Genetics in Endocrinology: Autosomal dominant osteopetrosis revisited: lessons from recent studies

Effects of antiresorptive therapies on glucose metabolism: Results from the FIT, HORIZON-PFT, and FREEDOM trials

(2013) Ann V Schwartz et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Bone Density, Turnover, and Estimated Strength in Postmenopausal Women Treated With Odanacatib: A Randomized Trial

(2013) Kim Brixen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A specific subtype of osteoclasts secretes factors inducing nodule formation by osteoblasts

(2012) Kim Henriksen et al.   BONE

Disruption of the V-ATPase Functionality as a Way to Uncouple Bone Formation and Resorption - A Novel Target for Treatment of Osteoporosis

(2012) C. S. Thudium et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Cross-talk between Insulin and Wnt Signaling in Preadipocytes

(2012) Jane Palsgaard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osteopetrosis rescue upon RANKL administration toRankl−/−mice: A new therapy for human RANKL-dependent ARO

(2012) Nadia Lo Iacono et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Incidence, risk factors, and outcomes of osteonecrosis of the jaw: integrated analysis from three blinded active-controlled phase III trials in cancer patients with bone metastases

(2011) F. Saad et al.   ANNALS OF ONCOLOGY

Identification of the first deletion in the LRP5 gene in a patient with Autosomal Dominant Osteopetrosis type I

(2011) Alessandra Pangrazio et al.   BONE

High-bone-mass-producing mutations in the Wnt signaling pathway result in distinct skeletal phenotypes

(2011) Paul J. Niziolek et al.   BONE

Bisphosphonates for postmenopausal osteoporosis

(2011) Richard Eastell et al.   BONE

Safety of bisphosphonates

(2011) Michael Pazianas et al.   BONE

Serum concentrations of osteocalcin, procollagen type 1 N-terminal propeptide and beta-CrossLaps in obese subjects with varying degrees of glucose tolerance

(2011) P. Iglesias et al.   CLINICAL ENDOCRINOLOGY

ClC-7 is a slowly voltage-gated 2Cl−/1H+-exchanger and requires Ostm1 for transport activity

(2011) Lilia Leisle et al.   EMBO JOURNAL

Osteoclast Activity and Subtypes as a Function of Physiology and Pathology—Implications for Future Treatments of Osteoporosis

(2011) K. Henriksen et al.   ENDOCRINE REVIEWS

Update on Wnt signaling in bone cell biology and bone disease

(2011) David G. Monroe et al.   GENE

Levels of serotonin, sclerostin, bone turnover markers as well as bone density and microarchitecture in patients with high-bone-mass phenotype due to a mutation in Lrp5

(2011) Morten Frost et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Five years of denosumab exposure in women with postmenopausal osteoporosis: Results from the first two years of the FREEDOM extension

(2011) Socrates Papapoulos et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Change in Undercarboxylated Osteocalcin Is Associated with Changes in Body Weight, Fat Mass, and Adiponectin: Parathyroid Hormone (1-84) or Alendronate Therapy in Postmenopausal Women with Osteoporosis (the PaTH Study)

(2011) Anne L. Schafer et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A Rate-Limiting Role for Dickkopf-1 in Bone Formation and the Remediation of Bone Loss in Mouse and Primate Models of Postmenopausal Osteoporosis by an Experimental Therapeutic Antibody

(2011) H. Glantschnig et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Denosumab and bone-metastasis-free survival in men with castration-resistant prostate cancer: results of a phase 3, randomised, placebo-controlled trial

(2011) Matthew R Smith et al.   LANCET

Lrp5 functions in bone to regulate bone mass

(2011) Yajun Cui et al.   NATURE MEDICINE

Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis

(2011) B.Y. Chan et al.   OSTEOARTHRITIS AND CARTILAGE

Circulating osteocalcin level is associated with improved glucose tolerance, insulin secretion and sensitivity independent of the plasma adiponectin level

(2011) Y.-C. Hwang et al.   OSTEOPOROSIS INTERNATIONAL

‘Sink or swim’: an evaluation of the clinical characteristics of individuals with high bone mass

(2011) C. L. Gregson et al.   OSTEOPOROSIS INTERNATIONAL

Dissociation of Bone Resorption and Bone Formation in Adult Mice with a Non-Functional V-ATPase in Osteoclasts Leads to Increased Bone Strength

(2011) Kim Henriksen et al.   PLoS One

Wnt Antagonists Bind through a Short Peptide to the First β-Propeller Domain of LRP5/6

(2011) Eric Bourhis et al.   STRUCTURE

Glucocorticoid-induced bone fragility

(2010) Nancy E. Lane et al.   Annals of the New York Academy of Sciences

Calcitonin impairs the anabolic effect of PTH in young rats and stimulates expression of sclerostin by osteocytes

(2010) J.H. Gooi et al.   BONE

Low-density lipoprotein receptor-related protein 5 (LRP5) variation in fracture prone children

(2010) Anne Saarinen et al.   BONE

Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition

(2010) Keertik Fulzele et al.   CELL

Insulin Signaling in Osteoblasts Integrates Bone Remodeling and Energy Metabolism

(2010) Mathieu Ferron et al.   CELL

Potential Involvement of Twist2 and Erk in the Regulation of Osteoblastogenesis by HB-EGF-EGFR Signaling

(2010) Takashi Nakamura et al.   CELL STRUCTURE AND FUNCTION

Sclerosteosis - An autosomal recessive disorder

(2010) Peter Beighton et al.   CLINICAL GENETICS

Osteopetrosis

(2010) Jens Bollerslev   CLINICAL GENETICS

Two novel WTX mutations underscore the unpredictability of male survival in osteopathia striata with cranial sclerosis

(2010) B Perdu et al.   CLINICAL GENETICS

Severe developmental bone phenotype in ClC-7 deficient mice

(2010) A.V. Neutzsky-Wulff et al.   DEVELOPMENTAL BIOLOGY

Reduced serum total osteocalcin is associated with metabolic syndrome in older men via waist circumference, hyperglycemia, and triglyceride levels

(2010) Bu B Yeap et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Wnt receptors, bone mass, and fractures: gene-wide association analysis of LRP5 and LRP6 polymorphisms with replication

(2010) José A Riancho et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Sclerostin monoclonal antibody therapy with AMG 785: a potential treatment for osteoporosis

(2010) E Michael Lewiecki   EXPERT OPINION ON BIOLOGICAL THERAPY

Generation and Selection of Novel Fully Human Monoclonal Antibodies That Neutralize Dickkopf-1 (DKK1) Inhibitory Functionin Vitroand Increase Bone Massin Vivo

(2010) Helmut Glantschnig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elevated serum lactate dehydrogenase isoenzymes and aspartate transaminase distinguish Albers-Schönberg disease (Chloride Channel 7 Deficiency Osteopetrosis) among the sclerosing bone disorders

(2010) Michael P Whyte et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Patients with high-bone-mass phenotype owing to Lrp5-T253I mutation have low plasma levels of serotonin

(2010) Morten Frost et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Sclerostin and the regulation of bone formation: Effects in hip osteoarthritis and femoral neck fracture

(2010) Jon Power et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Inhibition of sclerostin by monoclonal antibody increases bone formation, bone mass, and bone strength in aged male rats

(2010) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody

(2010) Desmond Padhi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Odanacatib in the treatment of postmenopausal women with low bone mineral density: Three-year continued therapy and resolution of effect

(2010) John A Eisman et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Increased Sclerostin Serum Levels Associated with Bone Formation and Resorption Markers in Patients with Immobilization-Induced Bone Loss

(2010) Agostino Gaudio et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Characterization of the bone phenotype and fracture repair in osteopetrotic Incisors absent rats

(2010) Michelle M. McDonald et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Osteocyte Wnt/ -Catenin Signaling Is Required for Normal Bone Homeostasis

(2010) I. Kramer et al.   MOLECULAR AND CELLULAR BIOLOGY

Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis

(2010) Vijay K Yadav et al.   NATURE MEDICINE

Hematopoietic Stem Cell Transplantation for Osteopetrosis

(2010) Colin G. Steward   PEDIATRIC CLINICS OF NORTH AMERICA

The G215R Mutation in the Cl−/H+-Antiporter ClC-7 Found in ADO II Osteopetrosis Does Not Abolish Function but Causes a Severe Trafficking Defect

(2010) Patrick Schulz et al.   PLoS One

γ-Carboxylation of osteocalcin and insulin resistance in older men and women

(2009) M Kyla Shea et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Local communication on and within bone controls bone remodeling

(2009) Kim Henriksen et al.   BONE

Osteocalcin Is Related to Enhanced Insulin Secretion in Gestational Diabetes Mellitus

(2009) Y. Winhofer et al.   DIABETES CARE

Safety and Tolerability of Pioglitazone in High-Risk Patients with Type 2 Diabetes

(2009) John Dormandy et al.   DRUG SAFETY

Molecular and clinical heterogeneity in CLCN7-dependent osteopetrosis: report of 20 novel mutations

(2009) Alessandra Pangrazio et al.   HUMAN MUTATION

Effects of aging on human skeletal muscle after immobilization and retraining

(2009) C. Suetta et al.   JOURNAL OF APPLIED PHYSIOLOGY

Transforming Growth Factor-β1 (TGF-β1) Induces Human Osteoclast Apoptosis by Up-regulating Bim

(2009) Nicolas Houde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wnt signaling in bone metabolism

(2009) Takuo Kubota et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Osteopathia striata with cranial sclerosis owing to WTX gene defect

(2009) Bram Perdu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Associations between Body Composition, Circulating Interleukin-1 Receptor Antagonist, Osteocalcin, and Insulin Metabolism in Active Acromegaly

(2009) Thor Ueland et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Human Osteoclast-Poor Osteopetrosis with Hypogammaglobulinemia due to TNFRSF11A (RANK) Mutations

(2008) Matteo M. Guerrini et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Wnt signaling: A win for bone

(2008) Elke Piters et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Osteoclasts secrete non-bone derived signals that induce bone formation

(2008) Morten A. Karsdal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterization of acid flux in osteoclasts from patients harboring a G215R mutation in ClC-7

(2008) Kim Henriksen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Osteocytes, mechanosensing and Wnt signaling

(2008) Lynda F. Bonewald et al.   BONE

Bone density, strength, and formation in adult cathepsin K (−/−) mice

(2008) B. Pennypacker et al.   BONE

Characterization of the Bone Phenotype in ClC-7-Deficient Mice

(2008) Anita Vibsig Neutzsky-Wulff et al.   CALCIFIED TISSUE INTERNATIONAL

The Binding Between Sclerostin and LRP5 is Altered by DKK1 and by High-Bone Mass LRP5 Mutations

(2008) Wendy Balemans et al.   CALCIFIED TISSUE INTERNATIONAL

Lrp5 Controls Bone Formation by Inhibiting Serotonin Synthesis in the Duodenum

(2008) Vijay K. Yadav et al.   CELL

Relationship between osteocalcin and glucose metabolism in postmenopausal women

(2008) Jee-Aee Im et al.   CLINICA CHIMICA ACTA

Effect of Exogenous Intermittent Recombinant Human PTH 1–34 Administration and Chronic Endogenous Parathyroid Hormone Excess on Glucose Homeostasis and Insulin Sensitivity

(2008) A. Anastasilakis et al.   HORMONE AND METABOLIC RESEARCH

Advances in osteoclast biology resulting from the study of osteopetrotic mutations

(2008) T. Segovia-Silvestre et al.   HUMAN GENETICS

Large-Scale Analysis of Association Between LRP5 and LRP6 Variants and Osteoporosis

(2008) Joyce B. J. van Meurs   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Sclerostin Antibody Treatment Increases Bone Formation, Bone Mass, and Bone Strength in a Rat Model of Postmenopausal Osteoporosis*

(2008) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Association between Serum Osteocalcin and Markers of Metabolic Phenotype

(2008) Anastassios G. Pittas et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Relationship of Serum Osteocalcin Concentration to Insulin Secretion, Sensitivity, and Disposal with Hypocaloric Diet and Resistance Training

(2008) Jose Manuel Fernández-Real et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study

(2008) JB Richards et al.   LANCET

Roles of Wnt/β-catenin signaling in adipogenic differentiation potential of adipose-derived mesenchymal stem cells

(2008) Hui-Xia Li et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Germline mutations in WTX cause a sclerosing skeletal dysplasia but do not predispose to tumorigenesis

(2008) Zandra A Jenkins et al.   NATURE GENETICS

Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate

(2008) L. Pederson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetics, pathogenesis and complications of osteopetrosis

(2007) Andrea Del Fattore et al.   BONE

Cathepsin K inhibitors prevent matrix-derived growth factor degradation by human osteoclasts

(2007) Karen Fuller et al.   BONE