Use of Transgenic and Knockout Mouse Models to Assess Solute Carrier Transporter Function

Organic Cation Transporter 2 Mediates Cisplatin-Induced Oto- and Nephrotoxicity and Is a Target for Protective Interventions

(2010) Giuliano Ciarimboli et al.   AMERICAN JOURNAL OF PATHOLOGY

Disruption of multidrug and toxin extrusion MATE1 potentiates cisplatin-induced nephrotoxicity

(2010) Takanori Nakamura et al.   BIOCHEMICAL PHARMACOLOGY

Hepatic OATP and OCT uptake transporters: their role for drug-drug interactions and pharmacogenetic aspects

(2010) Christina Fahrmayr et al.   DRUG METABOLISM REVIEWS

Liver X receptor α and farnesoid X receptor are major transcriptional regulators of OATP1B1

(2010) Henriette E. Meyer zu Schwabedissen et al.   HEPATOLOGY

Organic anion transporting polypeptide 1a/1b–knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs

(2010) Evita van de Steeg et al.   JOURNAL OF CLINICAL INVESTIGATION

Reduced Renal Clearance of a Zwitterionic Substrate Cephalexin in Mate1-Deficient Mice

(2010) S. Watanabe et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Contribution of Organic Cation Transporter 2 (OCT2) to Cisplatin-Induced Nephrotoxicity

(2009) K K Filipski et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Targeted Disruption of the Multidrug and Toxin Extrusion 1 (Mate1) Gene in Mice Reduces Renal Secretion of Metformin

(2009) M. Tsuda et al.   MOLECULAR PHARMACOLOGY

Methotrexate Pharmacokinetics in Transgenic Mice with Liver-Specific Expression of Human Organic Anion-Transporting Polypeptide 1B1 (SLCO1B1)

(2008) E. van de Steeg et al.   DRUG METABOLISM AND DISPOSITION

Utility of a Novel Oatp1b2 Knockout Mouse Model for Evaluating the Role of Oatp1b2 in the Hepatic Uptake of Model Compounds

(2008) C. Chen et al.   DRUG METABOLISM AND DISPOSITION

Limited Brain Distribution of [3R,4R,5S]-4-Acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate Phosphate (Ro 64-0802), a Pharmacologically Active Form of Oseltamivir, by Active Efflux across the Blood-Brain Barrier Mediated by Organic Anion Transporter 3 (Oat3/Slc22a8) and Multidrug Resistance-Associated Protein 4 (Mrp4/Abcc4)

(2008) A. Ose et al.   DRUG METABOLISM AND DISPOSITION

Targeted Disruption of Murine Organic Anion-Transporting Polypeptide 1b2 (oatp1b2/Slco1b2) Significantly Alters Disposition of Prototypical Drug Substrates Pravastatin and Rifampin

(2008) H. Zaher et al.   MOLECULAR PHARMACOLOGY

Organic Anion Transporter 3 (Oat3/Slc22a8) Interacts with Carboxyfluoroquinolones, and Deletion Increases Systemic Exposure to Ciprofloxacin

(2008) A. L. VanWert et al.   MOLECULAR PHARMACOLOGY

Characterization of Organic Anion Transporting Polypeptide 1b2-null Mice: Essential Role in Hepatic Uptake/Toxicity of Phalloidin and Microcystin-LR

(2008) Hong Lu et al.   TOXICOLOGICAL SCIENCES