Different Impact of Gadopentetate and Gadobutrol on Inflammation-Promoted Retention and Toxicity of Gadolinium Within the Mouse Brain

Speciation Analysis of Gadolinium in the Water-Insoluble Rat Brain Fraction After Administration of Gadolinium-Based Contrast Agents

(2021) Izabela Strzeminska et al.   INVESTIGATIVE RADIOLOGY

Reviewing the Significance of Blood–Brain Barrier Disruption in Multiple Sclerosis Pathology and Treatment

(2021) Rodica Balasa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2021 MAGNIMS–CMSC–NAIMS consensus recommendations on the use of MRI in patients with multiple sclerosis

(2021) Mike P Wattjes et al.   LANCET NEUROLOGY

Repeat and single dose administration of gadodiamide to rats to investigate concentration and location of gadolinium and the cell ultrastructure

(2021) Julie Davies et al.   Scientific Reports

Contribution of Tissue Inflammation and Blood-Brain Barrier Disruption to Brain Softening in a Mouse Model of Multiple Sclerosis

(2021) Rafaela Vieira Silva et al.   Frontiers in Neuroscience

Long-Term Evaluation of Gadolinium Retention in Rat Brain After Single Injection of a Clinically Relevant Dose of Gadolinium-Based Contrast Agents

(2020) Izabela Strzeminska et al.   INVESTIGATIVE RADIOLOGY

No Changes in T1 Relaxometry After a Mean of 11 Administrations of Gadobutrol

(2020) Katerina Deike-Hofmann et al.   INVESTIGATIVE RADIOLOGY

MR Elastography-Based Assessment of Matrix Remodeling at Lesion Sites Associated With Clinical Severity in a Model of Multiple Sclerosis

(2020) Shuangqing Wang et al.   Frontiers in Neurology

Choroid plexus and the blood–cerebrospinal fluid barrier in disease

(2020) Peter Solár et al.   Fluids and Barriers of the CNS

Toward Formal Analysis of Thermodynamic Stability: Le Chatelier—Brown Principle

(2020) Dmitry Gromov et al.   Entropy

Re-Examining the Role of TNF in MS Pathogenesis and Therapy

(2020) Diego Fresegna et al.   Cells

The Macrocyclic Gadolinium-Based Contrast Agents Gadobutrol and Gadoteridol Show Similar Elimination Kinetics From the Brain After Repeated Intravenous Injections in Rabbits

(2020) Thomas Frenzel et al.   INVESTIGATIVE RADIOLOGY

Comprehensive phenotyping revealed transient startle response reduction and histopathological gadolinium localization to perineuronal nets after gadodiamide administration in rats

(2020) Johanna Habermeyer et al.   Scientific Reports

MRI features suggestive of gadolinium retention do not correlate with Expanded Disability Status Scale worsening in Multiple Sclerosis

(2019) Sirio Cocozza et al.   NEURORADIOLOGY

Increased Retention of Gadolinium in the Inflamed Brain After Repeated Administration of Gadopentetate Dimeglumine

(2019) Shuangqing Wang et al.   INVESTIGATIVE RADIOLOGY

Gadolinium-Based MRI Contrast Agents Induce Mitochondrial Toxicity and Cell Death in Human Neurons, and Toxicity Increases With Reduced Kinetic Stability of the Agent

(2019) Danielle V. Bower et al.   INVESTIGATIVE RADIOLOGY

Gadolinium Retention in the Brain: An MRI Relaxometry Study of Linear and Macrocyclic Gadolinium-Based Contrast Agents in Multiple Sclerosis

(2019) Y. Forslin et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Gadolinium Deposition in the Brain in a Large Animal Model

(2019) Alexander Radbruch et al.   INVESTIGATIVE RADIOLOGY

Gadolinium Retention in Erythrocytes and Leukocytes From Human and Murine Blood Upon Treatment With Gadolinium-Based Contrast Agents for Magnetic Resonance Imaging

(2019) Enza Di Gregorio et al.   INVESTIGATIVE RADIOLOGY

Effect of Long-Term Retention of Gadolinium on Metabolism of Deep Cerebellar Nuclei After Repeated Injections of Gadodiamide in Rats

(2019) Dounia El Hamrani et al.   INVESTIGATIVE RADIOLOGY

Gadolinium-based contrast agents induce gadolinium deposits in cerebral vessel walls, while the neuropil is not affected: an autopsy study

(2018) Stefanie Fingerhut et al.   ACTA NEUROPATHOLOGICA

Gadolinium Retention, Brain T1 Hyperintensity, and Endogenous Metals

(2018) Marlène Rasschaert et al.   INVESTIGATIVE RADIOLOGY

Multimodal Imaging Study of Gadolinium Presence in Rat Cerebellum

(2018) Marlène Rasschaert et al.   INVESTIGATIVE RADIOLOGY

Effective Utilization of MRI in the Diagnosis and Management of Multiple Sclerosis

