Interplay of Dissolution, Solubility, and Nonsink Permeation Determines the Oral Absorption of the Hedgehog Pathway Inhibitor GDC-0449 in Dogs: An Investigation Using Preclinical Studies and Physiologically Based Pharmacokinetic Modeling

Published 2010 View Full Article

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Title
Interplay of Dissolution, Solubility, and Nonsink Permeation Determines the Oral Absorption of the Hedgehog Pathway Inhibitor GDC-0449 in Dogs: An Investigation Using Preclinical Studies and Physiologically Based Pharmacokinetic Modeling
Authors
Keywords
-
Journal
DRUG METABOLISM AND DISPOSITION
Volume 38, Issue 7, Pages 1029-1038
Publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)
Online
2010-04-21
DOI
10.1124/dmd.110.032680

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