Targeting unimolecular G-quadruplex nucleic acids: a new paradigm for the drug discovery?

Folding and Unfolding Pathways of the Human Telomeric G-Quadruplex

(2014) Robert D. Gray et al.   JOURNAL OF MOLECULAR BIOLOGY

Atomistic Picture for the Folding Pathway of a Hybrid-1 Type Human Telomeric DNA G-quadruplex

(2014) Yunqiang Bian et al.   PLoS Computational Biology

The G-Triplex DNA

(2013) Vittorio Limongelli et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Human Papillomavirus G-Quadruplexes

(2013) Katarína Tlučková et al.   BIOCHEMISTRY

Detection of base excision repair enzyme activity using a luminescent G-quadruplex selective switch-on probe

(2013) Ka-Ho Leung et al.   CHEMICAL COMMUNICATIONS

Label-free luminescence switch-on detection of T4 polynucleotide kinase activity using a G-quadruplex-selective probe

(2013) Hong-Zhang He et al.   CHEMICAL COMMUNICATIONS

Targeting Non-B-Form DNA in Living Cells

(2013) Yuhao Du et al.   CHEMICAL RECORD

FDA-approved Drugs Selected Using Virtual Screening Bind Specifically to G-quadruplex DNA

(2013) Daimel Castillo-Gonzalez et al.   CURRENT PHARMACEUTICAL DESIGN

Toward the design of new DNA G-quadruplex ligands through rational analysis of polymorphism and binding data

(2013) Anna Artese et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification and Characterization of New DNA G-Quadruplex Binders Selected by a Combination of Ligand and Structure-Based Virtual Screening Approaches

(2013) Stefano Alcaro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Exploring the Chemical Space of G-Quadruplex Binders: Discovery of a Novel Chemotype Targeting the Human Telomeric Sequence

(2013) Francesco Saverio Di Leva et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Dynamic G-Quadruplex Region Regulates the HIV-1 Long Terminal Repeat Promoter

(2013) Rosalba Perrone et al.   JOURNAL OF MEDICINAL CHEMISTRY

Interactions of the Human Telomere Sequence with the Nanocavity of the α-Hemolysin Ion Channel Reveal Structure-Dependent Electrical Signatures for Hybrid Folds

(2013) Na An et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bulges in G-Quadruplexes: Broadening the Definition of G-Quadruplex-Forming Sequences

(2013) Vineeth Thachappilly Mukundan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Solution Structure of an Intramolecular (3 + 1) Human Telomeric G-Quadruplex Bound to a Telomestatin Derivative

(2013) Wan Jun Chung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Differential scanning calorimetry to investigate G-quadruplexes structural stability

(2013) Bruno Pagano et al.   METHODS

Identification of New Natural DNA G-Quadruplex Binders Selected by a Structure-Based Virtual Screening Approach

(2013) Anna Artese et al.   MOLECULES

G-Quadruplex Structures in the Human Genome as Novel Therapeutic Targets

(2013) Joanna Bidzinska et al.   MOLECULES

Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Quantitative visualization of DNA G-quadruplex structures in human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Detection of G-quadruplex DNA in mammalian cells

(2013) A. Henderson et al.   NUCLEIC ACIDS RESEARCH

Structural dynamics of possible late-stage intermediates in folding of quadruplex DNA studied by molecular simulations

(2013) P. Stadlbauer et al.   NUCLEIC ACIDS RESEARCH

Polyethylene glycol binding alters human telomere G-quadruplex structure by conformational selection

(2013) Robert Buscaglia et al.   NUCLEIC ACIDS RESEARCH

Specific recognition and stabilization of monomeric and multimeric G-quadruplexes by cationic porphyrin TMPipEOPP under molecular crowding conditions

(2013) Li-Na Zhu et al.   NUCLEIC ACIDS RESEARCH

Structure of the human telomere in Na+ solution: an antiparallel (2+2) G-quadruplex scaffold reveals additional diversity

(2013) Kah Wai Lim et al.   NUCLEIC ACIDS RESEARCH

Kinetic Partitioning Modulates Human Telomere DNA G-Quadruplex Structural Polymorphism

(2013) Xi Long et al.   PLoS One

Conformation and Stability of Intramolecular Telomeric G-Quadruplexes: Sequence Effects in the Loops

