Article
Biochemistry & Molecular Biology
Chipeng Guo, Lizhu Liang, Jingbin Zheng, Yang Xie, Xiaonan Qiu, Guozhen Tan, Jingang Huang, Liangchun Wang
Summary: In this study, it was found that UCHL1 was significantly upregulated in keloid fibroblasts and played a role in the pathological process of keloid by promoting collagen I and alpha-SMA expression. UCHL1 expression was also found to be promoted by M2 macrophages via TGF-beta 1. These findings expand our understanding of the pathogenesis of keloid and provide potential therapeutic targets for the disease.
Review
Pharmacology & Pharmacy
Fan Feng, Mingying Liu, Lianhong Pan, Jiaqin Wu, Chunli Wang, Li Yang, Wanqian Liu, Wei Xu, Mingxing Lei
Summary: Keloids are a fibroproliferative skin disorder caused by abnormal healing of injured or irritated skin. Mechanical stimulation can lead to excessive fibroblast proliferation, extracellular matrix deposition, and increase of keloid matrix stiffness, while matrix mechanics further activates the fibrotic phenotype. The TGF-beta/Smad signaling pathway, integrin signaling pathway, YAP/TAZ signaling pathway, and calcium ion pathway are involved in keloid formation. Understanding the role of biomechanical factors in keloid formation may facilitate the development of therapeutic interventions.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Dermatology
Edward J. Macarak, Peter J. Wermuth, Joel Rosenbloom, Jouni Uitto
Summary: Keloid disorder is a fibroproliferative skin disease characterized by the accumulation of extracellular matrix in skin, mainly collagen, with a strong genetic predisposition in individuals of African and Asian ancestry. The activation of biosynthetic pathways leading to ECM accumulation is driven by several cytokines, notably TGF-beta signaling, and the mechanical properties of the cellular microenvironment also play a critical role in the cell's response to these signals. Studies have shown that fibroblasts derived from keloids demonstrate different biosynthetic capacities when cultured on substrata with different degrees of stiffness, highlighting the complexity of factors involved in keloid pathogenesis.
EXPERIMENTAL DERMATOLOGY
(2021)
Review
Cell Biology
Mengwen Zhang, Hailong Chen, Huan Qian, Chen Wang
Summary: Keloids, a fibroproliferative skin disorder, exhibit cancer-like behaviors and have similar genetic and epigenetic modifications in the keloid microenvironment. The keloid microenvironment consists of keratinocytes, fibroblasts, myofibroblasts, vascular endothelial cells, immune cells, stem cells, and collagen fibers.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Oncology
Hiroyoshi Y. Tanaka, Takuya Nakazawa, Atsushi Enomoto, Atsushi Masamune, Mitsunobu R. Kano
Summary: Pancreatic cancer is difficult to treat and novel treatment strategies are urgently needed. The use of nanomedicines is being explored as a potential solution, but the fibrotic barrier in pancreatic cancer hinders their delivery. This review discusses strategies to overcome this barrier and highlights gaps in our understanding.
Article
Biology
Jill T. Kuwabara, Akitoshi Hara, Sumit Bhutada, Greg S. Gojanovich, Jasmine Chen, Kanani Hokutan, Vikram Shettigar, Anson Y. Lee, Lydia P. DeAngelo, Jack R. Heckl, Julia R. Jahansooz, Dillon K. Tacdol, Mark T. Ziolo, Suneel S. Apte, Michelle D. Tallquist
Summary: Reducing fibroblasts in the heart has a protective effect and can alleviate cardiac fibrosis after injury. The loss of fibroblasts does not significantly alter the quantitative composition of the extracellular matrix (ECM) but reduces the distribution and quantity of collagen VI. This study has important implications for the treatment of heart disease.
Article
Cell Biology
Yitian Zhang, Xiaoli Li, Wei Liu, Guanglei Hu, Hanjiang Gu, Xiao Cui, Dewu Zhang, Weihui Zeng, Yumin Xia
Summary: The TWEAK/Fn14 signaling pathway plays an important role in the pathogenesis of keloids. TWEAK can inhibit the formation and development of keloids by reducing the levels of collagen and alpha-SMA, promoting the expression of matrix metalloproteinases, and increasing the apoptosis activity of keloid fibroblasts.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shikun Zhang, Binghui Liu, Wenjuan Wang, Luye Lv, Dunqin Gao, Mi Chai, Mansheng Li, Zhihong Wu, Yunping Zhu, Jie Ma, Ling Leng
Summary: Through large-scale quantitative proteomic analysis, this study identified differential expression of dermal ECM components in patients with keloids, which could contribute to keloid formation. The results indicate that skin mechanical properties and biological processes are disrupted in keloids, potentially involving multiple signaling pathways.
