Article
Medicine, General & Internal
Kyu Hyun Park, Seung-Ah Choe, Ju-Young Shin, Young June Choe
Summary: This study describes the changing patterns of antibiotic use in children with acute otitis media in South Korea. The prescription of amoxicillin has increased while cephalosporin and macrolide use has decreased. Multifaceted approaches are needed to control antimicrobial resistance.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Tzu Yu Chen, John D. F. Hale, John R. Tagg, Rohit Jain, Abigail L. Voss, Nikki Mills, Emma J. Best, Duncan S. Stevenson, Philip A. Bird, Tony Walls
Summary: This study assessed the in vitro inhibitory activity of Streptococcus salivarius BLIS K12 against otitis media pathogens, showing that 48% of isolates were inhibited by S. salivarius BLIS K12. This bacteriocin is effective in inhibiting the growth of the most common otitis media pathogens.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2021)
Article
Immunology
Hannah Griffith, Andrew D. Wiese, Edward F. Mitchel, Carlos G. Grijalva
Summary: The introduction of PCV13 vaccine led to reductions in otitis media among US children, but its impact on antibiotic use for otitis media remained stable among Tennessee children under 2 years of age.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Review
Biochemistry & Molecular Biology
Su Young Jung, Dokyoung Kim, Dong Choon Park, Eun Hye Lee, Yong-Sung Choi, Jeewon Ryu, Sang Hoon Kim, Seung Geun Yeo
Summary: Otitis media is caused by various factors including infections, anatomo-physiological abnormalities, allergies, and environmental influences. This study highlights the immune responses in otitis media patients, focusing on antibodies and transcription factors produced by B cells, as well as the important functions of B cells in immune defense.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Saskia Hullegie, Anne G. M. Schilder, Paola Marchisio, Joline L. H. de Sevaux, Alike W. van der Velden, Alma C. van de Pol, Josi A. Boeijen, Tamara N. Platteel, Sara Torretta, Roger A. M. J. Damoiseaux, Roderick P. Venekamp
Summary: In the Netherlands, the incidence of childhood otitis media decreased significantly during the COVID-19 pandemic, leading to a decrease in patient visits for ear infections. However, the proportion of antibiotic prescriptions remained similar before and during the pandemic, suggesting a true decline in cases due to infection control measures.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Otorhinolaryngology
O. Cavel, O. J. Ungar, Y. Oron, R. Ben Ami, M. Dekel, O. Handzel
Summary: The study retrospectively evaluated the effectiveness of surgical treatment for ciprofloxacin-resistantP. aeruginosaCSOM, showing a high success rate in resolving infection and achieving tympanic graft take with tympanoplasty. No surgical complications occurred during the procedures, and the average follow-up period was 20 months.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Review
Virology
Soo-Young Choi, Dong-Keon Yon, Yong-Sung Choi, Jinseok Lee, Ki-Ho Park, Young-Ju Lee, Sung-Soo Kim, Sang-Hoon Kim, Seung-Geun Yeo
Summary: This review examines the impact of COVID-19 on otitis media and highlights the unexpected positive effects brought about by measures implemented in response to the pandemic. These effects include a drastic reduction in the incidence of otitis media, decrease in antibiotic prescriptions, lower occurrence of complications, and decreased number of patients visiting the emergency room for otitis media. The findings have significant implications for the treatment and prevention of otitis media.
Review
Biochemistry & Molecular Biology
Su Young Jung, Dokyoung Kim, Dong Choon Park, Sung Soo Kim, Tong In Oh, Dae Woong Kang, Sang Hoon Kim, Seung Geun Yeo
Summary: Otitis media is mainly caused by upper respiratory tract infection and eustachian tube dysfunction. The expression of Toll-like receptors (TLRs) is closely related to the occurrence, recurrence, chronicization, and complications of otitis media, playing an important role in the early response to external antigens.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Otorhinolaryngology
Jeannie Y. Chang Pitter, Lydia Zhong, Rana F. Hamdy, Diego Preciado, Hengameh Behzadpour, Ellen K. Hamburger
Summary: The use of intramuscular ceftriaxone, particularly for otitis-conjunctivitis, has increased in primary care academic practice. This study found a strong correlation between the presence of conjunctivitis and receipt of ceftriaxone treatment for acute otitis media. Younger patients were also more likely to receive ceftriaxone treatment.
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2022)
Article
Environmental Sciences
Laura C. Scott, Mark J. Wilson, Scott M. Esser, Nicholas L. Lee, Michael E. Wheeler, Alexandra Aubee, Tiong Gim Aw
Summary: The study revealed that human activities significantly impact the presence and abundance of antibiotic resistant bacteria and antibiotic resistance genes in national park environments. However, ecological factors such as water movement, soil texture, and season also play a role in the detection of these resistant substances.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Mathematical & Computational Biology
Wanying Dou, Hemn Barzan Abdalla, Xu Chen, Changyi Sun, Xuefei Chen, Qiwen Tian, Junyi Wang, Wei Zhou, Wei Chi, Xuan Zhou, Hailv Ye, Chuyun Bi, Xuechen Tian, Yixin Yang, Aloysius Wong
Summary: Drug resistance is a global threat, and the consumption of probiotic-containing foods with antibiotic resistant determinants raises health concerns. The lack of specific information about drug-resistant probiotics hampers efforts to combat drug resistance. Therefore, ProbResist, an online database, has been developed to provide quick access to information about drug resistance in probiotics for medical practitioners and policy makers.
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
(2022)
Article
Microbiology
Maria Daniela Silva, Antonio Lima, Nuno Marcal, Luis Dias, Miguel Gama, Sanna Sillankorva
Summary: Understanding the bacterial causes of otitis media is crucial for effective treatment. This study analyzed samples from 49 children with otitis media in Portugal, finding a correlation between bacteria in the middle ear fluid and nasopharynx. The most commonly identified species were Moraxella catarrhalis and Streptococcus pneumoniae, but Haemophilus influenzae was more prevalent in the middle ear fluid. The study also revealed the importance of polymicrobial infections in otitis media.
Article
Pharmacology & Pharmacy
Yue Su, Chu Wang, Hong Zhang, Lifang Guo, Yongshi Liang, Min Xiong, Xiaohua Feng, Daishi Chen, Zhaoyang Ke, Lu Wen, Gang Chen
Summary: This study reported an antibacterial nanocomposite composed of herbal antibacterial agents and Chitosan, combined with sonodynamic therapy for the treatment of otitis media. The nanocomposite demonstrated excellent antibacterial and anti-inflammatory activity, without inducing bacterial resistance and showing good biocompatibility.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Microbiology
Cristina Gavrilovici, Elena-Lia Spoiala, Ingrith-Crenguta Miron, Iuliana Magdalena Starcea, Codruta Olimpiada Iliescu Halitchi, Irina Nicoleta Zetu, Vasile Valeriu Lupu, Carmen Panzaru
Summary: Acute otitis media (AOM) remains a major reason for antibiotic use in children, despite the availability of pneumococcal conjugate vaccines. A study conducted in a pediatric emergency hospital in Romania found that Streptococcus pneumoniae and Haemophilus influenzae were the most common bacteria associated with AOM. Alarmingly, a high proportion of the Streptococcus pneumoniae strains were resistant to multiple drugs. This highlights the importance of addressing antimicrobial resistance to minimize the negative impact on healthcare costs.
Review
Microbiology
Wellison Amorim Pereira, Carlos Miguel N. Mendonca, Alejandro Villasante Urquiza, Viggo Por Marteinsson, Jean Guy LeBlanc, Paul D. Cotter, Elias Figueroa Villalobos, Jaime Romero, Ricardo P. S. Oliveira
Summary: In addition to human medicine, antimicrobials are used in food animals and aquaculture for therapeutic purposes against bacterial infections. However, their use in aquaculture can lead to environmental consequences and the spread of bacterial resistance genes. Probiotics and bacteriocins derived from lactic acid bacteria offer potential alternatives to antibiotics for controlling bacterial infections.