Article
Neurosciences
Dan Li, Yangnan Hu, Hao Wei, Wei Chen, Yun Liu, Xiaoqian Yan, Lingna Guo, Menghui Liao, Bo Chen, Renjie Chai, Mingliang Tang
Summary: SPIOs have good biocompatibility and adhesion, and can promote NSC proliferation in the presence of static magnetic field, which is of significant importance for tissue engineering and regenerative medicine.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Xiaojiang Liu, Yiqiu Cui, Jun Li, Cheng Guan, Shu Cai, Jinrong Ding, Jianhong Shen, Yixiang Guan
Summary: PTEN inhibitor bpv(pic) promotes the proliferation and differentiation of NSCs into neurons by regulating the expression and phosphorylation of the Akt/mTOR signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell & Tissue Engineering
Filipa F. Ribeiro, Filipa Ferreira, Rui S. Rodrigues, Rita Soares, Diogo M. Pedro, Marta Duarte-Samartinho, Rita I. Aroeira, Elisabete Ferreiro, Jorge Valero, Susana Sola, Helena Mira, Ana M. Sebastiao, Sara Xapelli
Summary: The activation of A(2A) receptors promotes neural stem cell self-renewal, protects committed neuronal cells from cell death, and increases the density of immature and mature neuronal cells. Furthermore, the endogenous activation of A(2A) receptors is essential for BDNF-mediated cell proliferation and neuronal differentiation.
Article
Cell Biology
Liang Li, Yue Sun, Alexander E. Davis, Sahil H. Shah, Lobna K. Hamed, Man-Ru Wu, Cheng-Hui Lin, Jun B. Ding, Sui Wang
Summary: Neural progenitor cells lengthen their cell cycle to prepare for differentiation, but it is unclear how they avoid being halted in the cell cycle. Our study shows that N6-methyladenosine (m6A) methylation of cell-cycle-related mRNAs ensures proper cell-cycle progression of late-born retinal progenitor cells. Conditional deletion of Mettl14, required for depositing m6A, delays cell-cycle exit of late-born RPCs, while having no effect on retinal development prior to birth. m6A methylation targets mRNAs involved in elongating the cell cycle for degradation and guarantees proper cell-cycle progression. Additionally, Zfp292 is identified as an m6A target and a potent inhibitor of RPC cell-cycle progression.
Article
Medicine, Research & Experimental
Lingxiao Huang, Zhenni Xu, Xudan Lei, Yujun Huang, Siyu Tu, Lu Xu, Jieying Xia, Dengqun Liu
Summary: This study reveals the important role of inducible nitric oxide synthase (iNOS) in the intestinal crypts and its effects on intestinal stem cell (ISC) proliferation and differentiation. iNOS deficiency leads to morphological changes in the intestine and alters gluconeogenesis and the adaptive immune response. These findings highlight the potential of iNOS as a therapeutic target for intestinal disorders.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Ana Sofia Rocha, Alejandro Collado-Sole, Osvaldo Grana-Castro, Jaime Redondo-Pedraza, Gonzalo Soria-Alcaide, Alex Cordero, Patricia G. Santamaria, Eva Gonzalez-Suarez
Summary: The Rank signaling pathway plays a crucial role in mammary gland homeostasis and epithelial cell differentiation. Loss of luminal Rank leads to abnormal alveolar differentiation and lactation failure, which can be restored by activating bipotency in basal cells during subsequent pregnancies.
NATURE COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Hau Jun Chan, Yanshree, Jaydeep Roy, George Lim Tipoe, Man-Lung Fung, Lee Wei Lim
Summary: Preclinical studies have shown the potential therapeutic effects of stem cell therapy in Alzheimer's disease, but issues like rejection, tumorigenicity, and ethical concerns remain as barriers to its advancement.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Shao-Qi Zhang, Qiao Deng, Qi Zhu, Zhuang-Li Hu, Li-Hong Long, Peng-Fei Wu, Jin-Gang He, Hong-Sheng Chen, Zhenyu Yue, Jia-Hong Lu, Fang Wang, Jian-Guo Chen
Summary: This study reveals the important role of dysfunctional autophagy in the pathogenesis of major depressive disorder (MDD). The expression of NRBF2 is attenuated in the dentate gyrus (DG) under chronic stress and its deficiency impairs autophagic flux in adult neural stem cells (aNSCs). Loss of NRBF2 disrupts the neurogenesis-related protein network and leads to the depression-like phenotype, while overexpressing NRBF2 rescues impaired adult hippocampal neurogenesis (AHN) and depression-like phenotype in mice.
