Human artificial chromosome-based gene delivery vectors for biomedicine and biotechnology

An induced pluripotent stem cell-mediated and integration-free factor VIII expression system

(2013) Yuwna Yakura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A new assay for measuring chromosome instability (CIN) and identification of drugs that elevate CIN in cancer cells

(2013) Hee-Sheung Lee et al.   BMC CANCER

Protecting a transgene expression from the HAC-based vector by different chromatin insulators

(2013) Nicholas CO Lee et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The transfer of human artificial chromosomes via cryopreserved microcells

(2013) Narumi Uno et al.   CYTOTECHNOLOGY

Gene therapy of primary T cell immunodeficiencies

(2013) Alain Fischer et al.   GENE

Re-engineering an alphoidtetO-HAC-based vector to enable high-throughput analyses of gene function

(2013) Artem V. Kononenko et al.   NUCLEIC ACIDS RESEARCH

Lgr5+ liver stem cells, hepatic organoids and regenerative medicine

(2013) Meritxell Huch et al.   Regenerative Medicine

Gene Therapy That Works

(2013) I. M. Verma   SCIENCE

Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications

(2013) T. Sato et al.   SCIENCE

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

(2013) Thomas Gaj et al.   TRENDS IN BIOTECHNOLOGY

A Review of Techniques for Gene Therapy in Bone Healing

(2013) Payam Tarassoli et al.   Current Stem Cell Research & Therapy

Protecting against wayward human induced pluripotent stem cells with a suicide gene

(2012) Fuyi Cheng et al.   BIOMATERIALS

A new generation of human artificial chromosomes for functional genomics and gene therapy

(2012) Natalay Kouprina et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The development of pluripotent stem cells

(2012) Paul J Gokhale et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Gene therapy for primary immunodeficiencies: part 1

(2012) Marina Cavazzana-Calvo et al.   CURRENT OPINION IN IMMUNOLOGY

Stem cell therapies for muscle disorders

(2012) Francesco S. Tedesco et al.   CURRENT OPINION IN NEUROLOGY

Breaking the HAC Barrier: Histone H3K9 acetyl/methyl balance regulates CENP-A assembly

(2012) Jun-ichirou Ohzeki et al.   EMBO JOURNAL

Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans

(2012) Yasuhiro Kazuki et al.   HUMAN MOLECULAR GENETICS

Virus-mediated gene delivery for human gene therapy

(2012) Mauro Giacca et al.   JOURNAL OF CONTROLLED RELEASE

The AAV Vector Toolkit: Poised at the Clinical Crossroads

(2012) Aravind Asokan et al.   MOLECULAR THERAPY

Transplantation of Genetically Corrected Human iPSC-Derived Progenitors in Mice with Limb-Girdle Muscular Dystrophy

(2012) F. S. Tedesco et al.   Science Translational Medicine

Organization of Synthetic Alphoid DNA Array in Human Artificial Chromosome (HAC) with a Conditional Centromere

(2012) Natalay Kouprina et al.   ACS Synthetic Biology

Lgr5+ve Stem/Progenitor Cells Contribute to Nephron Formation during Kidney Development

(2012) Nick Barker et al.   Cell Reports

A new chromosome 14-based human artificial chromosome (HAC) vector system for efficient transgene expression in human primary cells

(2011) Minoru Kakeda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rapid generation of long tandem DNA repeat arrays by homologous recombination in yeast to study their function in mammalian genomes

(2011) Vladimir N Noskov et al.   BIOLOGICAL PROCEDURES ONLINE

tRNA genes protect a reporter gene from epigenetic silencing in mouse cells

(2011) Thomas Ebersole et al.   CELL CYCLE

Mutability and mutational spectrum of chromosome transmission fidelity genes

(2011) Peter C. Stirling et al.   CHROMOSOMA

Human tRNA genes function as chromatin insulators

(2011) Jesse R Raab et al.   EMBO JOURNAL

Functional human artificial chromosomes are generated and stably maintained in human embryonic stem cells

(2011) Mohammad A. Mandegar et al.   HUMAN MOLECULAR GENETICS

Gene therapy for leukodystrophies

(2011) A. Biffi et al.   HUMAN MOLECULAR GENETICS

Human Artificial Chromosomes for Gene Delivery and the Development of Animal Models

(2011) Yasuhiro Kazuki et al.   MOLECULAR THERAPY

Therapeutic in vivo gene transfer for genetic disease using AAV: progress and challenges

(2011) Federico Mingozzi et al.   NATURE REVIEWS GENETICS

Induced pluripotent stem cells: opportunities and challenges

(2011) K. Okita et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

A Method for Producing Transgenic Cells Using a Multi-Integrase System on a Human Artificial Chromosome Vector

(2011) Shigeyuki Yamaguchi et al.   PLoS One

Derivation, Characterization, and Stable Transfection of Induced Pluripotent Stem Cells from Fischer344 Rats

(2011) Mikhail Liskovykh et al.   PLoS One

Integration-Free iPS Cells Engineered Using Human Artificial Chromosome Vectors

(2011) Masaharu Hiratsuka et al.   PLoS One

Human artificial chromosome (HAC) vector with a conditional centromere for correction of genetic deficiencies in human cells

(2011) J.-H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromosome missegregation in human cells arises through specific types of kinetochore-microtubule attachment errors

(2011) S. L. Thompson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stem Cell-Mediated Transfer of a Human Artificial Chromosome Ameliorates Muscular Dystrophy

