Reliable and Efficient Procedures for the Conjugation of Biomolecules through Huisgen Azide-Alkyne Cycloadditions

Cu-CATALYZED AZIDE-ALKYNE CYCLOADDITION: PREPARATION OF TRIS((1-BENZYL-1H-1,2,3-TRIAZOLYL)METHYL)AMINE

(2014)   ORGANIC SYNTHESES

Anaerobic conditions to reduce oxidation of proteins and to accelerate the copper-catalyzed “Click” reaction with a water-soluble bis(triazole) ligand

(2011) Amit Kumar et al.   CHEMICAL COMMUNICATIONS

Readily Accessible Bicyclononynes for Bioorthogonal Labeling and Three-Dimensional Imaging of Living Cells

(2010) Jan Dommerholt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Programmable DNA-Based Molecular Valve for Colloidal Mesoporous Silica

(2010) Axel Schlossbauer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Labeling Live Cells by Copper-Catalyzed Alkyne−Azide Click Chemistry

(2010) Vu Hong et al.   BIOCONJUGATE CHEMISTRY

Copper-Free Click Chemistry for Highly Luminescent Quantum Dot Conjugates: Application toin VivoMetabolic Imaging

(2010) Aude Bernardin et al.   BIOCONJUGATE CHEMISTRY

Facile Synthesis of β-Cyclodextrin-Dextran Polymers by “Click” Chemistry

(2010) Thorbjørn Terndrup Nielsen et al.   BIOMACROMOLECULES

Tailoring Thermoreversible Hyaluronan Hydrogels by “Click” Chemistry and RAFT Polymerization for Cell and Drug Therapy

(2010) Derek Mortisen et al.   BIOMACROMOLECULES

Modification of dextran using click-chemistry approach in aqueous media

(2010) Nikolaos Pahimanolis et al.   CARBOHYDRATE POLYMERS

Multivalent Display and Receptor-Mediated Endocytosis of Transferrin on Virus-Like Particles

(2010) Deboshri Banerjee et al.   CHEMBIOCHEM

Azide: A Unique Dipole for Metal-Free Bioorthogonal Ligations

(2010) Marjoke F. Debets et al.   CHEMBIOCHEM

Live-Cell Imaging of Cellular Proteins by a Strain-Promoted Azide-Alkyne Cycloaddition

(2010) Kimberly E. Beatty et al.   CHEMBIOCHEM

A new fixation strategy for addressable nano-network building blocks

(2010) Erik P. Lundberg et al.   CHEMICAL COMMUNICATIONS

Click chemistry with DNA

(2010) Afaf H. El-Sagheer et al.   CHEMICAL SOCIETY REVIEWS

Cu-free click cycloaddition reactions in chemical biology

(2010) John C. Jewett et al.   CHEMICAL SOCIETY REVIEWS

Peptide-Functionalized Click Hydrogels with Independently Tunable Mechanics and Chemical Functionality for 3D Cell Culture

(2010) Cole A. DeForest et al.   CHEMISTRY OF MATERIALS

Convergent Assembly and Surface Modification of Multifunctional Dendrimers by Three Consecutive Click Reactions

(2010) Petr A. Ledin et al.   CHEMISTRY-A EUROPEAN JOURNAL

High-Density DNA Functionalization by a Combination of Cu-Catalyzed and Cu-Free Click Chemistry

(2010) Katrin Gutsmiedl et al.   CHEMISTRY-A EUROPEAN JOURNAL

Strain-Promoted Alkyne Azide Cycloaddition for the Functionalization of Poly(amide)-Based Dendrons and Dendrimers

(2010) Cátia Ornelas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DNA-Templated Covalent Coupling of G4 PAMAM Dendrimers

(2010) Huajie Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

High Density Orthogonal Surface Immobilization via Photoactivated Copper-Free Click Chemistry

(2010) Sara V. Orski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemoselective Attachment of Small Molecule Effector Functionality to Human Adenoviruses Facilitates Gene Delivery to Cancer Cells

(2010) Partha Sarathi Banerjee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Strategy for the Selective Imaging of Glycans Using Caged Metabolic Precursors

(2010) Pamela V. Chang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tailored Ligand Acceleration of the Cu-Catalyzed Azide−Alkyne Cycloaddition Reaction: Practical and Mechanistic Implications

(2010) Stanislav I. Presolski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biocompatible Copper(I) Catalysts for in Vivo Imaging of Glycans

