Peptide nucleic acids: a review on recent patents and technology transfer

Potent and Selective Inhibition of A-to-I RNA Editing with 2′-O-Methyl/Locked Nucleic Acid-Containing Antisense Oligoribonucleotides

(2013) Rena A. Mizrahi et al.   ACS Chemical Biology

Quantitative and Multiplexed MicroRNA Sensing in Living Cells Based on Peptide Nucleic Acid and Nano Graphene Oxide (PANGO)

(2013) Soo-Ryoon Ryoo et al.   ACS Nano

PNA-assembled graphene oxide for sensitive and selective detection of DNA

(2013) Shuang Guo et al.   ANALYST

Surface plasmon resonance sensing of nucleic acids: A review

(2013) Hana Šípová et al.   ANALYTICA CHIMICA ACTA

Fluorescence Imaging of Single-Copy DNA Sequences within the Human Genome Using PNA-Directed Padlock Probe Assembly

(2013) Anastasia I. Yaroslavsky et al.   CHEMISTRY & BIOLOGY

Advances in the Techniques for the Prediction of microRNA Targets

(2013) Hao Zheng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Triplex-forming Peptide Nucleic Acids Induce Heritable Elevations in Gamma-globin Expression in Hematopoietic Progenitor Cells

(2013) Joanna Y Chin et al.   MOLECULAR THERAPY

Imaging mRNA expression levels in living cells with PNA·DNA binary FRET probes delivered by cationic shell-crosslinked nanoparticles

(2013) Zhenghui Wang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The analysis of major impurities of lipophilic-conjugated phosphorothioate oligonucleotides by ion-pair reversed-phase HPLC combined with MALDI-TOF-MS

(2012) Cai-Hong Liu et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Nano RNA aptamer wire for analysis of vitamin B12

(2012) L.S. Selvakumar et al.   ANALYTICAL BIOCHEMISTRY

PNA FIT-Probes for the Dual Color Imaging of Two Viral mRNA Targets in Influenza H1N1 Infected Live Cells

(2012) Susann Kummer et al.   BIOCONJUGATE CHEMISTRY

Cellular Uptakes, Biostabilities and Anti-miR-210 Activities of Chiral Arginine-PNAs in Leukaemic K562 Cells

(2012) Alex Manicardi et al.   CHEMBIOCHEM

Clear-cut observation of PNA invasion using nanomechanical DNA origami devices

(2012) Takahiro Yamazaki et al.   CHEMICAL COMMUNICATIONS

PNA-based microRNA inhibitors elicit anti-inflammatory effects in microglia cells

(2012) Peter N. Brown et al.   CHEMICAL COMMUNICATIONS

Comparison of a PNA Clamp PCR and an ARMS/Scorpion PCR Assay for the Detection of K-ras Mutations

(2012) Oddmund Nordgård et al.   DIAGNOSTIC MOLECULAR PATHOLOGY

Alternative options for DNA-based experimental therapy of β-thalassemia

(2012) Roberto Gambari   EXPERT OPINION ON BIOLOGICAL THERAPY

Multiplexed nucleic acid-based assays for molecular diagnostics of human disease

(2012) Alina Deshpande et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Systemic delivery of triplex-forming PNA and donor DNA by nanoparticles mediates site-specific genome editing of human hematopoietic cells in vivo

(2012) N A McNeer et al.   GENE THERAPY

Improved Synthesis Strategy for Peptide Nucleic Acids (PNA) appropriate for Cell-specific Fluorescence Imaging

(2012) Rüdiger Pipkorn et al.   International Journal of Medical Sciences

The Upcoming Field of Theranostic Nanomedicine: An Overview

(2012) Priyanka Prabhu et al.   Journal of Biomedical Nanotechnology

EGFRmutation testing in lung cancer: a review of available methods and their use for analysis of tumour tissue and cytology samples

(2012) Gillian Ellison et al.   JOURNAL OF CLINICAL PATHOLOGY

Sequence-specific Nucleic Acid Detection from Binary Pore Conductance Measurement

(2012) Leyla Esfandiari et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Detection of Endogenous K-ras mRNA in Living Cells at a Single Base Resolution by a PNA Molecular Beacon

