Gambogic acid triggers vacuolization-associated cell death in cancer cells via disruption of thiol proteostasis

Therapeutic potential of gambogic acid, a caged xanthone, to target cancer

(2018) Kishore Banik et al.   CANCER LETTERS

Pyrrolidine dithiocarbamate reverses Bcl-xL-mediated apoptotic resistance to doxorubicin by inducing paraptosis

(2018) Seok Soon Park et al.   CARCINOGENESIS

Mitochondrial MDM2 Regulates Respiratory Complex I Activity Independently of p53

(2018) Giuseppe Arena et al.   MOLECULAR CELL

Alkylating Agent–Induced NRF2 Blocks Endoplasmic Reticulum Stress–Mediated Apoptosis via Control of Glutathione Pools and Protein Thiol Homeostasis

(2016) Alfeu Zanotto-Filho et al.   MOLECULAR CANCER THERAPEUTICS

Paraptosis in the anti-cancer arsenal of natural products

(2016) Dongjoo Lee et al.   PHARMACOLOGY & THERAPEUTICS

Gambogic acid identifies an isoform-specific druggable pocket in the middle domain of Hsp90β

(2016) Kendrick H. Yim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gambogic acid inhibits the growth of ovarian cancer tumors by regulating p65 activity

(2016) Qiusha Tang et al.   Oncology Letters

ClpX stimulates the mitochondrial unfolded protein response (UPRmt) in mammalian cells

(2015) Natalie Al-Furoukh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondria-targeted antioxidants

(2015) Anne O. Oyewole et al.   FASEB JOURNAL

Broad targeting of resistance to apoptosis in cancer

(2015) Ramzi M. Mohammad et al.   SEMINARS IN CANCER BIOLOGY

Gambogic acid induces apoptosis and inhibits colorectal tumor growthviamitochondrial pathways

(2015) Guang-Ming Huang   WORLD JOURNAL OF GASTROENTEROLOGY

Gambogic acid induces apoptosis in diffuse large B-cell lymphoma cells via inducing proteasome inhibition

(2015) Xianping Shi et al.   Scientific Reports

Endoplasmic Reticulum Stress in Malignancy

(2014) Hanna J. Clarke et al.   CANCER CELL

Suppression of NF-κB Signaling and P-glycoprotein Function by Gambogic Acid Synergistically Potentiates Adriamycin -induced Apoptosis in Lung Cancer

(2014) Li-Hui Wang et al.   CURRENT CANCER DRUG TARGETS

Stronger proteasomal inhibition and higher CHOP induction are responsible for more effective induction of paraptosis by dimethoxycurcumin than curcumin

(2014) M J Yoon et al.   Cell Death & Disease

Biochemical methods for monitoring protein thiol redox states in biological systems

(2014) Olena Rudyk et al.   Redox Biology

Gambogic acid synergistically potentiates cisplatin-induced apoptosis in non-small-cell lung cancer through suppressing NF-κB and MAPK/HO-1 signalling

(2013) L-H Wang et al.   BRITISH JOURNAL OF CANCER

Gambogic Acid Induces Apoptosis in Imatinib-Resistant Chronic Myeloid Leukemia Cells via Inducing Proteasome Inhibition and Caspase-Dependent Bcr-Abl Downregulation

(2013) X. Shi et al.   CLINICAL CANCER RESEARCH

α-Mangostin and Gambogic Acid as Potential Inhibitors of the p53–MDM2 Interaction Revealed by a Yeast Approach

(2013) Mariana Leão et al.   JOURNAL OF NATURAL PRODUCTS

The combination of proteasome inhibitors bortezomib and gambogic acid triggers synergistic cytotoxicity in vitro but not in vivo

(2013) Ningning Liu et al.   TOXICOLOGY LETTERS

Manumycin A inhibits triple-negative breast cancer growth through LC3-mediated cytoplasmic vacuolation death

(2013) P K Singha et al.   Cell Death & Disease

New targets for the antitumor activity of gambogic acid in hematologic malignancies

(2012) Li-jing Yang et al.   ACTA PHARMACOLOGICA SINICA

Unfolded protein response to autophagy as a promising druggable target for anticancer therapy

(2012) Dong Hoon Suh et al.   Annals of the New York Academy of Sciences

Gambogic Acid is a Novel Anti-cancer Agent that Inhibits Cell Proliferation, Angiogenesis and Metastasis

(2012) Xu Wang et al.   Anti-Cancer Agents in Medicinal Chemistry

Simultaneous mitochondrial Ca2+ overload and proteasomal inhibition are responsible for the induction of paraptosis in malignant breast cancer cells

(2012) Mi Jin Yoon et al.   CANCER LETTERS

Gambogic Acid Deactivates Cytosolic and Mitochondrial Thioredoxins by Covalent Binding to the Functional Domain

(2012) Jing Yang et al.   JOURNAL OF NATURAL PRODUCTS

Gambogic Acid Is a Tissue-Specific Proteasome Inhibitor In Vitro and In Vivo

(2012) Xiaofen Li et al.   Cell Reports

Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy

(2011) Subash C. Gupta et al.   ANTIOXIDANTS & REDOX SIGNALING

Gambogic acid covalently modifies IκB kinase-β subunit to mediate suppression of lipopolysaccharide-induced activation of NF-κB in macrophages

(2009) Umamaheshwari D. Palempalli et al.   BIOCHEMICAL JOURNAL

General pharmacological properties, developmental toxicity, and analgesic activity of gambogic acid, a novel natural anticancer agent

(2009) Li Zhao et al.   DRUG AND CHEMICAL TOXICOLOGY

Superoxide anion and proteasomal dysfunction contribute to curcumin-induced paraptosis of malignant breast cancer cells

(2009) Mi Jin Yoon et al.   FREE RADICAL BIOLOGY AND MEDICINE

A novel role for MAP1 LC3 in nonautophagic cytoplasmic vacuolation death of cancer cells

(2009) R Kar et al.   ONCOGENE

Reactive oxygen species accumulation contributes to gambogic acid-induced apoptosis in human hepatoma SMMC-7721 cells

(2009) Feifei Nie et al.   TOXICOLOGY

Gambogic acid, a potent inhibitor of survivin, reverses docetaxel resistance in gastric cancer cells

(2008) Tingting Wang et al.   CANCER LETTERS

Gambogic Acid Inhibits Angiogenesis and Prostate Tumor Growth by Suppressing Vascular Endothelial Growth Factor Receptor 2 Signaling

(2008) T. Yi et al.   CANCER RESEARCH