Article
Pharmacology & Pharmacy
Nathan Hayes, Mark Fogarty, Laura Sadofsky, Huw Simon Jones
Summary: Age-related frailty is a significant health and social care burden, and there is a lack of suitable cell culture model for screening compounds to promote healthy skeletal muscle function. This study used C2C12 cells to characterize the changes in reactive oxygen and nitrogen species (RONS) signaling in young and aged myoblasts and myotubes, and assessed the effect of dietary polyphenols on RONS signaling in aged cultures. The findings showed increased RONS levels in aged cells and identified kaempferol and resveratrol as compounds that can modulate RONS signaling in skeletal muscle cells.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Biology
Francesco Bellanti, Aurelio Lo Buglio, Gianluigi Vendemiale
Summary: Age-related muscle wasting, or sarcopenia, is characterized by changes in muscle quality and mitochondrial homeostasis. Mitochondrial dysfunction plays a significant role in the pathogenesis of sarcopenia, and targeting mitochondria may be a potential strategy for preventing and treating this age-related condition.
Article
Neurosciences
Xiaoyan Zhang, Hawley E. Kunz, Kevin Gries, Corey R. Hart, Eric C. Polley, Ian R. Lanza
Summary: Healthy older adults exhibit lower cardiorespiratory fitness (V?O2peak) compared to young individuals, mainly due to changes in central hemodynamics. While total physical activity levels do not differ by age, moderate-to-vigorous physical activity is lower in older adults. Moderate-to-vigorous physical activity is associated with V?O2peak and muscle oxidative capacity, but cannot fully explain the age-related decline in fitness.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Physiology
Ryan Neil Marshall, James McKendry, Benoit Smeuninx, Alex Peter Seabright, Paul T. Morgan, Carolyn Greig, Leigh Breen
Summary: Ageing is associated with changes in skeletal muscle oxidative metabolism, which may be influenced by physical activity status. The effect of resistance exercise training on skeletal muscle mitochondrial regulation is unclear.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jonathan M. Memme, Mikhaela Slavin, Neushaw Moradi, David A. Hood
Summary: Periods of muscle disuse can lead to mitochondrial changes that affect muscle health and atrophy. Research has shown that abnormalities in mitochondrial quality control pathways can cause muscle atrophy due to inactivity, highlighting the need for further investigation into how mitochondria contribute to disuse-induced muscle atrophy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Maude Dulac, Jean-Philippe Leduc-Gaudet, Marina Cefis, Marie-Belle Ayoub, Olivier Reynaud, Anwar Shams, Alaa Moamer, Marcos Francisco Nery Ferreira, Sabah Na Hussain, Gilles Gouspillou
Summary: The study found that silencing or overexpressing Drp1 in late middle-aged mice is detrimental to skeletal muscle function and mitochondrial health. Modulating Drp1 expression is unlikely to be a viable approach to counteract the muscle ageing process.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Review
Physiology
Christine M. Latham, Camille R. Brightwell, Alexander R. Keeble, Brooke D. Munson, Nicholas T. Thomas, Alyaa M. Zagzoog, Christopher S. Fry, Jean L. Fry
Summary: Vitamin D plays a crucial role in muscle regeneration and maintenance, protecting muscle structure and mitochondrial function, and promoting the activity of muscle stem cells.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Emily Jie-Ning Yang, Pin-Chao Liao, Liza Pon
Summary: Mitochondria are crucial for cellular function and play a role in aging and age-related diseases. Mechanisms for mitochondrial protein and organelle quality control are important for cellular repair and degradation, as well as regulating cellular health, stress response, and lifespan control.
Article
Food Science & Technology
Moloya Gogoi, Jyoti L. Hati Boruah, Pranjit Kumar Bora, Deep Jyoti Das, Vanlalhruaii Famhawite, Anupam Biswas, Nusalu Puro, Jatin Kalita, Saikat Haldar, Rinku Baishya
Summary: The study demonstrated the inhibitory effect of Citrus macroptera peel extract on human non-small cell lung cancer cells through prooxidant induced apoptosis. CPEA was found to induce oxidative stress and mitochondrial membrane potential damage in A549 cells, resulting in cell death through apoptosis pathways.
