Latest advances in predicting DILI in human subjects: focus on biomarkers

Genetic polymorphisms of NAT2, CYP2E1 and GST enzymes and the occurrence of antituberculosis drug-induced hepatitis in Brazilian TB patients

(2014) Raquel Lima de Figueiredo Teixeira et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Serum proteomic profiling in patients with drug-induced liver injury

(2012) L. N. Bell et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

NAT2 and CYP2E1 polymorphisms associated with antituberculosis drug-induced hepatotoxicity in Chinese patients

(2012) Hui-Ru An et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Lapatinib-Induced Liver Injury Characterized by Class II HLA and Gilbert's Syndrome Genotypes

(2012) C F Spraggs et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA-B Genotype and Abacavir Dosing

(2012) M A Martin et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Acetaminophen and acetylcysteine dose and duration: Past, present and future

(2012) Barry H Rumack et al.   CLINICAL TOXICOLOGY

The primary role of hepatic metabolism in idiosyncratic drug-induced liver injury

(2012) David E Amacher   Expert Opinion on Drug Metabolism & Toxicology

In silicomodels for drug-induced liver injury – current status

(2012) Katarzyna R Przybylak et al.   Expert Opinion on Drug Metabolism & Toxicology

UGT1A1 polymorphisms associated with risk of induced liver disorders by anti-tuberculosis medications [Short communication]

(2012) J-C. Chang et al.   INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

Mechanistic biomarkers in acute liver injury: Are we there yet?

(2012) Danielle Adebayo et al.   JOURNAL OF HEPATOLOGY

Successful Translation of Pharmacogenetics into the Clinic

(2012) Elizabeth Phillips et al.   Molecular Diagnosis & Therapy

Proteomics in the search for mechanisms and biomarkers of drug-induced hepatotoxicity

(2012) Anke Van Summeren et al.   TOXICOLOGY IN VITRO

Genetic variants in antioxidant pathway: Risk factors for hepatotoxicity in tuberculosis patients

(2012) Kazutaka Nanashima et al.   TUBERCULOSIS

Using Genome-Wide Association Studies to Identify Genes Important in Serious Adverse Drug Reactions

(2011) Ann K. Daly   Annual Review of Pharmacology and Toxicology

Reactive Aldehyde Metabolites from the Anti-HIV Drug Abacavir: Amino Acid Adducts as Possible Factors in Abacavir Toxicity

(2011) Catarina Charneira et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States

(2011) Antonia F. Stepan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Is Toxicogenomics a More Reliable and Sensitive Biomarker than Conventional Indicators from Rats To Predict Drug-Induced Liver Injury in Humans?

(2011) Min Zhang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The role of the glutathione S-transferase genes GSTT1, GSTM1, and GSTP1 in acetaminophen-poisoned patients

(2011) Anders Buchard et al.   CLINICAL TOXICOLOGY

The Role of Metabonomics at the Interface Between Drug Metabolism and Safety Assessment

(2011) Nigel J. Waters   CURRENT DRUG METABOLISM

Metabolic activation in drug-induced liver injury

(2011) Louis Leung et al.   DRUG METABOLISM REVIEWS

Susceptibility to Amoxicillin-Clavulanate-Induced Liver Injury Is Influenced by Multiple HLA Class I and II Alleles

(2011) M. Isabel Lucena et al.   GASTROENTEROLOGY

Circulating microRNAs as potential markers of human drug-induced liver injury

(2011) Philip J. Starkey Lewis et al.   HEPATOLOGY

Human leukocyte antigen (HLA) and pharmacogenetics: screening for HLA-B*57:01 among human immunodeficiency virus–positive patients from southern Alberta

(2011) Noureddine Berka et al.   HUMAN IMMUNOLOGY

Initiating allopurinol therapy: do we need to know the patient's human leucocyte antigen status?

(2011) M. H. Lee et al.   INTERNAL MEDICINE JOURNAL

In vitro transcriptomic prediction of hepatotoxicity for early drug discovery

(2011) Feng Cheng et al.   JOURNAL OF THEORETICAL BIOLOGY

Pharmacogenetic & Pharmacokinetic Biomarker for Efavirenz Based ARV and Rifampicin Based Anti-TB Drug Induced Liver Injury in TB-HIV Infected Patients

(2011) Getnet Yimer et al.   PLoS One

Rapid screening for the detection of HLA-B57 and HLA-B58 in prevention of drug hypersensitivity

(2011) L. Kostenko et al.   TISSUE ANTIGENS

Pathophysiological Relevance of Proteomics Investigations of Drug-Induced Hepatotoxicity in HepG2 Cells

(2011) Hartmut Jaeschke et al.   TOXICOLOGICAL SCIENCES

Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps)