(2011) F. S. Tedesco et al.   Science Translational Medicine

The Complete Spectrum of Yeast Chromosome Instability Genes Identifies Candidate CIN Cancer Genes and Functional Roles for ASTRA Complex Components

(2011) Peter C. Stirling et al.   PLoS Genetics

Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity

(2011) Chuanfeng Wu et al.   Frontiers of Medicine

Exploitation of the interaction of measles virus fusogenic envelope proteins with the surface receptor CD46 on human cells for microcell-mediated chromosome transfer

(2010) Motonobu Katoh et al.   BMC BIOTECHNOLOGY

Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA

(2010) Luigi Warren et al.   Cell Stem Cell

Mechanisms of Chromosomal Instability

(2010) Sarah L. Thompson et al.   CURRENT BIOLOGY

Human Artificial Chromosome with a Conditional Centromere for Gene Delivery and Gene Expression

(2010) Y. Iida et al.   DNA RESEARCH

Retroviral vectors for gene therapy

(2010) Patrick Maier et al.   Future Microbiology

Refined human artificial chromosome vectors for gene therapy and animal transgenesis

(2010) Y Kazuki et al.   GENE THERAPY

Escherichia coli-Cloned CFTR Loci Relevant for Human Artificial Chromosome Therapy

(2010) Lucia Rocchi et al.   HUMAN GENE THERAPY

Recent Advances in Lentiviral Vector Development and Applications

(2010) Janka Mátrai et al.   MOLECULAR THERAPY

Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia

(2010) Marina Cavazzana-Calvo et al.   NATURE

Isolation of circular yeast artificial chromosomes for synthetic biology and functional genomics studies

(2010) Vladimir N Noskov et al.   Nature Protocols

Transfer of human artificial chromosome vectors into stem cells

(2010) Mitsuo Oshimura et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Human Induced Pluripotent Stem Cells Develop Teratoma More Efficiently and Faster Than Human Embryonic Stem Cells Regardless the Site of Injection

(2010) Ivan Gutierrez-Aranda et al.   STEM CELLS

The generation of stable, high MAb expressing CHO cell lines based on the artificial chromosome expression (ACE) technology

(2009) Malcolm L. Kennard et al.   BIOTECHNOLOGY AND BIOENGINEERING

Generation of Induced Pluripotent Stem Cells Using Recombinant Proteins

(2009) Hongyan Zhou et al.   Cell Stem Cell

Progress and prospects: Biological properties and technological advances of herpes simplex virus type 1-based amplicon vectors

(2009) A L Epstein   GENE THERAPY

Integrase-defective lentiviral vectors: progress and applications

(2009) M B Banasik et al.   GENE THERAPY

Human gamma-satellite DNA maintains open chromatin structure and protects a transgene from epigenetic silencing

(2009) J.-H. Kim et al.   GENOME RESEARCH

Integration-deficient Lentiviral Vectors: A Slow Coming of Age

(2009) Klaus Wanisch et al.   MOLECULAR THERAPY

Complete Genetic Correction of iPS Cells From Duchenne Muscular Dystrophy

(2009) Yasuhiro Kazuki et al.   MOLECULAR THERAPY

Antigen-specific human polyclonal antibodies from hyperimmunized cattle

(2009) Yoshimi Kuroiwa et al.   NATURE BIOTECHNOLOGY

Manipulating transgenes using a chromosome vector

(2009) M. Ikeno et al.   NUCLEIC ACIDS RESEARCH

Cell to cell transfer of the chromatin-packaged human β-globin gene cluster

(2009) Nobutaka Suzuki et al.   NUCLEIC ACIDS RESEARCH

Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells

(2009) Aniek Janssen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hematopoietic Stem Cell Gene Therapy with a Lentiviral Vector in X-Linked Adrenoleukodystrophy

(2009) N. Cartier et al.   SCIENCE

Lentiviral vectors with measles virus glycoproteins – dream team for gene transfer?

(2009) Christian J. Buchholz et al.   TRENDS IN BIOTECHNOLOGY

Inactivation of a Human Kinetochore by Specific Targeting of Chromatin Modifiers

(2008) Megumi Nakano et al.   DEVELOPMENTAL CELL

Correction of a genetic defect in multipotent germline stem cells using a human artificial chromosome

(2008) Y Kazuki et al.   GENE THERAPY

Introduction of a CD40L genomic fragment via a human artificial chromosome vector permits cell-type-specific gene expression and induces immunoglobulin secretion

(2008) Hidetoshi Yamada et al.   JOURNAL OF HUMAN GENETICS

Advances in High-capacity Extrachromosomal Vector Technology: Episomal Maintenance, Vector Delivery, and Transgene Expression

(2008) Michele MP Lufino et al.   MOLECULAR THERAPY

A highly Stable and Nonintegrated Human Artificial Chromosome (HAC) Containing the 2.4 Mb Entire Human Dystrophin Gene

(2008) Hidetoshi Hoshiya et al.   MOLECULAR THERAPY

Selective isolation of genomic loci from complex genomes by transformation-associated recombination cloning in the yeast Saccharomyces cerevisiae

(2008) Natalay Kouprina et al.   Nature Protocols

Induced Pluripotent Stem Cells Generated Without Viral Integration

(2008) M. Stadtfeld et al.   SCIENCE

Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors

(2008) K. Okita et al.   SCIENCE

Input DNA Ratio Determines Copy Number of The 33 kb Factor IX Gene on De Novo Human Artificial Chromosomes

(2007) Amy M Breman et al.   MOLECULAR THERAPY