Article
Integrative & Complementary Medicine
Lin Kai-li, Zhang Ji, Chung Hau-lam, Wu Xin-yi, Liu Bin, Zhao Bo-xin, Stephen Cho-wing Sze, Zhou Ping-zheng, Yung Ken Kin-lam, Zhang Shi-qing
Summary: The study found that total ginsenosides extract can promote the proliferation and differentiation of neural stem cells (NSCs) by inactivating the GSK-3 beta pathway.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Review
Engineering, Biomedical
Jay R. K. Samal, Vignesh K. Rangasami, Sumanta Samanta, Oommen P. Varghese, Oommen P. Oommen
Summary: Studies have shown that culturing MSCs in a low oxygen environment can upregulate stem cell markers and promote cell proliferation in an undifferentiated state. However, there is ambiguity in the results due to differences in oxygen gradients and culture conditions among different studies. This progress report focuses on conflicting findings related to the application of hypoxic conditions for improving MSC proliferation or differentiation, aiming to decipher the factors influencing MSC characteristics under hypoxia.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Neurosciences
Ugomma C. Eze, Aparna Bhaduri, Maximilian Haeussler, Tomasz J. Nowakowski, Arnold R. Kriegstein
Summary: Through single-cell RNA sequencing, nine progenitor populations at the earliest stages of human brain development were identified, including a highly prevalent mesenchymal-like population that disappears once neurogenesis begins. Comparison with mouse progenitor populations revealed two clusters enriched in the early stages of human cortical development. Organoid systems displayed low fidelity to neuroepithelial and early radial glia cell types, but improved as neurogenesis progressed.
NATURE NEUROSCIENCE
(2021)
Article
Plant Sciences
Ruishuang Ma, Lucy Zhao, Yuming Zhao, Yue Li
Summary: This review summarizes and discusses the physiological impact of Puerarin on various stem cell populations, and provides new insights into the prevention and treatment of geriatric diseases.
Article
Engineering, Multidisciplinary
Jianlong He, Min Hao, Jiazhi Duan, He Xia, Weiran Li, Hao Xue, Shuhua Wang, Wei Liu, Dong Li, Yuanhua Sang, Hong Liu
Summary: Rapid differentiation of neural stem cells can be achieved through the endocytosis of one-dimensional HAp nanomaterials, showing great potential for therapy of neurodegenerative diseases.
COMPOSITES PART B-ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Lakshmi Kiran Chelluri, Yamuna Mohanram, Rashi Jain, Chandra Shekar Mallarpu, Meenakshi Ponnana, Deepak Kumar, Venkata Vamsi Krishna Venuganti, Ravindranath Kancherla, Rao VL. Papineni, Rheal Towner, Partha Ghosal
Summary: This study presents a scientific approach to fabricate a nanoprobe for labeling cardiac precursor cells, allowing for efficient tracking of their distribution in vivo via MRI. The results indicate high accumulation of the nanoprobe in cardiac muscles compared to liver and spleen, suggesting its potential benefits in treating heart failure.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Lu Liu, Juanyan Wu, Shuanghu Wang, Liu Kun, Junbin Gao, Bin Chen, Yicheng Ye, Fei Wang, Fei Tong, Jiamiao Jiang, Juanfeng Ou, Daniela A. Wilson, Yingfeng Tu, Fei Peng
Summary: The study presents a minimally invasive micromotor platform for precise navigation and targeting of neural stem cells, which can be directed to differentiate into specific neuron types by tuning ultrasound intensity. This platform has the potential to serve as a controllable wireless tool for bioelectronics and neuronal regenerative therapy.
