Diabetes mellitus contributes to higher cerebrospinal fluid tau levels selectively in Alzheimer's disease patients with the APOE4 genotype

Safety, Efficacy, and Feasibility of Intranasal Insulin for the Treatment of Mild Cognitive Impairment and Alzheimer Disease Dementia

(2020) Suzanne Craft et al.   JAMA Neurology

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

Interactions between Atrial Fibrillation, Cardiovascular Risk Factors, and ApoE Genotype in Promoting Cognitive Decline in Patients with Alzheimer’s Disease: A Prospective Cohort Study

(2018) Lorenzo Falsetti et al.   JOURNAL OF ALZHEIMERS DISEASE

Intranasal insulin in Alzheimer’s dementia or mild cognitive impairment: a systematic review

(2018) Konstantinos Ioannis Avgerinos et al.   JOURNAL OF NEUROLOGY

Human ApoE Isoforms Differentially Modulate Brain Glucose and Ketone Body Metabolism: Implications for Alzheimer's Disease Risk Reduction and Early Intervention

(2018) Long Wu et al.   JOURNAL OF NEUROSCIENCE

Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications

(2018) Geert Jan Biessels et al.   Nature Reviews Endocrinology

Are Alzheimer's disease and other neurodegenerative disorders caused by impaired signalling of insulin and other hormones?

(2018) Christian Hölscher et al.   NEUROPHARMACOLOGY

Apolipoprotein E Genotype and Cerebrovascular Alterations Can Influence Conversion to Dementia in Patients with Mild Cognitive Impairment

(2018) Giovanna Viticchi et al.   JOURNAL OF ALZHEIMERS DISEASE

Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes

(2017) Na Zhao et al.   NEURON

CSF tau is associated with impaired cortical plasticity, cognitive decline and astrocyte survival only in APOE4-positive Alzheimer’s disease

(2017) Giacomo Koch et al.   Scientific Reports

Insulin and the Future Treatment of Alzheimer's Disease

(2016) Roberta Semprini et al.   CNS & Neurological Disorders-Drug Targets

An Update on Type 2 Diabetes Mellitus as a Risk Factor for Dementia

(2016) Wei Li et al.   JOURNAL OF ALZHEIMERS DISEASE

Changes in insulin and insulin signaling in Alzheimer’s disease: cause or consequence?

(2016) Molly Stanley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cerebrospinal Fluid Markers of Neurodegeneration and Rates of Brain Atrophy in Early Alzheimer Disease

(2015) Rawan Tarawneh et al.   JAMA Neurology

Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease

(2014) F. G. De Felice et al.   DIABETES

Increased Alzheimer’s Disease Neuropathology is Associated with Type 2 Diabetes and ApoE ε4 Carrier Status

(2013) Michael Malek-Ahmadi et al.   Current Alzheimer Research

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Marilyn S. Albert et al.   Alzheimers & Dementia

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

(2011) Suzanne Craft   ARCHIVES OF NEUROLOGY

Possible implications of insulin resistance and glucose metabolism in Alzheimer’s disease pathogenesis

(2011) Domenico Bosco et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

CSF biomarkers predict a more malignant outcome in Alzheimer disease

(2010) A. K. Wallin et al.   NEUROLOGY

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

(2010) E. Kickstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased Tau Phosphorylation and Cleavage in Mouse Models of Type 1 and Type 2 Diabetes

(2009) Bhumsoo Kim et al.   ENDOCRINOLOGY