(2013) Giovanna Sattin et al.   PLoS One

Understanding Ligand Interaction with Different Structures of G-Quadruplex DNA: Evidence of Kinetically Controlled Ligand Binding and Binding-Mode Assisted Quadruplex Structure Alteration

(2012) Sachin Dev Verma et al.   ANALYTICAL CHEMISTRY

A Metal-Based Inhibitor of Tumor Necrosis Factor-α

(2012) Chung-Hang Leung et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Telomere shortening and cell senescence induced by perylene derivatives in A549 human lung cancer cells

(2012) Thanachai Taka et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structural polymorphism of human telomere G-quadruplex induced by a pyridyl carboxamide molecule

(2012) Liang Xu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A highly selective G-quadruplex-based luminescent switch-on probe for the detection of gene deletion

(2012) Hong-Zhang He et al.   CHEMICAL COMMUNICATIONS

A luminescent G-quadruplex switch-on probe for the highly selective and tunable detection of cysteine and glutathione

(2012) Ka-Ho Leung et al.   CHEMICAL COMMUNICATIONS

Telomestatin Impairs Glioma Stem Cell Survival and Growth through the Disruption of Telomeric G-Quadruplex and Inhibition of the Proto-oncogene,c-Myb

(2012) Takeshi Miyazaki et al.   CLINICAL CANCER RESEARCH

State-of-the-Art Methodologies for the Discovery and Characterization of DNA G-Quadruplex Binders

(2012) Bruno Pagano et al.   CURRENT PHARMACEUTICAL DESIGN

Energetic Basis of Human Telomeric DNA Folding into G-Quadruplex Structures

(2012) Matjaž Bončina et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Populated Intermediates in the Thermal Unfolding of the Human Telomeric Quadruplex

(2012) Robert D. Gray et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Methods for studying quadruplexes: Sequence, structure, recognition and biological behaviour

(2012) Stephen Neidle   METHODS

Structure, function and targeting of human telomere RNA

(2012) Yan Xu et al.   METHODS

NMR spectroscopy of G-quadruplexes

(2012) Michael Adrian et al.   METHODS

DNA secondary structures: stability and function of G-quadruplex structures

(2012) Matthew L. Bochman et al.   NATURE REVIEWS GENETICS

Interaction of human telomeric DNA with N- methyl mesoporphyrin IX

(2012) John M. Nicoludis et al.   NUCLEIC ACIDS RESEARCH

Hybrid ligand–alkylating agents targeting telomeric G-quadruplex structures

(2012) Filippo Doria et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Conformational studies and solvent-accessible surface area analysis of known selective DNA G-Quadruplex binders

(2011) Stefano Alcaro et al.   BIOCHIMIE

A structural analysis of G-quadruplex/ligand interactions

(2011) Shozeb M. Haider et al.   BIOCHIMIE

Targeting pancreatic cancer with a G-quadruplex ligand

(2011) Mekala Gunaratnam et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A natural product-like inhibitor of NEDD8-activating enzyme

(2011) Chung-Hang Leung et al.   CHEMICAL COMMUNICATIONS

Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA

(2011) Yan Xu   CHEMICAL SOCIETY REVIEWS

Structural Basis of Telomeric RNA Quadruplex−Acridine Ligand Recognition

(2011) Gavin W. Collie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of Human Telomeric DNA in Crowded Solution

(2011) Brahim Heddi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

G-Quadruplexes: From Guanine Gels to Chemotherapeutics

(2011) Tracy M. Bryan et al.   MOLECULAR BIOTECHNOLOGY

TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA

(2011) Rachel Litman Flynn et al.   NATURE

Explaining the varied glycosidic conformational, G-tract length and sequence preferences for anti-parallel G-quadruplexes

(2011) Xiaohui Cang et al.   NUCLEIC ACIDS RESEARCH

Role of telomeres and telomerase in cancer

(2011) Jerry W. Shay et al.   SEMINARS IN CANCER BIOLOGY

Structure-Based Discovery of Natural-Product-like TNF-α Inhibitors

(2010) Daniel Shiu-Hin Chan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Monomorphic RNA G-Quadruplex and Polymorphic DNA G-Quadruplex Structures Responding to Cellular Environmental Factors