(2011) Zhichao Liu et al.   PLoS Computational Biology

Single-Center Experience With Drug-Induced Liver Injury From India: Causes, Outcome, Prognosis and Predictors of Mortality

(2010) Harshad Devarbhavi et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism

(2010) C-F Xu et al.   BRITISH JOURNAL OF CANCER

The Application of Metabonomics to Predict Drug-Induced Liver Injury

(2010) T M O'Connell et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Use of Pharmaco-Metabonomics for Early Prediction of Acetaminophen-Induced Hepatotoxicity in Humans

(2010) J H Winnike et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The potential of cytokines as safety biomarkers for drug-induced liver injury

(2010) Hugh G. Laverty et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Pharmacogenetics of drug-induced liver injury

(2010) Stefan Russmann et al.   HEPATOLOGY

Drug-induced acute liver failure: Results of a U.S. multicenter, prospective study

(2010) Adrian Reuben et al.   HEPATOLOGY

Human leucocyte antigen class II genotype in susceptibility and resistance to co-amoxiclav-induced liver injury

(2010) Peter T. Donaldson et al.   JOURNAL OF HEPATOLOGY

Antituberculosis drug-induced liver injury in chronic hepatitis and cirrhosis

(2010) Wan Beom Park et al.   JOURNAL OF INFECTION

Cytokine-associated drug toxicity in human hepatocytes is associated with signaling network dysregulation

(2010) Benjamin D. Cosgrove et al.   Molecular BioSystems

A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury

(2010) Jonathan B Singer et al.   NATURE GENETICS

Genome-wide association studies and genetic risk assessment of liver diseases

(2010) Marcin Krawczyk et al.   Nature Reviews Gastroenterology & Hepatology

Economic Efficiency of Genetic Screening to Inform the Use of Abacavir Sulfate in the Treatment of HIV

(2010) Teresa L. Kauf et al.   PHARMACOECONOMICS

Pharmacogenetics of drug hypersensitivity

(2010) Elizabeth J Phillips et al.   PHARMACOGENOMICS

Drug-induced liver injury: past, present and future

(2010) Ann K Daly   PHARMACOGENOMICS

Genomic indicators in the blood predict drug-induced liver injury

(2010) J Huang et al.   PHARMACOGENOMICS JOURNAL

Proteomics Investigations of Drug-Induced Hepatotoxicity in HepG2 Cells

(2010) Anke Van Summeren et al.   TOXICOLOGICAL SCIENCES

The discovery and development of proteomic safety biomarkers for the detection of drug-induced liver toxicity

(2010) David E. Amacher   TOXICOLOGY AND APPLIED PHARMACOLOGY

Biomarkers for drug-induced liver injury

(2010) Qiang Shi et al.   Expert Review of Gastroenterology & Hepatology

Increased susceptibility to exacerbated liver injury in hypercholesterolemic ApoE-deficient mice: potential involvement of oxysterols

(2009) Natàlia Ferré et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Can In Vitro Metabolism-Dependent Covalent Binding Data Distinguish Hepatotoxic from Nonhepatotoxic Drugs? An Analysis Using Human Hepatocytes and Liver S-9 Fraction

(2009) Jonathon N. Bauman et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Use of Over-the-Counter Analgesics Is Not Associated With Acute Decompensation in Patients With Cirrhosis

(2009) Sakib K. Khalid et al.   Clinical Gastroenterology and Hepatology

Serum proteomics and biomarker discovery across the spectrum of nonalcoholic fatty liver disease

(2009) Lauren N. Bell et al.   HEPATOLOGY

Phenotypic characterization of idiosyncratic drug-induced liver injury: The influence of age and sex

(2009) M. Isabel Lucena et al.   HEPATOLOGY

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin

(2009) Ann K Daly et al.   NATURE GENETICS

Genetic Association Studies in Drug-Induced Liver Injury

(2009) Ann Daly et al.   SEMINARS IN LIVER DISEASE

Biomarkers for the Diagnosis and Management of Drug-Induced Liver Injury

(2009) Paul Watkins   SEMINARS IN LIVER DISEASE

The Liver Toxicity Biomarker Study: Phase I Design and Preliminary Results

(2009) Robert N. Mcburney et al.   TOXICOLOGIC PATHOLOGY

Abacavir-induced hepatotoxicity: a report of two cases

(2008) Suneeta Soni et al.   AIDS

Causes, Clinical Features, and Outcomes From a Prospective Study of Drug-Induced Liver Injury in the United States

(2008) Naga Chalasani et al.   GASTROENTEROLOGY

Relationship between daily dose of oral medications and idiosyncratic drug-induced liver injury: Search for signals

(2008) Craig Lammert et al.   HEPATOLOGY

HLA-B*5701 Screening for Hypersensitivity to Abacavir

(2008) Simon Mallal et al.   NEW ENGLAND JOURNAL OF MEDICINE