(2010) David Soriano del Amo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rapid Cu-Free Click Chemistry with Readily Synthesized Biarylazacyclooctynones

(2010) John C. Jewett et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thermo- and pH-Responsive Association Behavior of Dual Hydrophilic Graft Chitosan Terpolymer Synthesized via ATRP and Click Chemistry

(2010) Hongqian Bao et al.   MACROMOLECULES

Reaction Rates and Mechanisms for Radical, Photoinitated Addition of Thiols to Alkynes, and Implications for Thiol−Yne Photopolymerizations and Click Reactions

(2010) Benjamin D. Fairbanks et al.   MACROMOLECULES

Polyvalent Oligonucleotide Iron Oxide Nanoparticle “Click” Conjugates

(2010) Joshua I. Cutler et al.   NANO LETTERS

DNA-controlled assembly of a NaTl lattice structure from gold nanoparticles and protein nanoparticles

(2010) Petr Cigler et al.   NATURE MATERIALS

Non-Nucleoside Building Blocks for Copper-Assisted and Copper-Free Click Chemistry for the Efficient Synthesis of RNA Conjugates

(2010) K. N. Jayaprakash et al.   ORGANIC LETTERS

Synthesis of Oligoribonucleic Acid Conjugates Using a Cyclooctyne Phosphoramidite

(2010) Pieter van Delft et al.   ORGANIC LETTERS

New strategy for the synthesis of chemically modified RNA constructs exemplified by hairpin and hammerhead ribozymes

(2010) A. H. El-Sagheer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Visualizing enveloping layer glycans during zebrafish early embryogenesis

(2010) J. M. Baskin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Copper-free click chemistry in living animals

(2010) P. V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Copper-Free Clickable Coatings

(2009) Luiz A. Canalle et al.   ADVANCED FUNCTIONAL MATERIALS

Functionalized Chitosan as a Green, Recyclable, Biopolymer-Supported Catalyst for the [3+2] Huisgen Cycloaddition

(2009) Mélanie Chtchigrovsky et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Polysaccharide-block-polypeptide Copolymer Vesicles: Towards Synthetic Viral Capsids

(2009) Christophe Schatz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selective Fluorescence Labeling of Lipids in Living Cells

(2009) Anne B. Neef et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Analysis and Optimization of Copper-Catalyzed Azide–Alkyne Cycloaddition for Bioconjugation

(2009) Vu Hong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and Applications of Biomedical and Pharmaceutical Polymers via Click Chemistry Methodologies

(2009) Maarten van Dijk et al.   BIOCONJUGATE CHEMISTRY

Synthesis of 6-N,N,N-Trimethyltriazole Chitosan via “Click Chemistry” and Evaluation for Gene Delivery

(2009) Yu Gao et al.   BIOMACROMOLECULES

Probing the Activity of Matrix Metalloproteinase II with a Sequentially Click-Labeled Silica Nanoparticle FRET Probe

(2009) Daniela E. Achatz et al.   CHEMBIOCHEM

A click chemistry based coordination polymer inside small heat shock protein

(2009) Janice Lucon et al.   CHEMICAL COMMUNICATIONS

Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition

(2009) Marjoke F. Debets et al.   CHEMICAL COMMUNICATIONS

Risks of Copper and Iron Toxicity during Aging in Humans

(2009) George J. Brewer   CHEMICAL RESEARCH IN TOXICOLOGY

Applications of Orthogonal “Click” Chemistries in the Synthesis of Functional Soft Materials

(2009) Rhiannon K. Iha et al.   CHEMICAL REVIEWS

Synthesis of Mannose and Galactose Oligonucleotide Conjugates by Bi-click chemistry

(2009) Gwladys Pourceau et al.   JOURNAL OF ORGANIC CHEMISTRY

Glaser coupling of polymers: Side-reaction in Huisgens “click” coupling reaction and opportunity for polymers with focal diacetylene units in combination with ATRP

(2009) Christopher J. Duxbury et al.   JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY

Buckyballs Meet Viral Nanoparticles: Candidates for Biomedicine

(2009) Nicole F. Steinmetz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Surpassing the Use of Copper in the Click Functionalization of Polymeric Nanostructures: A Strain-Promoted Approach

(2009) Enrique Lallana et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective Labeling of Living Cells by a Photo-Triggered Click Reaction

(2009) Andrei A. Poloukhtine et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sequential click reactions for synthesizing and patterning three-dimensional cell microenvironments

