Evolutionary history and metabolic insights of ancient mammalian uricases

Impulsivity is Associated with Uric Acid: Evidence from Humans and Mice

(2013) Angelina R. Sutin et al.   BIOLOGICAL PSYCHIATRY

Hyperstability and Substrate Promiscuity in Laboratory Resurrections of Precambrian β-Lactamases

(2013) Valeria A. Risso et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure-based characterization of canine–human chimeric uricases and its evolutionary implications

(2012) Chun Zhang et al.   BIOCHIMIE

Uricases as Therapeutic Agents to Treat Refractory Gout: Current States and Future Directions

(2012) Xiaolan Yang et al.   DRUG DEVELOPMENT RESEARCH

Uric Acid Induces Hepatic Steatosis by Generation of Mitochondrial Oxidative Stress

(2012) Miguel A. Lanaspa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Counteracting Roles of AMP Deaminase and AMP Kinase in the Development of Fatty Liver

(2012) Miguel A. Lanaspa et al.   PLoS One

Uric Acid: A Danger Signal From the RNA World That May Have a Role in the Epidemic of Obesity, Metabolic Syndrome, and Cardiorenal Disease: Evolutionary Considerations

(2011) Richard J. Johnson et al.   SEMINARS IN NEPHROLOGY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Evolutionary Fate of the Genes Encoding the Purine Catabolic Enzymes in Hominoids, Birds, and Reptiles

(2010) A. C. Keebaugh et al.   MOLECULAR BIOLOGY AND EVOLUTION

Robustness of Ancestral Sequence Reconstruction to Phylogenetic Uncertainty

(2010) Victor Hanson-Smith et al.   MOLECULAR BIOLOGY AND EVOLUTION

Treating gout with pegloticase, a PEGylated urate oxidase, provides insight into the importance of uric acid as an antioxidant in vivo

(2010) M. S. Hershfield et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of 2-Bromoethanamine on TonEBP Expression and Its Possible Role in Induction of Renal Papillary Necrosis in Mice

(2010) Ana Andres-Hernando et al.   TOXICOLOGICAL SCIENCES

Hypothesis: Could Excessive Fructose Intake and Uric Acid Cause Type 2 Diabetes?

(2009) Richard J. Johnson et al.   ENDOCRINE REVIEWS

ZAC1 Is Up-regulated by Hypertonicity and Decreases Sorbitol Dehydrogenase Expression, Allowing Accumulation of Sorbitol in Kidney Cells

(2009) Miguel A. Lanaspa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein structure prediction on the Web: a case study using the Phyre server

(2009) Lawrence A Kelley et al.   Nature Protocols

Structures ofArthrobacter globiformisurate oxidase–ligand complexes

(2008) Ella Czarina Magat Juan et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Lessons from comparative physiology: could uric acid represent a physiologic alarm signal gone awry in western society?

(2008) Richard J. Johnson et al.   JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY

The planetary biology of ascorbate and uric acid and their relationship with the epidemic of obesity and cardiovascular disease

(2008) Richard J. Johnson et al.   MEDICAL HYPOTHESES

Palaeotemperature trend for Precambrian life inferred from resurrected proteins

(2008) Eric A. Gaucher et al.   NATURE