Recent developments in design and synthesis of bicyclic azasugars, carbasugars and related molecules as glycosidase inhibitors

Developing inhibitors of glycan processing enzymes as tools for enabling glycobiology

(2012) Tracey M Gloster et al.   Nature Chemical Biology

Total Synthesis of (+)-Hyacinthacine A1, (+)-7a-epi-Hyacinthacine A1, (6R)-6-Hydroxyhyacinthacine A1 and (6S)-6-Hydroxy-7a-epi-hyacinthacine A1

(2011) Giampiero D'Adamio et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Recent Advances in the Total Synthesis of Indolizidine Iminosugars

(2011) In Su Kim et al.   HETEROCYCLES

Ceric Ammonium Nitrate-Catalyzed Azidation of 1,2-Anhydro Sugars: Application in the Synthesis of Structurally Diverse Sugar-Derived Morpholine 1,2,3-Triazoles and 1,4-Oxazin-2-ones

(2011) Y. Suman Reddy et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Fully Substituted Polyhydroxylated Pyrrolizidines via Cope–House Cyclization

(2011) Wei Zhang et al.   ORGANIC LETTERS

Synthesis of N-, S-, and C-glycoside castanospermine analogues with selective neutral α-glucosidase inhibitory activity as antitumour agents

(2010) Elena M. Sánchez-Fernández et al.   CHEMICAL COMMUNICATIONS

Iminosugars past, present and future: medicines for tomorrow

(2010) Graeme Horne et al.   DRUG DISCOVERY TODAY

Synthesis, Biological Activity, and Molecular Modeling Studies of 1H-1,2,3-Triazole Derivatives of Carbohydrates as α-Glucosidases Inhibitors

(2010) Sabrina B. Ferreira et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, computational study and glycosidase inhibitory activity of polyhydroxylated conidine alkaloids—a bicyclic iminosugar

(2010) Shrihari P. Sanap et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and Glycosidase Inhibition of the Enantiomer of (−)-Steviamine, the First Example of a New Class of Indolizidine Alkaloid

(2010) Xiang-Guo Hu et al.   ORGANIC LETTERS

Steviamine, a new indolizidine alkaloid from Stevia rebaudiana

(2010) Agnieszka Michalik et al.   Phytochemistry Letters

Pochonicine, a polyhydroxylated pyrrolizidine alkaloid from fungus Pochonia suchlasporia var. suchlasporia TAMA 87 as a potent β-N-acetylglucosaminidase inhibitor

(2009) Hirokazu Usuki et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of fused pyran-carbahexopyranoses as glycosidase inhibitors

(2009) Venkata Ramana Doddi et al.   CARBOHYDRATE RESEARCH

Stereocontrolled Cyclic Nitrone Cycloaddition Strategy for the Synthesis of Pyrrolizidine and Indolizidine Alkaloids

(2009) Alberto Brandi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Glycosidase inhibition by ring-modified castanospermine analogues: tackling enzyme selectivity by inhibitor tailoring

(2009) Matilde Aguilar-Moncayo et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and glycosidase-inhibitory activity of novel polyhydroxylated quinolizidines derived from d-glycals

(2009) Nitee Kumari et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Structural Analysis of Golgi α-Mannosidase II Inhibitors Identified from a Focused Glycosidase Inhibitor Screen†‡

(2008) Douglas A. Kuntz et al.   BIOCHEMISTRY

Synthesis and evaluation of sulfamide-type indolizidines as glycosidase inhibitors

(2008) Mahmoud Benltifa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Total Synthesis of L-(+)-Swainsonine and Other Indolizidine Azasugars from D-Glucose

(2008) Mohammad Abrar Alam et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Hybrids of D-Glucose and D-Galactose with Pyrrolidine-Based Iminosugars as Glycosidase Inhibitors

(2008) Venkata Ramana Doddi et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of hybrids of d-glucose and d-galactose with 1-deoxynojirimycin analogues using ring-closing metathesis

(2008) Amit Kumar et al.   TETRAHEDRON

Discovery of novel α-glucosidase inhibitors based on the virtual screening with the homology-modeled protein structure

(2007) Hwangseo Park et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of the naringinase inhibitors l-swainsonine and related 6-C-methyl-l-swainsonine analogues: (6R)-C-methyl-l-swainsonine is a more potent inhibitor of l-rhamnosidase by an order of magnitude than l-swainsonine

(2007) Anders E. Håkansson et al.   TETRAHEDRON LETTERS