Cell-penetrating peptides for the delivery of nucleic acids

Targeting human epidermal growth factor receptor 2 by a cell-penetrating peptide–affibody bioconjugate

(2011) Srinath Govindarajan et al.   BIOMATERIALS

Scavenger receptor-mediated uptake of cell-penetrating peptide nanocomplexes with oligonucleotides

(2011) Kariem Ezzat et al.   FASEB JOURNAL

To Be Targeted: Is the Magic Bullet Concept a Viable Option for Synthetic Nucleic Acid Therapeutics?

(2011) Manfred Ogris et al.   HUMAN GENE THERAPY

NickFects, Phosphorylated Derivatives of Transportan 10 for Cellular Delivery of Oligonucleotides

(2011) Nikita Oskolkov et al.   International Journal of Peptide Research and Therapeutics

Insights into the cellular trafficking of splice redirecting oligonucleotides complexed with chemically modified cell-penetrating peptides

(2011) Fatouma Said Hassane et al.   JOURNAL OF CONTROLLED RELEASE

A Peptide-based Vector for Efficient Gene Transfer In Vitro and In Vivo

(2011) Taavi Lehto et al.   MOLECULAR THERAPY

Fluorescent peptides highlight peripheral nerves during surgery in mice

(2011) Michael A Whitney et al.   NATURE BIOTECHNOLOGY

State-of-the-art gene-based therapies: the road ahead

(2011) Mark A. Kay   NATURE REVIEWS GENETICS

Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo

(2011) Samir EL Andaloussi et al.   NUCLEIC ACIDS RESEARCH

PepFect 14, a novel cell-penetrating peptide for oligonucleotide delivery in solution and as solid formulation

(2011) Kariem Ezzat et al.   NUCLEIC ACIDS RESEARCH

Direct Translocation as Major Cellular Uptake for CADY Self-Assembling Peptide-Based Nanoparticles

(2011) Anna Rydström et al.   PLoS One

Gene Therapists Celebrate a Decade of Progress

(2011) J. Kaiser   SCIENCE

EPR effect based drug design and clinical outlook for enhanced cancer chemotherapy

(2010) Hiroshi Maeda et al.   ADVANCED DRUG DELIVERY REVIEWS

RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform

(2010) C. Frank Bennett et al.   Annual Review of Pharmacology and Toxicology

Happy birthday cell penetrating peptides: Already 20 years

(2010) Robert Brasseur et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structural polymorphism of non-covalent peptide-based delivery systems: Highway to cellular uptake

(2010) Sébastien Deshayes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

RNA-targeted splice-correction therapy for neuromuscular disease

(2010) M. J. A. Wood et al.   BRAIN

Induction of in vivo synthetic lethal RNAi responses to treat glioblastoma

(2010) Hiroyuki Michiue et al.   CANCER BIOLOGY & THERAPY

Peptide-Based Matrices as Drug Delivery Vehicles

(2010) Kariem Ezzat et al.   CURRENT PHARMACEUTICAL DESIGN

Construction of cell penetrating peptide vectors with N-terminal stearylated nuclear localization signal for targeted delivery of DNA into the cell nuclei

(2010) Hui-Yuan Wang et al.   JOURNAL OF CONTROLLED RELEASE

POD Nanoparticles Expressing GDNF Provide Structural and Functional Rescue of Light-induced Retinal Degeneration in an Adult Mouse

(2010) Sarah P Read et al.   MOLECULAR THERAPY

Functional Rescue of Dystrophin-deficient mdx Mice by a Chimeric Peptide-PMO

(2010) HaiFang Yin et al.   MOLECULAR THERAPY

Bioresponsive polymers for the delivery of therapeutic nucleic acids

(2010) Daniel Edinger et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Delivery of Macromolecules Using Arginine-Rich Cell-Penetrating Peptides: Ways to Overcome Endosomal Entrapment

(2009) Ayman El-Sayed et al.   AAPS Journal

Cellular siRNA delivery using cell-penetrating peptides modified for endosomal escape

(2009) Tamaki Endoh et al.   ADVANCED DRUG DELIVERY REVIEWS

Recent advances in the use of cell-penetrating peptides for medical and biological applications☆

