Disulfide Formation Strategies in Peptide Synthesis

Immobilized N-Chlorosuccinimide as a Friendly Peptide Disulfide-Forming Reagent

(2014) Tobias M. Postma et al.   ACS Combinatorial Science

Side reactions in the SPPS of Cys-containing peptides

(2013) Panagiotis Stathopoulos et al.   AMINO ACIDS

Enzyme-Labile Protecting Groups for the Synthesis of Natural Products: Solid-Phase Synthesis of Thiocoraline

(2013) Judit Tulla-Puche et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reinvestigation of the Oxidative Folding Pathways of Hen Egg White Lysozyme: Switching of the Major Pathways by Temperature Control

(2013) Kenta Arai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Evaluation of acid-labileS-protecting groups to prevent Cys racemization in Fmoc solid-phase peptide synthesis

(2013) Hajime Hibino et al.   JOURNAL OF PEPTIDE SCIENCE

Understanding Acid Lability of Cysteine Protecting Groups

(2013) Iván Ramos-Tomillero et al.   MOLECULES

The phenacyl group as an efficient thiol protecting group in a peptide condensation reaction by the thioester method

(2013) Hidekazu Katayama et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

N-Chlorosuccinimide, an Efficient Reagent for On-Resin Disulfide Formation in Solid-Phase Peptide Synthesis

(2013) Tobias M. Postma et al.   ORGANIC LETTERS

Aqueous Microwave-Assisted Solid-Phase Peptide Synthesis Using Fmoc Strategy. II. Racemization Studies and Water Based Synthesis of Cysteine- Containing Peptides

(2013) Keiko Hojo et al.   PROTEIN AND PEPTIDE LETTERS

N-chlorosuccinimide, an efficient peptide disulfide bond-forming reagent in aqueous solution

(2013) Tobias M. Postma et al.   RSC Advances

Reagentless Oxidative Folding of Disulfide-Rich Peptides Catalyzed by an Intramolecular Diselenide

(2012) Andrew M. Steiner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Strategic Use of Non-Native Diselenide Bridges to Steer Oxidative Protein Folding

(2012) Norman Metanis et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selenocysteine in Thiol/Disulfide-Like Exchange Reactions

(2012) Robert J. Hondal et al.   ANTIOXIDANTS & REDOX SIGNALING

Eco-Friendly Combination of the Immobilized PGA Enzyme and theS-Phacm Protecting Group for the Synthesis of Cys-Containing Peptides

(2012) Miriam Góngora-Benítez et al.   CHEMISTRY-A EUROPEAN JOURNAL

Therapeutic Potential of Cone Snail Venom Peptides (Conopeptides)

(2012) Irina Vetter et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Cyclotides as a basis for drug design

(2012) David J Craik et al.   Expert Opinion on Drug Discovery

Conotoxins that Confer Therapeutic Possibilities

(2012) Magbubah Essack et al.   Marine Drugs

Chemical Synthesis, Backbone Cyclization and Oxidative Folding of Cystine-knot Peptides — Promising Scaffolds for Applications in Drug Design

(2012) Michael Reinwarth et al.   MOLECULES

Turbo-charged crosslinking

(2012) David J. Craik   Nature Chemistry

Drug pipeline is flush with new options for chronic constipation

(2012) Elie Dolgin   NATURE MEDICINE

Trimethoxyphenylthio as a Highly Labile Replacement for tert-Butylthio Cysteine Protection in Fmoc Solid Phase Synthesis

(2012) Tobias M. Postma et al.   ORGANIC LETTERS

4-Methoxybenzyloxymethyl Group, a Racemization-Resistant Protecting Group for Cysteine in Fmoc Solid Phase Peptide Synthesis

(2012) Hajime Hibino et al.   ORGANIC LETTERS

Acid-Labile Cys-Protecting Groups for the Fmoc/tBu Strategy: Filling the Gap

(2012) Miriam Góngora-Benítez et al.   ORGANIC LETTERS

Cover Picture: Rapid and Quantitative Disulfide Bond Formation for a Polypeptide Chain Using a Cyclic Selenoxide Reagent in an Aqueous Medium (Chem. Eur. J. 2/2011)

(2011) Kenta Arai et al.   CHEMISTRY-A EUROPEAN JOURNAL

Oxyfold: A Simple and Efficient Solid-Supported Reagent for Disulfide Bond Formation

(2011) Pascal Verdié et al.   Chemistry-An Asian Journal

Venoms as a platform for human drugs: translating toxins into therapeutics

(2011) Glenn F King   EXPERT OPINION ON BIOLOGICAL THERAPY

Cyclotides: a patent review

(2011) Amanda B Smith et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

2,2′-Dithiobis(5-nitropyridine) (DTNP) as an effective and gentle deprotectant for common cysteine protecting groups

