Review
Immunology
Min Hu, Natasha M. Rogers, Jennifer Li, Geoff Y. Zhang, Yuan Min Wang, Karli Shaw, Philip J. O'Connell, Stephen Alexander
Summary: Tregs play a crucial role in kidney transplantation by limiting immune activation and potentially reducing the need for immunosuppression. Studies have shown their importance in improving allo-specific Treg function in both animal and human models.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Jason Cheung, Beata Zahorowska, Michael Suranyi, Jeffrey K. W. Wong, Jason Diep, Stephen T. T. Spicer, Nirupama D. D. Verma, Suzanne J. Hodgkinson, Bruce M. M. Hall
Summary: The immune response to an allograft can activate lymphocytes that cause rejection. The activation of T regulatory cells can reduce allograft rejection and induce immune tolerance. Activated T regulatory cells can be distinguished by various markers. A more detailed characterization of these cells may help reduce non-specific immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Severine Menoret, Laurent Tesson, Severine Remy, Victor Gourain, Celine Serazin, Claire Usal, Aude Guiffes, Vanessa Chenouard, Laure-Helene Ouisse, Malika Gantier, Jean-Marie Heslan, Cynthia Fourgeux, Jeremie Poschmann, Carole Guillonneau, Ignacio Anegon
Summary: In this study, a Foxp3-EGFP rat transgenic line was created to genetically tag CD4(+) and CD8(+) FOXP3(+) regulatory T cells. CD4(+)EGFP(+) Treg were found to be 5-10 times more frequent than CD8(+)EGFP(+) Treg. RNAseq analysis provided insights into the transcriptome of CD8(+) Treg, allowing for a better understanding of their phenotype and function.
Review
Immunology
Qi Jiang, Guocan Yang, Qi Liu, Shengjun Wang, Dawei Cui
Summary: Rheumatoid arthritis is a systemic and heterogeneous autoimmune disease characterized by symmetrical polyarthritis, with dysfunction of regulatory T (Treg) cells potentially contributing to the breakdown of self-tolerance. The ideal treatment strategy for RA should focus on re-inducing self-tolerance to prevent obvious tissue injury.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Yannick D. Muller, Leonardo M. R. Ferreira, Emilie Ronin, Patrick Ho, Vinh Nguyen, Gaetano Faleo, Yu Zhou, Karim Lee, Kevin L. Leung, Nikolaos Skartsis, Anupurna M. Kaul, Arend Mulder, Frans H. J. Claas, James A. Wells, Jeffrey A. Bluestone, Qizhi Tang
Summary: The study demonstrates that genome-engineered mono-antigen-specific A2-CAR Tregs can localize to HLA-A2-expressing grafts and exhibit antigen-dependent in vivo suppression. These Tregs do not impair the function of islets and can delay graft-versus-host disease. This approach may be applied towards developing precision Treg cell therapies for transplant tolerance.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Nina Pilat, Romy Steiner, Jonathan Sprent
Summary: The limited success of solid organ transplantation is influenced by the insufficiency of immunosuppressive regimens to control chronic rejection and late graft loss. However, regulatory T cells (Tregs) have shown potential in inducing allograft tolerance and prolonging graft survival. The first Treg-based clinical trials have yielded promising results, demonstrating the feasibility and safety of Treg therapy in organ transplantation. Nevertheless, there are still unresolved questions regarding Treg phenotype, dosage, antigen-specificity, adjunct immunosuppressants, and efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Ruoyu Li, Hui Li, Xiaoyan Yang, Huiru Hu, Peidong Liu, Hongbo Liu
Summary: This review summarizes the interaction and protective mechanisms between dendritic cells (DCs) and regulatory T cells (Tregs) in multiple sclerosis (MS), explores their potential value in the treatment of MS, and proposes new therapeutic directions.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Christopher Tay, Atsushi Tanaka, Shimon Sakaguchi
Summary: Regulatory T cells (Tregs) in tumor tissues can be selectively targeted to enhance anti-tumor immune responses, while maintaining immune homeostasis in healthy organs. Current strategies such as immune checkpoint blockade (ICB) antibodies and differential targeting of surface and intracellular molecules show promise in this regard. Combining Treg targeting with ICB antibodies may enhance the efficacy of cancer immunotherapy.