(2009) Sonali B. Fonseca et al.   ADVANCED DRUG DELIVERY REVIEWS

Peptide-Morpholino Conjugate: A Promising Therapeutic for Duchenne Muscular Dystrophy

(2009) Hong M. Moulton et al.   Annals of the New York Academy of Sciences

Long-term improvement in mdx cardiomyopathy after therapy with peptide-conjugated morpholino oligomers†

(2009) Natee Jearawiriyapaisarn et al.   CARDIOVASCULAR RESEARCH

Cell penetrating peptides: overview and applications to the delivery of oligonucleotides

(2009) F. Said Hassane et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Chemically modified cell-penetrating peptides for the delivery of nucleic acids

(2009) Maarja Mäe et al.   Expert Opinion on Drug Delivery

A fusion peptide directs enhanced systemic dystrophin exon skipping and functional restoration in dystrophin-deficient mdx mice

(2009) HaiFang Yin et al.   HUMAN MOLECULAR GENETICS

A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo

(2009) Hiroto Hatakeyama et al.   JOURNAL OF CONTROLLED RELEASE

Delivery of nucleic acids with a stearylated (RxR)4 peptide using a non-covalent co-incubation strategy

(2009) Taavi Lehto et al.   JOURNAL OF CONTROLLED RELEASE

A poly(ethylene) glycolylated peptide for ocular delivery compacts DNA into nanoparticles for gene delivery to post-mitotic tissuesin vivo

(2009) Sarah Parker Read et al.   JOURNAL OF GENE MEDICINE

Efficient siRNA delivery into primary cells by a peptide transduction domain–dsRNA binding domain fusion protein

(2009) Akiko Eguchi et al.   NATURE BIOTECHNOLOGY

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting cyclin B1 through peptide-based delivery of siRNA prevents tumour growth

(2009) L. Crombez et al.   NUCLEIC ACIDS RESEARCH

RNA repair restores hemoglobin expression in IVS2-654 thalassemic mice

(2009) S. Svasti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An endosomolytic Tat peptide produced by incorporation of histidine and cysteine residues as a nonviral vector for DNA transfection

(2008) Seong Loong Lo et al.   BIOMATERIALS

Cell-penetrating peptide-conjugated antisense oligonucleotides restore systemic muscle and cardiac dystrophin expression and function

(2008) HaiFang Yin et al.   HUMAN MOLECULAR GENETICS

High gene delivery in tumor by intratumoral injection of tetraarginine-PEG lipid-coated protamine/DNA

(2008) Takashi Fujita et al.   JOURNAL OF CONTROLLED RELEASE

A stearylated CPP for delivery of splice correcting oligonucleotides using a non-covalent co-incubation strategy

(2008) Maarja Mäe et al.   JOURNAL OF CONTROLLED RELEASE

S413-PV cell penetrating peptide and cationic liposomes act synergistically to mediate intracellular delivery of plasmid DNA

(2008) Sara Trabulo et al.   JOURNAL OF GENE MEDICINE

Sustained Dystrophin Expression Induced by Peptide-conjugated Morpholino Oligomers in the Muscles of mdx Mice

(2008) Natee Jearawiriyapaisarn et al.   MOLECULAR THERAPY

A New Potent Secondary Amphipathic Cell–penetrating Peptide for siRNA Delivery Into Mammalian Cells

(2008) Laurence Crombez et al.   MOLECULAR THERAPY

Nanoparticle therapeutics: an emerging treatment modality for cancer

(2008) Mark E. Davis et al.   NATURE REVIEWS DRUG DISCOVERY

Delivery of steric block morpholino oligomers by (R-X-R)4 peptides: structure-activity studies

(2008) R. Abes et al.   NUCLEIC ACIDS RESEARCH

Improved cell-penetrating peptide–PNA conjugates for splicing redirection in HeLa cells and exon skipping in mdx mouse muscle

(2008) Gabriela D. Ivanova et al.   NUCLEIC ACIDS RESEARCH

Cell-penetrating Peptide for Enhanced Delivery of Nucleic Acids and Drugs to Ocular Tissues Including Retina and Cornea

(2007) Leslie N Johnson et al.   MOLECULAR THERAPY