POMC: The Physiological Power of Hormone Processing

Desacetyl-α-melanocyte stimulating hormone and α-melanocyte stimulating hormone are required to regulate energy balance

(2018) Kathleen G. Mountjoy et al.   Molecular Metabolism

A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs

(2016) Eleanor Raffan et al.   Cell Metabolism

Proopiomelanocortin interference in the measurement of adrenocorticotrophic hormone: a United Kingdom National External Quality Assessment Service study

(2016) P.J. Monaghan et al.   CLINICAL ENDOCRINOLOGY

PCSK1 Mutations and Human Endocrinopathies: From Obesity to Gastrointestinal Disorders

(2016) Pieter Stijnen et al.   ENDOCRINE REVIEWS

Glucocorticoid Fast Feedback Inhibition of Stress-Induced ACTH Secretion in the Male Rat: Rate Independence and Stress-State Resistance

(2016) Chad D. Osterlund et al.   ENDOCRINOLOGY

Cushing syndrome in a child due to pro-opiomelanocortin (POMC) secretion from a yolk sac tumor

(2016) Evelien F Gevers et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Endoplasmic reticulum-associated degradation of the mouse PC1/3-N222D hypomorph and human PCSK1 mutations contributes to obesity

(2016) P Stijnen et al.   INTERNATIONAL JOURNAL OF OBESITY

Differentiation of Keratinocytes Modulates Skin HPA Analog

(2016) Justyna M. Wierzbicka et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Late Diagnosis of POMC Deficiency and in vitro evidence of residual translation from allele with c.-11C>A mutation

(2016) Aleksandra S. Anisimova et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

60 YEARS OF POMC: From the prohormone theory to pro-opiomelanocortin and to proprotein convertases (PCSK1 to PCSK9)

(2016) Michel Chrétien et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

60 YEARS OF POMC: Transcriptional and epigenetic regulation ofPOMCgene expression

(2016) Jacques Drouin   JOURNAL OF MOLECULAR ENDOCRINOLOGY

60 YEARS OF POMC: Lipotropin and beta-endorphin: a perspective

(2016) D G Smyth   JOURNAL OF MOLECULAR ENDOCRINOLOGY

60 YEARS OF POMC: N-terminal POMC peptides and adrenal growth

(2016) Andrew B Bicknell   JOURNAL OF MOLECULAR ENDOCRINOLOGY

60 YEARS OF POMC: Adrenal and extra-adrenal functions of ACTH

(2016) Nicole Gallo-Payet   JOURNAL OF MOLECULAR ENDOCRINOLOGY

60 YEARS OF POMC: Biosynthesis, trafficking, and secretion of pro-opiomelanocortin-derived peptides

(2016) Niamh X Cawley et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Carboxypeptidase E and Secretogranin III Coordinately Facilitate Efficient Sorting of Proopiomelanocortin to the Regulated Secretory Pathway in AtT20 Cells

(2016) Niamh X. Cawley et al.   MOLECULAR ENDOCRINOLOGY

Expression and Localization of Opioid Receptors in Male Germ Cells and the Implication for Mouse Spermatogenesis

(2016) Haizea Estomba et al.   PLoS One

Comparative Effect of ACTH and Related Peptides on Proliferation and Growth of Rat Adrenal Gland

(2016) Claudimara Ferini Pacicco Lotfi et al.   Frontiers in Endocrinology

Activation of Brainstem Pro-opiomelanocortin Neurons Produces Opioidergic Analgesia, Bradycardia and Bradypnoea

(2016) Serena Cerritelli et al.   PLoS One

Proopiomelanocortin, agouti-related protein, and leptin in human cerebrospinal fluid: correlations with body weight and adiposity

(2015) Gabrielle Page-Wilson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Conditional Expression ofPomcin theLepr-Positive Subpopulation of POMC Neurons Is Sufficient for Normal Energy Homeostasis and Metabolism

(2015) Daniel D. Lam et al.   ENDOCRINOLOGY

Rapid Glucocorticoid Feedback Inhibition of ACTH Secretion Involves Ligand-Dependent Membrane Association of Glucocorticoid Receptors

(2015) Qiong Deng et al.   ENDOCRINOLOGY

ACTH controls thymocyte homeostasis independent of glucocorticoids

(2015) Gergely Talaber et al.   FASEB JOURNAL

60 YEARS OF POMC: Purification and biological characterisation of melanotrophins and corticotrophins

(2015) Philip Lowry   JOURNAL OF MOLECULAR ENDOCRINOLOGY

60 YEARS OF POMC: The proopiomelanocortin gene: discovery, deletion and disease

(2015) Adrian J L Clark   JOURNAL OF MOLECULAR ENDOCRINOLOGY

60 YEARS OF POMC: POMC: an evolutionary perspective

(2015) Sandra Navarro et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

60 YEARS OF POMC: From POMC and α-MSH to PAM, molecular oxygen, copper, and vitamin C

(2015) Dhivya Kumar et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

The Importance of Biological Oscillators for Hypothalamic-Pituitary-Adrenal Activity and Tissue Glucocorticoid Response: Coordinating Stress and Neurobehavioural Adaptation

(2015) G. M. Russell et al.   JOURNAL OF NEUROENDOCRINOLOGY

Large conductance Ca2+-activated K+(BK) channels promote secretagogue-induced transition from spiking to bursting in murine anterior pituitary corticotrophs

(2015) Peter J. Duncan et al.   JOURNAL OF PHYSIOLOGY-LONDON

Hypothalamic POMC neurons promote cannabinoid-induced feeding

(2015) Marco Koch et al.   NATURE

Melanin production through novel processing of proopiomelanocortin in the extracellular compartment of the auricular skin of C57BL/6 mice after UV-irradiation

(2015) Hiroyuki Yamamoto et al.   Scientific Reports

Unraveling the functions of the membrane-bound glucocorticoid receptors: first clues on origin and functional activity

(2014) Cindy Strehl et al.   Annals of the New York Academy of Sciences

A nonsense loss-of-function mutation in PCSK1 contributes to dominantly inherited human obesity

(2014) J Philippe et al.   INTERNATIONAL JOURNAL OF OBESITY

Clinical Utility of Plasma POMC and AgRP Measurements in the Differential Diagnosis of ACTH-Dependent Cushing's Syndrome

(2014) Gabrielle Page-Wilson et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Congenital Proprotein Convertase 1/3 Deficiency Causes Malabsorptive Diarrhea and Other Endocrinopathies in a Pediatric Cohort

(2013) Martín G. Martín et al.   GASTROENTEROLOGY

Bioinactive ACTH Causing Glucocorticoid Deficiency

(2013) Mark E. Samuels et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Steroidogenesis in the skin: Implications for local immune functions

(2013) Andrzej Slominski et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Opioid receptor expression in human brain and peripheral tissues using absolute quantitative real-time RT-PCR

(2012) Jinsong Peng et al.   DRUG AND ALCOHOL DEPENDENCE

β-Endorphin Antagonizes the Effects of α-MSH on Food Intake and Body Weight

(2012) Roxanne Dutia et al.   ENDOCRINOLOGY

An Atypical Case of Familial Glucocorticoid Deficiency without Pigmentation Caused by Coexistent Homozygous Mutations inMC2R(T152K) andMC1R(R160W)

(2012) Serap Turan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cerebrospinal Fluid Levels of Leptin, Proopiomelanocortin, and Agouti-Related Protein in Human Pregnancy: Evidence for Leptin Resistance

(2012) Gabrielle Page-Wilson et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Obesity-programmed mice are rescued by early genetic intervention

(2012) Viviana F. Bumaschny et al.   JOURNAL OF CLINICAL INVESTIGATION

The Origin of Glucocorticoid Hormone Oscillations

(2012) Jamie J. Walker et al.   PLOS BIOLOGY

Cutaneous hypothalamic-pituitary-adrenal axis homolog: regulation by ultraviolet radiation

(2011) Cezary Skobowiat et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Circadian rhythm of adrenal glucocorticoid: Its regulation and clinical implications

(2011) Sooyoung Chung et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Comparative effect of FGF2, synthetic peptides 1-28 N-POMC and ACTH on proliferation in rat adrenal cell primary cultures

(2011) Gabriele E. Mattos et al.   CELL AND TISSUE RESEARCH

Heterozygous Mutations Causing Partial Prohormone Convertase 1 Deficiency Contribute to Human Obesity

(2011) J. W. M. Creemers et al.   DIABETES

Defining POMC Neurons Using Transgenic Reagents: Impact of TransientPomcExpression in Diverse Immature Neuronal Populations

(2011) Stephanie L. Padilla et al.   ENDOCRINOLOGY

Structure, function and regulation of the melanocortin receptors

(2011) Yingkui Yang   EUROPEAN JOURNAL OF PHARMACOLOGY

Obese carboxypeptidase E knockout mice exhibit multiple defects in peptide hormone processing contributing to low bone mineral density

(2010) Niamh X. Cawley et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Functions for pro-opiomelanocortin-derived peptides in obesity and diabetes

(2010) Kathleen G. Mountjoy   BIOCHEMICAL JOURNAL

Synthetic modified N-POMC1–28 controls in vivo proliferation and blocks apoptosis in rat adrenal cortex

(2010) Thompson Eusebio Pavan Torres et al.   CELL AND TISSUE RESEARCH

Possible Relevance between Prohormone Convertase 2 Expression and Tumor Growth in Human Adrenocorticotropin-Producing Pituitary Adenoma

