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Pharmacology & Pharmacy
Gianluca Paventi, Maria Virginia Soldovieri, Ilenio Servettini, Vincenzo Barrese, Francesco Miceli, Maria Jose Sisalli, Paolo Ambrosino, Ilaria Mosca, Iolanda Vinciguerra, Lara Testai, Antonella Scorziello, Gennaro Raimo, Vincenzo Calderone, Salvatore Passarella, Maurizio Taglialatela
Summary: This study provides experimental evidence for the expression and functional role of Kv7.4 channels in regulating K+ permeability of neuronal mitochondria. The findings suggest that Kv7.4 channels are involved in the modulation of mitochondrial membrane potential, ROS production, and Ca2+ uptake.
BIOCHEMICAL PHARMACOLOGY
(2022)
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Neurosciences
Yael Almog, Saja Fadila, Marina Brusel, Anat Mavashov, Karen Anderson, Moran Rubinstein
Summary: Dravet syndrome is a rare and severe childhood-onset epilepsy caused by mutations in the SCN1A gene. Studies on Dravet mice showed persistent reduced function in inhibitory neurons and changes in excitatory neurons during different disease stages. This suggests a complex pathophysiological mechanism with reciprocal functional changes in both excitatory and inhibitory neurons influencing the developmental trajectory of the disease.
NEUROBIOLOGY OF DISEASE
(2021)
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Clinical Neurology
Isamu Aiba, Jeffrey L. Noebels
Summary: The potassium channel subunit Kcnq2/K(v)7.2 has been identified as a key modulatory gene in spreading depolarization, affecting seizure-spreading depolarization transition threshold, bilateral cortical expression, and diurnal susceptibility. Pharmacological intervention or genetic mutations can directly impact the threshold and properties of cortical spreading depolarizations.
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Neurosciences
Joseph Cichon, Andrzej Z. Wasilczuk, Loren L. Looger, Diego Contreras, Max B. Kelz, Alex Proekt
Summary: This study demonstrates that ketamine can cause a switch in the active population of excitatory neurons in the cortical layers, which leads to impairments in sensory processing and dissociative-like state. These findings provide insights into how the brain can become disconnected from the environment while maintaining internal subjective experiences.
NATURE NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Tae-Kyeong Lee, Myoung Cheol Shin, Ji Hyeon Ahn, Dae Won Kim, Bora Kim, Hyejin Sim, Jae-Chul Lee, Jun Hwi Cho, Joon Ha Park, Young-Myeong Kim, Moo-Ho Won, Choong-Hyun Lee
Summary: This study investigated the time-dependent changes in CD200 expression in the hippocampus after transient forebrain ischemia in gerbils. The results showed that transient ischemia led to specific and selective neuronal death in the CA1 field, with CD200 expression changing over time. Interestingly, treatment with risperidone did not alter CD200 expression, indicating protection of CA1 pyramidal neurons from ischemic injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Lingjun Ding, Giuseppe Balsamo, Hongbiao Chen, Eduardo Blanco-Hernandez, Ioannis S. Zouridis, Robert Naumann, Patricia Preston-Ferrer, Andrea Burgalossi
Summary: Neural circuits are composed of diverse neuronal cell types, and this diversity plays a crucial role in brain function during natural behavior. In this study, the combination of juxtacellular recording, labeling, and optogenetics enabled the investigation of molecularly defined cell classes in freely moving mice, revealing the weaker spatial modulation and information transmission of Calbindin-positive CA1 pyramidal cells.
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Neurosciences
Hadas E. Sloin, Amir Levi, Shirly Someck, Lidor Spivak, Eran Stark
Summary: Single hippocampal cells can encode the spatial position of an animal through phase rolling, a faster and distinct form of phase change compared to phase precession. Place fields exhibiting phase rolling are larger in size than nonrolling fields.
