标题
Rho kinase inhibitors: a patent review (2012 – 2013)
作者
关键词
-
出版物
EXPERT OPINION ON THERAPEUTIC PATENTS
Volume 24, Issue 3, Pages 295-307
出版商
Informa Healthcare
发表日期
2013-11-28
DOI
10.1517/13543776.2014.863279
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Phase 2 Randomized Clinical Study of a Rho Kinase Inhibitor, K-115, in Primary Open-Angle Glaucoma and Ocular Hypertension
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- 3-[2-(Aminomethyl)-5-[(pyridin-4-yl)carbamoyl]phenyl] benzoates as soft ROCK inhibitors
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- The Neuroprotective Potential of Rho-Kinase Inhibition in Promoting Cell Survival and Reducing Reactive Gliosis in Response to Hypoxia in Isolated Bovine Retina
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- The Rho-kinase inhibitor fasudil restores normal motor nerve conduction velocity in diabetic rats by assuring the proper localization of adhesion-related molecules in myelinating Schwann cells
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- Synthesis and Biological Evaluation of Urea Derivatives as Highly Potent and Selective Rho Kinase Inhibitors
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- Inhibition of Rho kinase mediates the neuroprotective effects of estrogen in the MPTP model of Parkinson's disease
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- Correlation between Rho-kinase pathway gene expressions and development and progression of glioblastoma multiforme
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- Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease
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- RhoA Activation and Effect of Rho-kinase Inhibitor in the Development of Retinal Neovascularization in a Mouse Model of Oxygen-induced Retinopathy
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- Rho Kinase Inhibitors: Potential Treatments for Diabetes and Diabetic Complications
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- Synthesis and biological evaluation of 4-quinazolinones as Rho kinase inhibitors
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- Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I)
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- Discovery and optimization of indole and 7-azaindoles as Rho kinase (ROCK) inhibitors (Part-II)
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- LIM Kinase 1 Modulates Cortical Actin and CXCR4 Cycling and Is Activated by HIV-1 to Initiate Viral Infection
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- Rhos and Rho kinases in the rat prostate: their possible functional roles and distributions
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- The development of benzimidazoles as selective rho kinase inhibitors
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- Benzothiophene containing Rho kinase inhibitors: Efficacy in an animal model of glaucoma
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- Rho-kinase inhibitor, fasudil, suppresses glioblastoma cell line progression in vitro and in vivo
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- Aberrant ROCK activation promotes the development of type I diabetes in NOD mice
- (2010) Partha S. Biswas et al. CELLULAR IMMUNOLOGY
- Chikungunya virus mobilizes the apoptotic machinery to invade host cell defenses
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- Tetrahydroisoquinoline Derivatives As Highly Selective and Potent Rho Kinase Inhibitors
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- Antinociceptive Effects of AS1892802, a Novel Rho Kinase Inhibitor, in Rat Models of Inflammatory and Noninflammatory Arthritis
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- RhoA/Rho kinase pathway contributes to the pathogenesis of thermal hyperalgesia in diabetic mice
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- Reduced Expression of the ROCK Inhibitor Rnd3 Is Associated with Increased Invasiveness and Metastatic Potential in Mesenchymal Tumor Cells
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- Discovery of Potent and Selective Urea-Based ROCK Inhibitors and Their Effects on Intraocular Pressure in Rats
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- Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors
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- Rho Kinase: An Important Mediator of Atherosclerosis and Vascular Disease
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- Effects of ROCK inhibitor, Y-27632, on adhesion and mobility in esophageal squamous cell cancer cells
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- Intraocular Pressure–Lowering Effects and Safety of Topical Administration of a Selective ROCK Inhibitor, SNJ-1656, in Healthy Volunteers
- (2008) Hidenobu Tanihara ARCHIVES OF OPHTHALMOLOGY
- Detection of myosin light chain phosphorylation—A cell-based assay for screening Rho-kinase inhibitors
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- Benzimidazole- and benzoxazole-based inhibitors of Rho kinase
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- Chroman-3-amides as potent Rho kinase inhibitors
- (2008) Yen Ting Chen et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Differential effects of two ROCK inhibitors, Fasudil and Y-27632, on optic nerve regeneration in adult cats
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- Nuclear Factor- B Induction by Visfatin in Human Vascular Endothelial Cells: Its role in MMP-2/9 production and activation
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- Rho kinase inhibitors: A novel therapeutical intervention in asthma?
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- Cardiovascular effects of a novel potent and highly selective azaindole-based inhibitor of Rho-kinase
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