Review
Cell Biology
Diaoyi Tan, Wei Yin, Fei Guan, Wanjiang Zeng, Pamela Lee, Fabio Candotti, Louisa K. James, Niels Olsen Saraiva Camara, S. M. Mansour Haeryfar, Yan Chen, Kamel Benlagha, Lewis Zhichang Shi, Jiahui Lei, Quan Gong, Zheng Liu, Chaohong Liu
Summary: In this article, the authors summarize the regulatory relationship between B cells and T cells, mainly focusing on T follicular regulatory cells and regulatory B cells. They introduce a new subset of regulatory T cells induced by B cells, and discuss the role of B cells in ensuring the survival of regulatory T cells. This review provides an updated overview of immunoregulatory networks and identifies potential targets for therapeutic interventions against cancer, autoimmune diseases, and allograft rejection.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Immunology
Guirong Liu, Manman Liu, Junjuan Wang, Yao Mou, Huilian Che
Summary: The increasing prevalence of food allergies has spurred research on novel treatment strategies like EPIT, which has shown potential in inducing immune tolerance. Treg cells play a key role in immune tolerance induced by EPIT but further exploration is needed to understand its mechanism.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Payal Grover, Peeyush N. Goel, Mark I. Greene
Summary: T regulatory cells employ various immunosuppressive mechanisms to limit immune responses, including secretion of cytokines, cell cytolysis, metabolic perturbation, guiding antigen-presenting cell function, etc.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Kumar Abhishek, Malavika Nidhi, Srinandhini Chandran, Sergey S. Shevkoplyas, Chandra Mohan
Summary: Regulatory T cells (Tregs) are a type of lymphocyte that regulate the immune system by suppressing unwanted immune responses, preventing autoimmune diseases and inappropriate inflammatory reactions. They have shown promise in preventing graft vs. host disease, alleviating autoimmune symptoms, and promoting transplant tolerance. This review provides an overview of Treg cells, including important markers and subsets, as well as the methodology used for manufacturing adoptive regulatory T cell therapies (TRACT). The approaches and outcomes of several clinical trials involving adoptive transfer of Tregs to patients are also discussed.
CLINICAL IMMUNOLOGY
(2023)
Review
Cell Biology
Jianhui Wu, Bowen Ren, Daochao Wang, Hui Lin
Summary: This review discusses the role and mechanisms of regulatory T cells (Tregs) in skeletal muscle repair and regeneration, as well as new strategies for Treg immunotherapy in skeletal muscle diseases.
CELL DEATH & DISEASE
(2022)
Article
Immunology
Xiaopei Cui, Chun-Guang Li, Haiqing Gao, Mei Cheng, Fan Jiang
Summary: Regulatory T cells (Tregs) play critical roles in immune balance and anti-inflammatory responses. Recent studies have shown that CX-5461 can promote Treg differentiation and prevent allogeneic acute rejection through a unique molecular mechanism. These findings suggest a potential role of p53 in mediating Treg differentiation and regulating Treg function through various mechanisms. Pharmacological p53 activators may offer new possibilities for enhancing Treg-mediated immune tolerance.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Genetics & Heredity
Sabine Muth, Annekatrin Klaric, Markus Radsak, Hansjoerg Schild, Hans Christian Probst
Summary: Treg-expressed CD27 maintains DC tolerogenic in steady state and limits anti-tumor immunity; Ablation of Treg-expressed CD27 synergizes with PD-1 blockade to improve CTL-mediated tumor control.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Review
Nanoscience & Nanotechnology
Benedetta Ferrara, Sabrina Belbekhouche, Damien Habert, Claire Houppe, Benoit Vallee, Sandrine Bourgoin-Voillard, Jose L. Cohen, Ilaria Cascone, Jose Courty
Summary: Nanoparticles are being studied as a targeted delivery system for cancer treatment, with nucleolin identified as an interesting therapeutic target. Antagonists of nucleolin from various sources have shown promise as potential anti-cancer agents.
