Mechanisms in Endocrinology: Notch signaling in skeletal health and disease

Collaborative Meta-analysis: Associations of 150 Candidate Genes With Osteoporosis and Osteoporotic Fracture

(2013) J. Brent Richards   ANNALS OF INTERNAL MEDICINE

Notch activation inhibits AML growth and survival: a potential therapeutic approach

(2013) Sankaranarayanan Kannan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Endogenous Bone Marrow MSCs Are Dynamic, Fate-Restricted Participants in Bone Maintenance and Regeneration

(2012) Dongsu Park et al.   Cell Stem Cell

The mechanism of somite formation in mice

(2012) Yumiko Saga   CURRENT OPINION IN GENETICS & DEVELOPMENT

Cartilage-specific RBPj -dependent and -independent Notch signals regulate cartilage and bone development

(2012) A. Kohn et al.   DEVELOPMENT

Chondroitin sulfate synthase 1 (Chsy1) is required for bone development and digit patterning

(2012) Deanna G. Wilson et al.   DEVELOPMENTAL BIOLOGY

Notch Suppresses Nuclear Factor of Activated T Cells (Nfat) Transactivation andNfatc1Expression in Chondrocytes

(2012) Stefano Zanotti et al.   ENDOCRINOLOGY

Osteoblast Lineage-Specific Effects of Notch Activation in the Skeleton

(2012) Ernesto Canalis et al.   ENDOCRINOLOGY

Notch gain of function inhibits chondrocyte differentiation via Rbpj-dependent suppression ofSox9

(2012) Shan Chen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The molecular basis of T cell acute lymphoblastic leukemia

(2012) Pieter Van Vlierberghe et al.   JOURNAL OF CLINICAL INVESTIGATION

Lfng regulates the synchronized oscillation of the mouse segmentation clock via trans-repression of Notch signalling

(2012) Yusuke Okubo et al.   Nature Communications

Genetic and clinical profiles of spondylocostal dysostosis patients in Taiwan

(2011) Chung-Hsing Wang et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Hajdu-Cheney syndrome with severe dural ectasia

(2011) Kristiina Avela et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Notch Regulation of Bone Development and Remodeling and Related Skeletal Disorders

(2011) Stefano Zanotti et al.   CALCIFIED TISSUE INTERNATIONAL

Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells

(2011) Nilay Sethi et al.   CANCER CELL

A step forward on the path towards understanding osteoporosis

(2011) E Fisher   CLINICAL GENETICS

Serpentine fibula polycystic kidney syndrome is part of the phenotypic spectrum of Hajdu–Cheney syndrome

(2011) Mary J Gray et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Cranial neural crest ablation of Jagged1 recapitulates the craniofacial phenotype of Alagille syndrome patients

(2011) Ryan Humphreys et al.   HUMAN MOLECULAR GENETICS

Serpentine fibula-polycystic kidney syndrome caused by truncating mutations in NOTCH2

(2011) Bertrand Isidor et al.   HUMAN MUTATION

Mutations in NOTCH2 in families with Hajdu-Cheney syndrome

(2011) Jacek Majewski et al.   HUMAN MUTATION

The cautionary tale of side effects of chronic Notch1 inhibition

(2011) Sandra W. Ryeom   JOURNAL OF CLINICAL INVESTIGATION

Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice

(2011) Zhenyi Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

NOTCH2mutations in Alagille syndrome

(2011) Binita Maya Kamath et al.   JOURNAL OF MEDICAL GENETICS

Truncating mutations in the last exon of NOTCH2 cause a rare skeletal disorder with osteoporosis

(2011) Bertrand Isidor et al.   NATURE GENETICS

Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss

(2011) Michael A Simpson et al.   NATURE GENETICS

Hypoxia-induced Jagged2 promotes breast cancer metastasis and self-renewal of cancer stem-like cells

(2011) F Xing et al.   ONCOGENE

Initial testing (stage 1) by the pediatric preclinical testing program of RO4929097, a γ-secretase inhibitor targeting notch signaling

(2011) E. Anders Kolb et al.   PEDIATRIC BLOOD & CANCER

Loss of CHSY1, a Secreted FRINGE Enzyme, Causes Syndromic Brachydactyly in Humans via Increased NOTCH Signaling

(2010) Jing Tian et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Association of JAG1 with Bone Mineral Density and Osteoporotic Fractures: A Genome-wide Association Study and Follow-up Replication Studies

(2010) Annie W.C. Kung et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Notch3 in Human Breast Cancer Cell Lines Regulates Osteoblast-Cancer Cell Interactions and Osteolytic Bone Metastasis

(2010) Zhiyuan Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

RBPj -dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development

(2010) Y. Dong et al.   DEVELOPMENT

Two novel missense mutations in HAIRY-AND-ENHANCER-OF-SPLIT-7 in a family with spondylocostal dysostosis

(2010) Duncan B Sparrow et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Jagged1 (JAG1) mutations in patients with tetralogy of fallot or pulmonic stenosis

(2010) Robert C. Bauer et al.   HUMAN MUTATION

HES1 (Hairy and Enhancer of Split 1) Is a Determinant of Bone Mass

(2010) Stefano Zanotti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osteosclerosis owing to Notch gain of function is solely Rbpj-dependent

(2010) Jianning Tao et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The amazing osteocyte

(2010) Lynda F Bonewald   JOURNAL OF BONE AND MINERAL RESEARCH

Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma

(2009) Suk-young Lee et al.   CANCER SCIENCE

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Notch Signaling: The Core Pathway and Its Posttranslational Regulation

(2009) Mark E. Fortini   DEVELOPMENTAL CELL

Notch signaling contributes to the pathogenesis of human osteosarcomas

(2009) F. Engin et al.   HUMAN MOLECULAR GENETICS

Advanced Vertebral Fracture Among Newly Diagnosed Children With Acute Lymphoblastic Leukemia: Results of the Canadian Steroid-Associated Osteoporosis in the Pediatric Population (STOPP) Research Program

(2009) Jacqueline Halton et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Notch and the Skeleton

(2009) S. Zanotti et al.   MOLECULAR AND CELLULAR BIOLOGY

Direct inhibition of the NOTCH transcription factor complex

(2009) Raymond E. Moellering et al.   NATURE

Notch pathway regulation of chondrocyte differentiation and proliferation during appendicular and axial skeleton development

(2009) T. J. Mead et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in the MESP2 Gene Cause Spondylothoracic Dysostosis/Jarcho-Levin Syndrome

(2008) Alberto S. Cornier et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Defective Notch activation in microenvironment leads to myeloproliferative disease

(2008) Y.-W. Kim et al.   BLOOD

Critical Role of Notch Signaling in Osteosarcoma Invasion and Metastasis

(2008) P. Zhang et al.   CLINICAL CANCER RESEARCH

Notch Inhibits Osteoblast Differentiation and Causes Osteopenia

(2008) Stefano Zanotti et al.   ENDOCRINOLOGY

Mutation of HAIRY-AND-ENHANCER-OF-SPLIT-7 in humans causes spondylocostal dysostosis

(2008) D. B. Sparrow et al.   HUMAN MOLECULAR GENETICS

The Association of Notch2 and NF- B Accelerates RANKL-Induced Osteoclastogenesis

(2008) H. Fukushima et al.   MOLECULAR AND CELLULAR BIOLOGY

Dimorphic effects of Notch signaling in bone homeostasis

(2008) Feyza Engin et al.   NATURE MEDICINE

Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation

(2008) Matthew J Hilton et al.   NATURE MEDICINE

Brachydactyly

(2008) Samia A Temtamy et al.   Orphanet Journal of Rare Diseases

Hajdu-Cheney syndrome associated with serpentine fibulae and polycystic kidney disease

(2008) Guido Currarino   PEDIATRIC RADIOLOGY