(2010) Kazumi Iino et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Analysis of peptides in prohormone convertase 1/3 null mouse brain using quantitative peptidomics

(2010) Jonathan H. Wardman et al.   JOURNAL OF NEUROCHEMISTRY

Glucocorticoid Ultradian Rhythmicity Directs Cyclical Gene Pulsing of the Clock Gene Period 1 in Rat Hippocampus

(2010) B. L . Conway-Campbell et al.   JOURNAL OF NEUROENDOCRINOLOGY

Rapid Glucocorticoid Receptor-Mediated Inhibition of Hypothalamic-Pituitary-Adrenal Ultradian Activity in Healthy Males

(2010) G. M. Russell et al.   JOURNAL OF NEUROSCIENCE

Pomc-expressing progenitors give rise to antagonistic neuronal populations in hypothalamic feeding circuits

(2010) Stephanie L Padilla et al.   NATURE MEDICINE

γ2-Melanocyte stimulation hormone (γ2-MSH) truncation studies results in the cautionary note that γ2-MSH is not selective for the mouse MC3R over the mouse MC5R

(2010) Christine G. Joseph et al.   PEPTIDES

Origin of ultradian pulsatility in the hypothalamic-pituitary-adrenal axis

(2010) J. J. Walker et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Peptidylglycine α-amidating monooxygenase: A multifunctional protein with catalytic, processing, and routing domains

(2010) Betty A. Eipper et al.   PROTEIN SCIENCE

TIF1β/KAP-1 Is a Coactivator of the Orphan Nuclear Receptor NGFI-B/Nur77

(2009) Juliette Rambaud et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prolylcarboxypeptidase regulates food intake by inactivating α-MSH in rodents

(2009) Nicholas Wallingford et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuropeptidomic analysis establishes a major role for prohormone convertase-2 in neuropeptide biosynthesis

(2009) Xin Zhang et al.   JOURNAL OF NEUROCHEMISTRY

The MOR-1 Opioid Receptor Regulates Glucose Homeostasis by Modulating Insulin Secretion

(2009) Ting Wen et al.   MOLECULAR ENDOCRINOLOGY

Ultradian hormone stimulation induces glucocorticoid receptor-mediated pulses of gene transcription

(2009) Diana A. Stavreva et al.   NATURE CELL BIOLOGY

Mutational Analysis of the Pro-opiomelanocortin Gene in French Obese Children Led to the Identification of a Novel Deleterious Heterozygous Mutation Located in the α-Melanocyte Stimulating Hormone Domain

(2009) Beatrice Dubern et al.   PEDIATRIC RESEARCH

Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules

(2009) S. K. Maji et al.   SCIENCE

In vivo multiplex quantitative analysis of 3 forms of alpha melanocyte stimulating hormone in pituitary of prolyl endopeptidase deficient mice

(2009) Bertrand Perroud et al.   Molecular Brain

Adrenal gland development and defects

(2008) Petra Kempná et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Amylin Proprotein Processing Generates Progressively More Amyloidogenic Peptides that Initially Sample the Helical State†

(2008) Isaac T. Yonemoto et al.   BIOCHEMISTRY

Energetic Responses Are Triggered by Caudal Brainstem Melanocortin Receptor Stimulation and Mediated by Local Sympathetic Effector Circuits

(2008) Karolina P. Skibicka et al.   ENDOCRINOLOGY

Unexpected Endocrine Features and Normal Pigmentation in a Young Adult Patient Carrying a Novel Homozygous Mutation in the POMC Gene

(2008) Karine Clément et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mutations in the Amino-Terminal Region of Proopiomelanocortin (POMC) in Patients with Early-Onset Obesity Impair POMC Sorting to the Regulated Secretory Pathway

(2008) John W. M. Creemers et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Peptidomics ofCpefat/fatmouse brain regions: implications for neuropeptide processing

(2008) Xin Zhang et al.   JOURNAL OF NEUROCHEMISTRY

Weak Functional Coupling of the Melanocortin-1 Receptor Expressed in Human Adipocytes

(2008) Matthias Hoch et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

The stimulation of mitogenic signaling pathways by N-POMC peptides

(2008) David J. Pepper et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Lys-gamma3-MSH: A global regulator of hormone sensitive lipase activity?

(2008) Katrina A. Bicknell et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Carboxypeptidase E Cytoplasmic Tail-Driven Vesicle Transport Is Key for Activity-Dependent Secretion of Peptide Hormones

(2008) Joshua J. Park et al.   MOLECULAR ENDOCRINOLOGY

Common nonsynonymous variants in PCSK1 confer risk of obesity

(2008) Michael Benzinou et al.   NATURE GENETICS

Glucocorticoids: exemplars of multi-tasking

(2006) Julia C Buckingham   BRITISH JOURNAL OF PHARMACOLOGY