Article
Multidisciplinary Sciences
Emilie Ronin, Charlotte Pouchy, Maryam Khosravi, Morgane Hilaire, Sylvie Gregoire, Armanda Casrouge, Sahar Kassem, David Sleurs, Gaelle H. Martin, Noemie Chanson, Yannis Lombardi, Guilhem Lalle, Harald Wajant, Cedric Auffray, Bruno Lucas, Gilles Marodon, Yenkel Grinberg-Bleyer, Benoit L. Salomon
Summary: The study reveals that TNFR2-expressing Treg cells play a crucial role in suppressing autoimmune diseases in the central nervous system during peak disease, maintaining their functionality and sustained expression of suppressive genes. This late effect also provides insights into the treatment outcomes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Microbiology
Christophe Rodriguez, Nicolas de Prost, Slim Fourati, Claudie Lamoureux, Guillaume Gricourt, Melissa N'debi, Florence Canoui-Poitrine, Isaac Desveaux, Oriane Picard, Vanessa Demontant, Elisabeth Trawinski, Raphael Lepeule, Laure Surgers, William Vindrios, Jean-Daniel Lelievre, Nicolas Mongardon, Olivier Langeron, Jose L. Cohen, Armand Mekontso-Dessap, Paul-Louis Woerther, Jean-Michel Pawlotsky
Summary: This study utilized shotgun metagenomics and in-depth bioanalysis to investigate the role of viral genomics, microorganism metagenomics, and host transcriptomics in the severity of COVID-19. Severe COVID-19 pneumonia was associated with overexpression of cytokine transcripts activating the CXCR2 pathway, while patients with benign disease presented with a specific T cell profile and a lower mortality rate. Excess neutrophil infiltration leading to enhanced inflammatory response and prolonged tissue damage was identified as a key factor in the most severe cases of COVID-19. The study suggests that CXCR2 antagonists, especially IL-8 antagonists, could be promising candidates for treating severe COVID-19 patients.
Article
Endocrinology & Metabolism
Severine Olivier, Camille Pochard, Hanna Diounou, Vanessa Castillo, Jordane Divoux, Joshua Alcantara, Jocelyne Leclerc, Sandra Guilmeau, Camille Huet, Wafa Charifi, Thibault V. Varin, Noemie Daniel, Marc Foretz, Michel Neunlist, Benoit L. Salomon, Pradipta Ghosh, Andre Marette, Malvyne Rolli-Derkinderen, Benoit Viollet
Summary: Intestinal AMPK plays a significant role in maintaining the integrity of distal colon IEB, but its function in regulating glucose homeostasis is limited.
MOLECULAR METABOLISM
(2021)
Article
Acoustics
Linda Chami, Alain Giron, Malek Ezziane, Veronique Leblond, Frederic Charlotte, Claire Pellot-Barakat, Olivier Lucidarme
Summary: The study evaluated the diagnostic contribution of 2-D shear-wave elastography in managing superficial lymph nodes and found that SWE improved the sensitivity of LN diagnosis while decreasing its specificity, influenced by the location and histology type of the lymph nodes.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Eric Savier, Lorena Simon-Gracia, Frederic Charlotte, Pierre Tuffery, Tambet Teesalu, Olivier Scatton, Angelita Rebollo
Summary: The study demonstrated that bi-functional tumor-penetrating and interfering peptides are internalized in malignant hepatocytes, inducing apoptosis, while having no effect on non-malignant cells. The degree of peptide internalization correlated with receptor expression levels and tumor aggressiveness.
Article
Oncology
Audrey Moatti, Anais Debesset, Caroline Pilon, Asma Beldi-Ferchiou, Mathieu Leclerc, Rabah Redjoul, Frederic Charlotte, Nhu Hanh To, Adeline Bak, Yazid Belkacemi, Benoit Laurent Salomon, Fadi Issa, David Michonneau, Sebastien Maury, Jose Laurent Cohen, Allan Thiolat
Summary: This study reveals the potential of targeting TNFR2 to enhance anti-tumor responses and treat relapse of blood malignancies. The researchers also found that TNFR2 is over-expressed in Tregs from healthy donors and patients with leukemia relapse or GVHD. These findings provide new perspectives for the development of immunotherapies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Gastroenterology & Hepatology
Julien Calderaro, Luca Di Tommaso, Pascale Maille, Aurelie Beaufrere, Cong Trung Nguyen, Lara Heij, Viviane Gnemmi, Rondell P. Graham, Frederic Charlotte, Suzanne Chartier, Dominique Wendum, Mukul Vij, Daniela Allende, Alba Diaz, Carla Fuster, Benjamin Riviere, Astrid Herrero, Jeremy Augustin, Katja Evert, Diego Francesco Calvisi, Wei Qiang Leow, Howard Ho Wai Leung, Jan Bednarsch, Emmanuel Boleslawski, Mohamed Rela, Anthony Wing-Hung Chan, Alejandro Forner, Maria Reig, Anais Pujals, Loetitia Favre, Manon Allaire, Olivier Scatton, Arnaud Uguen, Eric Trepo, Lukas Otero Sanchez, Denis Chatelain, Myriam Remmelink, Camille Boulagnon-Rombi, Celine Bazille, Nathalie Sturm, Benjamin Menahem, Eric Frouin, David Tougeron, Christophe Tournigand, Emmanuelle Kempf, Haeryoung Kim, Massih Ningarhari, Sophie Michalak-Provost, Jakob Nikolas Kather, Annette S. H. Gouw, Purva Gopal, Raffaele Brustia, Eric Vibert, Kornelius Schulze, Darius F. Ruther, Soren A. Weidemann, Rami Rhaiem, Jean-Charles Nault, Alexis Laurent, Giuliana Amaddeo, Helene Regnault, Eleonora de Martin, Christine Sempoux, Pooja Navale, Jayendra Shinde, Ketan Bacchuwar, Maria Westerhoff, Regina Cheuk-Lam Lo, Mylene Sebbagh, Catherine Guettier, Marie Lequoy, Mina Komuta, Marianne Ziol, Valerie Paradis, Jeanne Shen, Stefano Caruso
Summary: Nestin protein is a valuable biomarker for diagnosis and prognosis assessment in cHCC-CCA. It can distinguish cHCC-CCA from HCC and has high prognostic value. Nestin immunohistochemistry may be used to refine risk stratification and improve treatment allocation for patients with this highly aggressive malignancy.
JOURNAL OF HEPATOLOGY
(2022)
Editorial Material
Multidisciplinary Sciences
Benoit L. Salomon
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Matteo Ponzo, Anais Debesset, Melissande Cossutta, Mounira Chalabi-Dchar, Claire Houppe, Caroline Pilon, Alba Nicolas-Boluda, Sylvain Meunier, Fabio Raineri, Allan Thiolat, Remy Nicolle, Federica Maione, Serena Brundu, Carina Florina Cojocaru, Philippe Bouvet, Corinne Bousquet, Florence Gazeau, Christophe Tournigand, Jose Courty, Enrico Giraudo, Jose L. Cohen, Ilaria Cascone
Summary: This study explores the effects of a selective inhibitor of nucleolin (NCL) on the immune microenvironment of pancreatic ductal adenocarcinoma (PDAC), and highlights a new therapeutic strategy to restrain immunosuppressive cells, promote T-cell recruitment and activation, and re-program the tumor stroma of PDAC.
Article
Cardiac & Cardiovascular Systems
Levi-Dan Azoulay, Marine Bravetti, Fleur Cohen-Aubart, Jean-Francois Emile, Danielle Seilhean, Isabelle Plu, Frederic Charlotte, Xavier Waintraub, Fabrice Carrat, Zahir Amoura, Philippe Cluzel, Julien Haroche
Summary: This study investigated the prevalence and clinical features of cardiac involvement in Erdheim-Chester disease (ECD). It found that nearly half of the patients had cardiac involvement, which was associated with BRAFV600E mutation and complications (pericarditis, cardiac tamponade, and conduction disorders), but not with lower survival.
EUROPEAN HEART JOURNAL
(2023)
Letter
Oncology
Marine Armand, Michael Degaud, Bruno Tesson, Cecile Laurent, Manon Vavasseur, Melanie Parisot, Benedicte Hoareau-Coudert, Danielle Canioni, Jean Marie Michot, Frederic Charlotte, Veronique Meignin, Camille Laurent, Alexandra Traverse-Glehen, Diane Damotte, Emmanuel Bachy, Caroline Besson, Olivier Hermine, Frederic Davi, Lucile Couronne
Letter
Hematology
Levi-Dan Azoulay, Marine Bravetti, Fleur Cohen-Aubart, Jean-Francois Emile, Frederic Charlotte, Zahir Amoura, Philippe Cluzel, Julien Haroche
Article
Gastroenterology & Hepatology
Fleur Cohen-Aubart, Irena Ungureanu, Jerome Razanamahery, Frederic Charlotte, Severine Valmary-Degano, Zofia Helias-Rodzewicz, Dominique Cazals-Hatem, Peggy Dartigues, Manuela Delage-Corre, Janick Selves, Patrick Tas, Sebastien Humbert, Alexandre Malakhia, Merja Kunnamo, Liana Veresezan, Chrystalla Prokopiou, Andreas Seeber, Abdellatif Tazi, Jean Donadieu, Olivier Lucidarme, Julien Haroche, Jean-Francois Emile
Summary: Mesenteric or peritoneal tumors can present difficulties in diagnosis, especially when histiocytosis is involved. Biopsies infiltrated by histiocytes can mimic other conditions, such as inflammation or mesenteric sclerosis. Mutations in BRAF or MAP2K1 genes are important diagnostic markers for histiocytosis.
BMJ OPEN GASTROENTEROLOGY
(2021)