Otitis media among high-risk populations: can probiotics inhibit Streptococcus pneumoniae colonisation and the risk of disease?

Clinical evaluation of the oral probioticStreptococcus salivariusK12 in the prevention of recurrent pharyngitis and/or tonsillitis caused byStreptococcus pyogenesin adults

(2013) Francesco Di Pierro et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

In VitroFunctional and Immunomodulatory Properties of the Lactobacillus helveticus MIMLh5-Streptococcus salivarius ST3 Association That Are Relevant to the Development of a Pharyngeal Probiotic Product

(2012) Valentina Taverniti et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Viral–Bacterial Interactions in Acute Otitis Media

(2012) Tal Marom et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Bacteriocin-producing oral streptococci and inhibition of respiratory pathogens

(2012) Maria Santagati et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Probiotics and otitis media in children

(2012) Leena Niittynen et al.   INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY

Beneficial effects of probiotics in upper respiratory tract infections and their mechanical actions to antagonize pathogens

(2012) M. Popova et al.   JOURNAL OF APPLIED MICROBIOLOGY

Nasopharyngeal Microbiota in Infants With Acute Otitis Media

(2012) Markus Hilty et al.   JOURNAL OF INFECTIOUS DISEASES

Regulation of bacterial trafficking in the nasopharynx

(2012) Stephen I. Pelton   Paediatric Respiratory Reviews

Increased Nasopharyngeal Bacterial Titers and Local Inflammation Facilitate Transmission of Streptococcus pneumoniae

(2012) K. R. Short et al.   mBio

Protecting against Pneumococcal Disease: Critical Interactions between Probiotics and the Airway Microbiome

(2012) Paul V. Licciardi et al.   PLoS Pathogens

Salivaricin D, a Novel Intrinsically Trypsin-Resistant Lantibiotic from Streptococcus salivarius 5M6c Isolated from a Healthy Infant

(2011) Dagim Jirata Birri et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The Otologic MicrobiomeA Study of the Bacterial Microbiota in a Pediatric Patient With Chronic Serous Otitis Media Using 16SrRNA Gene-Based Pyrosequencing

(2011) Cindy M. Liu   ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY

Viral-bacterial co-infection in Australian Indigenous children with acute otitis media

(2011) Michael J Binks et al.   BMC INFECTIOUS DISEASES

Evaluation of safety and human tolerance of the oral probiotic Streptococcus salivarius K12: A randomized, placebo-controlled, double-blind study

(2011) J.P. Burton et al.   FOOD AND CHEMICAL TOXICOLOGY

Lactic acid bacteria in the prevention of pneumococcal respiratory infection: Future opportunities and challenges

(2011) Julio Villena et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Epidemiology of acute otitis media in children of Latin America and the Caribbean: A systematic review and meta-analysis

(2011) Ariel Bardach et al.   INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY

Viral-Bacterial Interactions and Risk of Acute Otitis Media Complicating Upper Respiratory Tract Infection

(2011) Melinda M. Pettigrew et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Influenza Virus Induces Bacterial and Nonbacterial Otitis Media

(2011) Kirsty R. Short et al.   JOURNAL OF INFECTIOUS DISEASES

High detection rates of nucleic acids of a wide range of respiratory viruses in the nasopharynx and the middle ear of children with a history of recurrent acute otitis media

(2011) Selma P. Wiertsema et al.   JOURNAL OF MEDICAL VIROLOGY

Variability and Diversity of Nasopharyngeal Microbiota in Children: A Metagenomic Analysis

(2011) Debby Bogaert et al.   PLoS One

Impact of the 10-valent pneumococcal non-typeable Haemophilus influenzae Protein D conjugate vaccine (PHiD-CV) on bacterial nasopharyngeal carriage

(2011) Roman Prymula et al.   VACCINE

Microbial Communities of the Upper Respiratory Tract and Otitis Media in Children

(2011) A. S. Laufer et al.   mBio

Oral Bacteria as Potential Probiotics for the Pharyngeal Mucosa

(2010) S. Guglielmetti et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Dynamic models of pneumococcal carriage and the impact of the Heptavalent Pneumococcal Conjugate Vaccine on invasive pneumococcal disease

(2010) Alessia Melegaro et al.   BMC INFECTIOUS DISEASES

Bifidobacterium animalis subsp. lactis BB-12 in reducing the risk of infections in infancy

(2010) Teemu Taipale et al.   BRITISH JOURNAL OF NUTRITION

Therapeutical use of probiotic formulations in clinical practice

(2010) T. Iannitti et al.   CLINICAL NUTRITION

Influenza A virus facilitates Streptococcus pneumoniae transmission and disease

(2010) Dimitri A. Diavatopoulos et al.   FASEB JOURNAL

Immunomodulatory activity of Lactobacillus rhamnosus strains isolated from goat milk: Impact on intestinal and respiratory infections

(2010) Susana Salva et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

Diagnosis, Microbial Epidemiology, and Antibiotic Treatment of Acute Otitis Media in Children

(2010) Tumaini R. Coker et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Systematic Evaluation of Serotypes Causing Invasive Pneumococcal Disease among Children Under Five: The Pneumococcal Global Serotype Project

(2010) Hope L. Johnson et al.   PLOS MEDICINE

Biofilms and chronic otitis media: an initial exploration into the role of biofilms in the pathogenesis of chronic otitis media

(2009) Michael Hoa et al.   AMERICAN JOURNAL OF OTOLARYNGOLOGY

Pneumococcal vaccination and otitis media in Australian Aboriginal infants: comparison of two birth cohorts before and after introduction of vaccination

(2009) Grant Austin Mackenzie et al.   BMC Pediatrics

Effect of Long-Term Consumption of Milk Supplemented with Probiotic Lactobacilli and Fluoride on Dental Caries and General Health in Preschool Children: A Cluster-Randomized Study

(2009) C. Stecksén-Blicks et al.   CARIES RESEARCH

Streptococcal bacteriocins and the case forStreptococcus salivariusas model oral probiotics

(2009) Philip A Wescombe et al.   Future Microbiology

Epidemiology, natural history, and risk factors: Panel report from the Ninth International Research Conference on Otitis Media

(2009) Kathleen A. Daly et al.   INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY

Enhanced immune response to pneumococcal infection in malnourished mice nasally treated with heat-killedLactobacillus casei

(2009) Julio Villena et al.   MICROBIOLOGY AND IMMUNOLOGY

Effect of vaccination with pneumococcal capsular polysaccharides conjugated to Haemophilus influenzae-derived protein D on nasopharyngeal carriage of Streptococcus pneumoniae and H. influenzae in children under 2 years of age

(2009) Roman Prymula et al.   VACCINE

Spray bacteriotherapy decreases middle ear fluid in children with secretory otitis media

(2008) S Skovbjerg et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Characterization of biofilm matrix, degradation by DNase treatment and evidence of capsule downregulation in Streptococcus pneumoniae clinical isolates

(2008) Luanne Hall-Stoodley et al.   BMC MICROBIOLOGY

Compared to placebo, long-term antibiotics resolve otitis media with effusion (OME) and prevent acute otitis media with perforation (AOMwiP) in a high-risk population: A randomized controlled trial

(2008) Amanda J Leach et al.   BMC Pediatrics

Specific probiotics in reducing the risk of acute infections in infancy – a randomised, double-blind, placebo-controlled study

(2008) Samuli Rautava et al.   BRITISH JOURNAL OF NUTRITION

Preliminary investigations of the colonisation of upper respiratory tract tissues of infants using a paediatric formulation of the oral probiotic Streptococcus salivarius K12

(2008) D. A. Power et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Mechanisms of action of probiotics: Recent advances

(2008) S. C. Ng et al.   INFLAMMATORY BOWEL DISEASES

The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease

(2008) Aras Kadioglu et al.   NATURE REVIEWS MICROBIOLOGY

The role of chronic infection in children with otitis media with effusion: Evidence for intracellular persistence of bacteria

(2008) Harvey Coates AO et al.   OTOLARYNGOLOGY-HEAD AND NECK SURGERY

THE GLOBAL BURDEN OF CHILDHOOD OTITIS MEDIA AND HEARING IMPAIRMENT: A SYSTEMATIC REVIEW

(2008) Hasantha Gunasekera et al.   PEDIATRICS

Middle ear infections

(2008) Gösta Granström   PERIODONTOLOGY 2000

Immunisation coverage in Australian Indigenous children: Time to move the goal posts

(2008) Kerry-Ann O’Grady et al.   VACCINE

Interventions for prevention of otitis media may be most effective if implemented in the first weeks of life

(2007) Heidi Smith-Vaughan et al.   INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY