Functional Investigation of a Neuronal Microcircuit in the CA1 Area of the Hippocampus Reveals Synaptic Dysfunction in Dravet Syndrome Mice

Development of an antiseizure drug screening platform for Dravet syndrome at the NINDS contract site for the Epilepsy Therapy Screening Program

(2021) Chelsea D. Pernici et al.   EPILEPSIA

Proteomic signature of the Dravet syndrome in the genetic Scn1a-A1783V mouse model

(2021) Nina Miljanovic et al.   NEUROBIOLOGY OF DISEASE

Paradoxical hyperexcitability from NaV1.2 sodium channel loss in neocortical pyramidal cells

(2021) Perry W.E. Spratt et al.   Cell Reports

Modeling NaV1.1/SCN1A sodium channel mutations in a microcircuit with realistic ion concentration dynamics suggests differential GABAergic mechanisms leading to hyperexcitability in epilepsy and hemiplegic migraine

(2021) Louisiane Lemaire et al.   PLoS Computational Biology

Dravet Variant SCN1AA1783V Impairs Interneuron Firing Predominantly by Altered Channel Activation

(2021) Nikolas Layer et al.   Frontiers in Cellular Neuroscience

SCN 1A /Na V 1.1 channelopathies: Mechanisms in expression systems, animal models, and human iPSC models

(2020) Massimo Mantegazza et al.   EPILEPSIA

Interneuron desynchronization precedes seizures in a mouse model of Dravet syndrome

(2020) Conny H. Tran et al.   JOURNAL OF NEUROSCIENCE

Electrophysiological Alterations of Pyramidal Cells and Interneurons of the CA1 Region of the Hippocampus in a Novel Mouse Model of Dravet Syndrome

(2020) David A. Dyment et al.   GENETICS

Convulsive seizures and some behavioral comorbidities are uncoupled in the Scn1a A1783V Dravet syndrome mouse model

(2020) Saja Fadila et al.   EPILEPSIA

Developmental alterations in firing properties of hippocampal CA1 inhibitory and excitatory neurons in a mouse model of Dravet syndrome

(2020) Yael Almog et al.   NEUROBIOLOGY OF DISEASE

A two-hit story: Seizures and genetic mutation interaction sets phenotype severity in SCN1A epilepsies

(2019) Ana Rita Salgueiro-Pereira et al.   NEUROBIOLOGY OF DISEASE

Increased Excitation-Inhibition Ratio Stabilizes Synapse and Circuit Excitability in Four Autism Mouse Models

(2019) Michelle W. Antoine et al.   NEURON

Augmented Reticular Thalamic Bursting and Seizures in Scn1a-Dravet Syndrome

(2019) Stefanie Ritter-Makinson et al.   Cell Reports

In vivo, in vitro and in silico correlations of four de novo SCN1A missense mutations

(2019) Andreea Nissenkorn et al.   PLoS One

Disordered breathing in a mouse model of Dravet syndrome

(2019) Fu-Shan Kuo et al.   eLife

Hippocampal deletion of NaV1.1 channels in mice causes thermal seizures and cognitive deficit characteristic of Dravet Syndrome

(2019) Rachael E. Stein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delayed maturation of GABAergic signaling in the Scn1a and Scn1b mouse models of Dravet Syndrome

(2019) Yukun Yuan et al.   Scientific Reports

Vasoactive intestinal peptide-expressing interneurons are impaired in a mouse model of Dravet syndrome

(2019) Kevin M Goff et al.   eLife

Single‐cell RNA‐Seq characterization of anatomically identified OLM interneurons in different transgenic mouse lines

(2019) Jochen Winterer et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Impairment of sharp-wave ripples in a murine model of Dravet Syndrome

(2019) Christine S. Cheah et al.   JOURNAL OF NEUROSCIENCE

Epilepsy and neuropsychiatric comorbidities in mice carrying a recurrent Dravet syndrome SCN1A missense mutation

(2019) Ana Ricobaraza et al.   Scientific Reports

Impairments in social novelty recognition and spatial memory in mice with conditional deletion of Scn1a in parvalbumin-expressing cells

(2018) Tetsuya Tatsukawa et al.   NEUROBIOLOGY OF DISEASE

Role of sodium channel subtype in action potential generation by neocortical pyramidal neurons

(2018) Efrat Katz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Transient Developmental Window of Fast-Spiking Interneuron Dysfunction in a Mouse Model of Dravet Syndrome

(2018) Morgana Favero et al.   JOURNAL OF NEUROSCIENCE

Selective NaV1.1 activation rescues Dravet syndrome mice from seizures and premature death

(2018) Kay L. Richards et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene expression profiling in a mouse model of Dravet syndrome

(2018) Nicole A. Hawkins et al.   EXPERIMENTAL NEUROLOGY

Unaltered Network Activity and Interneuronal Firing During Spontaneous Cortical Dynamics In Vivo in a Mouse Model of Severe Myoclonic Epilepsy of Infancy

(2016) Angela Michela De Stasi et al.   CEREBRAL CORTEX

Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain

(2016) Jeremiah D. Osteen et al.   NATURE

Hipposeq: a comprehensive RNA-seq database of gene expression in hippocampal principal neurons

(2016) Mark S Cembrowski et al.   eLife

Dissecting the phenotypes of Dravet syndrome by gene deletion

(2015) Moran Rubinstein et al.   BRAIN

Dendritic integration: 60 years of progress

(2015) Greg J Stuart et al.   NATURE NEUROSCIENCE

Genetic background modulates impaired excitability of inhibitory neurons in a mouse model of Dravet syndrome

(2015) Moran Rubinstein et al.   NEUROBIOLOGY OF DISEASE

Functional and structural deficits of the dentate gyrus network coincide with emerging spontaneous seizures in an Scn1a mutant Dravet Syndrome model during development

(2015) Ming-Shian Tsai et al.   NEUROBIOLOGY OF DISEASE

Impaired Action Potential Initiation in GABAergic Interneurons Causes Hyperexcitable Networks in an Epileptic Mouse Model Carrying a Human NaV1.1 Mutation

(2014) U. B. S. Hedrich et al.   JOURNAL OF NEUROSCIENCE

Strain- and age-dependent hippocampal neuron sodium currents correlate with epilepsy severity in Dravet syndrome mice

(2014) Akshitkumar M. Mistry et al.   NEUROBIOLOGY OF DISEASE

Impaired excitability of somatostatin- and parvalbumin-expressing cortical interneurons in a mouse model of Dravet syndrome

(2014) C. Tai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippocampal hyperexcitability and specific epileptiform activity in a mouse model of Dravet syndrome

(2013) Camille Liautard et al.   EPILEPSIA

Mapping genetic modifiers of survival in a mouse model of Dravet syndrome

(2013) A. R. Miller et al.   GENES BRAIN AND BEHAVIOR

Nav1.1 haploinsufficiency in excitatory neurons ameliorates seizure-associated sudden death in a mouse model of Dravet syndrome

(2013) Ikuo Ogiwara et al.   HUMAN MOLECULAR GENETICS

Autistic-like behaviour in Scn1a +/− mice and rescue by enhanced GABA-mediated neurotransmission

(2012) Sung Han et al.   NATURE

Transient Sodium Current at Subthreshold Voltages: Activation by EPSP Waveforms

(2012) Brett C. Carter et al.   NEURON

Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome

(2012) C. S. Cheah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The core Dravet syndrome phenotype

(2011) Charlotte Dravet   EPILEPSIA

A Blueprint for the Spatiotemporal Origins of Mouse Hippocampal Interneuron Diversity

(2011) L. Tricoire et al.   JOURNAL OF NEUROSCIENCE

NaV1.1 channels and epilepsy

(2010) William A. Catterall et al.   JOURNAL OF PHYSIOLOGY-LONDON

Molecular Identity of Dendritic Voltage-Gated Sodium Channels

(2010) A. Lorincz et al.   SCIENCE

Distinct contributions of Nav1.6 and Nav1.2 in action potential initiation and backpropagation

(2009) Wenqin Hu et al.   NATURE NEUROSCIENCE