(2009) Cole A. DeForest et al.   NATURE MATERIALS

Small molecule induced control in duplex and triplex DNA-directed chemical reactions

(2009) Mikkel F. Jacobsen et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

N-PEG’ylation of chitosan via “click chemistry” reactions

(2009) Ruta Kulbokaite et al.   REACTIVE & FUNCTIONAL POLYMERS

Copper-Free Azide–Alkyne Cycloadditions: New Insights and Perspectives

(2008) Jean-François Lutz   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visualizing Metabolically Labeled Glycoconjugates of Living Cells by Copper-Free and Fast Huisgen Cycloadditions

(2008) Xinghai Ning et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Postsynthetic DNA Modification through the Copper-Catalyzed Azide-Alkyne Cycloaddition Reaction

(2008) Philipp M. E. Gramlich et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dual Labeling of Biomolecules by Using Click Chemistry: A Sequential Approach

(2008) Péter Kele et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A β-Cyclodextrin “Click Cluster” Decorated with Seven Paramagnetic Chelates Containing Two Water Exchange Sites

(2008) Joshua M. Bryson et al.   BIOCONJUGATE CHEMISTRY

Site-Specific Modification ofCandida antarcticaLipase B via Residue-Specific Incorporation of a Non-Canonical Amino Acid

(2008) Sanne Schoffelen et al.   BIOCONJUGATE CHEMISTRY

Versatile supramolecular pDNA vehicles via “click polymerization” of β-cyclodextrin with oligoethyleneamines

(2008) Sathya Srinivasachari et al.   BIOMATERIALS

Cu-free cycloaddition for identifying catalytic active adenylation domains of nonribosomal peptide synthetases by phage display

(2008) Yekui Zou et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Electrochemically Protected Copper(I)-Catalyzed Azide-Alkyne Cycloaddition

(2008) Vu Hong et al.   CHEMBIOCHEM

Rapid and Efficient DNA Strand Cross-Linking by Click Chemistry

(2008) Petr Kočalka et al.   CHEMBIOCHEM

Copper-free click chemistry for the in situ crosslinking of photodegradable star polymers

(2008) Jeremiah A. Johnson et al.   CHEMICAL COMMUNICATIONS

Cu-Catalyzed Azide−Alkyne Cycloaddition

(2008) Morten Meldal et al.   CHEMICAL REVIEWS

Synthesis, Serum Stability and Cell Uptake of Cyclic and Hairpin Decoy Oligonucleotides for TCF/LEF and GLI Transcription Factors

(2008) Afaf H. El-Sagheer et al.   International Journal of Peptide Research and Therapeutics

EdU, a new thymidine analogue for labelling proliferating cells in the nervous system

(2008) Fatemah Chehrehasa et al.   JOURNAL OF NEUROSCIENCE METHODS

Synthesis of Multimeric MR Contrast Agents for Cellular Imaging

(2008) Ying Song et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Second-Generation Difluorinated Cyclooctynes for Copper-Free Click Chemistry

(2008) Julian A. Codelli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct In-Gel Fluorescence Detection and Cellular Imaging ofO-GlcNAc-Modified Proteins

(2008) Peter M. Clark et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Degradable Multilayer Films and Hollow Capsules via a ‘Click’ Strategy

(2008) Bruno G. De Geest et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Polymer “Clicking” by CuAAC Reactions

(2008) Morten Meldal   MACROMOLECULAR RAPID COMMUNICATIONS

In Vivo Imaging of Membrane-Associated Glycans in Developing Zebrafish

(2008) S. T. Laughlin et al.   SCIENCE

Click chemistry as a means to functionalize macroporous PolyHIPE

(2008) David Cummins et al.   Soft Matter

A Very Stable Cyclic DNA Miniduplex with Just Two Base Pairs

(2007) Afaf H. El-Sagheer et al.   CHEMBIOCHEM

Biodegradable microcapsules designed via ‘click’ chemistry

(2007) Bruno G. De Geest et al.   CHEMICAL COMMUNICATIONS

Chain-like assembly of gold nanoparticles on artificial DNA templates via ‘click chemistry’

(2007) Monika Fischler et al.   CHEMICAL COMMUNICATIONS

New Strategies for Cyclization and Bicyclization of Oligonucleotides by Click Chemistry Assisted by Microwaves

(2007) Jory Lietard et al.   JOURNAL OF ORGANIC CHEMISTRY