(2011) Alayne L. Schroll et al.   JOURNAL OF PEPTIDE SCIENCE

N-Methyl-phenacyloxycarbamidomethyl (Pocam) group: a novel thiol protecting group for solid-phase peptide synthesis and peptide condensation reactions

(2011) Hidekazu Katayama et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Hydrazine-Sensitive Thiol Protecting Group for Peptide and Protein Chemistry

(2011) Fei Shen et al.   ORGANIC LETTERS

Disulfide bond prolongs the half-life of therapeutic peptide-GLP-1

(2011) Ying Li et al.   PEPTIDES

p-Nitrobenzyl protection for cysteine and selenocysteine: A more stable alternative to the acetamidomethyl group

(2010) Markus Muttenthaler et al.   BIOPOLYMERS

Invited reviewnative chemical ligation applied to the synthesis and bioengineering of circular peptides and proteins

(2010) Richard J. Clark et al.   BIOPOLYMERS

Optimized Fmoc solid-phase synthesis of the cysteine-rich peptide linaclotide

(2010) Miriam Góngora-Benítez et al.   BIOPOLYMERS

2,2,4,6,7-Pentamethyl-2,3-dihydrobenzofuran-5-methyl (Pbfm) as an Alternative to the Trityl Group for the Side-Chain Protection of Cysteine and Asparagine/Glutamine

(2010) Oscar Garcia et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Solving the α-Conotoxin Folding Problem: Efficient Selenium-Directed On-Resin Generation of More Potent and Stable Nicotinic Acetylcholine Receptor Antagonists

(2010) Markus Muttenthaler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract

(2010) Alexander P. Bryant et al.   LIFE SCIENCES

Preparation and Use of Cysteine Orthoesters for Solid-Supported Synthesis of Peptides

(2010) Zedu Huang et al.   ORGANIC LETTERS

Discovery, structure and biological activities of cyclotides☆

(2009) Norelle L. Daly et al.   ADVANCED DRUG DELIVERY REVIEWS

Direct Visualization of Disulfide Bonds through Diselenide Proxies Using77Se NMR Spectroscopy

(2009) Mehdi Mobli et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Protein Disulfide Isomerase: A Critical Evaluation of Its Function in Disulfide Bond Formation

(2009) Feras Hatahet et al.   ANTIOXIDANTS & REDOX SIGNALING

The selenium to selenoprotein pathway in eukaryotes: More molecular partners than anticipated

(2009) Christine Allmang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Cyclotides as templates in drug design

(2009) Sónia Troeira Henriques et al.   DRUG DISCOVERY TODAY

Peptide nanocarriers for intracellular delivery of photosensitizers

(2009) Albert J. van Hell et al.   JOURNAL OF CONTROLLED RELEASE

Wavelength-Selective Photoactivatable Protecting Groups for Thiols

(2009) Nico Kotzur et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Use of Disulfide “Staples” To Stabilize β-Sheet Quaternary Structure

(2009) Omid Khakshoor et al.   ORGANIC LETTERS

Stabilization of Peptide Vesicles by Introducing Inter-Peptide Disulfide Bonds

(2009) Albert J. van Hell et al.   PHARMACEUTICAL RESEARCH

Disulfide-Linked Protein Folding Pathways

(2008) Bharath S. Mamathambika et al.   Annual Review of Cell and Developmental Biology

Self-crosslinked and reducible fusogenic peptides for intracellular delivery of siRNA

(2008) Hyejung Mok et al.   BIOPOLYMERS

Enhanced microwave-assisted method for on-bead disulfide bond formation: Synthesis of α-conotoxin MII

(2008) Athanassios S. Galanis et al.   BIOPOLYMERS

Total chemical synthesis of proteins

(2008) Stephen B. H. Kent   CHEMICAL SOCIETY REVIEWS

Simultaneous Post-cysteine(S-Acm) Group Removal Quenching of Iodine and Isolation of Peptide by One Step Ether Precipitation

(2008) Suode Zhang et al.   International Journal of Peptide Research and Therapeutics

Direct Observation of Conformational Folding Coupled with Disulphide Rearrangement by Using a Water-soluble Selenoxide Reagent—A Case of Oxidative Regeneration of Ribonuclease A under Weakly Basic Conditions

(2008) Michio Iwaoka et al.   JOURNAL OF BIOCHEMISTRY

Oxidative folding of synthetic polypeptidesS-protected astert-butylthio derivatives

(2008) Antonio Verdini et al.   JOURNAL OF PEPTIDE SCIENCE

Balancing Conformational and Oxidative Kinetic Traps during the Folding of Bovine Pancreatic Trypsin Inhibitor (BPTI) with Glutathione and Glutathione Disulfide

(2008) Farhana M. Kibria et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY