monitor cellular autoimmunity. The method successfully detected the activation of islet antigen-specific CD8(+) T-cell responses, indicating the potential for non-invasive detection of pancreatic beta-cell damage due to recurrent autoimmunity.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Meeting Abstract
Oncology
Akihiko Shimomura, Hiroshi Ohtsu, Chikako Shimizu, Kazuhiro Sase
Article
Infectious Diseases
Michiyo Suzuki, Kayoko Hayakawa, Yusuke Asai, Nobuaki Matsunaga, Mari Terada, Hiroshi Ohtsu, Ako Toyoda, Jin Takasaki, Masayuki Hojo, Yasuaki Yanagawa, Sho Saito, Kei Yamamoto, Satoshi Ide, Yutaro Akiyama, Tetsuya Suzuki, Ataru Moriya, Kazuhisa Mezaki, Norio Ohmagari
Summary: The detection of other pathogens in hospitalized COVID-19 patients in Japan is not frequent. Bacterial culture was more common, but the types of bacteria detected were limited. Larger cohort studies are needed to evaluate the impact of different pathogens on the clinical course of COVID-19.
JAPANESE JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Peripheral Vascular Disease
Junnichi Ishii, Kosuke Kashiwabara, Yukio Ozaki, Hiroshi Takahashi, Fumihiko Kitagawa, Hideto Nishimura, Hideki Ishii, Satoshi Iimuro, Hideki Kawai, Takashi Muramatsu, Hiroyuki Naruse, Hiroshi Iwata, Sadako Tanizawa-Motoyama, Hiroyasu Ito, Eiichi Watanabe, Yutaka Matsuyama, Yoshihiro Fukumoto, Ichiro Sakuma, Yoshihisa Nakagawa, Kiyoshi Hibi, Takafumi Hiro, Seiji Hokimoto, Katsumi Miyauchi, Hiroshi Ohtsu, Hideo Izawa, Hisao Ogawa, Hiroyuki Daida, Hiroaki Shimokawa, Yasushi Saito, Takeshi Kimura, Masunori Matsuzaki, Ryozo Nagai
Summary: This study investigated the relationship between small dense low-density cholesterol (sdLDL-C) and the risk of major adverse cardiovascular events (MACE) in patients treated with high or low-dose statin therapy. The findings suggest that high-dose statin therapy can reduce the risk of MACE in patients with the highest baseline sdLDL-C.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2022)
Article
Cardiac & Cardiovascular Systems
Hiroshi Ohtsu, Akihiko Shimomura, Sakiko Miyazaki, Naohiro Yonemoto, Shinichiro Ueda, Chikako Shimizu, Kazuhiro Sase
Summary: This study aims to analyze the cardiotoxicity of trastuzumab using a nationwide claim-based database. The results show a higher rate of heart failure development in breast cancer patients treated with trastuzumab, indicating the need for further research to improve cardiovascular risk assessment in these patients.
Article
Orthopedics
Yasuhiro Homma, Xu Zhuang, Hiroshi Ohtsu, Seiya Ishii, Yuichi Shirogane, Koju Hayashi, Taiji Watari, Tomonori Baba, Muneaki Ishijima
Summary: In this study, a machine learning algorithm was developed to predict post-operative subsidence with high accuracy using acoustic parameters and additional pre-operative features. The results represent a step towards the realization of acoustic monitoring to avoid complication in cementless total hip arthroplasty.
INTERNATIONAL ORTHOPAEDICS
(2023)
Article
Peripheral Vascular Disease
Makiko Egawa, Eiichiro Kanda, Hiroshi Ohtsu, Tomohiro Nakamura, Masayuki Yoshida
Summary: This study examined the impact of a history of hypertensive disorders of pregnancy (HDP) on the possibility of cardiovascular disease (CVD) in middle-aged and older Japanese women. The study found that a history of HDP was associated with an increased risk of CVD, particularly when combined with chronic hypertension (HT). These findings emphasize the importance of understanding pregnancy outcomes in health management.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2023)
Article
Infectious Diseases
Sho Saito, Pham Thi Ngoc Thao, Masahiro Ishikane, Phan Thi Xuan, Satoshi Kutsuna, Huynh Quang Dai, Hiroshi Ohtsu, Tomomi Kimura, Hiroyuki Kiyohara, Yasuyuki Shimada, Yutaka Maruoka, Pham Thi Phuong Thuy, Truong Thien Phu, Huynh Kim Phuong, Ton Thanh Tra, Nguyen Ly Minh Duy, Hiroshi Ohara, Hitomi Kurosu, Nguyen Truong Son, Norio Ohmagari
Summary: Physical oral care without medication can effectively reduce the incidence of ventilator-associated pneumonia (VAP) in the intensive care unit (ICU). This method can be widely used in countries with limited medical resources.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2022)
Correction
Oncology
Takuji Iwase, Shigehira Saji, Kotaro Iijima, Kenji Higaki, Shoichiro Ohtani, Yasuyuki Sato, Yasuo Hozumi, Yoshie Hasegawa, Yasuhiro Yanagita, Hiroyuki Takei, Maki Tanaka, Hideji Masuoka, Masahiko Tanabe, Chiyomi Egawa, Yoshifumi Komoike, Toshitaka Nakamura, Hiroshi Ohtsu, Hirofumi Mukai
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Dermatology
Matthew J. Davis, Gokul Srinivasan, Rachael Chacko, Sophie Chen, Anish Suvarna, Louis J. Vaickus, Veronica C. Torres, Sassan Hodge, Eunice Y. Chen, Sarah Preum, Kimberley S. Samkoe, Brock C. Christensen, Matthew R. Leboeuf, Joshua J. Levy
Summary: The development and application of AI algorithms are of great significance for the removal of cSCC, as they can improve operational efficiency and accuracy, especially for moderately and poorly differentiated tumors/ neoplasms. Further improvement is needed to maintain sensitivity to surrounding tissue and determine anatomical positioning.
EXPERIMENTAL DERMATOLOGY
(2024)
Article
Dermatology
Lingjing Chen, Qing Yu, Feiying Guo, Xuewen Wang, Zhenying Cai, Qiang Zhou
Summary: This study investigated the role and mechanisms of NTS in stress-induced hair growth inhibition. The results demonstrated that NTS effectively counteracted hair growth inhibition caused by stress and regulated the expression of multiple genes related to hair growth at the transcriptional level.
EXPERIMENTAL DERMATOLOGY
(2024)