Article
Endocrinology & Metabolism
Karl Schoknecht, Majed Kikhia, Coline L. Lemale, Agustin Liotta, Svetlana Lublinsky, Susanne Mueller, Philipp Boehm-Sturm, Alon Friedman, Jens P. Dreier
Summary: The study found that ketamine may help counteract the early progression of ischemic injury, reducing the onset of SDs, lesion volume, and neuronal injury.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Mateusz C. Ambrozkiewicz, Ekaterina Borisova, Manuela Schwark, Silvia Ripamonti, Theres Schaub, Alina Smorodchenko, A. Ioana Weber, Hong Jun Rhee, Bekir Altas, Ruestem Yilmaz, Susanne Mueller, Lars Piepkorn, Stephen T. Horan, Rachel Straussberg, Sami Zaqout, Olaf Jahn, Ekrem Dere, Marta Rosario, Philipp Boehm-Sturm, Guntram Borck, Katrin Willig, JeongSeop Rhee, Victor Tarabykin, Hiroshi Kawabe
Summary: Kaufman oculocerebrofacial syndrome (KOS) is a severe autosomal recessive disorder caused by biallelic mutations of UBE3B gene. Studies show that Ube3b regulates dendritic branching and spine density autonomously, with knockout leading to altered synaptic physiology and behavior in mice models. This work provides insights into the molecular pathologies underlying intellectual disability-like phenotypes.
MOLECULAR PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Philipp Boehm-Sturm, Susanne Mueller, Nancy Freitag, Sophia Borowski, Marco Foddis, Stefan P. Koch, Sebastian Temme, Ulrich Floegel, Sandra M. Blois
Summary: Placental hypoperfusion and hypoxia play key roles in fetal complications like growth restriction and preeclampsia. This study successfully established a technique for noninvasively characterizing placental oxygen levels in mouse models of preeclampsia using F-19 MRI. Results showed a decrease in oxygenation in knockout mice under low oxygen conditions, highlighting the potential of MRI in studying placental malfunction.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Rebecca Heinz, Susan Brandenburg, Melina Nieminen-Kelhae, Irina Kremenetskaia, Philipp Boehm-Sturm, Peter Vajkoczy, Ulf C. Schneider
Summary: Two interventions targeting microglia, inflammatory preconditioning and pharmacological deactivation, showed significant reductions in neuronal cell death in a murine SAH model. Both approaches also led to decreased microglia accumulation and activation, highlighting their potential as therapeutic strategies for secondary brain injury after SAH.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Neurosciences
Katharina Hecklau, Susanne Mueller, Stefan Paul Koch, Mustafa Hussain Mehkary, Busra Kilic, Christoph Harms, Philipp Boehm-Sturm, Ferah Yildirim
Summary: Selective inhibition of HDAC1 and HDAC3 by RGFP109 can alleviate transcriptional dysregulation of multiple genes, especially those associated with the insulin-like growth factor pathway, in Huntington's disease. Treatment with RGFP109 modestly improved motor skill learning and coordination deficits in R6/1 mice, without affecting their locomotor and anxiety-like phenotypes. Additionally, volumetric MRI revealed widespread brain atrophy in R6/1 mice at the symptomatic disease stage, which was not significantly affected by RGFP109.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Anna Kufner, Ahmed A. Khalil, Ivana Galinovic, Elias Kellner, Ralf Mekle, Torsten Rackoll, Philipp Boehm-Sturm, Jochen B. Fiebach, Agnes Floel, Martin Ebinger, Matthias Endres, Alexander H. Nave
Summary: This study found that MRI-based VSI can assess cerebral microvasculature and tissue perfusion in the subacute phases of ischemic stroke, and may have relevant prognostic value in terms of lesion volume and stroke severity.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Clinical Neurology
Gerard R. Hall, Philipp Boehm-Sturm, Ulrich Dirnagl, Carsten Finke, Marco Foddis, Christoph Harms, Stefan Paul Koch, Joseph Kuchling, Christopher R. Madan, Susanne Mueller, Celeste Sassi, Stamatios N. Sotiropoulos, Rebecca C. Trueman, Marcus D. Wallis, Ferah Yildirim, Tracy D. Farr
Summary: This study presents a pipeline for structural and functional connectivity analysis of the mouse brain and applies it to a mouse model of vascular dementia. The findings reveal brain lesions in the model and provide insights into the mouse connectome and how it is affected by vascular insufficiency.