(2012) Yossi Kam et al.   MOLECULAR PHARMACEUTICS

MicroRNA Regulation of the Synaptic Plasticity-Related Gene Arc

(2012) Karin Wibrand et al.   PLoS One

Inhibition of 5′-UTR RNA Conformational Switching in HIV-1 Using Antisense PNAs

(2012) Braham Parkash et al.   PLoS One

Evaluation of Peptide Nucleic Acid Probe-based Real-time PCR for Detection ofMycobacterium tuberculosisComplex and Nontuberculous Mycobacteria in Respiratory Specimens

(2012) Young Jin Choi et al.   Annals of Laboratory Medicine

Direct Detection of Point Mutations in Nonamplified Human Genomic DNA

(2011) Roberta D’Agata et al.   ANALYTICAL CHEMISTRY

Fluorescence Imaging of Influenza H1N1 mRNA in Living Infected Cells Using Single-Chromophore FIT-PNA

(2011) Susann Kummer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Expression of miR-210 during erythroid differentiation and induction of γ-globin gene expression

(2011) Nicoletta Bianchi et al.   BMB Reports

FIT for Purpose: PNA-Based Probes Enable mRNA Imaging in Living Cells

(2011) Jens Tilsner et al.   CHEMBIOCHEM

Colorimetric detection of c-Kit mutations using electrostatic attraction induced aggregation of peptide nucleic acid modified gold nanoparticles

(2011) Hosub Lee et al.   CHEMICAL COMMUNICATIONS

Phosphorothioate Nucleotides and Oligonucleotides - Recent Progress in Synthesis and Application

(2011) Piotr Guga et al.   CHEMISTRY & BIODIVERSITY

Modulation of the Biological Activity of microRNA-210 with Peptide Nucleic Acids (PNAs)

(2011) Enrica Fabbri et al.   ChemMedChem

Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy

(2011) R. Tonelli et al.   CLINICAL CANCER RESEARCH

Artificial Restriction DNA Cutters to Promote Homologous Recombination in Human Cells

(2011) Hitoshi Katada et al.   CURRENT GENE THERAPY

Synthesis, characterisation and bioimaging of a fluorescent rhenium-containing PNA bioconjugate

(2011) Gilles Gasser et al.   DALTON TRANSACTIONS

Real time RNA transcription monitoring by Thiazole Orange (TO)-conjugated Peptide Nucleic Acid (PNA) probes: norovirus detection

(2011) Alessandro Tonelli et al.   Molecular BioSystems

Chemical structure requirements and cellular targeting of microRNA-122 by peptide nucleic acids anti-miRs

(2011) Adrian G. Torres et al.   NUCLEIC ACIDS RESEARCH

Decoy oligodeoxyribonucleotides and peptide nucleic acids–DNA chimeras targeting nuclear factor kappa-B: Inhibition of IL-8 gene expression in cystic fibrosis cells infected with Pseudomonas aeruginosa

(2010) Roberto Gambari et al.   BIOCHEMICAL PHARMACOLOGY

Imaging Human Pancreatic Cancer Xenografts by Targeting MutantKRAS2mRNA with [111In]DOTAn-Poly(diamidopropanoyl)m-KRAS2PNA-d(Cys-Ser-Lys-Cys) Nanoparticles

(2010) Nariman V. Amirkhanov et al.   BIOCONJUGATE CHEMISTRY

Synthesis and Splice-Redirecting Activity of Branched, Arginine-Rich Peptide Dendrimer Conjugates of Peptide Nucleic Acid Oligonucleotides

(2010) Amer F. Saleh et al.   BIOCONJUGATE CHEMISTRY

Cancer therapy via modulation of micro RNA levels: a promising future

(2010) Satya K. Kota et al.   DRUG DISCOVERY TODAY

A Peptide Nucleic Acid Embedding a Pseudopeptide Nuclear Localization Sequence in the Backbone Behaves as a Peptide Mimic

(2010) Stefano Sforza et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Use of fully modified 2′-O-methyl antisense oligos for loss-of-function studies in vertebrate embryos

