Why target PIM1 for cancer diagnosis and treatment?

Pim-1 Kinase Expression Predicts Radiation Response in Squamocellular Carcinoma of Head and Neck and Is under the Control of Epidermal Growth Factor Receptor

(2015) Katriina Peltola et al.   NEOPLASIA

The p21 and PCNA partnership: A new twist for an old plot

(2011) Carol Prives et al.   CELL CYCLE

Pim1 promotes human prostate cancer cell tumorigenicity and c-MYC transcriptional activity

(2010) Jongchan Kim et al.   BMC CANCER

Cancer Screening in the United States, 2010: A Review of Current American Cancer Society Guidelines and Issues in Cancer Screening

(2010) R. A. Smith et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Hypoxia-inducible proto-oncogene Pim-1 is a prognostic marker in pancreatic ductal adenocarcinoma

(2010) Carolin Reiser-Erkan et al.   CANCER BIOLOGY & THERAPY

PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers

(2010) L. Brault et al.   HAEMATOLOGICA

Pim-2 phosphorylation of p21Cip1/WAF1 enhances its stability and inhibits cell proliferation in HCT116 cells

(2010) Zeping Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Pim1 kinase synergizes with c-MYC to induce advanced prostate carcinoma

(2010) J Wang et al.   ONCOGENE

Pim1 Regulates Androgen-Dependent Survival Signaling in Prostate Cancer Cells

(2010) H.G. van der Poel et al.   UROLOGIA INTERNATIONALIS

Hypoxia-Mediated Up-Regulation of Pim-1 Contributes to Solid Tumor Formation

(2009) Jian Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Pim-1 expression and monoclonal antibody targeting in human leukemia cell lines

(2009) Jie Li et al.   EXPERIMENTAL HEMATOLOGY

Proviral integration site for Moloney murine leukemia virus 1, but not phosphatidylinositol-3 kinase, is essential in the antiapoptotic signaling cascade initiated by IL-5 in eosinophils

(2009) Nicola Andina et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Hit to Lead Account of the Discovery of a New Class of Inhibitors of Pim Kinases and Crystallographic Studies Revealing an Unusual Kinase Binding Mode†

(2009) Kevin Qian et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of 3H-Benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective, and Orally Bioavailable Inhibitors of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM) Kinases

(2009) Zhi-Fu Tao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, Kinase Inhibitory Potencies, and in Vitro Antiproliferative Evaluation of New Pim Kinase Inhibitors

(2009) Rufine Akué-Gédu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of Tumor-associated Autoantigens for the Diagnosis of Colorectal Cancer in Serum Using High Density Protein Microarrays

(2009) Ingrid Babel et al.   MOLECULAR & CELLULAR PROTEOMICS

Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes

(2009) S. M. Mumenthaler et al.   MOLECULAR CANCER THERAPEUTICS

PIM1 phosphorylates and negatively regulates ASK1-mediated apoptosis

(2009) J J Gu et al.   ONCOGENE

Isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: Chemistry, biological activities, and molecular modeling

(2008) Yunsong Tong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

EPO receptor circuits for primary erythroblast survival

(2008) P. Sathyanarayana et al.   BLOOD

IL-3 induces a Pim1-dependent antiapoptotic pathway in primary human basophils

(2008) S. A. Didichenko et al.   BLOOD

Pim Kinases Promote Cell Cycle Progression by Phosphorylating and Down-regulating p27Kip1 at the Transcriptional and Posttranscriptional Levels

(2008) D. Morishita et al.   CANCER RESEARCH

MDM2 mRNA Expression in the p53 Pathway May Predict the Potential of Invasion and Liver Metastasis in Colorectal Cancer

(2008) Ito Kondo et al.   DISEASES OF THE COLON & RECTUM

Potential roles for the PIM1 kinase in human cancer – A molecular and therapeutic appraisal

(2008) Nilesh Shah et al.   EUROPEAN JOURNAL OF CANCER

The PIM1 Kinase Is a Critical Component of a Survival Pathway Activated by Docetaxel and Promotes Survival of Docetaxel-treated Prostate Cancer Cells

(2008) Marina Zemskova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of the JAK2 Inhibitor, AZ960, on Pim/BAD/BCL-xL Survival Signaling in the Human JAK2 V617F Cell Line SET-2

(2008) Joseph M. Gozgit et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elevated Levels of Oncogenic Protein Kinase Pim-1 Induce the p53 Pathway in Cultured Cells and Correlate with Increased Mdm2 in Mantle Cell Lymphoma

(2008) Carol Hogan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Docking Study Yields Four Novel Inhibitors of the Protooncogene Pim-1 Kinase†

(2008) Albert C. Pierce et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Evaluation of Novel Inhibitors of Pim-1 and Pim-2 Protein Kinases

(2008) Zuping Xia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ki67 and PIM1 expression predict outcome in mantle cell lymphoma treated with high dose therapy, stem cell transplantation and rituximab: a Cancer and Leukemia Group B 59909 correlative science study

(2008) Eric D. Hsi et al.   LEUKEMIA & LYMPHOMA

Real-time quantitative RT-PCR assessment of PIM-1 and hK2 mRNA expression in benign prostate hyperplasia and prostate cancer

(2008) Hui-chan He et al.   MEDICAL ONCOLOGY

ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

(2008) Jer-Yen Yang et al.   NATURE CELL BIOLOGY

Pim kinase-dependent inhibition of c-Myc degradation

(2008) Y Zhang et al.   ONCOGENE

A Role for Polyploidy in the Tumorigenicity of Pim-1-Expressing Human Prostate and Mammary Epithelial Cells

(2008) Meejeon Roh et al.   PLoS One