Advances in MRSA drug discovery: where are we and where do we need to be?

Activity of a Novel Cyclic Lipopeptide, CB-183,315, against Resistant Clostridium difficile and Other Gram-Positive Aerobic and Anaerobic Intestinal Pathogens

(2012) D. R. Snydman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In VitroandIn VivoCharacterization of CB-183,315, a Novel Lipopeptide Antibiotic for Treatment of Clostridium difficile

(2012) Carmela T. M. Mascio et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Target- and Resistance-Based Mechanistic Studies with TP-434, a Novel Fluorocycline Antibiotic

(2012) Trudy H. Grossman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

NXL104 Irreversibly Inhibits the β-Lactamase from Mycobacterium tuberculosis

(2012) Hua Xu et al.   BIOCHEMISTRY

Development of novel antibacterial agents against methicillin-resistant Staphylococcus aureus

(2012) Hao-Chieh Chiu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and Potent In vitro Activity of Novel 1H-Benzimidazoles as Anti-MRSA Agents

(2012) Hacer Karataş et al.   Chemical Biology & Drug Design

Oritavancin: Mechanism of Action

(2012) George G. Zhanel et al.   CLINICAL INFECTIOUS DISEASES

Global patient safety and antiretroviral drug-drug interactions in the resource-limited setting

(2012) K. Seden et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Antimicrobial activity of the novel pleuromutilin antibiotic BC-3781 against organisms responsible for community-acquired respiratory tract infections (CARTIs)

(2012) H. S. Sader et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Lipodepsipeptide Empedopeptin Inhibits Cell Wall Biosynthesis through Ca2+-dependent Complex Formation with Peptidoglycan Precursors

(2012) Anna Müller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of Marinopyrrole A (Maritoclax) as a Selective Mcl-1 Antagonist that Overcomes ABT-737 Resistance by Binding to and Targeting Mcl-1 for Proteasomal Degradation

(2012) Kenichiro Doi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disk Diffusion and MIC Quality Control Ranges for BC-3205 and BC-3781, Two Novel Pleuromutilin Antibiotics

(2012) J. E. Ross et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Discovery of Selective Menaquinone Biosynthesis Inhibitors against Mycobacterium tuberculosis

(2012) Joy Debnath et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Ureidomuraymycidine Derivatives for Structure– Activity Relationship Studies of Muraymycins

(2012) Bilal A. Aleiwi et al.   JOURNAL OF ORGANIC CHEMISTRY

Solid-Phase Synthesis of Lysobactin (Katanosin B): Insights into Structure and Function

(2012) Edward A. Hall et al.   ORGANIC LETTERS

Whole Genome Characterization of the Mechanisms of Daptomycin Resistance in Clinical and Laboratory Derived Isolates of Staphylococcus aureus

(2012) Anton Y. Peleg et al.   PLoS One

Inferring Reasons for the Failure of Staphylococcus aureus Vaccines in Clinical Trials

(2012) Fabio Bagnoli et al.   Frontiers in Cellular and Infection Microbiology

Pharmacological Properties of the Marine Natural Product Marinopyrrole A against Methicillin-Resistant Staphylococcus aureus

(2011) Nina M. Haste et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antistaphylococcal Activity of TD-1792, a Multivalent Glycopeptide-Cephalosporin Antibiotic

(2011) Johanne Blais et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In VivoPharmacodynamics of Torezolid Phosphate (TR-701), a New Oxazolidinone Antibiotic, against Methicillin-Susceptible and Methicillin-Resistant Staphylococcus aureus Strains in a Mouse Thigh Infection Model

(2011) Arnold Louie et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacodynamics of β-Lactamase Inhibition by NXL104 in Combination with Ceftaroline: Examining Organisms with Multiple Types of β-Lactamases

(2011) Arnold Louie et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacodynamics of TD-1792, a Novel Glycopeptide-Cephalosporin Heterodimer Antibiotic Used against Gram-Positive Bacteria, in a Neutropenic Murine Thigh Model

(2011) Sharath S. Hegde et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Feglymycin is an Inhibitor of the Enzymes MurA and MurC of the Peptidoglycan Biosynthesis Pathway

(2011) Saskia Rausch et al.   CHEMBIOCHEM

Best Alternative to Vancomycin for Serious Methicillin-Resistant Staphylococcus aureus Infections: Let's Just Say It

(2011) L. M. Bush   CLINICAL INFECTIOUS DISEASES

Pharmacokinetics and Unexpected Safety Issues of LBM415, a Novel Oral Peptide Deformylase Inhibitor

(2011) P Rolan et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Platensimycin and platencin: promising antibiotics for future application in human medicine