Article
Oncology
Yoon-Ha Go, Woo Hee Choi, Won Jung Bae, Sook-In Jung, Chang-Hoon Cho, Seung Ah Lee, Joon Seong Park, Ji Mi Ahn, Sung Won Kim, Kyung Jin Lee, Dakeun Lee, Jongman Yoo
Summary: Pancreatic cancer is highly resistant to anticancer drugs due to its complex microenvironment, particularly the extracellular matrix components produced by cancer-associated fibroblasts (CAFs). In this study, a novel CAF-integrated pancreatic cancer organoid (CIPCO) model was developed to mimic the tumor microenvironment, which showed similar gene expression and pathological characteristics to human cancer tissue. This model has the potential to be used for preclinical studies and the development of individualized therapies.
Article
Engineering, Biomedical
Andrea Mazzocchi, Kyung Min Yoo, Kylie G. Nairon, L. Madison Kirk, Elaheh Rahbar, Shay Soker, Aleksander Skardal
Summary: This study developed a crosslinkable hydrogel using hyaluronic acid maleimide that mimics the extracellular matrix of liver tissue. The addition of RGD peptides and TGF-ss supplementation had significant effects on cell phenotype and liver functionality.
BIOMEDICAL MATERIALS
(2022)
Review
Oncology
James O. Jones, William M. Moody, Jacqueline D. Shields
Summary: The successful establishment of a tumor relies on interactions between cancer cells and stromal cells in a evolving microenvironment, with key players transitioning from tumor elimination to promotion. While the tumor-stroma crosstalk in established tumors is well-studied, the early tumor microenvironment has received less attention due to challenges in studying this process in clinic or mouse models. Understanding the key factors in the early microenvironment may provide insights for clinical applications.
MOLECULAR ONCOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Yutian Su, Xichen Zhang, Liling Lei, Baolei Liu, Shishan Wu, Jian Shen
Summary: The BAGM nanozyme is an intelligent nanotheranostic platform with multiple therapeutic modalities, enhancing treatment efficacy through a cascade catalytic reaction in the tumor microenvironment.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Nanoscience & Nanotechnology
Jiali Luo, Jing Cao, Guangrong Ma, Xue Wang, Yu Sun, Cong Zhang, Zhan Shi, Yiqing Zeng, Tao Zhang, Pintong Huang
Summary: In this study, collagenase-loaded hollow TiO2 nanoparticles were synthesized to degrade stromal barriers in pancreatic cancer and generate reactive oxygen species. These nanoparticles effectively reduced intratumoral pressure and enhanced the penetration and retention within tumor tissues. Moreover, they improved intratumoral ultrasound signal and provided a highly effective sonodynamic therapy for pancreatic cancer.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Jiali Luo, Jing Cao, Guangrong Ma, Xue Wang, Yu Sun, Cong Zhang, Zhan Shi, Yiqing Zeng, Tao Zhang, Pintong Huang
Summary: This study synthesized collagenase-loaded hollow TiO2 nanoparticles capable of degrading stromal barriers and generating sufficient reactive oxygen species in pancreatic cancer. It showed improved sonodynamic therapy efficacy by decreasing interstitial fluid pressure, enhancing nanoparticle penetration, and providing ultrasound imaging-guided treatment.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Cell Biology
Corinne S. Smith, Jacob A. Orkwis, Andrew E. Bryan, Zhenyuan Xu, Greg M. Harris
Summary: This article reviews the recent advancements in biomaterials and cell stimulation strategies in the field of nerve regeneration, with a specific focus on the behavior of SCs in the microenvironment and functional repair. By promoting regenerative phenotypic responses, the regenerative capacity of multiple biomaterials can be enhanced, and innovative technologies for traumatic injury are proposed.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2022)
Article
Engineering, Biomedical
