Targeted Silencing of Elongation Factor 2 Kinase Suppresses Growth and Sensitizes Tumors to Doxorubicin in an Orthotopic Model of Breast Cancer

Silencing of Bcl-2 expression by small interfering RNA induces autophagic cell death in MCF-7 breast cancer cells

(2014) Ugur Akar et al.   Autophagy

Investigating the Kinetic Mechanism of Inhibition of Elongation Factor 2 Kinase by NH125: Evidence of a Common in Vitro Artifact

(2012) Ashwini K. Devkota et al.   BIOCHEMISTRY

Calcium/Calmodulin Stimulates the Autophosphorylation of Elongation Factor 2 Kinase on Thr-348 and Ser-500 To Regulate Its Activity and Calcium Dependence

(2012) Clint D. J. Tavares et al.   BIOCHEMISTRY

Impaired associative taste learning and abnormal brain activation in kinase-defective eEF2K mice

(2012) I. Gildish et al.   LEARNING & MEMORY

Expression of elongation factor-2 kinase contributes to anoikis resistance and invasion of human glioma cells

(2011) Li Zhang et al.   ACTA PHARMACOLOGICA SINICA

Inhibition of eEF-2 kinase sensitizes human glioma cells to TRAIL and down-regulates Bcl-xL expression

(2011) Yi Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

eEF-2 Kinase Dictates Cross-Talk between Autophagy and Apoptosis Induced by Akt Inhibition, Thereby Modulating Cytotoxicity of Novel Akt Inhibitor MK-2206

(2011) Y. Cheng et al.   CANCER RESEARCH

Sumoylation of eukaryotic elongation factor 2 is vital for protein stability and anti-apoptotic activity in lung adenocarcinoma cells

(2011) Chih-Yi Chen et al.   CANCER SCIENCE

1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) Induces Phosphorylation of Eukaryotic Elongation Factor-2 (eEF2)

(2011) Zehan Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Compartment-specific, differential regulation of eukaryotic elongation factor 2 and its kinase within Aplysia sensory neurons

(2011) Daniel B. Weatherill et al.   JOURNAL OF NEUROCHEMISTRY

Purification and characterization of tagless recombinant human elongation factor 2 kinase (eEF-2K) expressed in Escherichia coli

(2011) Olga Abramczyk et al.   PROTEIN EXPRESSION AND PURIFICATION

Other Options in the Treatment of Advanced Breast Cancer

(2011) Melody A. Cobleigh   SEMINARS IN ONCOLOGY

TheBCL-25′ Untranslated Region Contains an RNA G-Quadruplex-Forming Motif That Modulates Protein Expression

(2010) Ramla Shahid et al.   BIOCHEMISTRY

Targeting p70S6K Prevented Lung Metastasis in a Breast Cancer Xenograft Model

(2010) U. Akar et al.   MOLECULAR CANCER THERAPEUTICS

Cytoprotective Effect of the Elongation Factor-2 Kinase-Mediated Autophagy in Breast Cancer Cells Subjected to Growth Factor Inhibition

(2010) Yan Cheng et al.   PLoS One

Gefitinib induces apoptosis and decreases telomerase activity in MDA-MB-231 human breast cancer cells

(2009) Dong-Oh Moon et al.   ARCHIVES OF PHARMACAL RESEARCH

Silencing of Elongation Factor-2 Kinase Potentiates the Effect of 2-Deoxy-D-Glucose against Human Glioma Cells through Blunting of Autophagy

(2009) H. Wu et al.   CANCER RESEARCH

Nanomedicine based approaches for the delivery of siRNA in cancer

(2009) B. Ozpolat et al.   JOURNAL OF INTERNAL MEDICINE

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting Src in breast cancer

(2008) R. S. Finn   ANNALS OF ONCOLOGY

A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death

(2008) M Boyce et al.   CELL DEATH AND DIFFERENTIATION

Elongation Factor 2 and Fragile X Mental Retardation Protein Control the Dynamic Translation of Arc/Arg3.1 Essential for mGluR-LTD

(2008) Sungjin Park et al.   NEURON