(2011) Evan Martens et al.   JOURNAL OF ANTIBIOTICS

Determination of Disk Diffusion and MIC Quality Control Ranges for GSK1322322, a Novel Peptide Deformylase Inhibitor

(2011) James E. Ross et al.   JOURNAL OF CLINICAL MICROBIOLOGY

4-Aminothiazolyl Analogues of GE2270 A: Antibacterial Lead Finding

(2011) Matthew J. LaMarche et al.   JOURNAL OF MEDICINAL CHEMISTRY

In Vitro Activity of the New Multivalent Glycopeptide-Cephalosporin Antibiotic TD-1792 against Vancomycin-Nonsusceptible Staphylococcus Isolates

(2010) K. D. Leuthner et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vivo Pharmacodynamic Activity of Tomopenem (formerly CS-023) against Pseudomonas aeruginosa and Methicillin-Resistant Staphylococcus aureus in a Murine Thigh Infection Model

(2010) K. Sugihara et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Phase 2, Randomized, Double-Blind, Dose-Ranging Study Evaluating the Safety, Tolerability, Population Pharmacokinetics, and Efficacy of Oral Torezolid Phosphate in Patients with Complicated Skin and Skin Structure Infections

(2010) P. Prokocimer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Comparative In Vitro Antimicrobial Activities of Torezolid (TR-700), the Active Moiety of a New Oxazolidinone, Torezolid Phosphate (TR-701), Determination of Tentative Disk Diffusion Interpretive Criteria, and Quality Control Ranges

(2010) S. D. Brown et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Investigation of the Potential for Mutational Resistance to XF-73, Retapamulin, Mupirocin, Fusidic Acid, Daptomycin, and Vancomycin in Methicillin-ResistantStaphylococcus aureusIsolates during a 55-Passage Study

(2010) David J. Farrell et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Distribution of Fusidic Acid Resistance Determinants in Methicillin-ResistantStaphylococcus aureus

(2010) F. B. McLaws et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Oritavancin Disrupts Membrane Integrity of Staphylococcus aureus and Vancomycin-Resistant Enterococci To Effect Rapid Bacterial Killing

(2010) A. Belley et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Contrasting Effects of Acidic pH on the Extracellular and Intracellular Activities of the Anti-Gram-Positive Fluoroquinolones Moxifloxacin and Delafloxacin againstStaphylococcus aureus

(2010) Sandrine Lemaire et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Acyldepsipeptide Antibiotics Induce the Formation of a Structured Axial Channel in ClpP: A Model for the ClpX/ClpA-Bound State of ClpP

(2010) Dominic Him Shun Li et al.   CHEMISTRY & BIOLOGY

Genomics-inspired discovery of natural products

(2010) Jaclyn M Winter et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Phage Therapy in Clinical Practice: Treatment of Human Infections

(2010) Elizabeth Kutter et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Clinical Outbreak of Linezolid-Resistant Staphylococcus aureus in an Intensive Care Unit

(2010) Miguel Sánchez García   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Antibiotic discovery in the twenty-first century: current trends and future perspectives

(2010) Stefano Donadio et al.   JOURNAL OF ANTIBIOTICS

Nosokomycins, new antibiotics discovered in an in vivo-mimic infection model using silkworm larvae. I: Fermentation, isolation and biological properties

(2010) Ryuji Uchida et al.   JOURNAL OF ANTIBIOTICS

Activity of chequerboard combinations of ceftaroline and NXL104 versus  -lactamase-producing Enterobacteriaceae

(2010) S. Mushtaq et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Reduction of Clofazimine by Mycobacterial Type 2 NADH:Quinone Oxidoreductase

(2010) Takahiro Yano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vitro postantibiotic effects of tomopenem (CS-023) against Staphylococcus aureus and Pseudomonas aeruginosa

(2010) T. Tomozawa et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Vitamin K2 in Electron Transport System: Are Enzymes Involved in Vitamin K2 Biosynthesis Promising Drug Targets?

