MECHANISMS IN ENDOCRINOLOGY: Biological role, clinical significance, and therapeutic possibilities of the recently discovered metabolic hormone fibroblastic growth factor 21

Serum fibroblast growth factor 21 was elevated in subjects with type 2 diabetes mellitus and was associated with the presence of carotid artery plaques

(2012) So-Yeon An et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

FGF21 regulates PGC-1  and browning of white adipose tissues in adaptive thermogenesis

(2012) f. M. Fisher et al.   GENES & DEVELOPMENT

Relationship of Serum Fibroblast Growth Factor 21 with Abnormal Glucose Metabolism and Insulin Resistance: The Baltimore Longitudinal Study of Aging

(2012) Richard D. Semba et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Fibroblast Growth Factor 21 (FGF-21) and Its Relation to Obesity, Metabolic Syndrome, and Nonalcoholic Fatty Liver in Children: A Longitudinal Analysis

(2012) Thomas Reinehr et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Serum Fibroblast Growth Factor 21 Is Associated with Renal Function and Chronic Kidney Disease in Community-Dwelling Adults

(2012) Candace Crasto et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Various Oscillation Patterns of Serum Fibroblast Growth Factor 21 Concentrations in Healthy Volunteers

(2012) Sang Ah Lee et al.   Diabetes & Metabolism Journal

Circadian Rhythm of Circulating Fibroblast Growth Factor 21 Is Related to Diurnal Changes in Fatty Acids in Humans

(2011) H. Yu et al.   CLINICAL CHEMISTRY

Plasma FGF21 displays a circadian rhythm during a 72-h fast in healthy female volunteers

(2011) Birgitte Andersen et al.   CLINICAL ENDOCRINOLOGY

Fibroblast growth factor 21: effects on carbohydrate and lipid metabolism in health and disease

(2011) Susan Kralisch et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Mitiglinide treatment may decreases plasma fibroblast growth factor-21 levels in individuals with new-onset T2DM

(2011) Bo Wang et al.   CYTOKINE

FGF21 Analogs of Sustained Action Enabled by Orthogonal Biosynthesis Demonstrate Enhanced Antidiabetic Pharmacology in Rodents

(2011) J. Mu et al.   DIABETES

Direct effects of FGF21 on glucose uptake in human skeletal muscle: implications for type 2 diabetes and obesity

(2011) Fredirick L. Mashili et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Exenatide decreases hepatic fibroblast growth factor 21 resistance in non-alcoholic fatty liver disease in a mouse model of obesity and in a randomised controlled trial

(2011) S. L. Samson et al.   DIABETOLOGIA

Serum FGF-21 Levels in Type 2 Diabetic Patients

(2011) Xingbo Cheng et al.   ENDOCRINE RESEARCH

Growth Hormone Stimulates Transcription of the Fibroblast Growth Factor 21 Gene in the Liver through the Signal Transducer and Activator of Transcription 5

(2011) Jie Yu et al.   ENDOCRINOLOGY

Lack of Overt FGF21 Resistance in Two Mouse Models of Obesity and Insulin Resistance

(2011) Clarence Hale et al.   ENDOCRINOLOGY

Growth Hormone Induces Hepatic Production of Fibroblast Growth Factor 21 through a Mechanism Dependent on Lipolysis in Adipocytes

(2011) Wei Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fibroblast Growth Factor 21 Induces Glucose Transporter-1 Expression through Activation of the Serum Response Factor/Ets-Like Protein-1 in Adipocytes

(2011) Xuan Ge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Changes in Serum Fibroblast Growth Factor 21 Levels in Different Subtypes of Diabetes

(2011) Yang Xiao et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Association between serum fibroblast growth factor 21 and diabetic nephropathy

(2011) Wei-Xia Jian et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The effects of fibroblast growth factor-21 knockdown and over-expression on its signaling pathway and glucose–lipid metabolism in vitro

(2011) Ke Li et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A Better Anti-Diabetic Recombinant Human Fibroblast Growth Factor 21 (rhFGF21) Modified with Polyethylene Glycol

(2011) Zhifeng Huang et al.   PLoS One

Circulating FGF21 Levels Are Progressively Increased from the Early to End Stages of Chronic Kidney Diseases and Are Associated with Renal Function in Chinese

(2011) Zhuofeng Lin et al.   PLoS One

Paradoxical Regulation of Human FGF21 by Both Fasting and Feeding Signals: Is FGF21 a Nutritional Adaptation Factor?

(2011) Takashi Uebanso et al.   PLoS One

Circulating Fibroblast Growth Factor 21 Levels Are Closely Associated with Hepatic Fat Content: A Cross-Sectional Study

(2011) Hongmei Yan et al.   PLoS One

Effects of Short-Term Continuous Subcutaneous Insulin Infusion on Fasting Plasma Fibroblast Growth Factor-21 Levels in Patients with Newly Diagnosed Type 2 Diabetes Mellitus

(2011) Mengliu Yang et al.   PLoS One

Amelioration of Type 2 Diabetes by Antibody-Mediated Activation of Fibroblast Growth Factor Receptor 1

(2011) A.-L. Wu et al.   Science Translational Medicine

Effects of postbariatric surgery weight loss on adipokines and metabolic parameters: comparison of laparoscopic Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy—a prospective randomized trial

(2011) Bettina Woelnerhanssen et al.   Surgery for Obesity and Related Diseases

Physiological modulation of circulating FGF21: relevance of free fatty acids and insulin

(2010) Knut Mai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Glucagon and lipid interactions in the regulation of hepatic AMPK signaling and expression of PPARα and FGF21 transcripts in vivo

(2010) Eric D. Berglund et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hepatic FGF21 Expression Is Induced at Birth via PPARα in Response to Milk Intake and Contributes to Thermogenic Activation of Neonatal Brown Fat

