Keloid progression: a stiffness gap hypothesis

Interfacial geometry dictates cancer cell tumorigenicity

(2016) Junmin Lee et al.   NATURE MATERIALS

Keloids and Hypertrophic Scars Can Now Be Cured Completely: Recent Progress in Our Understanding of the Pathogenesis of Keloids and Hypertrophic Scars and the Most Promising Current Therapeutic Strategy

(2016) Rei Ogawa et al.   JOURNAL OF NIPPON MEDICAL SCHOOL

Mechanical coupling of cytoskeletal elasticity and force generation is crucial for understanding the migrating nature of keloid fibroblasts

(2015) Hans I-Chen Harn et al.   EXPERIMENTAL DERMATOLOGY

Matrix rigidity regulates spatiotemporal dynamics of Cdc42 activity and vacuole formation kinetics of endothelial colony forming cells

(2014) Seung Joon Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The emergence of extracellular matrix mechanics and cell traction forces as important regulators of cellular self-organization

(2014) Sara Checa et al.   Biomechanics and Modeling in Mechanobiology

Retraction Note to: Stimulus-triggered fate conversion of somatic cells into pluripotency

(2014) Haruko Obokata et al.   NATURE

Materials as stem cell regulators

(2014) William L. Murphy et al.   NATURE MATERIALS

Biomechanical imaging of cell stiffness and prestress with subcellular resolution

(2013) Elizabeth P. Canović et al.   Biomechanics and Modeling in Mechanobiology

Stiffness Dependent Separation of Cells in a Microfluidic Device

(2013) Gonghao Wang et al.   PLoS One

Site-Specific Keloid Fibroblasts Alter the Behaviour of Normal Skin and Normal Scar Fibroblasts through Paracrine Signalling

(2013) Kevin J. Ashcroft et al.   PLoS One

Mechanosignaling pathways in cutaneous scarring

(2012) Chenyu Huang et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

The nanomechanical signature of breast cancer

(2012) Marija Plodinec et al.   Nature Nanotechnology

Notch signaling pathway in keloid disease: Enhanced fibroblast activity in a Jagged-1 peptide-dependent manner in lesional vs. extralesional fibroblasts

(2012) Farhatullah Syed et al.   WOUND REPAIR AND REGENERATION

The relationship between skin stretching/contraction and pathologic scarring: The important role of mechanical forces in keloid generation

(2012) Rei Ogawa et al.   WOUND REPAIR AND REGENERATION

Vascular smooth muscle contractility depends on cell shape

(2011) Patrick W. Alford et al.   Integrative Biology

Clinical Applications of Basic Research that Shows Reducing Skin Tension Could Prevent and Treat Abnormal Scarring: The Importance of Fascial/Subcutaneous Tensile Reduction Sutures and Flap Surgery for Keloid and Hypertrophic Scar Reconstruction

(2011) Rei Ogawa et al.   JOURNAL OF NIPPON MEDICAL SCHOOL

Mapping the cytoskeletal prestress

(2010) Chan Young Park et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells

(2010) Jörg Schrader et al.   HEPATOLOGY

Mechanical regulation of cell function with geometrically modulated elastomeric substrates

(2010) Jianping Fu et al.   NATURE METHODS

Matrix Rigidity Regulates Cancer Cell Growth and Cellular Phenotype

(2010) Robert W. Tilghman et al.   PLoS One

Endothelial cell traction and ECM density influence both capillary morphogenesis and maintenance in 3-D

(2009) Ekaterina Kniazeva et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Boundary Stiffness Regulates Fibroblast Behavior in Collagen Gels

(2009) Jeffrey John et al.   ANNALS OF BIOMEDICAL ENGINEERING

The Relationship Between Keloid Growth Pattern and Stretching Tension

(2009) Satoshi Akaishi et al.   ANNALS OF PLASTIC SURGERY

Prestress and Adhesion Site Dynamics Control Cell Sensitivity to Extracellular Stiffness

(2009) S. Féréol et al.   BIOPHYSICAL JOURNAL

Neutrophil morphology and migration are affected by substrate elasticity

(2009) P. W. Oakes et al.   BLOOD

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Local Cortical Tension by Myosin II Guides 3D Endothelial Cell Branching

(2009) Robert S. Fischer et al.   CURRENT BIOLOGY

A mechanosensitive transcriptional mechanism that controls angiogenesis

(2009) Akiko Mammoto et al.   NATURE

Tissue stiffness, latent TGF-β1 Activation, and mechanical signal transduction: Implications for the pathogenesis and treatment of fibrosis

(2009) Boris Hinz   Current Rheumatology Reports

The effects of matrix stiffness and RhoA on the phenotypic plasticity of smooth muscle cells in a 3-D biosynthetic hydrogel system

(2008) Shelly R. Peyton et al.   BIOMATERIALS

Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scar-like rigidity inhibits beating

(2008) A. J. Engler et al.   JOURNAL OF CELL SCIENCE

Keloid and hypertrophic scar: Neurogenic inflammation hypotheses

(2008) Satoshi Akaishi et al.   MEDICAL HYPOTHESES

Keloid and hypertrophic scarring may result from a mechanoreceptor or mechanosensitive nociceptor disorder

(2008) Rei Ogawa   MEDICAL HYPOTHESES

Biomechanical regulation of cell orientation and fate

(2008) J I Lopez et al.   ONCOGENE

Tensegrity-based mechanosensing from macro to micro

(2008) Donald E. Ingber   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY