Article
Neurosciences
Joseph R. Winer, Allison Morehouse, Laura Fenton, Theresa M. Harrison, Lylian Ayangma, Mark Reed, Samika Kumar, Suzanne L. Baker, William J. Jagust, Matthew P. Walker
Summary: This study found that early-stage tau and Aβ deposition in Alzheimer's disease can impact sleep, with tau burden leading to worse objective sleep and Aβ burden associated with decreased self-reported sleep quality. Aβ deposition also predicts a mismatch between objective and subjective sleep evaluation, with individuals underestimating their sleep, which is further linked to worse executive function.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Dongyuan Zhang, Yu Zhang, Jirong Pan, Jingjing Cao, Xiuping Sun, Xianglei Li, Ling Zhang, Chuan Qin
Summary: The degradation of NLRP3 through the ALP pathway, mediated by p62, reduces the pro-inflammatory response and pyroptosis of microglia, thus improving cognitive function in Alzheimer's disease.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Holly C. Hunsberger, Sharay E. Setti, Carolyn C. Rudy, Daniel S. Weitzner, Jeremiah C. Pfitzer, Kelli L. McDonald, Hao Hong, Subhrajit Bhattacharya, Vishnu Suppiramaniam, Miranda N. Reed
Summary: This study using a mouse model found that increased expression of P301L Tau in aged mice leads to memory deficits, potentially due to late-stage tau pathology and dysregulation of glutamate release and uptake.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geriatrics & Gerontology
Shannon N. Leslie, Jean Kanyo, Dibyadeep Datta, Rashaun S. Wilson, Caroline Zeiss, Alvaro Duque, TuKiet T. Lam, Amy F. T. Arnsten, Angus C. Nairn
Summary: Age is a significant risk factor for Alzheimer's disease, and this study identified age-related changes in tau phosphorylation in the prefrontal cortex of rhesus monkeys, suggesting the importance of the natural aging process in tau phosphorylation.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Rim Hamze, Etienne Delangre, Stefania Tolu, Manon Moreau, Nathalie Janel, Danielle Bailbe, Jamileh Movassat
Summary: The global prevalence of diabetes mellitus and Alzheimer's disease is increasing alarmingly with the aging of the population. There is a strong association between type 2 diabetes and an increased risk of dementia. The amyloid cascade, altered glucose metabolism, and insulin signaling may play key roles in the pathophysiology of Alzheimer's disease. Impaired insulin and IGF-1 signaling, as well as GSK3 beta and DYRK1A, could be potential therapeutic targets for both diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Geriatrics & Gerontology
Dibyadeep Datta
Summary: Aging rhesus macaques serve as an invaluable model for studying the etiological mechanisms of sporadic Alzheimer's disease (AD) and exploring novel therapeutic strategies. These macaques naturally exhibit amyloid and tau pathology, synaptic dysfunction, and cognitive impairments similar to human AD. Unique molecular mechanisms in the newly evolved primate dorsolateral prefrontal cortex, involving feedforward cyclic adenosine monophosphate (cAMP)-Protein kinase A (PKA)-calcium signaling, play a critical role in higher-order cognition. However, genetic predispositions and age-related insults can exacerbate these signaling pathways and lead to downstream effects, increasing susceptibility to atrophy.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Nicola Marrano, Giuseppina Biondi, Anna Borrelli, Martina Rella, Tommaso Zambetta, Ludovico Di Gioia, Mariangela Caporusso, Giancarlo Logroscino, Sebastio Perrini, Francesco Giorgino, Annalisa Natalicchio
Summary: Type 2 diabetes and Alzheimer's disease are major health issues with a close relationship. Lipotoxicity may be the missing link connecting the pathogenesis of these two diseases. Obesity, the main cause of lipotoxicity, is a major risk factor for both conditions. This review provides a comprehensive overview of the common molecular pathways activated by lipotoxicity in type 2 diabetes and Alzheimer's disease, suggesting potential new therapeutic perspectives.
Article
Medicine, General & Internal
Sasha A. Philbert, Sarah J. Schoenberger, Jingshu Xu, Stephanie J. Church, Richard D. Unwin, Garth J. S. Cooper
Summary: The study found that hippocampal copper levels were significantly elevated in patients with T2D, similar to untreated cases of Wilson's disease (WD), while hippocampal copper levels were markedly deficient in patients with sAD. These results suggest that hippocampal copper may play a role in the neurodegeneration and cognitive impairment in T2D, and therapeutic approaches targeting copper reduction, similar to those used in WD, may be applicable to patients with T2D.
Article
Neurosciences
Jenna N. Adams, Theresa M. Harrison, Anne Maass, Suzanne L. Baker, William J. Jagust
Summary: This study aimed to investigate the mechanisms underlying the initial accumulation of tau pathology and the predictive roles of age, AP, and neural activity in tau accumulation. The results showed that older age, higher neural activity, and higher baseline EC tau levels were associated with tau accumulation. Additionally, AP facilitated the spread of tau.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Jenna N. Adams, Anne Maass, David Berron, Theresa M. Harrison, Suzanne L. Baker, Wesley P. Thomas, Morgan Stanfill, William J. Jagust
Summary: Tau deposition in aging and Alzheimer's disease affects medial temporal lobe (MTL) neural function, impacting repetition suppression. Different levels of tau pathology are associated with activity changes in distinct MTL subregions, with high tau pathology leading to widespread neural dysfunction.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
Sigalit B. Manzali, Eric Yu, Ramit Ravona-Springer, Abigail Livny, Sapir Golan, Yuxia Ouyang, Orit Lesman-Segev, Lang Liu, Ithamar Ganmore, Anna Alkelai, Ziv Gan-Or, Hung-Mo Lin, Anthony Heymann, Michal Schnaider Beeri, Lior Greenbaum
Summary: The cumulative effect of late-onset Alzheimer's disease (LOAD) susceptibility loci is not associated with a greater rate of cognitive decline in older adults with type 2 diabetes (T2D), suggesting that other pathways may underlie this link.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Gabrielle Zuniga, Bess Frost
Summary: Emerging evidence suggests that errors in RNA processing contribute to neurodegeneration. Neurons are particularly vulnerable to these errors, which can lead to accumulation of misprocessed RNA transcripts. Furthermore, the protein tau, implicated in Alzheimer's disease and related disorders, is also involved in deficits in RNA processing and clearance.
PROGRESS IN NEUROBIOLOGY
(2023)
Article
Clinical Neurology
Fernando Gonzalez-Ortiz, Michael Turton, Przemyslaw R. Kac, Denis Smirnov, Enrico Premi, Roberta Ghidoni, Luisa Benussi, Valentina Cantoni, Claudia Saraceno, Jasmine Rivolta, Nicholas J. Ashton, Barbara Borroni, Douglas Galasko, Peter Harrison, Henrik Zetterberg, Kaj Blennow, Thomas K. Karikari
Summary: Blood-based biomarkers for amyloid beta and phosphorylated tau show good diagnostic accuracies and agreements with their corresponding CSF and neuroimaging biomarkers, while the blood-based neurodegeneration marker neurofilament light is not specific to Alzheimer's disease. A newly developed blood-based assay for brain-derived tau has shown equivalent diagnostic performance as CSF total-tau, accurately distinguishing Alzheimer's disease from other neurodegenerative diseases.
Review
Clinical Neurology
Andrea Gonzalez, Camila Calfio, Macarena Churruca, Ricardo B. Maccioni
Summary: This study explores the influence of glucose metabolism on Alzheimer's disease from three different perspectives, including its role as a regulator of energy source, its impact on immune system activation through metabolic abnormalities, and its regulation of post-translational modifications in key proteins. The findings support the hypothesis that AD is a new type of diabetes.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Clinical Neurology
Caterina Motta, Martina Assogna, Chiara Giuseppina Bonomi, Alfredo Paolo Mascolo, Vincenzo De Lucia, Roberta Semprini, Nicola Biagio Mercuri, Giacomo Koch, Alessandro Martorana
Summary: The study reveals a significant dependency of CSF t-tau levels on diabetes mellitus for APOE E4+ AD patients; Using A beta(1-42) and p-tau biomarkers is effective in discriminating between pathological changes in AD patients; Glucose metabolism dysfunction interacts with tau protein and APOE genotype to affect the pathological process.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Chemistry, Analytical
Sang Jun Park, Yun Ji Kim, Ji Su Kang, In Young Kim, Kyeong Sook Choi, Hwan Myung Kim
ANALYTICAL CHEMISTRY
(2018)
Article
Oncology
Seok Soon Park, Dong Min Lee, Jun Hee Lim, Dongjoo Lee, Sang Jun Park, Hwan Myung Kim, Seonghyang Sohn, Gyesoon Yoon, Young Woo Eom, Seong-Yun Jeong, Eun Kyung Choi, Kyeong Sook Choi
Article
Pharmacology & Pharmacy
In Young Kim, Min June Shim, Dong Min Lee, A. Reum Lee, Mi Ae Kim, Mi Jin Yoon, Mi Ri Kwon, Hae In Lee, Min Ji Seo, Yong Won Choi, Kyeong Sook Choi
BIOCHEMICAL PHARMACOLOGY
(2019)
Article
Cell Biology
Min Ji Seo, Dong Min Lee, In Young Kim, Dongjoo Lee, Min-Koo Choi, Joo-Youn Lee, Seok Soon Park, Seong-Yun Jeong, Eun Kyung Choi, Kyeong Sook Choi
CELL DEATH & DISEASE
(2019)
Article
Biochemistry & Molecular Biology
In-Hye Ham, Hye Jeong Oh, Hyejin Jin, Cheong A. Bae, Sang-Min Jeon, Kyeong Sook Choi, Sang-Yong Son, Sang-Uk Han, Rolf A. Brekken, Dakeun Lee, Hoon Hur
Article
Biochemistry & Molecular Biology
A. Reum Lee, Min Ji Seo, Jin Kim, Dong Min Lee, In Young Kim, Mi Jin Yoon, Hur Hoon, Kyeong Sook Choi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Chemistry, Analytical
Myoung Ki Cho, Min Ji Seo, Vinayak Juvekar, Jae Hyung Jo, Wontae Kim, Kyeong Sook Choi, Hwan Myung Kim
ANALYTICAL CHEMISTRY
(2020)
Article
Pharmacology & Pharmacy
Eunjung Jang, In Young Kim, Heeyeon Kim, Dong Min Lee, Dong Young Seo, Ju Ahn Lee, Kyeong Sook Choi, Eunhee Kim
BIOCHEMICAL PHARMACOLOGY
(2020)
Article
Oncology
Young-Kyoung Lee, So Mee Kwon, Eun-beom Lee, Gyeong-Hyeon Kim, Seongki Min, Sun-Mi Hong, Hee-Jung Wang, Dong Min Lee, Kyeong Sook Choi, Tae Jun Park, Gyesoon Yoon
Review
Cell Biology
Eunhee Kim, Dong Min Lee, Min Ji Seo, Hong Jae Lee, Kyeong Sook Choi
Summary: Paraptosis is a type of programmed cell death characterized by dilation of the endoplasmic reticulum and/or mitochondria. Ca2+ transport has been shown to play an important role in paraptosis induced by various agents, and perturbations of cellular proteostasis and ion homeostasis are believed to contribute critically to the process. The communication between the ER and mitochondria mediated by Ca2+ appears to be crucial in inducing paraptosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Analytical
Sang Jun Park, Myoung Ki Cho, Dong Joon Lee, Deuk Hwa Song, Chang Su Lim, Choong-Kyun Noh, Dong Min Lee, Kyeong Sook Choi, Sung Jae Shin, Hwan Myung Kim
Summary: A two-photon probe SCX was developed to reflect the level of COX-2 in colorectal cancer patients and distinguish between cancerous and normal tissue. In vitro and cell imaging studies showed that SCX could effectively differentiate the expression levels of COX-2 in cancerous and normal cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biochemistry & Molecular Biology
Dong Min Lee, Min Ji Seo, Hong Jae Lee, Hyo Joon Jin, Kyeong Sook Choi
Summary: Despite the success of proteasome inhibitors (PIs) in treating hematopoietic malignancies, their clinical efficacy is limited in solid tumors. This study investigated the involvement of the integrated stress response (ISR) in determining the fates of cells treated with the proteasome inhibitor, bortezomib (Bz). ISRIB, a small molecule that restores protein translation during ISR, reversed the ISR induced by Bz in both multiple myeloma (MM) cells and breast cancer cells, resulting in different outcomes: protecting MM cells from apoptosis and enhancing Bz sensitivity in breast cancer cells through inducing paraptosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Hong-Jae Lee, Dong-Min Lee, Min-Ji Seo, Ho-Chul Kang, Seok-Kyu Kwon, Kyeong-Sook Choi
Summary: PSMD14 is a potential prognostic marker and therapeutic target in cancer, and inducing paraptosis by targeting PSMD14 could overcome resistance to proteasome inhibitors or pro-apoptotic drugs in cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Jin Yeop Kim, Dong Min Lee, Hyun Goo Woo, Ki Deok Kim, Hong Jae Lee, Yong-Jun Kwon, Kyeong Sook Choi
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Dong Min Lee, In Young Kim, Min Ji Seo, Mi Ri Kwon, Kyeong Sook Choi
EXPERIMENTAL AND MOLECULAR MEDICINE
(2017)
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)