Journal
CHEMICAL COMMUNICATIONS
Volume 47, Issue 9, Pages 2511-2513Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc04927a
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- Hong Kong Baptist University [FRG1/10-11/008, FRG2/09-10/070]
- Centre for Cancer and Inflammation Research, School of Chinese Medicine (CCIR-SCM, HKBU)
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The natural product-like 6,6 ''-biapigenin has been identified as only the second inhibitor of NEDD8-activating enzyme using virtual screening. This compound was active in enzyme and cell-based assays, with potency in the micromolar range.
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