Protecting a transgene expression from the HAC-based vector by different chromatin insulators

A new generation of human artificial chromosomes for functional genomics and gene therapy

(2012) Natalay Kouprina et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

HACking the centromere chromatin code: insights from human artificial chromosomes

(2012) Jan H. Bergmann et al.   CHROMOSOME RESEARCH

Breaking the HAC Barrier: Histone H3K9 acetyl/methyl balance regulates CENP-A assembly

(2012) Jun-ichirou Ohzeki et al.   EMBO JOURNAL

Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans

(2012) Yasuhiro Kazuki et al.   HUMAN MOLECULAR GENETICS

Epigenetic engineering: histone H3K9 acetylation is compatible with kinetochore structure and function

(2012) J. H. Bergmann et al.   JOURNAL OF CELL SCIENCE

HDAC Inhibitors-New Generation of Target Specific Treatment

(2012) A. V. Chavan et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Active transcription and essential role of RNA polymerase II at the centromere during mitosis

(2012) F. L. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transplantation of Genetically Corrected Human iPSC-Derived Progenitors in Mice with Limb-Girdle Muscular Dystrophy

(2012) F. S. Tedesco et al.   Science Translational Medicine

Chromatin insulator elements: establishing barriers to set heterochromatin boundaries

(2012) Gráinne Barkess et al.   Epigenomics

Organization of Synthetic Alphoid DNA Array in Human Artificial Chromosome (HAC) with a Conditional Centromere

(2012) Natalay Kouprina et al.   ACS Synthetic Biology

tRNA genes protect a reporter gene from epigenetic silencing in mouse cells

(2011) Thomas Ebersole et al.   CELL CYCLE

Human tRNA genes function as chromatin insulators

(2011) Jesse R Raab et al.   EMBO JOURNAL

Human Artificial Chromosomes for Gene Delivery and the Development of Animal Models

(2011) Yasuhiro Kazuki et al.   MOLECULAR THERAPY

A Method for Producing Transgenic Cells Using a Multi-Integrase System on a Human Artificial Chromosome Vector

(2011) Shigeyuki Yamaguchi et al.   PLoS One

Human artificial chromosome (HAC) vector with a conditional centromere for correction of genetic deficiencies in human cells

(2011) J.-H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stem Cell-Mediated Transfer of a Human Artificial Chromosome Ameliorates Muscular Dystrophy

(2011) F. S. Tedesco et al.   Science Translational Medicine

Human Artificial Chromosome with a Conditional Centromere for Gene Delivery and Gene Expression

(2010) Y. Iida et al.   DNA RESEARCH

Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochore

(2010) Jan H Bergmann et al.   EMBO JOURNAL

Transfer of human artificial chromosome vectors into stem cells

(2010) Mitsuo Oshimura et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Human gamma-satellite DNA maintains open chromatin structure and protects a transgene from epigenetic silencing

(2009) J.-H. Kim et al.   GENOME RESEARCH

Hierarchical Inactivation of a Synthetic Human Kinetochore by a Chromatin Modifier

(2009) Stefano Cardinale et al.   MOLECULAR BIOLOGY OF THE CELL

Complete Genetic Correction of iPS Cells From Duchenne Muscular Dystrophy

(2009) Yasuhiro Kazuki et al.   MOLECULAR THERAPY

Inactivation of a Human Kinetochore by Specific Targeting of Chromatin Modifiers

(2008) Megumi Nakano et al.   DEVELOPMENTAL CELL

Selective isolation of genomic loci from complex genomes by transformation-associated recombination cloning in the yeast Saccharomyces cerevisiae

(2008) Natalay Kouprina et al.   Nature Protocols