(2010) Elayne Hondares et al.   Cell Metabolism

Fibroblast Growth Factor 21 Action in the Brain Increases Energy Expenditure and Insulin Sensitivity in Obese Rats

(2010) D. A. Sarruf et al.   DIABETES

Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State

(2010) f. M. Fisher et al.   DIABETES

Increased serum FGF21 levels in patients with nonalcoholic fatty liver disease

(2010) Yusuf Yilmaz et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Increased Fibroblast Growth Factor 21 in Obesity and Nonalcoholic Fatty Liver Disease

(2010) Jody Dushay et al.   GASTROENTEROLOGY

Serum fibroblast growth factor 21 levels in polycystic ovary syndrome

(2010) Suheyla Gorar et al.   GYNECOLOGICAL ENDOCRINOLOGY

Liver Fat But Not Other Adiposity Measures Influence Circulating FGF21 Levels in Healthy Young Adult Twins

(2010) Henna Tyynismaa et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride

(2010) Huating Li et al.   JOURNAL OF HEPATOLOGY

Serum fibroblast growth factor–21 concentration is associated with residual renal function and insulin resistance in end-stage renal disease patients receiving long-term peritoneal dialysis

(2010) Seung Hyeok Han et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Relation between fibroblast growth factor–21, adiposity, metabolism, and weight reduction

(2010) Knut Mai et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Serum Levels of FGF-21 Are Increased in Coronary Heart Disease Patients and Are Independently Associated with Adverse Lipid Profile

(2010) Zhuofeng Lin et al.   PLoS One

Fibroblast Growth Factor-21 as a Therapeutic Agent for Metabolic Diseases

(2009) Alexei Kharitonenkov et al.   BIODRUGS

Endocrine fibroblast growth factors as regulators of metabolic homeostasis

(2009) Hiroshi Kurosu et al.   BIOFACTORS

Free Fatty Acids Link Metabolism and Regulation of the Insulin-Sensitizing Fibroblast Growth Factor-21

(2009) K. Mai et al.   DIABETES

Fibroblast Growth Factor-21 Is Induced in Human Skeletal Muscles by Hyperinsulinemia

(2009) Pernille Hojman et al.   DIABETES

Circulating Fibroblast Growth Factor-21 Is Elevated in Impaired Glucose Tolerance and Type 2 Diabetes and Correlates With Muscle and Hepatic Insulin Resistance

(2009) A. O. Chavez et al.   DIABETES CARE

Fibroblast Growth Factor 21 Controls Glycemia via Regulation of Hepatic Glucose Flux and Insulin Sensitivity

(2009) Eric D. Berglund et al.   ENDOCRINOLOGY

Fibroblast Growth Factor 21 Regulates Lipolysis in White Adipose Tissue But Is Not Required for Ketogenesis and Triglyceride Clearance in Liver

(2009) Yuhei Hotta et al.   ENDOCRINOLOGY

Effects of rosiglitazone on fasting plasma fibroblast growth factor-21 levels in patients with type 2 diabetes mellitus

(2009) Ke Li et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 inob/obmice

(2009) Xiaofan Li et al.   FEBS LETTERS

Fibroblast Growth Factor 21 Reduces the Severity of Cerulein-Induced Pancreatitis in Mice

(2009) Charis L. Johnson et al.   GASTROENTEROLOGY

Molecular pathology of the fibroblast growth factor family

(2009) Pavel Krejci et al.   HUMAN MUTATION

Serum fibroblast growth factor 21 levels in gestational diabetes mellitus in relation to insulin resistance and dyslipidemia

(2009) Sebastian Stein et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The FGF family: biology, pathophysiology and therapy

(2009) Andrew Beenken et al.   NATURE REVIEWS DRUG DISCOVERY

The Circulating Metabolic Regulator FGF21 Is Induced by Prolonged Fasting and PPARα Activation in Man

(2008) Cecilia Gälman et al.   Cell Metabolism

Serum concentrations and tissue expression of a novel endocrine regulator fibroblast growth factor-21 in patients with type 2 diabetes and obesity

(2008) M. Mraz et al.   CLINICAL ENDOCRINOLOGY

Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans

(2008) X. Zhang et al.   DIABETES

Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice

(2008) J. Xu et al.   DIABETES

Serum Levels of the Adipokine FGF21 Depend on Renal Function

(2008) S. Stein et al.   DIABETES CARE

Plasma FGF-21 levels in type 2 diabetic patients with ketosis

(2008) Ling Li et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Fibroblast Growth Factor 21 Corrects Obesity in Mice

(2008) Tamer Coskun et al.   ENDOCRINOLOGY

FGF21 attenuates lipolysis in human adipocytes - A possible link to improved insulin sensitivity

(2008) Peter Arner et al.   FEBS LETTERS

Plasma Concentrations of Fibroblast Growth Factors 19 and 21 in Patients with Anorexia Nervosa

(2008) Ivana Dostálová et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Klotho gene family as a regulator of endocrine fibroblast growth factors

(2008) Hiroshi Kurosu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

βKlotho Is Required for Fibroblast Growth Factor (FGF) 21 Signaling through FGF Receptor (FGFR) 1c and FGFR3c

(2008) Masashi Suzuki et al.   MOLECULAR ENDOCRINOLOGY

Adipose Fibroblast Growth Factor 21 Is Up-Regulated by Peroxisome Proliferator-Activated Receptor   and Altered Metabolic States

(2008) E. S. Muise et al.   MOLECULAR PHARMACOLOGY

Endocrine FGFs and Klothos: emerging concepts

(2008) Makoto Kuro-o   TRENDS IN ENDOCRINOLOGY AND METABOLISM