(2010) Patricia N. Schneider et al.   GENESIS

Advantages of Peptide Nucleic Acids as Diagnostic Platforms for Detection of Nucleic Acids in Resource‐Limited Settings

(2010) Ning Zhang et al.   JOURNAL OF INFECTIOUS DISEASES

Optimization of Peptide Nucleic Acid Antisense Oligonucleotides for Local and Systemic Dystrophin Splice Correction in the mdx Mouse

(2010) HaiFang Yin et al.   MOLECULAR THERAPY

Optimizing anti-gene oligonucleotide ‘Zorro-LNA’ for improved strand invasion into duplex DNA

(2010) Eman M. Zaghloul et al.   NUCLEIC ACIDS RESEARCH

Efficient inhibition of miR-155 function in vivo by peptide nucleic acids

(2010) Martin M. Fabani et al.   NUCLEIC ACIDS RESEARCH

PNA-Based Antisense Oligonucleotides for MicroRNAs Inhibition in the Absence of a Transfection Reagent

(2010) Su Young Oh et al.   OLIGONUCLEOTIDES

Thiolated pyrrolidinyl peptide nucleic acids for the detection of DNA hybridization using surface plasmon resonance

(2009) Cheeraporn Ananthanawat et al.   BIOSENSORS & BIOELECTRONICS

Comparison of DNA, aminoethylglycyl PNA and pyrrolidinyl PNA as probes for detection of DNA hybridization using surface plasmon resonance technique

(2009) Cheeraporn Ananthanawat et al.   BIOSENSORS & BIOELECTRONICS

Strand invasion of conventional PNA to arbitrary sequence in DNA assisted by single-stranded DNA binding protein

(2009) Takumi Ishizuka et al.   CHEMICAL COMMUNICATIONS

Prospects for antisense peptide nucleic acid (PNA) therapies for HIV

(2009) Virendra N Pandey et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Aptamers: from bench side research towards patented molecules with therapeutic applications

(2009) Paromita Majumder et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Imaging of mRNA in Live Cells Using Nucleic Acid-Templated Reduction of Azidorhodamine Probes

(2009) Zbigniew Pianowski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Origin of High Fidelity in Target-Sequence Recognition by PNA−Ce(IV)/EDTA Combinations as Site-Selective DNA Cutters

(2009) Yoshitaka Miyajima et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Detection and identification of specific bacteria in wound biofilms using peptide nucleic acid fluorescent in situ hybridization (PNA FISH)

(2009) S. Malic et al.   MICROBIOLOGY-SGM

Antisense gapmers selectively suppress individual oncogenic p73 splice isoforms and inhibit tumor growth in vivo

(2009) Stephan Emmrich et al.   Molecular Cancer

A highly effective and long-lasting inhibition of miRNAs with PNA-based antisense oligonucleotides

(2009) Su Young Oh et al.   MOLECULES AND CELLS

Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications

(2009) Brian D. Brown et al.   NATURE REVIEWS GENETICS

Introduction of disulfide bond to the main chain of PNA to switch its hybridization and invasion activity

(2009) Yuichiro Aiba et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Femtomol SPR detection of DNA–PNA hybridization with the assistance of DNA-guided polyaniline deposition

(2008) Xiaodi Su et al.   BIOSENSORS & BIOELECTRONICS

SPR study of DNA hybridization with DNA and PNA probes under stringent conditions

(2008) Alex Ieng Kin Lao et al.   BIOSENSORS & BIOELECTRONICS

Peptide nucleic acid–locked nucleic acid polymerase chain reaction clamp-based detection test for gefitinib-refractory T790M epidermal growth factor receptor mutation

(2008) Hitoshi Miyazawa et al.   CANCER SCIENCE

Improved cell-penetrating peptide–PNA conjugates for splicing redirection in HeLa cells and exon skipping in mdx mouse muscle

(2008) Gabriela D. Ivanova et al.   NUCLEIC ACIDS RESEARCH

Correction of a splice-site mutation in the beta-globin gene stimulated by triplex-forming peptide nucleic acids

(2008) J. Y. Chin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Label-free DNA electrochemical sensor based on a PNA-functionalized conductive polymer

(2008) S. Reisberg et al.   TALANTA