(2018) Antonio Giorgio et al.   NEUROLOGIC CLINICS

Accumulation of Gadolinium in Human Cerebrospinal Fluid after Gadobutrol-enhanced MR Imaging: A Prospective Observational Cohort Study

(2018) Avinash K. Nehra et al.   RADIOLOGY

One-year Retention of Gadolinium in the Brain: Comparison of Gadodiamide and Gadoterate Meglumine in a Rodent Model

(2018) Philippe Robert et al.   RADIOLOGY

Gadolinium-based Contrast Media, Cerebrospinal Fluid and the Glymphatic System: Possible Mechanisms for the Deposition of Gadolinium in the Brain

(2018) Toshiaki Taoka et al.   Magnetic Resonance in Medical Sciences

Dechelation (Transmetalation)

(2018) Val M. Runge   INVESTIGATIVE RADIOLOGY

Long-term Excretion of Gadolinium-based Contrast Agents: Linear versus Macrocyclic Agents in an Experimental Rat Model

(2018) Gregor Jost et al.   RADIOLOGY

Impact of Treatment With Chelating Agents Depends on the Stability of Administered GBCAs

(2018) Janina Boyken et al.   INVESTIGATIVE RADIOLOGY

The Emerging Role of Zinc in the Pathogenesis of Multiple Sclerosis

(2017) Bo Choi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intrathecal Contrast-Enhanced Magnetic Resonance Imaging–Related Brain Signal Changes

(2017) Ali Yusuf Öner et al.   INVESTIGATIVE RADIOLOGY

Histology and Gadolinium Distribution in the Rodent Brain After the Administration of Cumulative High Doses of Linear and Macrocyclic Gadolinium-Based Contrast Agents

(2017) Jessica Lohrke et al.   INVESTIGATIVE RADIOLOGY

Quantification and Assessment of the Chemical Form of Residual Gadolinium in the Brain After Repeated Administration of Gadolinium-Based Contrast Agents

(2017) Thomas Frenzel et al.   INVESTIGATIVE RADIOLOGY

Moderate Renal Failure Accentuates T1 Signal Enhancement in the Deep Cerebellar Nuclei of Gadodiamide-Treated Rats

(2017) Marlène Rasschaert et al.   INVESTIGATIVE RADIOLOGY

Atlas registration for edema-corrected MRI lesion volume in mouse stroke models

(2017) Stefan Koch et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Differences in gadolinium retention after repeated injections of macrocyclic MR contrast agents to rats

(2017) Simona Bussi et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Inflammation-induced brain endothelial activation leads to uptake of electrostatically stabilized iron oxide nanoparticles via sulfated glycosaminoglycans

(2017) Dominique Berndt et al.   Nanomedicine-Nanotechnology Biology and Medicine

Application of Europium-Doped Very Small Iron Oxide Nanoparticles to Visualize Neuroinflammation with MRI and Fluorescence Microscopy

(2017) Jason M. Millward et al.   NEUROSCIENCE

Gadolinium Retention in the Rat Brain: Assessment of the Amounts of Insoluble Gadolinium-containing Species and Intact Gadolinium Complexes after Repeated Administration of Gadolinium-based Contrast Agents

(2017) Eliana Gianolio et al.   RADIOLOGY

Clearance of Gadolinium from the Brain with No Pathologic Effect after Repeated Administration of Gadodiamide in Healthy Rats: An Analytical and Histologic Study

(2017) Adrian P. L. Smith et al.   RADIOLOGY

Comparison of Gadolinium Concentrations within Multiple Rat Organs after Intravenous Administration of Linear versus Macrocyclic Gadolinium Chelates

(2017) Robert J. McDonald et al.   RADIOLOGY

Gadolinium Deposition in Human Brain Tissues after Contrast-enhanced MR Imaging in Adult Patients without Intracranial Abnormalities

(2017) Robert J. McDonald et al.   RADIOLOGY

Signal Change in the Dentate Nucleus on T1-Weighted MR Images After Multiple Administrations of Gadopentetate Dimeglumine Versus Gadobutrol

(2016) Yan Cao et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Zinc in Multiple Sclerosis

(2016) Mikkel Bredholt et al.   ASN Neuro

Penetration and distribution of gadolinium-based contrast agents into the cerebrospinal fluid in healthy rats: a potential pathway of entry into the brain tissue

(2016) Gregor Jost et al.   EUROPEAN RADIOLOGY

Signal Increase on Unenhanced T1-Weighted Images in the Rat Brain After Repeated, Extended Doses of Gadolinium-Based Contrast Agents

(2016) Gregor Jost et al.   INVESTIGATIVE RADIOLOGY

Linear Gadolinium-Based Contrast Agents Are Associated With Brain Gadolinium Retention in Healthy Rats

