Liposomal delivery of nucleic acid-based anticancer therapeutics: BP-100-1.01

Liposomal siRNA nanocarriers for cancer therapy

(2014) Bulent Ozpolat et al.   ADVANCED DRUG DELIVERY REVIEWS

Potential induction of anti-PEG antibodies and complement activation toward PEGylated therapeutics

(2014) Johan J.F. Verhoef et al.   DRUG DISCOVERY TODAY

XTEN-Annexin A5: XTEN Allows Complete Expression of Long-Circulating Protein-Based Imaging Probes as Recombinant Alternative to PEGylation

(2014) A. Haeckel et al.   JOURNAL OF NUCLEAR MEDICINE

Cell penetration: scope and limitations by the application of cell-penetrating peptides

(2014) Siegmund Reissmann   JOURNAL OF PEPTIDE SCIENCE

Generation, characterization and in vivo biological activity of two distinct monoclonal anti-PEG IgMs

(2014) Yosuke Hashimoto et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Multicellular Tumor Spheroids as a Model for Assessing Delivery of Oligonucleotides in Three Dimensions

(2014) Kyle Carver et al.   Molecular Therapy-Nucleic Acids

Intracellular Fate of Peptide-Mediated Delivered Cargoes

(2013) Irene Martin et al.   CURRENT PHARMACEUTICAL DESIGN

Single modification at position 14 of siRNA strand abolishes its gene-silencing activity by decreasing both RISC loading and target degradation

(2013) Jie Zheng et al.   FASEB JOURNAL

Cell-penetrating peptides: 20 years later, where do we stand?

(2013) Chérine Bechara et al.   FEBS LETTERS

Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial

(2013) Kevin Fitzgerald et al.   LANCET

An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study

(2013) Timothy M Miller et al.   LANCET NEUROLOGY

A window onto siRNA delivery

(2013) Yuhua Wang et al.   NATURE BIOTECHNOLOGY

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

(2013) Jerome Gilleron et al.   NATURE BIOTECHNOLOGY

Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

(2013) Gaurav Sahay et al.   NATURE BIOTECHNOLOGY

Safety and Efficacy of RNAi Therapy for Transthyretin Amyloidosis

(2013) Teresa Coelho et al.   NEW ENGLAND JOURNAL OF MEDICINE

The small molecule Retro-1 enhances the pharmacological actions of antisense and splice switching oligonucleotides

(2013) Xin Ming et al.   NUCLEIC ACIDS RESEARCH

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

(2012) Muthusamy Jayaraman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Antibodies against polyethylene glycol in healthy subjects and in patients treated with PEG-conjugated agents

(2012) Ricardo P Garay et al.   Expert Opinion on Drug Delivery

Targeted Silencing of Elongation Factor 2 Kinase Suppresses Growth and Sensitizes Tumors to Doxorubicin in an Orthotopic Model of Breast Cancer

(2012) Ibrahim Tekedereli et al.   PLoS One

miR-221 Silencing Blocks Hepatocellular Carcinoma and Promotes Survival

(2011) J.-K. Park et al.   CANCER RESEARCH

Unconventional internalization mechanisms underlying functional delivery of antisense oligonucleotides via cationic lipoplexes and polyplexes

(2011) Xin Ming et al.   JOURNAL OF CONTROLLED RELEASE

Liposome-induced complement activation and related cardiopulmonary distress in pigs: factors promoting reactogenicity of Doxil and AmBisome

(2011) János Szebeni et al.   Nanomedicine-Nanotechnology Biology and Medicine

Targeting RNA to treat neuromuscular disease

(2011) Francesco Muntoni et al.   NATURE REVIEWS DRUG DISCOVERY

Involvement of Grb2 Adaptor Protein in Nucleophosmin-Anaplastic Lymphoma Kinase (NPM-ALK)-mediated Signaling and Anaplastic Large Cell Lymphoma Growth

(2010) Ludovica Riera et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Silencing Kinase-Interacting Stathmin Gene Enhances Erlotinib Sensitivity by Inhibiting Ser10 p27 Phosphorylation in Epidermal Growth Factor Receptor-Expressing Breast Cancer

(2010) D. Zhang et al.   MOLECULAR CANCER THERAPEUTICS

Nanoparticles Modified With Tumor-targeting scFv Deliver siRNA and miRNA for Cancer Therapy

(2010) Yunching Chen et al.   MOLECULAR THERAPY

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

Targeted therapy for high-grade glioma with the TGF- 2 inhibitor trabedersen: results of a randomized and controlled phase IIb study

(2010) U. Bogdahn et al.   NEURO-ONCOLOGY

Lipid-like materials for low-dose, in vivo gene silencing

(2010) K. T. Love et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular delivery of siRNA by cell-penetrating peptides modified with cationic oligopeptides

(2009) Tsutomu Ishihara et al.   DRUG DELIVERY

A Novel Mechanism Is Involved in Cationic Lipid-Mediated Functional siRNA Delivery

(2009) James J. Lu et al.   MOLECULAR PHARMACEUTICS

Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection

(2009) R. E. Lanford et al.   SCIENCE

Synthesis and silencing properties of siRNAs possessing lipophilic groups at their 3′-termini

(2008) Yoshihito Ueno et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Therapeutic Significance of Elevated Tissue Transglutaminase Expression in Pancreatic Cancer

(2008) A. Verma et al.   CLINICAL CANCER RESEARCH

An efficient and low immunostimulatory nanoparticle formulation for systemic siRNA delivery to the tumor

(2008) Sumio Chono et al.   JOURNAL OF CONTROLLED RELEASE

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

(2008) Akin Akinc et al.   NATURE BIOTECHNOLOGY