JOURNAL OF NEUROSCIENCE
(2022)
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Neurosciences
Nissi Varghese, Anna Lauritano, Maurizio Taglialatela, Anastasios V. Tzingounis
Summary: Retigabine primarily targets KCNQ3 channels in excitatory neurons, and our findings suggest that retigabine controls neuronal firing properties primarily through these channels. The study provides new insights into retigabine's mechanism of action in forebrain neurons.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Rasha H. Mehder, Brian M. Bennett, R. David Andrew
Summary: This study investigated the relationship between oxidative damage in the dorsal hippocampal CA1 region and progressive cognitive impairment in a mouse model of Alzheimer's disease. Results showed that increased oxidative damage preceded synaptic trimming and may be associated with alterations in neuronal structure leading to cognitive decline.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Anatomy & Morphology
Denise Riquelme, Oscar Cerda, Elias Leiva-Salcedo
Summary: In this study, the localization and expression of TRPM4 in CA1 pyramidal neurons during postnatal development were examined using immunofluorescence and patch-clamp techniques in C57BL/6J mice. The results show that TRPM4 is expressed in the soma and apical dendrites of CA1 pyramidal neurons, associated with a TRPM4-like current that depolarizes the neurons. These findings suggest that TRPM4 may play a role in controlling membrane potential and action potential firing during critical periods of neuronal development, particularly in circuit establishment.
FRONTIERS IN NEUROANATOMY
(2021)
Article
Pharmacology & Pharmacy
Ying Zhang, Hai-Yan Yin, Patrizia Rubini, Peter Illes, Yong Tang
Summary: There is a dispute about whether CNS neurons possess ATP-sensitive P2X7 receptors. By genetically deleting P2X7 receptors in astrocytes and oligodendrocytes, it was found that these receptors indirectly modulate the neuronal input to neighboring neurons.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Tae-Kyeong Lee, Dae Won Kim, Hyejin Sim, Jae-Chul Lee, Hyung Il Kim, Myoung Cheol Shin, Jun Hwi Cho, Joon Ha Park, Choong-Hyun Lee, Moo-Ho Won, Ji Hyeon Ahn
Summary: According to this study, different subfields of the hippocampus (CA1 to CA3) have different vulnerabilities to ischemia. Hyperthermia exacerbates neuronal death and decreases the expression of HIF-1 alpha, while normothermia does not have the same effects.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Neurosciences
Yael Almog, Anat Mavashov, Marina Brusel, Moran Rubinstein
Summary: Dravet syndrome is a childhood-onset epilepsy caused by mutations in the SCN1A gene. This study found that the initial reduction in excitability of inhibitory neurons in Dravet syndrome led to further alterations in the CA1 microcircuit, affecting neuronal firing and synaptic connections.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Laurel Watkins de Jong, Mohammadreza Mohagheghi Nejad, Euisik Yoon, Sen Cheng, Kamran Diba
Summary: Recurrent connectivity and feedback inhibition from inhibitory neurons play crucial roles in determining the dynamics and computational properties of neuronal circuits. Through optogenetic manipulations and large-scale unit recordings, paradoxical responses were observed in both CA1 and CA3 regions of the hippocampus, where subsets of cells increased firing during photoinhibition while others decreased firing during photoexcitation. These paradoxical responses were more prominent in CA3 and simulations confirmed that both CA1 and CA3 hippocampal regions exhibit inhibition-stabilized networks with strong recurrent excitation.