(2016) Philippe Robert et al.   INVESTIGATIVE RADIOLOGY

Gadolinium tissue deposition in brain and bone

(2016) Nozomu Murata et al.   MAGNETIC RESONANCE IMAGING

Gadopentetate but not gadobutrol accumulates in the dentate nucleus of multiple sclerosis patients

(2016) Ludwig Schlemm et al.   Multiple Sclerosis Journal

Gadopentetate but not gadobutrol accumulates in the dentate nucleus of multiple sclerosis patients

(2016) Ludwig Schlemm et al.   Multiple Sclerosis Journal

Gadolinium-Based Contrast Agent Accumulation and Toxicity: An Update

(2015) J. Ramalho et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Gadodiamide and Dentate Nucleus T1 Hyperintensity in Patients With Meningioma Evaluated by Multiple Follow-Up Contrast-Enhanced Magnetic Resonance Examinations With No Systemic Interval Therapy

(2015) Carlo Cosimo Quattrocchi et al.   INVESTIGATIVE RADIOLOGY

Increased Signal Intensity in the Dentate Nucleus on Unenhanced T1-Weighted Images After Gadobenate Dimeglumine Administration

(2015) Lukas D. Weberling et al.   INVESTIGATIVE RADIOLOGY

T1-Weighted Hypersignal in the Deep Cerebellar Nuclei After Repeated Administrations of Gadolinium-Based Contrast Agents in Healthy Rats

(2015) Philippe Robert et al.   INVESTIGATIVE RADIOLOGY

High-Signal Intensity in the Dentate Nucleus and Globus Pallidus on Unenhanced T1-Weighted Images

(2015) Alexander Radbruch et al.   INVESTIGATIVE RADIOLOGY

High Signal Intensity in Globus Pallidus and Dentate Nucleus on Unenhanced T1-weighted MR Images: Evaluation of Two Linear Gadolinium-based Contrast Agents

(2015) Joana Ramalho et al.   RADIOLOGY

Gadolinium-based Contrast Agent Accumulates in the Brain Even in Subjects without Severe Renal Dysfunction: Evaluation of Autopsy Brain Specimens with Inductively Coupled Plasma Mass Spectroscopy

(2015) Tomonori Kanda et al.   RADIOLOGY

Intracranial Gadolinium Deposition after Contrast-enhanced MR Imaging

(2015) Robert J. McDonald et al.   RADIOLOGY

Progressive Increase of T1 Signal Intensity of the Dentate Nucleus on Unenhanced Magnetic Resonance Images Is Associated With Cumulative Doses of Intravenously Administered Gadodiamide in Patients With Normal Renal Function, Suggesting Dechelation

(2014) Yuri Errante et al.   INVESTIGATIVE RADIOLOGY

High Signal Intensity in the Dentate Nucleus and Globus Pallidus on Unenhanced T1-weighted MR Images: Relationship with Increasing Cumulative Dose of a Gadolinium-based Contrast Material

(2013) Tomonori Kanda et al.   RADIOLOGY

Speciation of Gd-based MRI contrast agents and potential products of transmetalation with iron ions or parenteral iron supplements

(2012) Lena Telgmann et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Gadolinium-containing magnetic resonance contrast media: investigation on the possible transchelation of Gd3+to the glycosaminoglycan heparin

(2012) Matthias Taupitz et al.   Contrast Media & Molecular Imaging

MRI contrast agents: Basic chemistry and safety

(2012) Dapeng Hao et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

A new approach for calibration of laser ablation inductively coupled plasma mass spectrometry using thin layers of spiked agarose gels as references

(2010) H.-J. Stärk et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Stability of Gadolinium-Based Magnetic Resonance Imaging Contrast Agents in Human Serum at 37°C

(2010) Thomas Frenzel et al.   INVESTIGATIVE RADIOLOGY

Gadolinium-induced oxidative stress triggers endoplasmic reticulum stress in rat cortical neurons

(2010) Qing Xia et al.   JOURNAL OF NEUROCHEMISTRY

Iron, Copper, and Zinc Distribution of the Cerebellum

(2009) Bogdan F. Gh. Popescu et al.   CEREBELLUM

Gadolinium-Induced Nephrogenic Systemic Fibrosis Is Associated with Insoluble Gd Deposits in Tissues:In VivoTransmetallation Confirmed by Microanalysis

(2009) Charu Thakral et al.   JOURNAL OF CUTANEOUS PATHOLOGY

Incorporation of excess gadolinium into human bone from medical contrast agents

(2009) Thomas H. Darrah et al.   Metallomics

Multiple Sclerosis: Hyperintense Dentate Nucleus on Unenhanced T1-weighted MR Images Is Associated with the Secondary Progressive Subtype

(2009) Luca Roccatagliata et al.   RADIOLOGY

Efficiency, thermodynamic and kinetic stability of marketed gadolinium chelates and their possible clinical consequences: a critical review

(2008) Marc Port et al.   BIOMETALS