Hepatobiliary transporters in drug-induced cholestasis: a perspective on the current identifying tools

Drug-induced Acute Liver Failure

(2013) William M. Lee   Clinics in Liver Disease

Mechanism-based Inhibition of CYP450: An Indicator of Drug-induced Hepatotoxicity

(2013) Shan Feng et al.   CURRENT DRUG METABOLISM

Evaluating the In Vitro Inhibition of UGT1A1, OATP1B1, OATP1B3, MRP2, and BSEP in Predicting Drug-Induced Hyperbilirubinemia

(2013) Jae H. Chang et al.   MOLECULAR PHARMACEUTICS

Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver

(2012) Evita van de Steeg et al.   JOURNAL OF CLINICAL INVESTIGATION

In Silico Identification of Potential Cholestasis-Inducing Agents via Modeling of Na+-Dependent Taurocholate Cotransporting Polypeptide Substrate Specificity

(2012) Rick Greupink et al.   TOXICOLOGICAL SCIENCES

OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies

(2011) Megan Roth et al.   BRITISH JOURNAL OF PHARMACOLOGY

Genetic variations of bile salt transporters as predisposing factors for drug-induced cholestasis, intrahepatic cholestasis of pregnancy and therapeutic response of viral hepatitis

(2011) Bruno Stieger et al.   Expert Opinion on Drug Metabolism & Toxicology

Susceptibility to Amoxicillin-Clavulanate-Induced Liver Injury Is Influenced by Multiple HLA Class I and II Alleles

(2011) M. Isabel Lucena et al.   GASTROENTEROLOGY

Drug-induced cholestasis

(2011) Manmeet S. Padda et al.   HEPATOLOGY

Canalicular ABC transporters and liver disease

(2011) Michael Nicolaou et al.   JOURNAL OF PATHOLOGY

Organic Anion Transporting Polypeptide 1B1: a Genetically Polymorphic Transporter of Major Importance for Hepatic Drug Uptake

(2011) M. Niemi et al.   PHARMACOLOGICAL REVIEWS

BSEP inhibition – In vitro screens to assess cholestatic potential of drugs

(2011) Emese Kis et al.   TOXICOLOGY IN VITRO

Risk assessment and mitigation strategies for reactive metabolites in drug discovery and development

(2010) Richard A. Thompson et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Hepatic OATP and OCT uptake transporters: their role for drug-drug interactions and pharmacogenetic aspects

(2010) Christina Fahrmayr et al.   DRUG METABOLISM REVIEWS

Sandwich-cultured hepatocytes: anin vitromodel to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity

(2010) Brandon Swift* et al.   DRUG METABOLISM REVIEWS

Drugs Associated with Hepatotoxicity and their Reporting Frequency of Liver Adverse Events in VigiBase™

(2010) Ayako Suzuki et al.   DRUG SAFETY

Causality assessment in drug-induced liver injury using a structured expert opinion process: Comparison to the Roussel-Uclaf causality assessment method

(2010) Don C. Rockey et al.   HEPATOLOGY

Generation of endoderm-derived human induced pluripotent stem cells from primary hepatocytes

(2010) Hua Liu et al.   HEPATOLOGY

Drug-induced acute liver failure: Results of a U.S. multicenter, prospective study

(2010) Adrian Reuben et al.   HEPATOLOGY

Induced pluripotent stem cells: A new era for hepatology

(2010) Samira Asgari et al.   JOURNAL OF HEPATOLOGY

Human leucocyte antigen class II genotype in susceptibility and resistance to co-amoxiclav-induced liver injury

(2010) Peter T. Donaldson et al.   JOURNAL OF HEPATOLOGY

Itraconazole-Induced Cholestasis: Involvement of the Inhibition of Bile Canalicular Phospholipid Translocator MDR3/ABCB4

(2010) T. Yoshikado et al.   MOLECULAR PHARMACOLOGY

The Bile Salt Export Pump: Clinical and Experimental Aspects of Genetic and Acquired Cholestatic Liver Disease

(2010) Ping Lam et al.   SEMINARS IN LIVER DISEASE

The Spectrum of Liver Diseases Related toABCB4Gene Mutations: Pathophysiology and Clinical Aspects

(2010) Anne Davit-Spraul et al.   SEMINARS IN LIVER DISEASE

Progress and Promise Towards Safe Induced Pluripotent Stem Cells for Therapy

(2010) Ali Seifinejad et al.   Stem Cell Reviews and Reports

Contribution of High Basolateral Bile Salt Efflux to the Lack of Hepatotoxicity in Rat in Response to Drugs Inducing Cholestasis in Human

(2010) Katalin Jemnitz et al.   TOXICOLOGICAL SCIENCES

Interference with Bile Salt Export Pump Function Is a Susceptibility Factor for Human Liver Injury in Drug Development

(2010) Ryan E. Morgan et al.   TOXICOLOGICAL SCIENCES

Technical Pitfalls and Improvements for High-speed Screening and QSAR Analysis to Predict Inhibitors of the Human Bile Salt Export Pump (ABCB11/BSEP)

