To Be Targeted: Is the Magic Bullet Concept a Viable Option for Synthetic Nucleic Acid Therapeutics?

The promotion of siRNA delivery to breast cancer overexpressing epidermal growth factor receptor through anti-EGFR antibody conjugation by immunoliposomes

(2011) Jie Gao et al.   BIOMATERIALS

EGFR-Homing dsRNA Activates Cancer-Targeted Immune Response and Eliminates Disseminated EGFR-Overexpressing Tumors in Mice

(2011) A. Shir et al.   CLINICAL CANCER RESEARCH

Epidermal Growth Factor Receptor-targeted 131I-therapy of Liver Cancer Following Systemic Delivery of the Sodium Iodide Symporter Gene

(2011) Kathrin Klutz et al.   MOLECULAR THERAPY

Expression of therapeutic proteins after delivery of chemically modified mRNA in mice

(2011) Michael S D Kormann et al.   NATURE BIOTECHNOLOGY

Engineering RNA for Targeted siRNA Delivery and Medical Application

(2010) Peixuan Guo et al.   ADVANCED DRUG DELIVERY REVIEWS

Development of Double-Stranded siRNA Labeling Method Using Positron Emitter and Its In Vivo Trafficking Analyzed by Positron Emission Tomography

(2010) Kentaro Hatanaka et al.   BIOCONJUGATE CHEMISTRY

Tumor-Selective Delivery of Macromolecular Drugs via the EPR Effect: Background and Future Prospects

(2010) Hiroshi Maeda   BIOCONJUGATE CHEMISTRY

Targeting of the prostacyclin specific IP1 receptor in lungs with molecular conjugates comprising prostaglandin I2 analogues

(2010) Johannes Geiger et al.   BIOMATERIALS

A leptin derived 30-amino-acid peptide modified pegylated poly-l-lysine dendrigraft for brain targeted gene delivery

(2010) Yang Liu et al.   BIOMATERIALS

Targeted minicircle DNA delivery using folate–poly(ethylene glycol)–polyethylenimine as non-viral carrier

(2010) Chao Zhang et al.   BIOMATERIALS

Image-Guided Breast Tumor Therapy Using a Small Interfering RNA Nanodrug

(2010) M. Kumar et al.   CANCER RESEARCH

Staying on message: design principles for controlling nonspecific responses to siRNA

(2010) Shirley Samuel-Abraham et al.   FEBS Journal

High-Density Lipoprotein Facilitates In Vivo Delivery of α-Tocopherol–Conjugated Short-Interfering RNA to the Brain

(2010) Yoshitaka Uno et al.   HUMAN GENE THERAPY

In Vitro and In Vivo gene delivery mediated by Lactosylated Dendrimer/α-Cyclodextrin Conjugates (G2) into Hepatocytes

(2010) Hidetoshi Arima et al.   JOURNAL OF CONTROLLED RELEASE

Targeted Intracellular Delivery of Antisense Oligonucleotides via Conjugation with Small-Molecule Ligands

(2010) Osamu Nakagawa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeted Enzyme Prodrug Therapies

(2010) N. Schellmann et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Nanoparticles Targeted With NGR Motif Deliver c-myc siRNA and Doxorubicin for Anticancer Therapy

(2010) Yunching Chen et al.   MOLECULAR THERAPY

Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

(2010) Akin Akinc et al.   MOLECULAR THERAPY

Targeted delivery of RNAi therapeutics for cancer therapy

(2010) Jun Li et al.   Nanomedicine

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Poly(I:C)-Mediated Tumor Growth Suppression in EGF-Receptor Overexpressing Tumors Using EGF-Polyethylene Glycol-Linear Polyethylenimine as Carrier

(2010) David Schaffert et al.   PHARMACEUTICAL RESEARCH

Locked nucleic acid as a novel class of therapeutic agents

(2010) Rakesh N. Veedu et al.   RNA Biology

Lipidic Systems for In Vivo siRNA Delivery

(2009) Sherry Y. Wu et al.   AAPS Journal

Ligand-Targeted Delivery of Small Interfering RNAs to Malignant Cells and Tissues

(2009) Mini Thomas et al.   Annals of the New York Academy of Sciences

Nanoparticles evading the reticuloendothelial system: Role of the supported bilayer

(2009) Shyh-Dar Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Targeted Gene Delivery Mediated by Folate-polyethylenimine-block-poly(ethylene glycol) with Receptor Selectivity

(2009) Han Cheng et al.   BIOCONJUGATE CHEMISTRY

Self-Assembly of Ternary Insulin−Polyethylenimine (PEI)−DNA Nanoparticles for Enhanced Gene Delivery and Expression in Alveolar Epithelial Cells

(2009) Markus Elfinger et al.   BIOMACROMOLECULES

Brain-targeting gene delivery and cellular internalization mechanisms for modified rabies virus glycoprotein RVG29 nanoparticles