(2010) Dong-Hao Zhang et al.   BIOCHEMISTRY

Rational Design, Synthesis, Biophysical and Antiproliferative Evaluation of Fluorenone Derivatives with DNA G-Quadruplex Binding Properties

(2010) Stefano Alcaro et al.   ChemMedChem

Structural insights into G-quadruplexes: towards new anticancer drugs

(2010) Danzhou Yang et al.   Future Medicinal Chemistry

Folding Pathways of Human Telomeric Type-1 and Type-2 G-Quadruplex Structures

(2010) Tomoko Mashimo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase

(2010) Sophie Redon et al.   NUCLEIC ACIDS RESEARCH

Non-B DB: a database of predicted non-B DNA-forming motifs in mammalian genomes

(2010) R. Z. Cer et al.   NUCLEIC ACIDS RESEARCH

Telomere and Telomerase as Targets for Cancer Therapy

(2009) Xiaoping Tian et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis

(2009) D. Drygin et al.   CANCER RESEARCH

Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes

(2009) Gavin Collie et al.   CHEMICAL COMMUNICATIONS

G-Quadruplex DNA Structures and Organic Chemistry: More Than One Connection

(2009) Marco Franceschin   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Human telomeric G-quadruplex: structures of DNA and RNA sequences

(2009) Anh Tuân Phan   FEBS Journal

Reduced or Diminished Stabilization of the Telomere G-Quadruplex and Inhibition of Telomerase by Small Chemical Ligands under Molecular Crowding Condition

(2009) Zhao Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of the Human Telomere in K+Solution: A Stable Basket-Type G-Quadruplex with Only Two G-Tetrad Layers

(2009) Kah Wai Lim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Predictable suppression of gene expression by 5′-UTR-based RNA quadruplexes

(2009) Kangkan Halder et al.   NUCLEIC ACIDS RESEARCH

Structure of a two-G-tetrad intramolecular G-quadruplex formed by a variant human telomeric sequence in K+ solution: insights into the interconversion of human telomeric G-quadruplex structures

(2009) Zhenjiang Zhang et al.   NUCLEIC ACIDS RESEARCH

Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G·C·G·C tetrad

(2009) Kah Wai Lim et al.   NUCLEIC ACIDS RESEARCH

Human telomeres that contain (CTAGGG)n repeats show replication dependent instability in somatic cells and the male germline

(2009) Aaron Mendez-Bermudez et al.   NUCLEIC ACIDS RESEARCH

Photocrosslinking of human telomeric G-quadruplex loops by anti cyclobutane thymine dimer formation

(2009) D. G. T. Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G-quadruplex structures: in vivo evidence and function

(2009) Hans J. Lipps et al.   TRENDS IN CELL BIOLOGY

Position and Stability Are Determining Factors for Translation Repression by an RNA G-Quadruplex-Forming Sequence within the 5′ UTR of theNRASProto-oncogene†

(2008) Sunita Kumari et al.   BIOCHEMISTRY

Polymorphism of human telomeric quadruplex structures

(2008) Jixun Dai et al.   BIOCHIMIE

Targeting telomerase for cancer therapeutics

(2008) J W Shay et al.   BRITISH JOURNAL OF CANCER

G-Quadruplex Formation by Human Telomeric Repeats-Containing RNA in Na+Solution

(2008) Yan Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

G-Quadruplex Stabilizer 3,6-Bis(1-Methyl-4-Vinylpyridinium)Carbazole Diiodide Induces Accelerated Senescence and Inhibits Tumorigenic Properties in Cancer Cells

(2008) F.-C. Huang et al.   MOLECULAR CANCER RESEARCH

Conserved elements with potential to form polymorphic G-quadruplex structures in the first intron of human genes

(2008) Johanna Eddy et al.   NUCLEIC ACIDS RESEARCH

Stability and kinetics of G-quadruplex structures

(2008) A. N. Lane et al.   NUCLEIC ACIDS RESEARCH

Targeting telomeres and telomerase

(2007) Anne De Cian et al.   BIOCHIMIE

Formation and temperature stability of G-quadruplex structures studied by electronic and vibrational circular dichroism spectroscopy combined with ab initio calculations

(2007) Jakub Nový et al.   BIOPOLYMERS