Review
Medicine, General & Internal
Marietta Zille, Tracy D. Farr, Richard F. Keep, Christine Roemer, Guohua Xi, Johannes Boltze
Summary: Intracerebral haemorrhage (ICH) is a common type of stroke that contributes to mortality and disability globally. Despite progress in surgical interventions and acute ICH management, there is a lack of effective therapies to improve patient outcomes. Recent research has uncovered new pathophysiological mechanisms underlying ICH, but gaps in animal models hinder their application. This review emphasizes the importance of understanding ICH etiology, the role of the haematoma, inflammation, and post-ICH pathology, as well as the involvement of other cell types and organs in successful interventions.
Article
Cardiac & Cardiovascular Systems
Melanie T. C. Kuffner, Stefan P. Koch, Marieluise Kirchner, Susanne Mueller, Janet Lips, Jeehye An, Philipp Mertins, Ulrich Dirnagl, Matthias Endres, Philipp Boehm-Sturm, Christoph Harms, Christian J. Hoffmann
Summary: This study investigates the effects of paracrine IL-6 on cerebral remodeling in early stages after asymptomatic carotid artery occlusion, aiming to identify new treatment targets.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lina Anderhalten, Rafaela Silva, Anna Morr, Shuangqing Wang, Alina Smorodchenko, Jessica Saatz, Heike Traub, Susanne Mueller, Philipp Boehm-Sturm, Yasmina Rodriguez-Sillke, Desiree Kunkel, Julia Hahndorf, Friedemann Paul, Matthias Taupitz, Ingolf Sack, Carmen Infante-Duarte
Summary: Using a murine model of multiple sclerosis, this study compared the retention profiles and neurotoxicity of macrocyclic and linear gadolinium-based contrast agents (GBCAs) in inflamed and healthy brains. The results showed that macrocyclic GBCAs had lower retention in inflammatory brains, while linear GBCAs exhibited persistent retention, and gadopentetate dimeglumine showed neurotoxicity.
INVESTIGATIVE RADIOLOGY
(2022)
Article
Physiology
Laura Golusda, Anja A. Kuehl, Malte Lehmann, Katja Dahlke, Susanne Mueller, Philipp Boehm-Sturm, Jessica Saatz, Heike Traub, Joerg Schnorr, Christian Freise, Matthias Taupitz, Karina Biskup, Veronique Blanchard, Oliver Klein, Ingolf Sack, Britta Siegmund, Daniela Paclik
Summary: Inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), are characterized by chronic inflammation of the gastrointestinal tract. This study utilized very small superparamagnetic iron oxide nanoparticles (VSOPs) in magnetic resonance imaging (MRI) to detect intestinal inflammation in mouse models. The results suggest that VSOPs can serve as a potential contrast agent for early non-invasive diagnosis of IBD, depending on the hyaluronic acid content.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Anna S. Morr, Marcin Nowicki, Gergely Bertalan, Rafaela Vieira Silva, Carmen Infante Duarte, Stefan Paul Koch, Philipp Boehm-Sturm, Ute Kruegel, Juergen Braun, Barbara Steiner, Josef A. Kaes, Thomas Fuhs, Ingolf Sack
Summary: In this study, the microscopic mechanical properties of hippocampal subregions were investigated using atomic force microscopy (AFM) and magnetic resonance elastography (MRE). The results showed that areas with high neurogenic activity exhibit lower stiffness, indicating the sensitivity of macroscopic mechanical properties to microstructural changes in the hippocampus.
SCIENTIFIC REPORTS
(2022)
Editorial Material
Neurosciences
Jing Guo, Stefan Hetzer, Philipp Boehm-Sturm, Jens Wuerfel
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Alexander D. Bungert, Ruth M. Urbantat, Claudius Jelgersma, Biniam M. Bekele, Susanne Mueller, Annett Mueller, Matthaeus Felsenstein, Silke Dusatko, Anne Blank, Adnan Ghori, Philipp Boehm-Sturm, Stefan P. Koch, Peter Vajkoczy, Susan Brandenburg
Summary: This study investigates the impact of Ccr2 deficiency on microglia and macrophages, revealing the balance between these two cell populations in glioma tissue and identifying the involvement of the CCR2/CCL2 axis in the immunologic function of microglia and macrophages beyond migration.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2023)