Article
Agriculture, Dairy & Animal Science
Randi N. Owen, Pier L. Semanchik, Christine M. Latham, Kristen M. Brennan, Sarah H. White-Springer
Summary: Maintenance of mitochondrial health is crucial for optimizing athletic performance. This study showed that feeding young horses a proprietary antioxidant blend containing elevated Se yeast improved mitochondrial characteristics, even with reduced vitE intake.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Ravi Tharakan, Ceereena Ubaida-Mohien, Yulan Piao, Myriam Gorospe, Luigi Ferrucci
Summary: As human muscle ages, the translation of proteins related to oxidative phosphorylation, especially those encoded by the mitochondrial genome, decreases, potentially leading to reduced strength and function in old skeletal muscle.
Article
Biochemistry & Molecular Biology
Weicheng Zhao, Amy C. Kelly, Rosa I. Luna-Ramirez, Christopher A. Bidwell, Miranda J. Anderson, Sean W. Limesand
Summary: This study found that skeletal muscle of fetuses with intrauterine growth restriction (FGR) has lower mitochondrial respiration rate and altered transcriptomic profiles associated with energy metabolism. FGR skeletal muscle showed attenuated pyruvate oxidation, possibly due to the inability of pyruvate to enter the TCA cycle, and fatty acid oxidation might compensate for the attenuated energy metabolism. The findings provide phenotypic and molecular evidence for adaptive deficiencies in FGR skeletal muscle.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Sinenhlanhla X. H. Mthembu, Phiwayinkosi Dludla, Khanyisani Ziqubu, Tawanda M. Nyambuya, Abidemi P. Kappo, Evelyn Madoroba, Thembeka A. Nyawo, Bongani B. Nkambule, Sonia Silvestri, Christo J. F. Muller, Sithandiwe E. Mazibuko-Mbeje
Summary: Polyphenols are natural compounds that have been increasingly studied for their potential health benefits, particularly in mitigating metabolic disorders. Research has shown the ability of polyphenols to improve mitochondrial function in skeletal muscle, which plays a crucial role in energy homeostasis.
Article
Clinical Neurology
Tingting Dong, Zai-Qiang Zhang, Li-Hong Sun, Weilong Zhang, Zhaohui Zhu, Lin Lin, Lin Yang, An Lv, Chunying Liu, Qing Li, Rui-Feng Yang, Xiuru Zhang, Yamei Niu, Hou-Zao Chen, De-Pei Liu, Wei-Min Tong
Summary: Haploinsufficiency of Mic60, a mitochondrial inner membrane protein, leads to progressive neurological abnormalities, mitochondrial structural damage, neuronal loss, reduced mitochondrial membrane potential and ATP production, increased reactive oxygen species, and altered oxidative phosphorylation complexes. It also compromises brain glucose intake and oxygen consumption, resembling human mitochondrial encephalomyopathies (ME) syndrome. MIC60 protein expression is significantly decreased in human ME, suggesting its contribution to the pathogenesis. Systemic administration of N-acetylcysteine, an antioxidant, reverses mitochondrial dysfunctions and metabolic disorders in mice with Mic60 haploinsufficiency and restores neurological symptoms.
Article
Physiology
Kenya Takahashi, Yuki Tamura, Yu Kitaoka, Yutaka Matsunaga, Hideo Hatta
Summary: Lactate administration alters mitochondrial respiratory function in skeletal muscle, enhancing pyruvate + malate- and glutamate + malate-induced respiration while decreasing succinate + rotenone-induced respiration.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cell Biology
Sara Della Torre, Nico Mitro, Clara Meda, Federica Lolli, Silvia Pedretti, Matteo Barcella, Luisa Ottobrini, Daniel Metzger, Donatella Caruso, Adriana Maggi
Article
Endocrinology & Metabolism
Thanuja Gali Ramamoorthy, Tiffany-Jayne Allen, Alison Davies, Erika Harno, Charlotte Sefton, Christopher Murgatroyd, Anne White
INTERNATIONAL JOURNAL OF OBESITY
(2018)
Article
Immunology
Maxime Parisotto, Elise Grelet, Rana El Bizri, Yongyuan Dai, Julie Terzic, Doriane Eckert, Laetitia Gargowitsch, Jean-Marc Bornert, Daniel Metzger
JOURNAL OF EXPERIMENTAL MEDICINE
(2018)
Article
Physiology
Julien Pottecher, Chris Adamopoulos, Anne Lejay, Jamal Bouitbir, Anne-Laure Charles, Alain Meyer, Mervyn Singer, Valerie Wolff, Pierre Diemunsch, Gilles Laverny, Daniel Metzger, Bernard Geny
FRONTIERS IN PHYSIOLOGY