Yang Zeng, Siyu Feng, Wei Liu, Qinyouen Fu, Yaqian Li, Xiaokang Li, Chun Chen, Chenyu Huang, Zigang Ge, Yanan Du
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2017)
Article
Dermatology
Chenyu Huang, Longwei Liu, Zhifeng You, Bingjie Wang, Yanan Du, Rei Ogawa
INTERNATIONAL WOUND JOURNAL
(2017)
Article
Engineering, Biomedical
Shumeng Jiang, Sabrina Cloud Li, Chenyu Huang, Barbara Pui Chan, Yanan Du
ADVANCED HEALTHCARE MATERIALS
(2018)
Review
Dermatology
Chenyu Huang, Longwei Liu, Zhifeng You, Yanan Du, Rei Ogawa
INTERNATIONAL WOUND JOURNAL
(2019)
Review
Engineering, Mechanical
Zhifeng You, Lyu Zhou, Wenjing Li, Chenyu Huang, Yanan Du
ACTA MECHANICA SINICA
(2019)
Article
Multidisciplinary Sciences
Shumeng Jiang, Cheng Lyu, Peng Zhao, Wenjing Li, Wenyu Kong, Chenyu Huang, Guy M. Genin, Yanan Du
NATURE COMMUNICATIONS
(2019)
Review
Biochemistry & Molecular Biology
Chenyu Huang, Rei Ogawa
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Multidisciplinary Sciences
Longwei Liu, Hongsheng Yu, Hui Zhao, Zhaozhao Wu, Yi Long, Jingbo Zhang, Xiaojun Yan, Zhifeng You, Lyu Zhou, Tie Xia, Yan Shi, Bailong Xiao, Yingxiao Wang, Chenyu Huang, Yanan Du
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Review
Biochemistry & Molecular Biology
Chenyu Huang, Rei Ogawa
Article
Engineering, Biomedical
Hongsheng Yu, Zhifeng You, Xiaojun Yan, Wei Liu, Zhirui Nan, Dan Xing, Chenyu Huang, Yanan Du
ADVANCED HEALTHCARE MATERIALS
(2020)
Article
Biochemistry & Molecular Biology
Longwei Liu, Hongsheng Yu, Yi Long, Zhifeng You, Rei Ogawa, Yanan Du, Chenyu Huang
Summary: Asporin is highly expressed in keloids, disrupting the orientation, reorganization, and contraction ability of dermal cells, ultimately leading to the formation of disorganized collagen network similar to keloids. This interference with collagen mechanosignaling prevents fibroblast activation and differentiation into mature myofibroblasts, promoting keloid growth and invasion. Asporin may serve as a new diagnostic biomarker and therapeutic target for keloids.
Article
Dermatology
Jie Ren, Hsiaohan Tuan, Chenyu Huang, Dan Shu, Dian Chen, Eray Yihui Zhou, Dehua Liu, Ping Tu, Yi Zhao
Summary: This study developed and validated an easy-to-use scoring system, FSASI, for evaluating facial port-wine stain (FPWS). The FSASI scoring system showed good intra- and inter-rater reliability, and was comparable to physician global assessment and traditional classification data. The FSASI scores decreased after vascular-targeted photodynamic therapy, indicating its potential for evaluating treatment effects in clinical practice and research.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Chenyu Huang, Rei Ogawa
Summary: Studies suggest that inflammasomes may participate in the formation of pathological scars. Keloids predominantly consist of anti-inflammatory macrophages, while inflammasome activation is observed in diabetic wound healing and fibrotic conditions. Mechanical stimuli can activate inflammasomes via the cytoskeleton and contribute to fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Surgery
Mohamed Abdelhakim, Carolina Soto Diez, Chenyu Huang, Ioannis Goutos, Dennis P. Orgill, Rei Ogawa
Summary: Plastic surgery requires extensive surgical knowledge, technical dexterity, and personal skills. International fellowship programs provide training opportunities for young plastic surgeons, but concerns around unconventional educational strategies limit overseas training opportunities. A unique international fellowship program at Nippon Medical School Hospital in Tokyo, Japan, offers advanced surgical techniques and education methods to promote international exchange in plastic surgery education.
PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN
(2021)
Review
Dermatology
C. Huang, L. Liu, Z. You, Y. Zhao, J. Dong, Y. Du, R. Ogawa
BRITISH JOURNAL OF DERMATOLOGY
(2017)