Article
Neurosciences
Paola Vitale, Fabio Librizzi, Andrea C. Vaiana, Elisa Capuana, Maurizio Pezzoli, Ying Shi, Armando Romani, Michele Migliore, Rosanna Migliore
Summary: The fundamental role of neurons in a network is to transform complex input patterns into output spikes, and understanding species-specific differences in this process is important. This study compared the morphological and electrophysiological properties of mouse and rat neurons to determine the parameters underlying their differences and created computational models to further investigate these distinctions.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
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Pharmacology & Pharmacy
Natalia M. Kowal, Philip K. Ahring, Vivian W. Y. Liao, Dinesh C. Indurti, Benjamin S. Harvey, Susan M. O'Connor, Mary Chebib, Elin S. Olafsdottir, Thomas Balle
BRITISH JOURNAL OF PHARMACOLOGY
(2018)
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Endocrinology & Metabolism
Andrew N. Clarkson, Lily Boothman-Burrell, Zita Dosa, Raghavendra Y. Nagaraja, Liang Jin, Kim Parker, Petra S. van Nieuwenhuijzen, Silke Neumann, Emma K. Gowing, Navnath Gavande, Philip K. Ahring, Mai M. Holm, Jane R. Hanrahan, Joseph A. Nicolazzo, Kimmo Jensen, Mary Chebib
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2019)
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Physiology
Philip Kiaer Ahring, Vivian Wan Yu Liao, Thomas Balle
JOURNAL OF GENERAL PHYSIOLOGY
(2018)
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Pharmacology & Pharmacy
Dinesh C. Indurthi, Taima Qudah, Vivian W. Liao, Philip K. Ahring, Trevor M. Lewis, Thomas Balle, Mary Chebib, Nathan L. Absalom
PHARMACOLOGICAL RESEARCH
(2019)
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Biochemistry & Molecular Biology
Nathan L. Absalom, Philip K. Ahring, Vivian W. Liao, Thomas Balle, Tian Jiang, Lyndsey L. Anderson, Jonathon C. Arnold, Iain S. McGregor, Michael T. Bowen, Mary Chebib
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
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Biochemistry & Molecular Biology
Natalia M. Kowal, Dinesh C. Indurthi, Philip K. Ahring, Mary Chebib, Elin S. Olafsdottir, Thomas Balle
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Physiology
Vivian Wan Yu Liao, Han Chow Chua, Natalia Magdalena Kowal, Mary Chebib, Thomas Balle, Philip Kiaer Ahring
JOURNAL OF GENERAL PHYSIOLOGY
(2019)
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Neurosciences
Silke Neumann, Lily Boothman-Burrell, Emma Gowing, Thomas A. Jacobsen, Philip K. Ahring, Sarah L. Young, Karin Sandager-Nielsen, Andrew Clarkson
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Pharmacology & Pharmacy
Marloes van Hout, Jessica Klein, Philip K. Ahring, David T. Brown, Siganya Thaneshwaran, Altair B. dos Santos, Anders A. Jensen, Kristi A. Kohlmeier, Palle Christophersen, Tino Dyhring
BIOCHEMICAL PHARMACOLOGY
(2020)
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Pharmacology & Pharmacy
Karin Sandager-Nielsen, Philip K. Ahring, Jessica Klein, Marloes van Hout, Siganya Thaneshwaran, Altair B. dos Santos, Thomas A. Jacobsen, Dipak Amrutkar, Dan Peters, Anders A. Jensen, Kristi A. Kohlmeier, Palle Christophersen, Tino Dyhring
BIOCHEMICAL PHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Vivian Wan Yu Liao, Ali Saad Kusay, Thomas Balle, Philip Kiaer Ahring
BRITISH JOURNAL OF PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Sebastian Oddsson, Natalia M. Kowal, Philip K. Ahring, Elin S. Olafsdottir, Thomas Balle
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Pharmacology & Pharmacy
Vivian Wan Yu Liao, Mary Chebib, Philip Kiaer Ahring
Summary: This study successfully obtained robust α1 β2 δ and α1 β3 δ GABA(A) receptors through novel delta-containing pentameric concatenated constructs, shedding light on the pharmacology and stoichiometry of delta-containing receptors. The findings pave the way for future drug discovery efforts and provide important insights for understanding the functional properties of these receptors.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Neurosciences
Grant Richter, Vivian W. Y. Liao, Philip K. Ahring, Mary Chebib
FRONTIERS IN NEUROSCIENCE
(2020)
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Clinical Neurology
Nathan L. Absalom, Vivian W. Y. Liao, Kavitha Kothur, Dinesh C. Indurthi, Bruce Bennetts, Christopher Troedson, Shekeeb S. Mohammad, Sachin Gupta, Iain S. McGregor, Michael T. Bowen, Damien Lederer, Sandrine Mary, Liesbeth De Waele, Katrien Jansen, Deepak Gill, Manju A. Kurian, Amy McTague, Rikke S. Moller, Philip K. Ahring, Russell C. Dale, Mary Chebib
BRAIN COMMUNICATIONS
(2020)