(2009) Yang Liu et al.   BIOMATERIALS

Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycol-modified polyamidoamine dendrimer

(2009) Weilun Ke et al.   BIOMATERIALS

Low molecular weight polyethylenimine cross-linked by 2-hydroxypropyl-γ-cyclodextrin coupled to peptide targeting HER2 as a gene delivery vector

(2009) Hongliang Huang et al.   BIOMATERIALS

Visualization of gene expression in the live subject using the Na/I symporter as a reporter gene: applications in biotherapy

(2009) Patrick Baril et al.   BRITISH JOURNAL OF PHARMACOLOGY

Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model

(2009) Janaiah Kota et al.   CELL

Targeted Radioiodine Therapy of Neuroblastoma Tumors following Systemic Nonviral Delivery of the Sodium Iodide Symporter Gene

(2009) K. Klutz et al.   CLINICAL CANCER RESEARCH

Targeting of the β2-adrenoceptor increases nonviral gene delivery to pulmonary epithelial cells in vitro and lungs in vivo

(2009) Markus Elfinger et al.   JOURNAL OF CONTROLLED RELEASE

Drug Nanocarriers Labeled With Near-infrared-emitting Quantum Dots (Quantoplexes): Imaging Fast Dynamics of Distribution in Living Animals

(2009) Arkadi Zintchenko et al.   MOLECULAR THERAPY

Synergistic Targeting of αvβ3Integrin and Galectin-1 with Heteromultivalent Paramagnetic Liposomes for Combined MR Imaging and Treatment of Angiogenesis

(2009) Ewelina Kluza et al.   NANO LETTERS

Dual targeting of a thermosensitive nanogel conjugated with transferrin and RGD-containing peptide for effective cell uptake and drug release

(2009) Chang-Yun Quan et al.   NANOTECHNOLOGY

Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells

(2009) Jiehua Zhou et al.   NUCLEIC ACIDS RESEARCH

Evaluation of Pharmacokinetics of Bioreducible Gene Delivery Vectors by Real-time PCR

(2009) Qing-Hui Zhou et al.   PHARMACEUTICAL RESEARCH

Peptide- and polymer-based delivery of therapeutic RNA

(2009) Thomas Fröhlich et al.   Soft Matter

Gene transfer to the lung: Lessons learned from more than 2 decades of CF gene therapy

(2008) Uta Griesenbach et al.   ADVANCED DRUG DELIVERY REVIEWS

Extracellular Targeting of Synthetic Therapeutic Nucleic Acid Formulations

(2008) Alexander Philipp et al.   CURRENT GENE THERAPY

Folate-linked lipid-based nanoparticles for synthetic siRNA delivery in KB tumor xenografts

(2008) Takashi Yoshizawa et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Gene therapy progress and prospects: synthetic polymer-based systems

(2008) D Schaffert et al.   GENE THERAPY

Delivery Vehicles for Small Interfering RNA In Vivo

(2008) Antonin R. de Fougerolles   HUMAN GENE THERAPY

A peptide-targeted delivery system with pH-sensitive amphiphilic cell membrane disruption for efficient receptor-mediated siRNA delivery

(2008) Xu-Li Wang et al.   JOURNAL OF CONTROLLED RELEASE

A North American brain tumor consortium phase II study of poly-ICLC for adult patients with recurrent anaplastic gliomas

(2008) Nicholas Butowski et al.   JOURNAL OF NEURO-ONCOLOGY

18F-Labeled BBN-RGD Heterodimer for Prostate Cancer Imaging

(2008) Z.-B. Li et al.   JOURNAL OF NUCLEAR MEDICINE

Efficient Oncogene Silencing and Metastasis Inhibition via Systemic Delivery of siRNA

(2008) Shyh-Dar Li et al.   MOLECULAR THERAPY

Novel Dual Inhibitory Function Aptamer–siRNA Delivery System for HIV-1 Therapy

(2008) Jiehua Zhou et al.   MOLECULAR THERAPY

CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression

(2008) Stephen C Hyde et al.   NATURE BIOTECHNOLOGY

5′-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma

(2008) Hendrik Poeck et al.   NATURE MEDICINE

Chemical Modification of siRNAs for In Vivo Use

(2008) Mark A. Behlke   OLIGONUCLEOTIDES

Systemic Leukocyte-Directed siRNA Delivery Revealing Cyclin D1 as an Anti-Inflammatory Target

(2008) D. Peer et al.   SCIENCE

Effective Exon Skipping and Restoration of Dystrophin Expression by Peptide Nucleic Acid Antisense Oligonucleotides in mdx Mice

(2007) Haifang Yin et al.   MOLECULAR THERAPY

Tumor-targeted Delivery of siRNA by Self-assembled Nanoparticles

(2007) Shyh-Dar Li et al.   MOLECULAR THERAPY