(2018)
Review
Physiology
Erika Harno, Thanuja Gali Ramamoorthy, Anthony P. Coll, Anne White
PHYSIOLOGICAL REVIEWS
(2018)
Editorial Material
Medicine, Research & Experimental
Elise Grelet, Maxime Parisotto, Daniel Metzger
M S-MEDECINE SCIENCES
(2018)
Article
Endocrinology & Metabolism
Derek B. J. Bone, Jaroslawna Meister, Jonas R. Knudsen, Diptadip Dattaroy, Amanda Cohen, Regina Lee, Huiyan Lu, Daniel Metzger, Thomas E. Jensen, Jurgen Wess
Article
Multidisciplinary Sciences
Daniela Rovito, Anna Y. Belorusova, Sandra Chalhoub, Anna-Isavella Rerra, Elvire Guiot, Arnaud Molin, Agnes Linglart, Natacha Rochel, Gilles Laverny, Daniel Metzger
NATURE COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Gareth B. Kitchen, Thomas Hopwood, Thanuja Gali Ramamoorthy, Polly Downton, Nicola Begley, Tracy Hussell, David H. Dockrell, Julie E. Gibbs, David W. Ray, Andrew S. Loudon
Summary: Robust inflammatory responses are crucial for survival after respiratory infections, and Epigenetic factors are increasingly being recognized as important determinants of immune responses. EZH2 acts differently in macrophages and neutrophils, affecting inflammatory responses and chemotaxis. Targeting EZH2 may have implications for mucosal immunity and conditions driven by pulmonary neutrophil influx.
Article
Multidisciplinary Sciences
Mohamed A. Abu el Maaty, Elise Grelet, Celine Keime, Anna-Isavella Rerra, Justine Gantzer, Camille Emprou, Julie Terzic, Regis Lutzing, Jean-Marc Bornert, Gilles Laverny, Daniel Metzger
Summary: The study found that Gemini-72 induced apoptosis in senescent prostatic intraepithelial neoplasia cells, normalized extracellular matrix remodeling by stromal fibroblasts, and reduced the infiltration of immunosuppressive myeloid-derived cells. Single-cell RNA-sequencing analysis showed that while a subset of luminal cells were lost after treatment, antiapoptotic pathways were induced in persistent luminal cells.
Article
Medicine, Research & Experimental
Julie Terzic, Mohamed A. Abu el Maaty, Regis Lutzing, Alexandre Vincent, Rana El Bizri, Matthieu Jung, Celine Keime, Daniel Metzger
Summary: Androgen deprivation therapy is a key treatment for prostate cancer, but some cases develop into castration-resistant prostate cancer (CRPC). In this study, it was found that the major luminal cell population in CRPC is castration-resistant, with enhanced expression of inflammation and stemness markers. Additionally, hypoxia-inducible factor 1 (HIF1) signaling, which promotes malignant progression, is further activated. Inhibition of HIF1A enhances the sensitivity of Pten-deficient prostatic tumors to castration and induces apoptotic signaling in human CRPC cell lines.
EMBO MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Anna Y. Belorusova, Daniela Rovito, Yassmine Chebaro, Stefanie Doms, Lieve Verlinden, Annemieke Verstuyf, Daniel Metzger, Natacha Rochel, Gilles Laverny
Summary: This study demonstrates that BXL-62 and Gemini-72, two C-20-modified vitamin D analogs, restore the transcriptional activities of VDR variants unresponsive to the natural ligand. The elucidated mechanisms of action highlight the mutual adaptation between the ligand and the VDR ligand-binding pocket.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Katsuya Miyajima, Chiaki Kawamoto, Satoshi Hara, Masayo Mori-Kojima, Tamae Ohye, Chiho Sumi-Ichinose, Nae Saito, Toshikuni Sasaoka, Daniel Metzger, Hiroshi Ichinose
Summary: The study revealed that dopamine (DA) supply in peripheral organs originates from sympathetic neurons, with decreased TH protein and NA levels leading to a decrease in DA content in the heart and pancreas. TH-immunoreactive cells were found in the stomach and lung, showing a decreasing trend in TH protein levels but not in DA levels. Additionally, there was a significant correlation between DA content in the kidney and plasma DOPA concentration.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Stephanie Paradis, Anne-Laure Charles, Isabelle Georg, Fabienne Goupilleau, Alain Meyer, Michel Kindo, Gilles Laverny, Daniel Metzger, Bernard Geny
Article
Oncology
Maxime Parisotto, Elise Grelet, Rana El Bizri, Daniel Metzger
MOLECULAR & CELLULAR ONCOLOGY
(2019)