(2010) Michio Kurosu et al.   MOLECULES

Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism

(2010) Byung-Gil Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An Efficient Large-Scale Synthesis of EDP-420, a First-in-Class Bridged Bicyclic Macrolide (BBM) Antibiotic Drug Candidate

(2010) Guoyou Xu et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Ceftaroline: A New Cephalosporin with Activity Against Resistant Gram-Positive Pathogens

(2010) Molly E Steed et al.   PHARMACOTHERAPY

Preparative isolation and purification of four prenylflavanones from microbial biotransformation of kurarinone by high-speed counter-current chromatography

(2010) Xiao-chi Ma et al.   SEPARATION AND PURIFICATION TECHNOLOGY

Total synthesis and biological evaluation of marinopyrrole A and analogs

(2010) K.C. Nicolaou et al.   TETRAHEDRON LETTERS

Total Synthesis of the Antiviral Peptide Antibiotic Feglymycin

(2009) Frank Dettner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In Vivo Characterization of the Peptide Deformylase Inhibitor LBM415 in Murine Infection Models

(2009) C. S. Osborne et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Efficacy Profiles of Daptomycin for Treatment of Invasive and Noninvasive Pulmonary Infections with Streptococcus pneumoniae

(2009) S. Henken et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Aquastatin A, a New Inhibitor of Enoyl-Acyl Carrier Protein Reductase from Sporothrix sp. FN611

(2009) Yun-Ju Kwon et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Telavancin: A Novel Lipoglycopeptide

(2009) Louis D. Saravolatz et al.   CLINICAL INFECTIOUS DISEASES

Cationic compounds with activity against multidrug-resistant bacteria: interest of a new compound compared with two older antiseptics, hexamidine and chlorhexidine

(2009) M. Grare et al.   CLINICAL MICROBIOLOGY AND INFECTION

Growth inhibitory and anti-tumour activities of OSU-03012, a novel PDK-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells

(2009) Tina X. Lee et al.   EUROPEAN JOURNAL OF CANCER

Ceftaroline: a cephalosporin with expanded Gram-positive activity

(2009) Zeina A Kanafani et al.   Future Microbiology

Iclaprim: a novel dihydrofolate reductase inhibitor for skin and soft tissue infections

(2009) Andrew Morgan et al.   Future Microbiology

Methicillin-Resistant Staphylococcus aureus Central Line–Associated Bloodstream Infections in US Intensive Care Units, 1997-2007

(2009) Deron C. Burton   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Viridicatumtoxin B, a new anti-MRSA agent from Penicillium sp. FR11

(2009) Chang-Ji Zheng et al.   JOURNAL OF ANTIBIOTICS

Nasal decolonization of Staphylococcus aureus with mupirocin: strengths, weaknesses and future prospects

(2009) T. Coates et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

XF-73, a novel antistaphylococcal membrane-active agent with rapid bactericidal activity

(2009) N. Ooi et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Vinaxanthone, a new FabI inhibitor from Penicillium sp.

(2009) C. J. Zheng et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Menaquinone synthesis is critical for maintaining mycobacterial viability during exponential growth and recovery from non-replicating persistence

(2009) Rakesh K. Dhiman et al.   MOLECULAR MICROBIOLOGY

Antimicrobial nucleoside antibiotics targeting cell wall assembly: Recent advances in structure–function studies and nucleoside biosynthesis

(2009) Michael Winn et al.   NATURAL PRODUCT REPORTS

Novel antibiotics for the treatment ofStaphylococcus aureus

(2009) Knut Ohlsen   Expert Review of Clinical Pharmacology

In Vitro Activity of Tomopenem (CS-023/RO4908463) against Anaerobic Bacteria

(2008) K. Tanaka et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Potent In Vitro Activity of Tomopenem (CS-023) against Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa

(2008) T. Koga et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro Activities of the Rx-01 Oxazolidinones against Hospital and Community Pathogens

(2008) L. Lawrence et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

R -01, a New Family of Oxazolidinones That Overcome Ribosome-Based Linezolid Resistance

(2008) E. Skripkin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Design at the atomic level: Design of biaryloxazolidinones as potent orally active antibiotics

(2008) Jiacheng Zhou et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of an anti-MRSA dihydrofolate reductase inhibitor from a diversity-oriented synthesis

(2008) Emma E. Wyatt et al.   CHEMICAL COMMUNICATIONS

Clinical and Microbiological Outcomes of Serious Infections with Multidrug-Resistant Gram-Negative Organisms Treated with Tigecycline

(2008) K. B. Anthony et al.   CLINICAL INFECTIOUS DISEASES

Management of Methicillin‐ResistantStaphylococcus aureusBacteremia

(2008) Sara E. Cosgrove et al.   CLINICAL INFECTIOUS DISEASES

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

(2008) Helen W. Boucher et al.   CLINICAL INFECTIOUS DISEASES

Vancomycin Revisited: A Reappraisal of Clinical Use

(2008) Burke A. Cunha   CRITICAL CARE CLINICS

Biosynthesis of Glycopeptides: Prospects for Improved Antibacterials

(2008) Stefano Donadio et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Potential of old-generation antibiotics to address current need for new antibiotics

(2008) Matthew E Falagas et al.   Expert Review of Anti-Infective Therapy