(2009) Hikaru Saito et al.   AAPS Journal

A Fresh Look at iPS Cells

(2009) Shinya Yamanaka   CELL

Transporter Pharmacogenetics and Statin Toxicity

(2009) M Niemi   CLINICAL PHARMACOLOGY & THERAPEUTICS

Pharmacogenetics of Drug Transporters

(2009) R. Franke et al.   CURRENT PHARMACEUTICAL DESIGN

An In Vitro Assay to Assess Transporter-Based Cholestatic Hepatotoxicity Using Sandwich-Cultured Rat Hepatocytes

(2009) J. H. Ansede et al.   DRUG METABOLISM AND DISPOSITION

Effect of Membrane Cholesterol on BSEP/Bsep Activity: Species Specificity Studies for Substrates and Inhibitors

(2009) E. Kis et al.   DRUG METABOLISM AND DISPOSITION

Drug-induced liver injury: what was new in 2008?

(2009) Gordon Liss et al.   Expert Opinion on Drug Metabolism & Toxicology

Genetic polymorphisms of uptake (OATP1B1, 1B3) and efflux (MRP2, BCRP) transporters: implications for inter-individual differences in the pharmacokinetics and pharmacodynamics of statins and other clinically relevant drugs

(2009) Ichiro Ieiri et al.   Expert Opinion on Drug Metabolism & Toxicology

The enterohepatic circulation of bile acids in mammals: form and functions

(2009) Alan et al.   Frontiers in Bioscience-Landmark

Compensatory role of P-glycoproteins in knockout mice lacking the bile salt export pump

(2009) Renxue Wang et al.   HEPATOLOGY

Oral medications with significant hepatic metabolism at higher risk for hepatic adverse events

(2009) Craig Lammert et al.   HEPATOLOGY

Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells

(2009) Karim Si-Tayeb et al.   HEPATOLOGY

Activity of the Bile Salt Export Pump (ABCB11) Is Critically Dependent on Canalicular Membrane Cholesterol Content

(2009) Coen C. Paulusma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histological patterns in drug-induced liver disease

(2009) R Ramachandran et al.   JOURNAL OF CLINICAL PATHOLOGY

Bile acid transporters

(2009) Paul A. Dawson et al.   JOURNAL OF LIPID RESEARCH

The influence of lead discovery strategies on the properties of drug candidates

(2009) György M. Keserü et al.   NATURE REVIEWS DRUG DISCOVERY

Progressive familial intrahepatic cholestasis

(2009) Anne Davit-Spraul et al.   Orphanet Journal of Rare Diseases

Epidemiology of Idiosyncratic Drug-Induced Liver Injury

(2009) Lauren Bell et al.   SEMINARS IN LIVER DISEASE

Bile Acid Sulfation: A Pathway of Bile Acid Elimination and Detoxification

(2009) Yazen Alnouti   TOXICOLOGICAL SCIENCES

Cell based approaches for evaluation of drug-induced liver injury

(2009) Mhairi L. Greer et al.   TOXICOLOGY

Use of cassette dosing in sandwich-cultured rat and human hepatocytes to identify drugs that inhibit bile acid transport

(2009) Kristina K. Wolf et al.   TOXICOLOGY IN VITRO

Bile acids: Chemistry, physiology, and pathophysiology

(2009) Maria J Monte et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Drug-Induced Liver Injury Network

(2008) Paul B. Watkins   AMERICAN JOURNAL OF GASTROENTEROLOGY

Cloning of the dog bile salt export pump (BSEP; ABCB11) and functional comparison with the human and rat proteins

(2008) Hikaru Yabuuchi et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Mitochondrial dysfunction and delayed hepatotoxicity: another lesson from troglitazone

(2008) N. L. Julie et al.   DIABETOLOGIA

Use of Sandwich-Cultured Human Hepatocytes to Predict Biliary Clearance of Angiotensin II Receptor Blockers and HMG-CoA Reductase Inhibitors

(2008) K. Abe et al.   DRUG METABOLISM AND DISPOSITION

Identification of interspecies difference in efflux transporters of hepatocytes from dog, rat, monkey and human

(2008) Meng Li et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Contribution of variant alleles of ABCB11 to susceptibility to intrahepatic cholestasis of pregnancy

(2008) P H Dixon et al.   GUT

Species-specific differences in coumarin-induced hepatotoxicity as an example toxicogenomics-based approach to assessing risk of toxicity to humans

(2008) T Uehara et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Efficient Differentiation of Hepatocytes from Human Embryonic Stem Cells Exhibiting Markers Recapitulating Liver Development In Vivo

(2008) David C. Hay et al.   STEM CELLS

Physiology of bile secretion

(2008) Alejandro Esteller   WORLD JOURNAL OF GASTROENTEROLOGY

Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump

(2008) Yvonne Meier et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Nuclear hormone receptor-dependent regulation of hepatic transporters and their role in the adaptive response in cholestasis

(2008) S. Stahl et al.   XENOBIOTICA